Home Carboxes 34408-14-5
34408-14-5,MFCD01076457
Catalog No.:AA00BYCQ

34408-14-5 | 8-Chloroadenosine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$215.00   $150.00
- +
10mg
≥98%
in stock  
$360.00   $252.00
- +
25mg
≥98%(HPLC)
in stock  
$807.00   $565.00
- +
50mg
≥98%(HPLC)
in stock  
$1,611.00   $1,128.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BYCQ
Chemical Name:
8-Chloroadenosine
CAS Number:
34408-14-5
Molecular Formula:
C10H12ClN5O4
Molecular Weight:
301.6864
MDL Number:
MFCD01076457
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1c(Cl)nc2c1ncnc2N
Properties
Properties
 
BP:
707.4°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
367  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
-0.1  

Literature

Title: Regioselective enzymatic undecylenoylation of 8-chloroadenosine and its analogs with biomass-based 2-methyltetrahydrofuran as solvent.

Journal: Bioresource technology 20120801

Title: E2F1 enhances 8-chloro-adenosine-induced G2/M arrest and apoptosis in A549 and H1299 lung cancer cells.

Journal: Biochemistry. Biokhimiia 20120301

Title: Integrative gene expression profiling reveals G6PD-mediated resistance to RNA-directed nucleoside analogues in B-cell neoplasms.

Journal: PloS one 20120101

Title: A unique RNA-directed nucleoside analog is cytotoxic to breast cancer cells and depletes cyclin E levels.

Journal: Breast cancer research and treatment 20100601

Title: Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.

Journal: The Journal of biological chemistry 20100312

Title: Preclinical activity of 8-chloroadenosine with mantle cell lymphoma: roles of energy depletion and inhibition of DNA and RNA synthesis.

Journal: British journal of haematology 20091101

Title: Inhibition of ATP synthase by chlorinated adenosine analogue.

Journal: Biochemical pharmacology 20090915

Title: Inhibition of CHK1 kinase by Gö6976 converts 8-chloro-adenosine-induced G2/M arrest into S arrest in human myelocytic leukemia K562 cells.

Journal: Biochemical pharmacology 20090301

Title: 8-Chloro-adenosine-induced E2F1 promotes p14ARF gene activation in H1299 cells through displacing Sp1 from multiple overlapping E2F1/Sp1 sites.

Journal: Journal of cellular biochemistry 20090215

Title: Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells.

Journal: Biochemical pharmacology 20090201

Title: Induction of p14ARF by E2F1 contributes to 8-chloro-adenosine-induced apoptosis in human lung cancer H1299 cells.

Journal: Chemotherapy 20090101

Title: Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine.

Journal: The Journal of clinical endocrinology and metabolism 20080301

Title: Multiple myeloma cell killing by depletion of the MET receptor tyrosine kinase.

Journal: Cancer research 20071015

Title: 8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells.

Journal: Biochemical pharmacology 20060828

Title: 8-chloroadenosine induced HL-60 cell growth inhibition, differentiation, and G(0)/G(1) arrest involves attenuated cyclin D1 and telomerase and up-regulated p21(WAF1/CIP1).

Journal: Journal of cellular biochemistry 20060101

Title: The combination of sulfinosine and 8-Cl-cAMP induces synergistic cell growth inhibition of the human neuroblastoma cell line in vitro.

Journal: Investigational new drugs 20060101

Title: [Mechanisms of sensitization by 8-chloro-adenosine of human tumor cells to TRAIL-induced apoptosis].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20051001

Title: 8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells.

Journal: Cancer research 20050601

Title: [Preparation of 8-chloro-adenosine long circulation liposomes and its pharmacokinetics in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050401

Title: 8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways: protein kinase C activation and cyclin B down-regulation.

Journal: Journal of cellular physiology 20041101

Title: 8-Chloro-adenosine sensitizes a human hepatoma cell line to TRAIL-induced apoptosis by caspase-dependent and -independent pathways.

Journal: Oncology reports 20040701

Title: [Inhibition of 8-chloroadenosine on proteasome activity of HL-60 cells].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20040201

Title: Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20040101

Title: 8-Cl-Adenosine enhances 1,25-dihydroxyvitamin D3-induced growth inhibition without affecting 1,25-dihydroxyvitamin D3-stimulated differentiation of primary mouse epidermal keratinocytes.

Journal: BMC pharmacology 20040101

Title: [The inhibitory effect of 8-chloroadenosine on tumor necrosis factor-induced proto-oncogene expression of retinal pigment epithelial cells].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20031201

Title: RNA-directed actions of 8-chloro-adenosine in multiple myeloma cells.

Journal: Cancer research 20031115

Title: [8-Chloro-adenosine increases the activity of transcription factor CREB by modification of phosphorylation].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20030401

Title: Anti-proliferative effects of 8-chloro-cAMP and other cAMP analogs are unrelated to their effects on protein kinase A regulatory subunit expression.

Journal: Journal of cellular physiology 20020801

Title: Plasma and cellular pharmacology of 8-chloro-adenosine in mice and rats.

Journal: Cancer chemotherapy and pharmacology 20020801

Title: Genome-wide expression profiling of 8-chloroadenosine- and 8-chloro-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray.

Journal: Experimental & molecular medicine 20020731

Title: Synthesis and hybridization properties of RNA containing 8-chloroadenosine.

Journal: Nucleosides, nucleotides & nucleic acids 20020101

Title: 8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs.

Journal: Cancer chemotherapy and pharmacology 20011201

Title: 8-chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells.

Journal: Cancer research 20010715

Title: 8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFalpha-induced apoptosis is via inactivation of NF-kappaB.

Journal: Leukemia research 20010501

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:34408-14-5 Molecular Formula|34408-14-5 MDL|34408-14-5 SMILES|34408-14-5 8-Chloroadenosine