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332012-40-5,MFCD18251453
Catalog No.:AA00C6H6

332012-40-5 | Telatinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$79.00   $55.00
- +
5mg
≥98%
in stock  
$140.00   $98.00
- +
10mg
98%
in stock  
$181.00   $127.00
- +
25mg
98%
in stock  
$322.00   $225.00
- +
50mg
98%
in stock  
$499.00   $349.00
- +
100mg
98%
in stock  
$852.00   $597.00
- +
250mg
95%
in stock  
$1,633.00   $1,143.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C6H6
Chemical Name:
Telatinib
CAS Number:
332012-40-5
Molecular Formula:
C20H16ClN5O3
Molecular Weight:
409.8257
MDL Number:
MFCD18251453
SMILES:
CNC(=O)c1nccc(c1)COc1nnc(c2c1occ2)Nc1ccc(cc1)Cl
Properties
Computed Properties
 
Complexity:
548  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
3.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:BAYERAG-EP1228063,2009,B1Locationinpatent:Page/Pagecolumn64

[2]CurrentPatentAssignee:BAYERAG-WO2007/118602,2007,A1Locationinpatent:Page/Pagecolumn90

[3]CurrentPatentAssignee:BAYERAG-US6689883,2004,B1Locationinpatent:Pagecolumn101-102

CASUnavailable 
  332012-35-8    332012-40-5    332012-41-6 

[1]CurrentPatentAssignee:BAYERAG-EP1228063,2009,B1Locationinpatent:Page/Pagecolumn45

[2]CurrentPatentAssignee:BAYERAG-WO2007/118602,2007,A1Locationinpatent:Page/Pagecolumn67;68

[3]CurrentPatentAssignee:BAYERAG-US6689883,2004,B1Locationinpatent:Pagecolumn60-61

[1]CurrentPatentAssignee:BAYERAG-WO2007/118602,2007,A1Locationinpatent:Page/Pagecolumn68;69;75;79

[2]CurrentPatentAssignee:BAYERAG-US6689883,2004,B1Locationinpatent:Pagecolumn61

[1]CurrentPatentAssignee:BAYERAG-EP1228063,2009,B1Locationinpatent:Page/Pagecolumn45-46

[2]CurrentPatentAssignee:BAYERAG-EP1228063,2009,B1Locationinpatent:Page/Pagecolumn50-51;54

[1]CurrentPatentAssignee:EDDINGPHARMCOLTD-CN104804008,2016,BLocationinpatent:Paragraph0029;0034;0035

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors.

Journal: Journal of medicinal chemistry 20121227

Title: The observed correlation between in vivo clinical pharmacokinetic parameters and in vitro potency of VEGFR-2 inhibitors. Can this be used as a prospective guide for the development of novel compounds?

Journal: Arzneimittel-Forschung 20120401

Title: Phase I evaluation of telatinib, a VEGF receptor tyrosine kinase inhibitor, in combination with bevacizumab in subjects with advanced solid tumors.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20111101

Title: Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib.

Journal: Journal of the National Cancer Institute 20110504

Title: Development of second-generation VEGFR tyrosine kinase inhibitors: current status.

Journal: Current oncology reports 20110401

Title: Targeted therapies for metastatic esophagogastric cancer.

Journal: Current treatment options in oncology 20110301

Title: Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors.

Journal: Investigational new drugs 20110201

Title: Common secondary causes of resistant hypertension and rational for treatment.

Journal: International journal of hypertension 20110101

Title: Vascular endothelial growth factor inhibitor-induced hypertension: basics for primary care providers.

Journal: Cardiology research and practice 20110101

Title: Phase I study of telatinib (BAY 57-9352): analysis of safety, pharmacokinetics, tumor efficacy, and biomarkers in patients with colorectal cancer.

Journal: Vascular cell 20110101

Title: Pharmacophore modeling and virtual screening studies for new VEGFR-2 kinase inhibitors.

Journal: European journal of medicinal chemistry 20101101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100901

Title: A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080.

Journal: Journal of pharmacokinetics and pharmacodynamics 20100801

Title: Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors.

Journal: Journal of the National Cancer Institute 20100505

Title: Phase I evaluation of telatinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in combination with irinotecan and capecitabine in patients with advanced solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100401

Title: Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090901

Title: Phase I dose escalation study of telatinib (BAY 57-9352) in patients with advanced solid tumours.

Journal: British journal of cancer 20081104

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20081001

Title: Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070101

Title: Steeghs N, et al. Hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor. Clin Cancer Res. 2008 Jun 1;14(11):3470-6.

Title: Langenberg MH, et al. Phase I evaluation of telatinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in combination with irinotecan and capecitabine in patients with advanced solid tumors. Clin Cancer Res. 2010 Apr 1;16(7):2187-97.

Title: Steeghs N, et al. Pharmacogenetics of telatinib, a VEGFR-2 and VEGFR-3 tyrosine kinase inhibitor, used in patients with solid tumors. Invest New Drugs. 2011 Feb;29(1):137-43.

Title: Sodani K, et al. Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo. Biochem Pharmacol. 2014 May 1;89(1):52-61.

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