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29925-17-5,MFCD00077397
Catalog No.:AA01E3ZT

29925-17-5 | Ro20-1724

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25mg
≥95%
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$46.00   $32.00
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50mg
≥95%
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$72.00   $50.00
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100mg
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$125.00   $87.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E3ZT
Chemical Name:
Ro20-1724
CAS Number:
29925-17-5
Molecular Formula:
C15H22N2O3
Molecular Weight:
278.3468
MDL Number:
MFCD00077397
SMILES:
CCCCOc1cc(ccc1OC)CC1CNC(=O)N1
Properties
Computed Properties
 
Complexity:
312  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.4  

Literature

Title: Evaluating the significance of cyclic adenosine monophosphate-mediated signaling in human prostate: a functional and biochemical study.

Journal: Urology 20121001

Title: Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats.

Journal: Pharmacology, biochemistry, and behavior 20120401

Title: Linalool from rosewood (Aniba rosaeodora Ducke) oil inhibits adenylate cyclase in the retina, contributing to understanding its biological activity.

Journal: Phytotherapy research : PTR 20120101

Title: Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness.

Journal: Journal of medicinal chemistry 20111208

Title: Inhibition of phosphodiesterase-4 decreases ethanol intake in mice.

Journal: Psychopharmacology 20111101

Title: Effect of phoshpodiesterase 4 (PDE4) inhibibtors on eotaxin expression in humen bronchial epithelial cells.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20110601

Title: S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.

Journal: Journal of biomedical science 20110101

Title: Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides.

Journal: Urology 20101201

Title: Regulation of 3',5'-cAMP in preglomerular smooth muscle and endothelial cells from genetically hypertensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Acute stress impairs hippocampal mossy fiber-CA3 long-term potentiation by enhancing cAMP-specific phosphodiesterase 4 activity.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100601

Title: Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.

Journal: Circulation research 20091009

Title: Regulation of renovascular adenosine 3',5'-cyclic monophosphate in spontaneously hypertensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20090801

Title: Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP.

Journal: American journal of physiology. Heart and circulatory physiology 20090301

Title: Intravenously administered phosphodiesterase 4 inhibitors dilate retinal blood vessels in rats.

Journal: European journal of pharmacology 20090105

Title: Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway.

Journal: Neuroscience letters 20090102

Title: Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.

Journal: Psychopharmacology 20090101

Title: Inhibition of phosphodiesterase has an additive effect on estrogen's ability to inhibit collagen synthesis in vascular smooth muscle cells.

Journal: Vascular pharmacology 20090101

Title: Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways.

Journal: PloS one 20090101

Title: Antipsychotic-like properties of phosphodiesterase 4 inhibitors: evaluation of 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (RO-20-1724) with auditory event-related potentials and prepulse inhibition of startle.

Journal: The Journal of pharmacology and experimental therapeutics 20080701

Title: Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.

Journal: Circulation research 20080509

Title: Effect of cyclic AMP on barrier function of human lymphatic microvascular tubes.

Journal: Microvascular research 20080501

Title: Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion.

Journal: Cellular signalling 20071201

Title: Autoregulation in PC12 cells via P2Y receptors: Evidence for non-exocytotic nucleotide release from neuroendocrine cells.

Journal: Purinergic signalling 20070901

Title: Differential regulation of synaptic transmission by adrenergic agonists via protein kinase A and protein kinase C in layer V pyramidal neurons of rat cerebral cortex.

Journal: Neuroscience 20070608

Title: Dual regulation of the ATP-sensitive potassium channel by caffeine.

Journal: American journal of physiology. Cell physiology 20070601

Title: The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4.

Journal: Toxicology letters 20070110

Title: Ca(2+)-dependent K(+) currents and spike-frequency adaptation in medial entorhinal cortex layer II stellate cells.

Journal: Hippocampus 20070101

Title: Chronic ethanol feeding suppresses beta-adrenergic receptor-stimulated lipolysis in adipocytes isolated from epididymal fat.

Journal: Endocrinology 20060901

Title: Characteristics of taurine release in slices from adult and developing mouse brain stem.

Journal: Amino acids 20060701

Title: Inhibition of PGI2 signaling by miconazole in vascular smooth muscle cells.

Journal: Prostaglandins & other lipid mediators 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.

Journal: Cellular signalling 20060301

Title: Phosphodiesterase IV and neutral endopeptidase in airways from developing and allergen sensitized rabbits.

Journal: Pulmonary pharmacology & therapeutics 20060101

Title: Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in the guinea pig gall bladder.

Journal: The Journal of veterinary medical science 20050701

Title: Role of the adenosine 3',5'-cyclic monophosphate (cAMP) in enhancing the efficacy of siRNA-mediated gene silencing in neuroblastoma cells.

Journal: Oncogene 20050609

Title: Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.

Journal: Molecular pharmacology 20050601

Title: Inhibition of mast cell histamine release by specific phosphodiesterase inhibitors.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050401

Title: NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.

Journal: European journal of pharmacology 20050131

Title: Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels.

Journal: The European journal of neuroscience 20041201

Title: Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats.

Journal: Journal of pharmacological sciences 20040701

Title: Phosphodiesterase-linked inhibition of nonmicturition activity in the isolated bladder.

Journal: BJU international 20040601

Title: Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability.

Journal: Cancer letters 20040210

Title: The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma.

Journal: Respiratory research 20040101

Title: Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus.

Journal: The Journal of physiology 20031201

Title: Effects of phosphodiesterase inhibitors on spontaneous nuclear maturation and cAMP concentrations in bovine oocytes.

Journal: Theriogenology 20031201

Title: Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes.

Journal: The Journal of physiology 20030815

Title: The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030701

Title: Type IV phosphodiesterase inhibition improves cardiac contractility in endotoxemic rats.

Journal: European journal of pharmacology 20030328

Title: 5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs.

Journal: European journal of pharmacology 20030214

Title: Norepinephrine induces slow calcium signalling in murine brown preadipocytes through the beta-adrenoceptor/cAMP/protein kinase A pathway.

Journal: Cellular signalling 20030201

Title: Lipopolysaccharide-induced acute renal failure in conscious rats: effects of specific phosphodiesterase type 3 and 4 inhibition.

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: Subtype-specific roles of cAMP phosphodiesterases in regulation of atrial natriuretic peptide release.

Journal: European journal of pharmacology 20020920

Title: Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of HT-1080 human fibrosarcoma cells in vitro and in vivo.

Journal: Molecular carcinogenesis 20020901

Title: Regulation of glypican-1, syndecan-1 and syndecan-4 mRNAs expression by follicle-stimulating hormone, cAMP increase and calcium influx during rat Sertoli cell development.

Journal: European journal of biochemistry 20020701

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease.

Journal: Diabetes 20020401

Title: Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: impact on phospholipase D activity and recruitment of small GTPases to membranes.

Journal: Journal of leukocyte biology 20020201

Title: Nucleotide-evoked relaxation of rat vas deferens: possible mechanisms.

Journal: European journal of pharmacology 20020201

Title: Caffeine eliminates gamma-ray-induced G2-phase delay in human tumor cells but not in normal cells.

Journal: Radiation research 20020101

Title: Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells.

Journal: British journal of pharmacology 20010901

Title: Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues.

Journal: British journal of pharmacology 20010701

Title: 17beta-estradiol modulates prostaglandin E2 release from human amnion-derived wish cells.

Journal: Biology of reproduction 20010601

Title: Modulation of excitability in Aplysia tail sensory neurons by tyrosine kinases.

Journal: Journal of neurophysiology 20010601

Title: Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.

Journal: Biochimica et biophysica acta 20010319

Title: Phthalic acid mimics 17beta-estradiol actions in WISH cells.

Journal: Toxicology letters 20010103

Title: Chronic type IV phosphodiesterase inhibition protects glomerular filtration rate and renal and mesenteric blood flow in a zymosan-induced model of multiple organ dysfunction syndrome treated with norepinephrine.

Journal: The Journal of pharmacology and experimental therapeutics 20010101

Title: [Inhibition of uterine contractions: new in vitro pharmacological approaches on the pregnant human myometrium].

Journal: Therapie 20010101

Title: Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors.

Journal: The Journal of allergy and clinical immunology 19981101

Title: Decreased presynaptic sensitivity to adenosine after cocaine withdrawal.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19981001

Title: Beta-adrenergic regulation of renin expression in differentiated U-937 monocytic cells.

Journal: Biochemical pharmacology 19970615

Title: Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D.

Journal: Biochemical and biophysical research communications 19970519

Title: Differential modulation of cytokine production by drugs: implications for therapy in heart failure.

Journal: Journal of molecular and cellular cardiology 19961201

Title: Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells.

Journal: European journal of pharmacology 19960205

Title: Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of S49 lymphoma cells by agents increasing cyclic AMP.

Journal: Journal of cyclic nucleotide research 19810101

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