Home Other Building Blocks 328-50-7
328-50-7,MFCD00270557
Catalog No.:AA003HF6

328-50-7 | 2-Ketoglutaric acid

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25g
99%
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$6.00   $4.00
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100g
99%
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$15.00   $10.00
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500g
98% HPLC-ELSD
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$58.00   $41.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003HF6
Chemical Name:
2-Ketoglutaric acid
CAS Number:
328-50-7
Molecular Formula:
C5H6O5
Molecular Weight:
146.0981
MDL Number:
MFCD00270557
SMILES:
OC(=O)CCC(=O)C(=O)O
NSC Number:
17391
FEMA Number:
3891
Properties
Properties
 
BP:
345.6°C at 760 mmHg  
Form:
Solid  
MP:
113-115 °C  
Refractive Index:
1.3920 (estimate)  
Solubility:
H2O: soluble0.1g/mL, clear, colorless  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
171  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
-0.9  

Upstream Synthesis Route

[1]GreenChemistry,2017,vol.19,#8,p.1866-1876

[1]JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999),1986,p.1565-1580

[1]Patent:CN106187910,2016,A,

[2]EuropeanJournalofMedicinalChemistry,2017,vol.137,p.598-611

[1]Patent:CN106187910,2016,A,

[2]EuropeanJournalofMedicinalChemistry,2017,vol.137,p.598-611

[1]JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999),1982,p.345-350

Downstream Synthesis Route

[1]JournalofBiologicalChemistry,1940,vol.136,p.574

[1]JournaloftheChemicalSociety,1922,vol.121,p.664

[1]CurrentPatentAssignee:YUMANITYTHERAPEUTICSINC-WO2019/183587,2019,A1Locationinpatent:Page/Pagecolumn283-284

[2]CurrentPatentAssignee:YUMANITYTHERAPEUTICSINC-WO2020/198026,2020,A1Locationinpatent:Page/Pagecolumn290;322;323;321

[3]CurrentPatentAssignee:ELILILLY&CO-US2873294,1958,A

[1]TetrahedronLetters,2013,vol.54,p.1384-1388

[2]JournalofPhysicalOrganicChemistry,2000,vol.13,p.388-394

[3]Patent:CN106187910,2016,A.Locationinpatent:Paragraph0118;0119

[4]EuropeanJournalofMedicinalChemistry,2017,vol.137,p.598-611

[5]BulletindelaSocieteChimiquedeFrance,1911,vol.<4>9,p.463

[6]ChemischeBerichte,1909,vol.42,p.657

[7]JournalfurpraktischeChemie(Leipzig1954),1927,vol.<2>116,p.156,158

[8]EuropeanJournalofMedicinalChemistry,2013,vol.64,p.512-528

[9]Patent:CN105017197,2017,B.Locationinpatent:Paragraph0179;0184;0186

[10]Patent:EP3459941,2019,A1.Locationinpatent:Paragraph0454

[1]Tibrewal,Nidhi;Elliott,GregoryI.[BioorganicandMedicinalChemistryLetters,2011,vol.21,#1,p.517-519]

[2]Hoffman,Christopher;Tanke,RobinS.;Miller,MarvinJ.[JournalofOrganicChemistry,1989,vol.54,#15,p.3750-3751]

[3]Blaise;Gault[BulletindelaSocieteChimiquedeFrance,1911,vol.<4>9,p.463]

[4]Woodetal.[1948,vol.1,p.42][Chem.Abstr.,1949,p.2276]

Literature

Title: Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35.

Title: Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.

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