Home Nitro Compounds 337536-53-5
337536-53-5,MFCD04118063
Catalog No.:AA00C0H9

337536-53-5 | 8-Nitro-D-guanosine

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10mg
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  • Technical Information
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Technical Information
Catalog Number:
AA00C0H9
Chemical Name:
8-Nitro-D-guanosine
CAS Number:
337536-53-5
Molecular Formula:
C10H12N6O7
Molecular Weight:
328.2383
MDL Number:
MFCD04118063
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1c(nc2c1[nH]c(N)nc2=O)[N+](=O)[O-]
Properties
Properties
 
MP:
>250°C (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
552  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
2  
XLogP3:
-1.7  

Literature

Title: Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.

Journal: Nature chemical biology 20120801

Title: [Critical role of nitrated cyclic guanine nucleotide signaling via protein S-guanylation in the antioxidant adaptive response].

Journal: Seikagaku. The Journal of Japanese Biochemical Society 20120201

Title: Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signalling.

Journal: The Biochemical journal 20120115

Title: Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy.

Journal: Experimental diabetes research 20120101

Title: Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3',5'-cyclic monophosphate formed in glia cells.

Journal: Nitric oxide : biology and chemistry 20110801

Title: Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides.

Journal: Amino acids 20110601

Title: Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice.

Journal: British journal of pharmacology 20110401

Title: Inhibition of intestinal polyp formation by pitavastatin, a HMG-CoA reductase inhibitor.

Journal: Cancer prevention research (Philadelphia, Pa.) 20110301

Title: Nucleotides function as endogenous chemical sensors for oxidative stress signaling.

Journal: Journal of clinical biochemistry and nutrition 20110101

Title: Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile.

Journal: Current topics in medicinal chemistry 20110101

Title: Cell signaling mediated by nitrated cyclic guanine nucleotide.

Journal: Nitric oxide : biology and chemistry 20101101

Title: The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response.

Journal: The Journal of biological chemistry 20100730

Title: A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide.

Journal: Journal of clinical biochemistry and nutrition 20100101

Title: Molecular, genetic and epigenetic pathways of peroxynitrite-induced cellular toxicity.

Journal: Interdisciplinary toxicology 20091201

Title: The Base Excision Repair system of Salmonella enterica serovar typhimurium counteracts DNA damage by host nitric oxide.

Journal: PLoS pathogens 20090501

Title: Nitric oxide modulates dynamic actin cytoskeleton and vesicle trafficking in a cell type-specific manner in root apices.

Journal: Journal of experimental botany 20090401

Title: Cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20090315

Title: [New paradigm of host defense against intracellular pathogens by nitric oxide].

Journal: Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association 20090201

Title: 8-Nitroguanosines as chemical probes of the protein S-guanylation.

Journal: Chemical communications (Cambridge, England) 20081207

Title: Epigenetic perturbations in the pathogenesis of mustard toxicity; hypothesis and preliminary results.

Journal: Interdisciplinary toxicology 20081201

Title: Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20081101

Title: Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages: involvement of estrogen receptor-dependent or -independent pathways.

Journal: Nitric oxide : biology and chemistry 20080501

Title: Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells.

Journal: Cancer letters 20080418

Title: Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.

Journal: Nature chemical biology 20071101

Title: Nitrative DNA damage in inflammation and its possible role in carcinogenesis.

Journal: Nitric oxide : biology and chemistry 20060301

Title: Nitrative stress through formation of 8-nitroguanosine: insights into microbial pathogenesis.

Journal: Nitric oxide : biology and chemistry 20060301

Title: Nitric oxide-induced nitrative stress involved in microbial pathogenesis.

Journal: Journal of pharmacological sciences 20050601

Title: Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative.

Journal: Biochemical and biophysical research communications 20031114

Title: Formation of 8-nitroguanosine in cellular RNA as a biomarker of exposure to reactive nitrogen species.

Journal: Chemico-biological interactions 20020220

Title: Analysis of peroxynitrite reactions with guanine, xanthine, and adenine nucleosides by high-pressure liquid chromatography with electrochemical detection: C8-nitration and -oxidation.

Journal: Chemical research in toxicology 20010401

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