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35386-24-4,MFCD00005958
Catalog No.:AA0032FR

35386-24-4 | 1-(2-methoxyphenyl)piperazine

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Purity
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5g
97%(GC)
in stock  
$24.00   $17.00
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25g
98%
in stock  
$45.00   $32.00
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100g
98%
in stock  
$115.00   $81.00
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500g
98%
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$429.00   $300.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0032FR
Chemical Name:
1-(2-methoxyphenyl)piperazine
CAS Number:
35386-24-4
Molecular Formula:
C11H16N2O
Molecular Weight:
192.2575
MDL Number:
MFCD00005958
SMILES:
COc1ccccc1N1CCNCC1
Properties
Properties
 
BP:
379.9°C at 760 mmHg  
Form:
Liquid  
MP:
35-40 °C(lit.)  
Refractive Index:
n20/D 1.575(lit.)  
Stability:
Air Sensitive  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
169  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
1.4  

Literature

Title: Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action.

Journal: Neurotoxicology 20151201

Title: Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Journal: Journal of medicinal chemistry 20120809

Title: A straightforward approach for engineering efficacy and selectivity at GPCRs.

Journal: Journal of medicinal chemistry 20120809

Title: Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.

Journal: Journal of medicinal chemistry 20120726

Title: Synthesis, characterization and biological evaluation of novel neutral fac-M(CO)3(SNO) complexes (M=Re, 99mTc) bearing the o-methoxyphenylpiperazine moiety.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20120601

Title: MDHS 25 revisited: part 2, modified sampling and analytical procedures applied to HDI-based isocyanates.

Journal: The Annals of occupational hygiene 20120501

Title: Amine-alkyl derivatives of hydantoin: new tool to combat resistant bacteria.

Journal: European journal of medicinal chemistry 20111201

Title: Synthesis, alpha-adrenoceptors affinity and alpha 1-adrenoceptor antagonistic properties of some 1,4-substituted piperazine derivatives.

Journal: Die Pharmazie 20111001

Title: Synthesis and in vivo evaluation of [O-methyl-11C] N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide as an imaging probe for 5-HT6 receptors.

Journal: Bioorganic & medicinal chemistry 20110901

Title: Effect of cyclosporin A on the uptake of D3-selective PET radiotracers in rat brain.

Journal: Nuclear medicine and biology 20110701

Title: Synthesis and biological evaluation of new [Tc(N)(PS)]-based mixed-ligand compounds useful in the design of target-specific radiopharmaceuticals: the 2-methoxyphenylpiperazine dithiocarbamate derivatives as an example.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110101

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: 3-(1-Adamant-yl)-1-{[4-(2-meth-oxy-phen-yl)piperazin-1-yl]meth-yl}-4-methyl-1H-1,2,4-triazole-5(4H)-thione.

Journal: Acta crystallographica. Section E, Structure reports online 20100701

Title: Synthesis and characterization of environment-sensitive fluorescent ligands for human 5-HT1A receptors with 1-arylpiperazine structure.

Journal: Journal of medicinal chemistry 20091210

Title: [(18)F]-labeled 2-methoxyphenylpiperazine derivative as a potential brain positron emission tomography imaging agent.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20091101

Title: 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.

Journal: Bioorganic & medicinal chemistry 20090715

Title: Aniline in hydrolyzed urine and plasma--possible biomarkers for phenylisocyanate exposure.

Journal: Journal of occupational and environmental hygiene 20081001

Title: Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.

Journal: Journal of medicinal chemistry 20080925

Title: Underestimation of toluene diisocyanate concentration using long-term sampling with 1-(2-methoxyphenyl) piperazine impregnated filters.

Journal: International journal of hygiene and environmental health 20080701

Title: Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin.

Journal: Bioorganic & medicinal chemistry 20080601

Title: Quantitative monitoring of dermal and inhalation exposure to 1,6-hexamethylene diisocyanate monomer and oligomers.

Journal: Journal of environmental monitoring : JEM 20080401

Title: Sampling and analytical methodology development for the determination of primary and secondary low molecular weight amines in ambient air.

Journal: Journal of environmental monitoring : JEM 20080301

Title: Abstracts of papers presented at the 2007 pittsburgh conference.

Journal: Journal of automated methods & management in chemistry 20070101

Title: Validation of a diffusive sampling method for airborne low-molecular isocyanates using 4-nitro-7-piperazinobenzo-2-oxa-1,3-diazole-impregnated filters and liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20061117

Title: The synthesis of L-carvone and limonene derivatives with increased antiproliferative effect and activation of ERK pathway in prostate cancer cells.

Journal: Bioorganic & medicinal chemistry 20061001

Title: Effects of humidity and filter material on diffusive sampling of isocyanates using reagent-coated filters.

Journal: Journal of environmental monitoring : JEM 20061001

Title: Synthesis and characterization of novel '3 + 2' oxorhenium complexes, ReO[SNO][NN].

Journal: Inorganic chemistry 20060710

Title: Determination of airborne isocyanates generated during the thermal degradation of car paint in body repair shops.

Journal: The Annals of occupational hygiene 20060601

Title: Tape-strip sampling for measuring dermal exposure to 1,6-hexamethylene diisocyanate.

Journal: Scandinavian journal of work, environment & health 20060601

Title: Selective antagonist at D3 receptors, but not non-selective partial agonists, influences the expression of cocaine-induced conditioned place preference in free-feeding rats.

Journal: Pharmacology, biochemistry, and behavior 20051201

Title: Validation of a solvent-free sampler for the determination of low molecular weight aliphatic isocyanates under thermal degradation conditions.

Journal: Journal of occupational and environmental hygiene 20050901

Title: 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands.

Journal: Bioorganic & medicinal chemistry letters 20050315

Title: Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.

Journal: Bioorganic & medicinal chemistry 20050103

Title: Characterisation of derivatised monomeric and prepolymeric isocyanates by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and structural elucidation by tandem mass spectrometry.

Journal: European journal of mass spectrometry (Chichester, England) 20050101

Title: Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives.

Journal: European journal of medicinal chemistry 20041201

Title: A study on application of impregnated synthetic peptide TLC stationary phases for the screening of 5-HT1A ligands. Part 2.

Journal: Biomedical chromatography : BMC 20041001

Title: Biological monitoring of exposure to toluene diisocyanate.

Journal: Scandinavian journal of work, environment & health 20041001

Title: A survey of airborne isocyanate exposure in 13 Swedish polyurethane industries.

Journal: The Annals of occupational hygiene 20040701

Title: Determination of isocyanates in air using 1-(2-methoxyphenyl)piperazine-impregnated filters: long-term sampling performance and field comparison with impingers with dibutylamine.

Journal: The Annals of occupational hygiene 20040701

Title: New imide 5-HT1A receptor ligands - modification of terminal fragment geometry.

Journal: Molecules (Basel, Switzerland) 20040227

Title: Serotonergic and dopaminergic influence of the duration of embryogenesis and intracapsular locomotion of Lymnaea stagnalis L.

Journal: Acta biologica Hungarica 20040101

Title: Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031225

Title: Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.

Journal: Journal of medicinal chemistry 20031204

Title: Evaluation of some aroxyethylamine derivatives for hypotensive properties and their affinities for adrenergic receptors.

Journal: Die Pharmazie 20031201

Title: Investigation of the competitive rate of derivatization of several secondary amines with phenylisocyanate (PHI), hexamethylene-1,6-diisocyanate (HDI), 4,4'-methylenebis(phenyl isocyanate) (MDI) and toluene diisocyanate (TDI) in liquid medium.

Journal: The Analyst 20030201

Title: Novel oxorhenium and oxotechnetium MO(NS)(S)2 complexes in the development of 5-HT1A receptor imaging agents.

Journal: Journal of inorganic biochemistry 20030115

Title: Workplace monitoring of isocyanates using ion trap liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: Synthesis, in vitro and in vivo 5-HT1A/5-HT2A serotonin receptor activity of new hybrid 1,2,3,4-tetrahydro-gamma-carbolines with 1-(2-methoxyphenyl)piperazine moiety.

Journal: Polish journal of pharmacology 20030101

Title: Oxotechnetium 99mTcO[SN(R)S][S] complexes as potential 5-HT1A receptor imaging agents.

Journal: Nuclear medicine and biology 20021101

Title: Development of a diffusive sampling method for determination of methyl isocyanate in air.

Journal: Journal of environmental monitoring : JEM 20021001

Title: Exposure to airborne isocyanates and other thermal degradation products at polyurethane-processing workplaces.

Journal: Journal of environmental monitoring : JEM 20021001

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Comparison of sampling methods for 1,6-hexamethylene diisocyanate, (HDI) in a commercial spray box.

Journal: The Analyst 20020101

Title: Two routes to [11C-carbonyl]organo-isocyanates utilizing [11C]phosgene ([11C]organo-isocyanates from [11C]phosgene).

Journal: Nuclear medicine and biology 20011101

Title: Substituted phenoxyalkylpiperazines as dopamine D3 receptor ligands.

Journal: Die Pharmazie 20010401

Title: Development of novel mixed-ligand oxotechnetium [SNS/S] complexes as potential 5-HT1A receptor imaging agents.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20010301

Title: A comparison of solid sampler methods for the determination of hexamethylene-based isocyanates in spray-painting operations.

Journal: AIHAJ : a journal for the science of occupational and environmental health and safety 20010101

Title: 2-H- and 2-acyl-9- [omega-[4-(2-methoxyphenyl)piperazinyl]-alkyl]-1,2,3,4-tetrahydro-beta-carbolines as ligands of 5-HT1A and 5-HT2A receptors.

Journal: Polish journal of pharmacology 20010101

Title: Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

Journal: The Journal of biological chemistry 19930825

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