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Title: Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry.
Journal: Nanomedicine (London, England) 20120901
Title: Flavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents.
Journal: Molecules (Basel, Switzerland) 20120703
Title: Gold nanoparticles uptake and cytotoxicity assessed on rat liver precision-cut slices.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120701
Title: In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120601
Title: Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models.
Journal: Analytical chemistry 20120501
Title: Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.
Journal: Journal of medicinal chemistry 20111222
Title: Overexpression of a cytochrome P450 monooxygenase, CYP6ER1, is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens.
Journal: Insect molecular biology 20111201
Title: Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity.
Journal: Biotechnology and bioengineering 20110601
Title: SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.
Journal: PLoS neglected tropical diseases 20110601
Title: Hydrogen peroxide-mediated dealkylation of 7-ethoxycoumarin by cytochrome P450 (CYP107AJ1) from Streptomyces peucetius ATCC27952.
Journal: Enzyme and microbial technology 20110208
Title: A cytochrome P450 monooxygenase commonly used for negative selection in transgenic plants causes growth anomalies by disrupting brassinosteroid signaling.
Journal: BMC plant biology 20110101
Title: Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases.
Journal: PloS one 20110101
Title: Exposure to sublethal doses of fipronil and thiacloprid highly increases mortality of honeybees previously infected by Nosema ceranae.
Journal: PloS one 20110101
Title: Deep sequencing of pyrethroid-resistant bed bugs reveals multiple mechanisms of resistance within a single population.
Journal: PloS one 20110101
Title: In vivo indirect measurement of cytochrome P450-associated activities in freshwater gastropod molluscs.
Journal: Environmental toxicology 20101201
Title: Extending hepatocyte functionality for drug-testing applications using high-viscosity alginate-encapsulated three-dimensional cultures in bioreactors.
Journal: Tissue engineering. Part C, Methods 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices.
Journal: Lab on a chip 20101021
Title: Percutaneous absorption and metabolism of [14C]-ethoxycoumarin in a pig ear skin model.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100801
Title: Expression and characterization of dog cytochrome P450 2A13 and 2A25 in baculovirus-infected insect cells.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100701
Title: Engineering cytochrome P450 monooxygenase CYP 116B3 for high dealkylation activity.
Journal: Biotechnology letters 20100601
Title: Cryopreservation of primary porcine liver cells in an organotypical sandwich model in a clinically relevant flat membrane bioreactor.
Journal: Biotechnology letters 20100601
Title: Systematic screening of Escherichia coli single-gene knockout mutants for improving recombinant whole-cell biocatalysts.
Journal: Applied microbiology and biotechnology 20100601
Title: Amplification of a cytochrome P450 gene is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae.
Journal: PLoS genetics 20100601
Title: Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100501
Title: Neurogenic-committed human pre-adipocytes express CYP1A isoforms.
Journal: Chemico-biological interactions 20100330
Title: Simultaneous determination of diosmin and diosmetin in human plasma by ion trap liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: Application to a clinical pharmacokinetic study.
Journal: Journal of pharmaceutical and biomedical analysis 20100311
Title: Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Journal: Journal of medicinal chemistry 20100114
Title: Analysis of hesperetin enantiomers in human urine after ingestion of blood orange juice by using nano-liquid chromatography.
Journal: Journal of pharmaceutical and biomedical analysis 20100105
Title: Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies.
Journal: Biotechnology and bioengineering 20100101
Title: Atypical kinetics of cytochromes P450 catalysing 3'-hydroxylation of flavone from the white-rot fungus Phanerochaete chrysosporium.
Journal: Journal of biochemistry 20100101
Title: Delayed-release oral suspension of omeprazole for the treatment of erosive esophagitis and gastroesophageal reflux disease in pediatric patients: a review.
Journal: Clinical and experimental gastroenterology 20100101
Title: Optimization of an isolated perfused rainbow trout liver model: Clearance studies with 7-ethoxycoumarin.
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20091127
Title: Directed evolution of the actinomycete cytochrome P450moxA (CYP105) for enhanced activity.
Journal: Bioscience, biotechnology, and biochemistry 20090901
Title: Silkworm as a model animal to evaluate drug candidate toxicity and metabolism.
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Title: The effect of insecticide synergists on the response of scabies mites to pyrethroid acaricides.
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Title: Does the clock make the poison? Circadian variation in response to pesticides.
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Title: Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies).
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Title: PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease.
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Title: Applications of nanomaterials in electrochemical enzyme biosensors.
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Title: Determination of CYP activity in precision-cut liver slices: whether to use intact slices or slice homogenate.
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Title: Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility.
Journal: Analytical and bioanalytical chemistry 20081101
Title: Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.
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Title: Bioconversion of small molecules by cytochrome P450 species expressed in Escherichia coli.
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Title: Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080701
Title: Cloning, expression and characterisation of CYP102A7, a self-sufficient P450 monooxygenase from Bacillus licheniformis.
Journal: Applied microbiology and biotechnology 20080701
Title: Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline.
Journal: Bioorganic & medicinal chemistry letters 20080701
Title: Designing a whole-cell biotransformation system in Escherichia coli using cytochrome P450 from Streptomyces peucetius.
Journal: Biotechnology letters 20080601
Title: Bioconversion by functional P450 1A9 and P450 1C1 of Anguilla japonica.
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Title: Antigenotoxic effect of Xanthohumol in rat liver slices.
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Title: Metabolism and absorption of auraptene (7-geranyloxylcoumarin) in male SD rats: comparison with 7-ethoxycoumarin.
Journal: Nutrition and cancer 20080101
Title: Role of cytochrome P450 in drug interactions.
Journal: Nutrition & metabolism 20080101
Title: In vitro evaluation of hepatic and extra-hepatic metabolism of coumarins using rat subcellular fractions: correlation of in vitro clearance with in vivo data.
Journal: Drug metabolism and drug interactions 20080101
Title: Induction of phase I and II drug metabolism in rat small intestine and colon in vitro.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070601
Title: Assessment of cryopreserved hepatocytes as an alternative to fresh hepatocytes for comparative interspecies metabolism studies with suitable acceptance criteria.
Journal: Drug metabolism letters 20070401
Title: Interactions between estrogen- and Ah-receptor signalling pathways in primary culture of salmon hepatocytes exposed to nonylphenol and 3,3',4,4'-tetrachlorobiphenyl (congener 77).
Journal: Comparative hepatology 20070101
Title: Modification of small molecules by using cytochrome P450 expressed in Escherichia coli.
Journal: Journal of industrial microbiology & biotechnology 20061201
Title: Characterization of CYP1A enzyme in Adélie penguin liver.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061001
Title: Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060901
Title: Culture of bovine hepatocytes: a non-perfusion technique for cell isolation.
Journal: Cytotechnology 20060601
Title: Empirical validation of a rat in vitro organ slice model as a tool for in vivo clearance prediction.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060401
Title: Use of the land snail Helix aspersa as sentinel organism for monitoring ecotoxicologic effects of urban pollution: an integrated approach.
Journal: Environmental health perspectives 20060101
Title: Monooxygenase activity in methidathion resistant and susceptible populations of Amblyseius womersleyi (Acari: Phytoseiidae).
Journal: Experimental & applied acarology 20060101
Title: Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families.
Journal: Methods in molecular biology (Clifton, N.J.) 20060101
Title: Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101
Title: Oxidative activities of heterologously expressed CYP107B1 and CYP105D1 in whole-cell biotransformation using Streptomyces lividans TK24.
Journal: Journal of bioscience and bioengineering 20051101
Title: Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
Journal: Bioorganic & medicinal chemistry letters 20050915
Title: The use of sandwich-cultured rat hepatocytes to determine the intrinsic clearance of compounds with different extraction ratios: 7-ethoxycoumarin and warfarin.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050901
Title: Determination and assay validation of pinosylvin in rat serum: application to drug metabolism and pharmacokinetics.
Journal: Journal of pharmaceutical and biomedical analysis 20050601
Title: Allogeneic cell therapy for the treatment of liver disease.
Journal: Progress in transplantation (Aliso Viejo, Calif.) 20050601
Title: Evaluation of evaporative light-scattering detection for metabolite quantification without authentic analytical standards or radiolabel.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050525
Title: Comparative acaricide susceptibility and detoxifying enzyme activities in field-collected resistant and susceptible strains of Tetranychus urticae.
Journal: Pest management science 20050501
Title: The influence of brain death on liver function.
Journal: Liver international : official journal of the International Association for the Study of the Liver 20050201
Title: Essential role of singlet oxygen species in cytochrome P450-dependent substrate oxygenation by rat liver microsomes.
Journal: Drug metabolism and pharmacokinetics 20050201
Title: Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract.
Journal: Toxicology and applied pharmacology 20050115
Title: A new technique for preparing precision-cut slices from small intestine and colon for drug biotransformation studies.
Journal: Journal of pharmacological and toxicological methods 20050101
Title: Prediction of in vitro intrinsic clearance from hepatocytes: comparison of suspensions and monolayer cultures.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050101
Title: Galactosylated poly(vinylidene difluoride) hollow fiber bioreactor for hepatocyte culture.
Journal: Tissue engineering 20050101
Title: A validated HPLC determination of the flavone aglycone diosmetin in human plasma.
Journal: Biomedical chromatography : BMC 20041201
Title: Functional diversity of cytochrome P450s of the white-rot fungus Phanerochaete chrysosporium.
Journal: Biochemical and biophysical research communications 20041105
Title: A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine.
Journal: Journal of pharmaceutical and biomedical analysis 20040921
Title: Metabolism of N,N',N'-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms.
Journal: The Journal of pharmacology and experimental therapeutics 20040901
Title: In vitro metabolism of [14C]methoxychlor in rat, mouse, Japanese quail and rainbow trout in precision-cut liver slices.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040801
Title: Metabolic and structural viability of precision-cut rat lung slices in culture.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040801
Title: Influence of polymer membrane porosity on C3A hepatoblastoma cell adhesive interaction and function.
Journal: Biomaterials 20040601
Title: Functional co-expression of xenobiotic metabolizing enzymes, rat cytochrome P450 1A1 and UDP-glucuronosyltransferase 1A6, in yeast microsomes.
Journal: Biochimica et biophysica acta 20040503
Title: Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040501
Title: Functional integrity of precision-cut liver slices from deer and cattle.
Journal: Journal of veterinary pharmacology and therapeutics 20040401
Title: Validated high-performance liquid chromatographic method utilizing solid-phase extraction for the simultaneous determination of naringenin and hesperetin in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040305
Title: Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040301
Title: Phase I and II enzyme characterization of two sources of HepG2 cell lines.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040301
Title: Catalytic Reaction of Basidiomycete Lentinula edodes Cytochrome P450, Le.CYP1 Enzyme Produced in Yeast.
Journal: Bioscience, biotechnology, and biochemistry 20040101
Title: [Induction of cytochrome P450 2A5 in transplanted mouse hepatoma].
Journal: Biomeditsinskaia khimiia 20040101
Title: Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040101
Title: Inhibition of cytochrome P450 mediated enzyme activity by alkylphosphocholines.
Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101
Title: A self-sufficient cytochrome p450 with a primary structural organization that includes a flavin domain and a [2Fe-2S] redox center.
Journal: The Journal of biological chemistry 20031205
Title: Cytochrome P450 expression and activities in rat, rabbit and bovine tongue.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20031201
Title: Dose-response studies on the induction of liver cytochromes P4501A1 and 1B1 by polycyclic aromatic hydrocarbons in arylhydrocarbon-responsive C57BL/6J mice.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030901
Title: Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20030801
Title: Tight-binding inhibition by alpha-naphthoflavone of human cytochrome P450 1A2.
Journal: Biochimica et biophysica acta 20030530
Title: Purification and characterization of a soluble form of rat liver NADPH-cytochrome P-450 reductase highly expressed in Escherichia coli.
Journal: Protein expression and purification 20030501
Title: Inhibition of cytochrome p450 enzymes by enrofloxacin in the sea bass (Dicentrarchus labrax).
Journal: Aquatic toxicology (Amsterdam, Netherlands) 20030110
Title: The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030101
Title: Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030101
Title: The relationship between oxidative metabolism and lipid peroxidation in rat liver microsomes.
Journal: Research communications in molecular pathology and pharmacology 20030101
Title: Effects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymes.
Journal: Japanese journal of pharmacology 20020701
Title: Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020501
Title: Some coumarins and triphenylethene derivatives as inhibitors of human testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD type 3): further studies with tamoxifen on the rat testes microsomal enzyme.
Journal: Journal of enzyme inhibition and medicinal chemistry 20020401
Title: A novel ISFET-type biosensor based on P450 monooxygenases.
Journal: Biosensors & bioelectronics 20020301
Title: Characterization by liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry of two coupled oxidative-conjugative metabolic pathways for 7-ethoxycoumarin in human liver microsomes treated with alamethicin.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020301
Title: Evidence for singlet oxygen involvement in rat and human cytochrome P450-dependent substrate oxidations.
Journal: Drug metabolism and pharmacokinetics 20020101
Title: Escape from tolerance of organic nitrate by induction of cytochrome P450.
Journal: Free radical biology & medicine 20011201
Title: Tissue slices revisited: evaluation and development of a short-term incubation for integrated drug metabolism.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20011001
Title: Growth and metabolic activity of immortalized porcine hepatocytes in extracorporeal hollow-fiber liver assist devices.
Journal: Artificial organs 20010701
Title: Influence of ligand binding to human cytochrome P-450 1A2: conformational activation and stabilization by alpha-naphthoflavone.
Journal: Biochimica et biophysica acta 20010407
Title: P450 enzyme expression patterns in the NCI human tumor cell line panel.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010301
Title: A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation.
Journal: Biochemical and biophysical research communications 20010301
Title: Phase 2 metabolites of N-hydroxylated amidines (amidoximes): synthesis, in vitro formation by pig hepatocytes, and mutagenicity testing.
Journal: Chemical research in toxicology 20010301
Title: Role of LYS271 and LYS279 residues in the interaction of cytochrome P4501A1 with NADPH-cytochrome P450 reductase.
Journal: Archives of biochemistry and biophysics 20010115
Title: Effects of medium composition on the morphology and function of rat hepatocytes cultured as spheroids and monolayers.
Journal: In vitro cellular & developmental biology. Animal 20010101
Title: Enzyme activity of the cytochrome P-450 monooxygenase system in the presence of single chain lipid molecules.
Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101
Title: Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
Journal: The Journal of pharmacology and experimental therapeutics 19980201
