Home Other Building Blocks 330786-25-9
330786-25-9,MFCD25976874
Catalog No.:AA00C6EB

330786-25-9 | Pci-29732

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$199.00   $139.00
- +
10mg
≥98%
in stock  
$329.00   $230.00
- +
25mg
≥99%(HPLC)
in stock  
$693.00   $485.00
- +
50mg
≥99%(HPLC)
in stock  
$1,047.00   $733.00
- +
100mg
≥99%(HPLC)
in stock  
$1,790.00   $1,253.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6EB
Chemical Name:
Pci-29732
CAS Number:
330786-25-9
Molecular Formula:
C22H21N5O
Molecular Weight:
371.4350
MDL Number:
MFCD25976874
SMILES:
Nc1ncnc2c1c(nn2C1CCCC1)c1ccc(cc1)Oc1ccccc1
Properties
Computed Properties
 
Complexity:
499  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
4.2  

Literature

Title: Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies.

Journal: Journal of medicinal chemistry 20120524

Title: Pan Z, et al. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. ChemMedChem. 2007 Jan;2(1):58-61.

Title: Ge C, et al. PCI29732, a Bruton's Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells. Cell Physiol Biochem. 2018;48(6):2302-2317.

Title: Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010;107(29):13075-13080.

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SDS
Tags:330786-25-9 Molecular Formula|330786-25-9 MDL|330786-25-9 SMILES|330786-25-9 Pci-29732