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320367-13-3,MFCD13194768
Catalog No.:AA00C6IL

320367-13-3 | Lixisenatide

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Purity
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Price(USD)
Quantity
  
1mg
99%
1 week  
$289.00   $202.00
- +
2mg
99%
1 week  
$400.00   $280.00
- +
5mg
99%
1 week  
$511.00   $358.00
- +
10mg
99%
1 week  
$670.00   $469.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6IL
Chemical Name:
Lixisenatide
CAS Number:
320367-13-3
Molecular Formula:
C215H347N61O65S
Molecular Weight:
4858.4904
MDL Number:
MFCD13194768
SMILES:
NCCCCC(C(=O)NC(C(=O)NCC(=O)NCC(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N)CCCCN)CCCCN)CCCCN)CCCCN)CCCCN)CCCCN)CO)C)CO)CO)CC(=O)N)NC(=O)C(NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C(NC(=O)C(C(CC)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(O)C)NC(=O)C(NC(=O)C(C(O)C)NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(Cc1nc[nH]c1)N)CCC(=O)O)Cc1ccccc1)CO)CC(=O)O)CC(C)C)CO)CCCCN)CCC(=O)N)CCSC)CCC(=O)O)CCC(=O)O)CCC(=O)O)C)CCCNC(=N)N)CC(C)C)Cc1ccccc1)CCC(=O)O)CC(C)C
Properties
Computed Properties
 
Complexity:
11800  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
42  
Heavy Atom Count:
342  
Hydrogen Bond Acceptor Count:
77  
Hydrogen Bond Donor Count:
70  
Rotatable Bond Count:
170  
XLogP3:
-30.8  

Literature

Title: Prediction of thyroid C-cell carcinogenicity after chronic administration of GLP1-R agonists in rodents.

Journal: Toxicology and applied pharmacology 20170401

Title: Effects of lixisenatide once daily on gastric emptying in type 2 diabetes--relationship to postprandial glycemia.

Journal: Regulatory peptides 20130810

Title: Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia).

Journal: Diabetes, obesity & metabolism 20121001

Title: [Basal insulin and GLP-1 agonist potentiate each other (interview by Dr. med Dirk Einecke)].

Journal: MMW Fortschritte der Medizin 20120628

Title: Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono).

Journal: Diabetes care 20120601

Title: Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis.

Journal: BMC neuroscience 20120101

Title: Effects of glucagon-like peptide-1 receptor agonists on body weight: a meta-analysis.

Journal: Experimental diabetes research 20120101

Title: Lixisenatide for type 2 diabetes mellitus.

Journal: Expert opinion on investigational drugs 20110401

Title: Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes.

Journal: Regulatory peptides 20100924

Title: Dose-dependent effects of the once-daily GLP-1 receptor agonist lixisenatide in patients with Type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled trial.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20100901

Title: Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus.

Journal: IDrugs : the investigational drugs journal 20090801

Title: Preclinical pharmacology of the new GLP-1 receptor agonist AVE0010.

Journal: Annales d'endocrinologie 20080401

Title: Glucagon-like peptide 1 receptor agonist ZP10A increases insulin mRNA expression and prevents diabetic progression in db/db mice.

Journal: The Journal of pharmacology and experimental therapeutics 20031101

Title: Ahrén B et al. Postprandial Glucagon Reductions Correlate to Reductions in Postprandial Glucose and Glycated Hemoglobin with Lixisenatide Treatment in Type 2 Diabetes Mellitus: A Post Hoc Analysis. Diabetes Ther. 2016 Jun 18

Title: Lorenz M, et al. Effects of lixisenatide once daily on gastric emptying in type 2 diabetes--relationship to postprandial glycemia. Regul Pept. 2013 Aug 10;185:1-8.

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