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Title: S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness.
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Title: Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.
Journal: Journal of biomedical science 20110101
Title: Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides.
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Title: Regulation of 3',5'-cAMP in preglomerular smooth muscle and endothelial cells from genetically hypertensive rats.
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Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
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Title: Acute stress impairs hippocampal mossy fiber-CA3 long-term potentiation by enhancing cAMP-specific phosphodiesterase 4 activity.
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Title: Regulation of renovascular adenosine 3',5'-cyclic monophosphate in spontaneously hypertensive rats.
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Title: Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP.
Journal: American journal of physiology. Heart and circulatory physiology 20090301
Title: Intravenously administered phosphodiesterase 4 inhibitors dilate retinal blood vessels in rats.
Journal: European journal of pharmacology 20090105
Title: Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway.
Journal: Neuroscience letters 20090102
Title: Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.
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Title: Inhibition of phosphodiesterase has an additive effect on estrogen's ability to inhibit collagen synthesis in vascular smooth muscle cells.
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Title: Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways.
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Title: Antipsychotic-like properties of phosphodiesterase 4 inhibitors: evaluation of 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (RO-20-1724) with auditory event-related potentials and prepulse inhibition of startle.
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Title: Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.
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Title: Effect of cyclic AMP on barrier function of human lymphatic microvascular tubes.
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Title: Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion.
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Title: Autoregulation in PC12 cells via P2Y receptors: Evidence for non-exocytotic nucleotide release from neuroendocrine cells.
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Title: Differential regulation of synaptic transmission by adrenergic agonists via protein kinase A and protein kinase C in layer V pyramidal neurons of rat cerebral cortex.
Journal: Neuroscience 20070608
Title: Dual regulation of the ATP-sensitive potassium channel by caffeine.
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Title: The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4.
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Title: Ca(2+)-dependent K(+) currents and spike-frequency adaptation in medial entorhinal cortex layer II stellate cells.
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Title: Chronic ethanol feeding suppresses beta-adrenergic receptor-stimulated lipolysis in adipocytes isolated from epididymal fat.
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Title: Characteristics of taurine release in slices from adult and developing mouse brain stem.
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Title: Inhibition of PGI2 signaling by miconazole in vascular smooth muscle cells.
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Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
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Title: Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.
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Title: Phosphodiesterase IV and neutral endopeptidase in airways from developing and allergen sensitized rabbits.
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Title: Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in the guinea pig gall bladder.
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Title: Role of the adenosine 3',5'-cyclic monophosphate (cAMP) in enhancing the efficacy of siRNA-mediated gene silencing in neuroblastoma cells.
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Title: Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.
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Title: Inhibition of mast cell histamine release by specific phosphodiesterase inhibitors.
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Title: NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.
Journal: European journal of pharmacology 20050131
Title: Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels.
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Title: Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats.
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Title: Phosphodiesterase-linked inhibition of nonmicturition activity in the isolated bladder.
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Title: Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability.
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Title: The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma.
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Title: Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.
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Title: Effects of phosphodiesterase inhibitors on spontaneous nuclear maturation and cAMP concentrations in bovine oocytes.
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Title: Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes.
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Title: The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.
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Title: Type IV phosphodiesterase inhibition improves cardiac contractility in endotoxemic rats.
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Title: Norepinephrine induces slow calcium signalling in murine brown preadipocytes through the beta-adrenoceptor/cAMP/protein kinase A pathway.
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Title: Subtype-specific roles of cAMP phosphodiesterases in regulation of atrial natriuretic peptide release.
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Title: Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of HT-1080 human fibrosarcoma cells in vitro and in vivo.
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Title: Regulation of glypican-1, syndecan-1 and syndecan-4 mRNAs expression by follicle-stimulating hormone, cAMP increase and calcium influx during rat Sertoli cell development.
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Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
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Title: Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease.
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Title: Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: impact on phospholipase D activity and recruitment of small GTPases to membranes.
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Title: 17beta-estradiol modulates prostaglandin E2 release from human amnion-derived wish cells.
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Title: Phthalic acid mimics 17beta-estradiol actions in WISH cells.
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Title: Chronic type IV phosphodiesterase inhibition protects glomerular filtration rate and renal and mesenteric blood flow in a zymosan-induced model of multiple organ dysfunction syndrome treated with norepinephrine.
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Title: [Inhibition of uterine contractions: new in vitro pharmacological approaches on the pregnant human myometrium].
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Title: Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors.
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Title: Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells.
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