Home Indole and Oxindoles 33162-17-3
33162-17-3,MFCD00444963
Catalog No.:AA00CLRR

33162-17-3 | 2,8-Dimethyl-2,3,4,4a,5,9b-hexahydro-1h-pyrido-[4,3-b]indole DiHCl

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Technical Information
Catalog Number:
AA00CLRR
Chemical Name:
2,8-Dimethyl-2,3,4,4a,5,9b-hexahydro-1h-pyrido-[4,3-b]indole DiHCl
CAS Number:
33162-17-3
Molecular Formula:
C13H20Cl2N2
Molecular Weight:
275.2173
MDL Number:
MFCD00444963
SMILES:
CN1CCC2C(C1)c1cc(C)ccc1N2.Cl.Cl
Properties
Computed Properties
 
Complexity:
241  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
3  
Undefined Atom Stereocenter Count:
2  

Literature

Title: Free-radical degradation of high-molar-mass hyaluronan induced by ascorbate plus cupric ions: testing of stobadine and its two derivatives in function as antioxidants.

Journal: General physiology and biophysics 20120301

Title: Effects of a long-term treatment with an antioxidant pyridoindole on vascular responsiveness in diabetes-induced aging rats.

Journal: Current aging science 20110701

Title: [Changes in membrane enzymes in warm liver ischemia].

Journal: Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 20101001

Title: Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose alpha-lipoic acid treatment.

Journal: General physiology and biophysics 20100301

Title: Effect of carboxymethylated pyridoindoles on free radical-induced haemolysis of rat erythrocytes in vitro.

Journal: Acta biochimica Polonica 20100101

Title: Reduction of oxidative stress in adjuvant arthritis. Comparison of efficacy of two pyridoindoles: stobadine dipalmitate and SMe1.2HCl.

Journal: Acta biochimica Polonica 20100101

Title: Glycoxidative and nitrosative stress in kidney of experimental diabetic rats: effects of the prydoindole antioxidant stobadine.

Journal: Neuro endocrinology letters 20100101

Title: Warm liver ischemia in experiment and lysosomal markers.

Journal: Bratislavske lekarske listy 20090101

Title: Protective effect of antioxidants against sarcoplasmic reticulum (SR) oxidation by Fenton reaction, however without prevention of Ca-pump activity.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20081001

Title: Protective effect of stobadine on NCV in streptozotocin-diabetic rats: augmentation by vitamin E.

Journal: General physiology and biophysics 20080601

Title: Stobadine-induced hastening of sensorimotor recovery after focal ischemia/reperfusion is associated with cerebrovascular protection.

Journal: Brain research 20080507

Title: Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells.

Journal: Cell biology international 20070901

Title: Effect of the pyridoindole antioxidant stobadine on ATP-utilisation by renal Na,K-ATPase in rats with streptozotocin-induced diabetes.

Journal: General physiology and biophysics 20070901

Title: Effects of stobadine and vitamin E in diabetes-induced retinal abnormalities: involvement of oxidative stress.

Journal: Archives of medical research 20070701

Title: Stobadine protects rat kidney against ischaemia/reperfusion injury.

Journal: Clinical and experimental pharmacology & physiology 20070301

Title: Inhibitory effect of stobadine on FMLP-induced chemiluminescence in human whole blood and isolated polymorphonuclear leukocytes.

Journal: Luminescence : the journal of biological and chemical luminescence 20070101

Title: Mesenteric ischemia/reperfusion-induced intestinal and vascular damage: effect of stobadine.

Journal: Methods and findings in experimental and clinical pharmacology 20070101

Title: Effects of antioxidant stobadine on protein carbonylation, advanced oxidation protein products and reductive capacity of liver in streptozotocin-diabetic rats: role of oxidative/nitrosative stress.

Journal: BioFactors (Oxford, England) 20070101

Title: Changes in the function and ultrastructure of vessels in the rat model of multiple low dose streptozotocin-induced diabetes.

Journal: General physiology and biophysics 20060901

Title: Ferritin oxidation and proteasomal degradation: protection by antioxidants.

Journal: Free radical research 20060701

Title: Effect of the pyridoindole antioxidant stobadine on the cardiac Na(+),K(+)-ATPase in rats with streptozotocin-induced diabetes.

Journal: General physiology and biophysics 20060601

Title: Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress.

Journal: Cellular and molecular neurobiology 20060101

Title: Influence of antioxidant effect of stobadine derivative in condition of kidney ischemia-reperfusion in a pre-clinical experiment (effect in therapy).

Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201

Title: Influence of antioxidant effect of stobadine derivative in condition of kidney ischemia-reperfusion in a pre-clinical experiment (effect in prophylaxis).

Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20051201

Title: Oxidative modification of rat eye lens proteins by peroxyl radicals in vitro: protection by the chain-breaking antioxidants stobadine and Trolox.

Journal: Biochimica et biophysica acta 20050630

Title: Reactive oxygen species mediate abnormal contractile response to sympathetic nerve stimulation and noradrenaline in the vas deferens of chronically diabetic rats: effects of in vivo treatment with antioxidants.

Journal: Fundamental & clinical pharmacology 20050201

Title: Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: comparison with vitamin E and BHT.

Journal: Molecular vision 20050119

Title: Antioxidants prevented oxidative injury of SR induced by Fe2+/H2O2/ascorbate system but failed to prevent Ca2+-ATPase activity decrease.

Journal: BioFactors (Oxford, England) 20050101

Title: Oxidative damage to Ca2+-ATPase sarcoplasmic reticulum by HOCl and protective effect of some antioxidants.

Journal: BioFactors (Oxford, England) 20050101

Title: Effect of the pyridoindole antioxidant stobadine on sodium handling of renal Na,K-ATPase in rats with streptozotocin-induced diabetes.

Journal: Acta diabetologica 20041201

Title: Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects.

Journal: Bioorganic & medicinal chemistry 20040901

Title: The effect of stobadine on the copper-induced peroxidation of egg yolk phosphatidylcholine in multilamellar liposomes.

Journal: General physiology and biophysics 20040901

Title: Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration.

Journal: Central European journal of public health 20040301

Title: Effect of stobadine on leukocyte free radical generation in streptozotocin-diabetic rats: comparison with vitamin E.

Journal: Pharmacology 20040101

Title: Stobadine-modulated human neutrophil functional responsiveness: effect on particular and soluble stimulation.

Journal: Methods and findings in experimental and clinical pharmacology 20040101

Title: Determination of selective biochemical variables in pregnant and lactating mice after stobadine administration.

Journal: Methods and findings in experimental and clinical pharmacology 20031101

Title: Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effects of stobadine and vitamin E.

Journal: Neurochemical research 20030601

Title: Standardized extracts of flavonoids increase the viability of PC12 cells treated with hydrogen peroxide: effects on oxidative injury.

Journal: Archives of toxicology 20030101

Title: Pyridoindole antioxidant stobadine protected bovine serum albumin against the hydroxyl radical mediated cross-linking in vitro.

Journal: Archives of gerontology and geriatrics 20030101

Title: The pyridoindole antioxidant stobadine attenuates albuminuria, enzymuria, kidney lipid peroxidation and matrix collagen cross-linking in streptozotocin-induced diabetic rats.

Journal: Methods and findings in experimental and clinical pharmacology 20021101

Title: In vivo treatment with stobadine prevents lipid peroxidation, protein glycation and calcium overload but does not ameliorate Ca2+ -ATPase activity in heart and liver of streptozotocin-diabetic rats: comparison with vitamin E.

Journal: Biochimica et biophysica acta 20021009

Title: The pyridoindole antioxidant stobadine attenuates histochemical changes in kidney of streptozotocin-induced diabetic rats.

Journal: Acta histochemica 20020101

Title: Dietary supplementation of the pyridoindole antioxidant stobadine reduces vascular impairment in streptozotocin-diabetic rats.

Journal: Methods and findings in experimental and clinical pharmacology 20010401

Title: In vitro effect of stobadine on Fe(2+)-induced oxidative stress in rat liver mitochondria.

Journal: Bratislavske lekarske listy 20010101

Title: Processes linked to the formation of reactive oxygen species are not necessarily involved in the development of isoproterenol-induced hypertrophy of the heart. The effect of stobadine.

Journal: Biomedica biochimica acta 19910101

Title: [Effect of the atypical neuroleptics carbidine and sulpiride on dopamine biosynthesis in the synaptosomes of the nucleus accumbens septi in rats].

Journal: Farmakologiia i toksikologiia 19870101

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Tags:33162-17-3 Molecular Formula|33162-17-3 MDL|33162-17-3 SMILES|33162-17-3 2,8-Dimethyl-2,3,4,4a,5,9b-hexahydro-1h-pyrido-[4,3-b]indole DiHCl