Title: Activation of the Constitutive Androstane Receptor by Monophthalates.
Journal: Chemical research in toxicology 20161017
Title: Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium.
Journal: PloS one 20150101
Title: Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor α, β, γ subtypes: an in silico approach.
Journal: Journal of applied toxicology : JAT 20140701
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths.
Journal: Toxicology letters 20130412
Title: Role of Peroxisome Proliferator-Activated Receptor β/δ and B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells.
Journal: PPAR research 20130101
Title: Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.
Journal: Cardiovascular research 20121201
Title: PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice.
Journal: Brain research 20121105
Title: Lipid effects of peroxisome proliferator-activated receptor-δ agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20120901
Title: Activation of PPARδ counteracts angiotensin II-induced ROS generation by inhibiting rac1 translocation in vascular smooth muscle cells.
Journal: Free radical research 20120701
Title: Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice.
Journal: Diabetes 20120701
Title: Total synthesis and dual PPARα/γ agonist effects of amorphastilbol and its synthetic derivatives.
Journal: Bioorganic & medicinal chemistry letters 20120615
Title: The PPARδ ligand L-165041 inhibits VEGF-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ.
Journal: Journal of cellular biochemistry 20120601
Title: Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production.
Journal: The Biochemical journal 20120515
Title: Roles of PPARs in NAFLD: potential therapeutic targets.
Journal: Biochimica et biophysica acta 20120501
Title: The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells.
Journal: Diabetologia 20120301
Title: Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.
Journal: Oncogene 20120223
Title: Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation.
Journal: Cancer prevention research (Philadelphia, Pa.) 20120101
Title: Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes.
Journal: PloS one 20120101
Title: A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis.
Journal: PloS one 20120101
Title: In vitro responsiveness of human muscle cell peroxisome proliferator-activated receptor δ reflects donors' insulin sensitivity in vivo.
Journal: European journal of clinical investigation 20111201
Title: Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer.
Journal: Molecular carcinogenesis 20111101
Title: Activation of peroxisome proliferators-activated receptor δ (PPARδ) promotes blastocyst hatching in mice.
Journal: Molecular human reproduction 20111001
Title: Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity.
Journal: The Journal of clinical endocrinology and metabolism 20111001
Title: Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes.
Journal: Diabetes 20110701
Title: PPARδ agonists have opposing effects on insulin resistance in high fat-fed rats and mice due to different metabolic responses in muscle.
Journal: British journal of pharmacology 20110601
Title: Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists.
Journal: Bioorganic & medicinal chemistry 20110515
Title: The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.
Journal: Endocrinology 20110501
Title: AP1-dependent repression of TGFα-mediated MMP9 upregulation by PPARδ agonists in keratinocytes.
Journal: Experimental dermatology 20110501
Title: Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet.
Journal: Drug testing and analysis 20110501
Title: Phenoxyacetic acids as PPARδ partial agonists: synthesis, optimization, and in vivo efficacy.
Journal: Bioorganic & medicinal chemistry letters 20110415
Title: Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells.
Journal: Biochemical and biophysical research communications 20110325
Title: PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells.
Journal: Biochimica et biophysica acta 20110201
Title: Endurance factors improve hippocampal neurogenesis and spatial memory in mice.
Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20110201
Title: Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.
Journal: Bioorganic & medicinal chemistry 20110115
Title: Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells.
Journal: Journal of cancer research and clinical oncology 20110101
Title: Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.
Journal: Bioorganic & medicinal chemistry letters 20110101
Title: Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation.
Journal: Bioorganic & medicinal chemistry letters 20110101
Title: Dual acting and pan-PPAR activators as potential anti-diabetic therapies.
Journal: Handbook of experimental pharmacology 20110101
Title: GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice.
Journal: PloS one 20110101
Title: Angiopoietin-like 4 regulates epidermal differentiation.
Journal: PloS one 20110101
Title: Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.
Journal: Molecular pharmacology 20100901
Title: Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis.
Journal: Immunology 20100801
Title: Oral administration of a PPAR-delta agonist to rodents worsens, not improves, maximal insulin-stimulated glucose transport in skeletal muscle of different fibers.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100801
Title: Synthesis of isosteric selenium analog of the PPARbeta/delta agonist GW501516 and comparison of biological activity.
Journal: Bioorganic & medicinal chemistry letters 20100715
Title: Synthesis and dual PPARalpha/delta agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516.
Journal: European journal of medicinal chemistry 20100701
Title: Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100505
Title: The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta.
Journal: Diabetes 20100401
Title: Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.
Journal: Endocrinology 20100401
Title: Modulation of nutrient sensing nuclear hormone receptors promotes weight loss through appetite suppression in mice.
Journal: Diabetes, obesity & metabolism 20100301
Title: Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
Journal: Journal of medicinal chemistry 20100225
Title: Rosiglitazone activation of PPARgamma suppresses fractalkine signaling.
Journal: Journal of molecular endocrinology 20100201
Title: Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells.
Journal: Biochemical and biophysical research communications 20100115
Title: Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.
Journal: Journal of medicinal chemistry 20100114
Title: PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1.
Journal: Endocrine journal 20100101
Title: Role of peroxisome proliferator-activated receptor beta/delta in chicken adipogenesis.
Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20091101
Title: Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells.
Journal: Anticancer research 20090901
Title: On the mechanism for PPAR agonists to enhance ABCA1 gene expression.
Journal: Atherosclerosis 20090801
Title: PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle.
Journal: American journal of physiology. Endocrinology and metabolism 20090701
Title: Selective, potent PPARgamma agonists with cyclopentenone core structure.
Journal: Bioorganic & medicinal chemistry letters 20090401
Title: Doping control analysis of emerging drugs in human plasma - identification of GW501516, S-107, JTV-519, and S-40503.
Journal: Rapid communications in mass spectrometry : RCM 20090401
Title: [Doping in the next generation: wringing extra performance from the genotype].
Journal: MMW Fortschritte der Medizin 20090319
Title: Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha.
Journal: American journal of respiratory cell and molecular biology 20090301
Title: Regulation of peroxisome proliferator-activated receptor-alpha by MDM2.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090301
Title: Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.
Journal: Bioorganic & medicinal chemistry letters 20090215
Title: PPARdelta is a ligand-dependent negative regulator of vitamin D3-induced monocyte differentiation.
Journal: Carcinogenesis 20090201
Title: PPARbeta/delta agonist increases the expression of PGE2 receptor subtype EP4 in human lung carcinoma cells.
Journal: Methods in molecular biology (Clifton, N.J.) 20090101
Title: Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination.
Journal: Journal of neuroinflammation 20090101
Title: Ligand activation of peroxisome proliferator-activated receptor-beta/delta inhibits cell proliferation in human HaCaT keratinocytes.
Journal: Molecular pharmacology 20081101
Title: Are 'exercise pills' the answer to the growing problem of physical inactivity?
Journal: British journal of sports medicine 20081101
Title: Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARalpha and PPARdelta.
Journal: The Journal of biological chemistry 20081024
Title: The exercise pill--too good to be true?
Journal: The New England journal of medicine 20081023
Title: Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.
Journal: Bioorganic & medicinal chemistry letters 20081015
Title: Small molecules can have big effects on endurance.
Journal: Nature chemical biology 20081001
Title: PPAR-beta/delta agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home.
Journal: Expert opinion on investigational drugs 20081001
Title: Discovery of a novel class of PPARdelta partial agonists.
Journal: Bioorganic & medicinal chemistry letters 20080915
Title: Peroxisome proliferator-activated receptor delta-agonist, GW501516, ameliorates insulin resistance, improves dyslipidaemia in monosodium L-glutamate metabolic syndrome mice.
Journal: Basic & clinical pharmacology & toxicology 20080901
Title: Peroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors.
Journal: Cancer research 20080815
Title: AMPK and PPARdelta agonists are exercise mimetics.
Journal: Cell 20080808
Title: Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2.
Journal: Diabetes 20080801
Title: Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.
Journal: Bioorganic & medicinal chemistry 20080801
Title: Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells.
Journal: Circulation research 20080703
Title: Endothelial progenitor cells and angiogenesis join the PPARty.
Journal: Circulation research 20080703
Title: PPARdelta increases expression of the human apolipoprotein A-II gene in human liver cells.
Journal: International journal of molecular medicine 20080601
Title: In vivo imaging reveals selective peroxisome proliferator activated receptor modulator activity of the synthetic ligand 3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886).
Journal: Molecular pharmacology 20080501
Title: Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.
Journal: Diabetes 20080201
Title: Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta.
Journal: The American journal of cardiology 20071203
Title: Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.
Journal: Carcinogenesis 20071201
Title: The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells.
Journal: FEBS letters 20071002
Title: Design of a partial PPARdelta agonist.
Journal: Bioorganic & medicinal chemistry letters 20070815
Title: Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists.
Journal: Bioorganic & medicinal chemistry letters 20070801
Title: Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.
Journal: Bioorganic & medicinal chemistry 20070801
Title: Activation of PPARdelta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts.
Journal: Cardiovascular research 20070801
Title: Indanylacetic acids as PPAR-delta activator insulin sensitizers.
Journal: Bioorganic & medicinal chemistry letters 20070801
Title: Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.
Journal: The Journal of biological chemistry 20070706
Title: Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists.
Journal: Bioorganic & medicinal chemistry letters 20070701
Title: Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
Journal: European journal of pharmacology 20070601
Title: Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.
Journal: Journal of medicinal chemistry 20070405
Title: PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.
Journal: Biochemical and biophysical research communications 20070323
Title: Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: synthesis, structure-activity relationship, and in vivo efficacy.
Journal: Journal of medicinal chemistry 20070308
Title: Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo.
Journal: The Journal of pharmacology and experimental therapeutics 20070301
Title: Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.
Journal: Journal of medicinal chemistry 20070222
Title: Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070201
Title: A novel positive feedback loop between peroxisome proliferator-activated receptor-delta and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth.
Journal: The Journal of biological chemistry 20061110
Title: Activation of PPAR-delta in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids.
Journal: Diabetologia 20061101
Title: BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells.
Journal: Diabetologia 20061001
Title: Studies towards the conception of new selective PPARbeta/delta ligands.
Journal: Bioorganic & medicinal chemistry letters 20060901
Title: Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet.
Journal: European journal of pharmacology 20060424
Title: PPARdelta activator GW-501516 has no acute effect on glucose transport in skeletal muscle.
Journal: American journal of physiology. Endocrinology and metabolism 20060401
Title: GW-501516 GlaxoSmithKline/Ligand.
Journal: Current opinion in investigational drugs (London, England : 2000) 20060401
Title: Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways.
Journal: Biochemical pharmacology 20060227
Title: Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs.
Journal: Bioorganic & medicinal chemistry letters 20060101
Title: Statins and PPARalpha agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment.
Journal: Toxicology and applied pharmacology 20051101
Title: Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta.
Journal: Carcinogenesis 20051001
Title: Activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) increases the expression of prostaglandin E2 receptor subtype EP4. The roles of phosphatidylinositol 3-kinase and CCAAT/enhancer-binding protein beta.
Journal: The Journal of biological chemistry 20050930
Title: Differential responses of PPARalpha, PPARdelta, and PPARgamma reporter cell lines to selective PPAR synthetic ligands.
Journal: Analytical biochemistry 20050901
Title: Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B.
Journal: Molecular pharmacology 20050701
Title: Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.
Journal: Neuropharmacology 20050601
Title: Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys.
Journal: Journal of lipid research 20050501
Title: Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis.
Journal: Cancer research 20050501
Title: Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta.
Journal: Diabetes 20050401
Title: Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.
Journal: Journal of lipid research 20050301
Title: Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism.
Journal: Arthritis and rheumatism 20050301
Title: PPAR delta: an uncompletely known nuclear receptor.
Journal: Diabetes & metabolism 20050201
Title: Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms.
Journal: Nuclear receptor 20050101
Title: [Activation of 'fat burning sensor' peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome].
Journal: Seikagaku. The Journal of Japanese Biochemical Society 20040601
Title: The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells.
Journal: Molecular endocrinology (Baltimore, Md.) 20031201
Title: A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta.
Journal: The Journal of organic chemistry 20031114
Title: Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.
Journal: Bioorganic & medicinal chemistry letters 20030505
Title: A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20010424
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Title: Yang X, et al. GW 501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice. PLoS One. 2011;6(9):e25271.
Title: Chen W, et al. A metabolomic study of the PPARδ agonist GW 501516 for enhancing running endurance in Kunming mice. Sci Rep. 2015 May 6;5:9884.
Title: Ji Y, et al. PPARβ/δ Agonist GW501516 Inhibits Tumorigenicity of Undifferentiated Nasopharyngeal Carcinoma in C666-1 Cells by Promoting Apoptosis. Front Pharmacol. 2018 Jun 28;9:648.
