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3222-50-2,MFCD00128869
Catalog No.:AA003LPU

3222-50-2 | 4-Methylpyridine-3-carboxylic acid

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250mg
98%
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$6.00   $4.00
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1g
98%
in stock  
$15.00   $11.00
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5g
98%
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$18.00   $13.00
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10g
98%
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$34.00   $24.00
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25g
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$81.00   $57.00
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100g
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$320.00   $224.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003LPU
Chemical Name:
4-Methylpyridine-3-carboxylic acid
CAS Number:
3222-50-2
Molecular Formula:
C7H7NO2
Molecular Weight:
137.1360
MDL Number:
MFCD00128869
SMILES:
OC(=O)c1cnccc1C
NSC Number:
22592
Properties
Properties
 
Form:
Solid  
MP:
217-221 °C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
136  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
0.7  

Literature

Title: Niacin subsensitivity is associated with functional impairment in schizophrenia.

Journal: Schizophrenia research 20120501

Title: Honeybees Apis mellifera can detect the scent of Mycobacterium tuberculosis.

Journal: Tuberculosis (Edinburgh, Scotland) 20110701

Title: Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion.

Journal: Physical chemistry chemical physics : PCCP 20110328

Title: Persistent erythema with niacin is not attributable to aspirin resistance.

Journal: Journal of clinical lipidology 20110101

Title: Niacin sensitivity and the arachidonic acid pathway in schizophrenia.

Journal: Schizophrenia research 20100901

Title: Alterations of niacin skin sensitivity in recurrent unipolar depressive disorder.

Journal: Journal of affective disorders 20100801

Title: Metabolomic investigations of American oysters using H-NMR spectroscopy.

Journal: Marine drugs 20100101

Title: In vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum.

Journal: The AAPS journal 20091201

Title: Excess substrate is a spectator ligand in a rhodium-catalyzed asymmetric [2 + 2 + 2] cycloaddition of alkenyl isocyanates with tolanes.

Journal: Organic letters 20091105

Title: The mechanism and mitigation of niacin-induced flushing.

Journal: International journal of clinical practice 20090901

Title: The scent of Mycobacterium tuberculosis--part II breath.

Journal: Tuberculosis (Edinburgh, Scotland) 20090701

Title: Effects of lipid nanocarriers on the performance of topical vehicles in vivo.

Journal: Journal of cosmetic dermatology 20090601

Title: Impaired flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives: the effect of genetic loading.

Journal: Schizophrenia bulletin 20090101

Title: Comparison of instruments for investigation of microcirculatory blood flow and red blood cell concentration.

Journal: Journal of biomedical optics 20090101

Title: Niacin-induced 'flush' involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model.

Journal: The Journal of pharmacology and experimental therapeutics 20081201

Title: The scent of Mycobacterium tuberculosis.

Journal: Tuberculosis (Edinburgh, Scotland) 20080701

Title: Evaluation of simultaneous permeation and metabolism of methyl nicotinate in human, snake, and shed snake skin.

Journal: Pharmaceutical development and technology 20080101

Title: The topical niacin sensitivity test: an inter- and intra-rater reliability study in healthy controls.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20080101

Title: Stability of methylnicotinate in aqueous solution as utilized in the 'niacin patch test'.

Journal: BMC research notes 20080101

Title: A new coordination mode of 6-methylnicotinic acid in trans-tetraaquabis(6-methylpyridine-3-carboxylato-kappaO)cobalt(II) tetrahydrate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20071201

Title: Cannabinoids influence lipid-arachidonic acid pathways in schizophrenia.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20071001

Title: Influence of skin colour on the detection of cutaneous erythema and tanning phenomena using reflectance spectrophotometry.

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20070801

Title: Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in schizophrenia.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20070801

Title: Percutaneous penetration of methyl nicotinate from ointments using the laser Doppler technique: bioequivalence and enhancer effects.

Journal: Journal of pharmacokinetics and pharmacodynamics 20061201

Title: Transfer of the experimental methodology described in the FDA guidance for corticosteroid bioequivalence testing to pharmacodynamic effects caused by nicotinates.

Journal: Journal of cosmetic dermatology 20061201

Title: A non-invasive method for the in vivo determination of skin antioxidant capacity (IAC-S).

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20061101

Title: Determination of the in vivo bioavailability of iontophoretically delivered diclofenac using a methyl nicotinate skin inflammation assay.

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20060801

Title: Anti-inflammatory activity in skin by biomimetic of Evodia rutaecarpa extract from traditional Chinese medicine.

Journal: Journal of dermatological science 20060401

Title: In-vitro and in-vivo evaluation of oligoethylene esters as dermal prodrugs of 18beta-glycyrrhetic acid.

Journal: The Journal of pharmacy and pharmacology 20060301

Title: Establishing a minimal erythema concentration of methyl nicotinate for optimum evaluation of anti-inflammatories.

Journal: Skin pharmacology and physiology 20060101

Title: Time of erythema onset after application of methyl nicotinate ointments as response parameter: influence of penetration kinetics and enhancing agents.

Journal: Skin pharmacology and physiology 20060101

Title: Pattern recognition analysis for classification of hypertensive model rats and diurnal variation using 1H-NMR spectroscopy of urine.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20051101

Title: Effect of charge and lipid concentration on in-vivo percutaneous absorption of methyl nicotinate from liposomal vesicles.

Journal: The Journal of pharmacy and pharmacology 20050901

Title: Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20050818

Title: Impaired niacin sensitivity in acute first-episode but not in multi-episode schizophrenia.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20050601

Title: Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family.

Journal: The Biochemical journal 20050515

Title: Clinical microneedle injection of methyl nicotinate: stratum corneum penetration.

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20050501

Title: The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature.

Journal: Nutrition journal 20050101

Title: Delayed vasodilatory response to methylnicotinate in patients with unipolar depressive disorder.

Journal: Journal of affective disorders 20041015

Title: Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema.

Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20040515

Title: Reduced vasodilatory response to methylnicotinate in schizophrenia as assessed by laser Doppler flowmetry.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20040501

Title: Preparation of deuterated methyl and dimethyl substituted nicotinoylating agents for derivatization of the N-terminal of protein.

Journal: Chemical & pharmaceutical bulletin 20031201

Title: Methyl nicotinate-induced vasodilation in generalized social phobia.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031001

Title: On the relationship between methylnicotinate-induced skin flush and fatty acids levels in acute psychosis.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20030901

Title: The niacin skin flush abnormality in schizophrenia: a quantitative dose-response study.

Journal: Schizophrenia research 20030801

Title: Determination of antioxidant efficacy of cosmetic formulations by non-invasive measurements.

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20030801

Title: Formulation study and anti-inflammatory efficacy of topical semi-solids containing a nitro ester of flurbiprofen.

Journal: Skin pharmacology and applied skin physiology 20030101

Title: Topical methyl nicotinate-induced skin vasodilation in diabetic neuropathy.

Journal: Journal of diabetes and its complications 20030101

Title: Normal phospholipid-related signal transduction in autism.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20021201

Title: Effect of chemical interactions in pentachlorophenol mixtures on skin and membrane transport.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20021001

Title: Influence of processing conditions in the manufacture of O/W creams: II. Effect on drug availability.

Journal: Farmaco (Societa chimica italiana : 1989) 20020501

Title: Impaired phospholipid-related signal transduction in advanced Huntington's disease.

Journal: Experimental physiology 20010901

Title: Mixture component effects on the in vitro dermal absorption of pentachlorophenol.

Journal: Archives of toxicology 20010801

Title: Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans after the application of cinnamic aldehyde.

Journal: Journal of the American Academy of Dermatology 20010701

Title: Selective fowler reductions: asymmetric total syntheses of isofagomine and other 1-azasugars from methyl nicotinate.

Journal: Organic letters 20010125

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