Home Aldehydes 347-54-6
347-54-6,MFCD01090997
Catalog No.:AA00346U

347-54-6 | 5-Fluoro-2-hydroxybenzaldehyde

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Purity
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1g
98%
in stock  
$11.00   $8.00
- +
10g
95%
in stock  
$21.00   $15.00
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500g
98%
in stock  
$815.00   $571.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00346U
Chemical Name:
5-Fluoro-2-hydroxybenzaldehyde
CAS Number:
347-54-6
Molecular Formula:
C7H5FO2
Molecular Weight:
140.1118
MDL Number:
MFCD01090997
SMILES:
O=Cc1cc(F)ccc1O
Properties
Properties
 
BP:
207.4°C at 760 mmHg  
Form:
Solid  
MP:
82-85 °C  
Stability:
Air Sensitive  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
127  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1.7  

Upstream Synthesis Route

[1]Heterocycles,2018,vol.96,#1,p.74-85

[1]JournaloftheAmericanChemicalSociety,1998,vol.120,#33,p.8340-8347

[2]Patent:WO2005/37763,2005,A1,.Locationinpatent:Page/Pagecolumn126

[3]Patent:US2017/37038,2017,A1,.Locationinpatent:Paragraph0372;0373;0374

[4]JournaloftheAmericanChemicalSociety,1946,vol.68,p.2502

[5]EuropeanJournalofMedicinalChemistry,1996,vol.31,#6,p.449-460

[1]OrganicSyntheses,2005,vol.82,p.64-68

[2]OrganicandBiomolecularChemistry,2017,vol.15,#6,p.1530-1536

[3]JournaloftheChemicalSociety,PerkinTransactions1:OrganicandBio-OrganicChemistry(1972-1999),1994,#13,p.1823-1832

[4]TetrahedronLetters,2005,vol.46,#19,p.3357-3358

[5]TetrahedronLetters,2005,vol.46,#32,p.5285-5287

[6]JournalofMedicinalChemistry,2000,vol.43,#24,p.4701-4710

[7]BioorganicandMedicinalChemistryLetters,2008,vol.18,#20,p.5591-5593

[8]BioorganicandMedicinalChemistryLetters,2010,vol.20,#6,p.1939-1943

[9]Chemistry-AEuropeanJournal,2017,vol.23,#68,p.17195-17198

[10]OrganicLetters,2017,vol.19,#23,p.6340-6343

[1]Patent:WO2016/201168,2016,A1,.Locationinpatent:Paragraph0512;0513

[1]SyntheticCommunications,2000,vol.30,#3,p.397-405

Downstream Synthesis Route

[1]SyntheticCommunications,2000,vol.30,p.397-405

[1]Blair;Kurrasch-Orbaugh;Marona-Lewicka;Gumbay;Watts;Barker;Nichols[JournalofMedicinalChemistry,2000,vol.43,#24,p.4701-4710]

347-54-6    137848-29-4   
2'-1-(5-Fluoro-2-hydroxy-phenyl)-meth-(E)-ylidene-amino}-1,1'binaphthalenyl-2-ol 

[1]Chemistry-AEuropeanJournal,2002,vol.8,p.5033-5042

[1]Song,Xiao-Guang;Zhu,Shou-Fei;Xie,Xiu-Lan;Zhou,Qi-Lin[AngewandteChemie-InternationalEdition,2013,vol.52,#9,p.2555-2558][Angew.Chem.,2013,vol.125,#9,p.2615-2618,4]

[2]CurrentPatentAssignee:ARVINAS;YALEUNIVERSITY-WO2018/119441,2018,A1Locationinpatent:Paragraph001010;101011

[3]CurrentPatentAssignee:GILEADSCIENCESINC-US2017/166584,2017,A1Locationinpatent:Paragraph0567-0569

[4]Chen,Han;Fan,Yun-Hua;Natarajan,Amarnath;Guo,Yuhong;Iyasere,Julia;Harbinski,Fred;Luus,Lia;Christ,William;Aktas,Huseyin;Halperin,JoseA.[BioorganicandMedicinalChemistryLetters,2004,vol.14,#21,p.5401-5405]

[5]Wang,Xiaoming;Wang,Xubin;Guo,Peihua;Wang,Zheng;Ding,Kuiling[AdvancedSynthesisandCatalysis,2013,vol.355,#14-15,p.2900-2907]

[6]CurrentPatentAssignee:ABBVIEINC-WO2017/89458,2017,A1Locationinpatent:Page/Pagecolumn78

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2017/4342,2017,A1Locationinpatent:Paragraph0500

[2]CurrentPatentAssignee:SHENZHENTARGETRXINC-EP3770161,2021,A1Locationinpatent:Paragraph0116;0117

[3]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2017/7759,2017,A1Locationinpatent:Paragraph0245;0252;0253

[4]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2017/15367,2017,A1Locationinpatent:Paragraph0412;0419;0420

[5]CurrentPatentAssignee:GUANGZHOUBAITINGMEDICINETECH-CN114763360,2022,ALocationinpatent:Paragraph0092-0096;0113-0117;0132-0136;0140-0144;...

[6]Pei,Dong;Wang,Zhouyu;Wei,Siyu;Zhang,Yu;Sun,Jian[OrganicLetters,2006,vol.8,#25,p.5913-5915]

[7]Zhao,Yun-Hui;Ren,Xin-Fang;Liu,Han-Wen[SyntheticCommunications,2015,vol.45,#13,p.1566-1573]

[8]Xiao,Xiaofei;Xu,Yunsheng;Yu,Xihua;Chen,Yinbo;Zhao,Weiwei;Xie,Zhendong;Zhu,Xueyan;Xu,Hongjiang;Yang,Yulei;Zhang,Peng[BioorganicandMedicinalChemistryLetters,2023,vol.89]

[9]Xiao,Xiaofei;Xu,Yunsheng;Yu,Xihua;Chen,Yinbo;Zhao,Weiwei;Xie,Zhendong;Zhu,Xueyan;Xu,Hongjiang;Yang,Yulei;Zhang,Peng[BioorganicandMedicinalChemistryLetters,2023,vol.89]

Literature

Title: 4-Fluoro-2-[(3-methyl-phen-yl)imino-meth-yl]phenol.

Journal: Acta crystallographica. Section E, Structure reports online 20120401

Title: (E)-4-Fluoro-2-[(4-hy-droxy-pheneth-yl)imino-meth-yl]phenol.

Journal: Acta crystallographica. Section E, Structure reports online 20120201

Title: 2-Fluoro-6-[(E)-(pyridin-2-yl)imino-meth-yl]phenol.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: Design and synthesis of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III (FabH) as potential antibacterial agents.

Journal: European journal of medicinal chemistry 20100901

Title: 4-Fluoro-2-[(E)-2-pyridyliminomethyl]phenol.

Journal: Acta crystallographica. Section E, Structure reports online 20090601

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