Home Other Building Blocks 345303-91-5
345303-91-5,MFCD30718168
Catalog No.:AA01E7NI

345303-91-5 | AZD 9056 HCl - Bio-X

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$102.00   $72.00
- +
2mg
95%
1 week  
$122.00   $85.00
- +
5mg
95%
1 week  
$164.00   $115.00
- +
10mg
95%
1 week  
$238.00   $167.00
- +
25mg
95%
1 week  
$460.00   $322.00
- +
50mg
95%
1 week  
$728.00   $510.00
- +
100mg
95%
1 week  
$1,016.00   $712.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01E7NI
Chemical Name:
AZD 9056 HCl - Bio-X
CAS Number:
345303-91-5
Molecular Formula:
C24H36Cl2N2O2
Molecular Weight:
455.4608
MDL Number:
MFCD30718168
SMILES:
OCCCNCCCc1ccc(c(c1)C(=O)NCC12C[C@@H]3C[C@H](C2)C[C@H](C1)C3)Cl.Cl
Properties
Computed Properties
 
Complexity:
514  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
10  

Downstream Synthesis Route

[1]Locationinpatent:schemeortableTeasdale,Andrew;Fenner,Simon;Ray,Andrew;Ford,Agnes;Phillips,Andrew[OrganicProcessResearchandDevelopment,2010,vol.14,#4,p.943-945]

Literature

Title: Seeland S, et al. ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacol Res Perspect. 2015 Mar;3(2):e00123.

Title: Elsby R, et al. In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate. Eur J Pharm Sci. 2011 May 18;43(1-2):41-9.

Title: Hu H, et al. Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis. Int J Mol Med. 2016 Dec;38(6):1922-1932.

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SDS
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Tags:345303-91-5 Molecular Formula|345303-91-5 MDL|345303-91-5 SMILES|345303-91-5 AZD 9056 HCl - Bio-X