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36085-73-1,MFCD00274573
Catalog No.:AA00BXB0

36085-73-1 | B-HT 920 DIHYDROCHLORIDE

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1mg
98%
in stock  
$93.00   $65.00
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5mg
≥95%
in stock  
$98.00   $68.00
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10mg
≥95%
in stock  
$173.00   $121.00
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50mg
≥95%
in stock  
$718.00   $502.00
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100mg
98%
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$1,182.00   $828.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BXB0
Chemical Name:
B-HT 920 DIHYDROCHLORIDE
CAS Number:
36085-73-1
Molecular Formula:
C10H17Cl2N3S
Molecular Weight:
282.2331
MDL Number:
MFCD00274573
SMILES:
C=CCN1CCc2c(CC1)nc(s2)N.Cl.Cl
Properties
Properties
 
Form:
Solid  
MP:
>227°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
210  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  

Literature

Title: The neuroprotective effect of talipexole from paraquat-induced cell death in dopaminergic neuronal cells.

Journal: Neurotoxicology 20101201

Title: [Dopaminergic neuroprotection and reconstruction of neural network tiara].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20101001

Title: Pharmacokinetic profile of talipexole in healthy volunteers is not altered when it is co-administered with Madopar (co-beneldopa).

Journal: Journal of clinical pharmacy and therapeutics 20090601

Title: Effective control of catatonia in Parkinson's disease by electroconvulsive therapy: a case report.

Journal: European journal of neurology 20090201

Title: Bromocriptine, a dopamine D(2) receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells.

Journal: European journal of pharmacology 20081119

Title: The frequency of cardiac valvular regurgitation in Parkinson's disease.

Journal: Movement disorders : official journal of the Movement Disorder Society 20080515

Title: Clinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients.

Journal: Movement disorders : official journal of the Movement Disorder Society 20080430

Title: Mechanism of decongestant activity of alpha 2-adrenoceptor agonists.

Journal: Pulmonary pharmacology & therapeutics 20080101

Title: Pharmacological modulation of dopaminergic brain activity and its reflection in spectral frequencies of the rat electropharmacogram.

Journal: Neuropsychobiology 20080101

Title: alpha2-adrenoceptor agonists as nasal decongestants.

Journal: Pulmonary pharmacology & therapeutics 20070101

Title: Pre-junctional alpha2-adrenoceptors modulation of the nitrergic transmission in the pig urinary bladder neck.

Journal: Neurourology and urodynamics 20070101

Title: Antagonistic activity of ascorbic acid (vitamin C) on dopaminergic modulation: apomorphine-induced stereotypic behavior in mice.

Journal: Pharmacology 20060101

Title: Immunohistochemical and functional evidence for a noradrenergic regulation in the horse penile deep dorsal vein.

Journal: International journal of impotence research 20041201

Title: Blood pressure and alpha-vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca.

Journal: European journal of pharmacology 20040405

Title: Effects of an alpha2-adrenoceptor agonist in nasal mucosa.

Journal: Archives of physiology and biochemistry 20031001

Title: Repeated administration of methamphetamine causes hypersensitivity of D2 receptor in rat ventral tegmental area.

Journal: Neuroscience letters 20030821

Title: Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture.

Journal: Neuroscience research 20030801

Title: Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20030401

Title: Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries.

Journal: Fundamental & clinical pharmacology 20020801

Title: Impaired endothelial alpha-2 adrenergic receptor-mediated vascular relaxation in the fructose-fed rat.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20020301

Title: Influence of sildenafil on central dopamine-mediated behaviour in male rats.

Journal: Life sciences 20020215

Title: alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator.

Journal: British journal of pharmacology 20011001

Title: Identification of the dopamine autoreceptor in the guinea-pig retina as D(2) receptor using novel subtype-selective antagonists.

Journal: British journal of pharmacology 20010801

Title: Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins.

Journal: Biochemical pharmacology 20010501

Title: Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole.

Journal: European journal of pharmacology 20010406

Title: Postjunctional alpha(2C)-adrenoceptor contractility in human saphenous vein.

Journal: European journal of pharmacology 20010216

Title: Nonlinear analysis of partial dopamine agonist effects on cAMP in C6 glioma cells.

Journal: Journal of pharmacological and toxicological methods 20010101

Title: Intranasal application of the alpha2-adrenoceptor agonist BHT-920 produces decongestion in the cat.

Journal: American journal of rhinology 20010101

Title: Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors.

Journal: British journal of pharmacology 20000401

Title: Talipexole protects dopaminergic neurons from methamphetamine toxicity in C57BL/6N mouse.

Journal: Neuroscience letters 19980515

Title: Dopaminergic modulation of lithium/pilocarpine-induced status epilepticus in rats.

Journal: Methods and findings in experimental and clinical pharmacology 19970901

Title: Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland.

Journal: The Journal of pharmacology and experimental therapeutics 19960401

Title: Behavioral and biochemical changes after bilateral electrolytic lesions of the red nucleus of rat.

Journal: Pharmacology, biochemistry, and behavior 19950501

Title: D1/D2 dopamine and N-methyl-D-aspartate (NMDA) receptor participation in experimental catalepsy in rats.

Journal: Psychopharmacology 19920101

Title: Alpha 2-adrenoceptor-mediated inhibition of prolactin release in suckling- or fenfluramine-induced hyperprolactinemia.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 19910501

Title: Effects of staurosporine on the pressor responses to alpha-adrenoceptor agonists in pithed rats: a comparison with nifedipine.

Journal: Pharmacology 19910101

Title: Alpha 2-adrenoceptor-blocking properties of midaglizole (DG-5128) in rats.

Journal: Archives internationales de pharmacodynamie et de therapie 19900101

Title: Comparison of the effects of haloperidol, remoxipride and raclopride on 'pre'- and postsynaptic dopamine receptors in the rat brain.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19880401

Title: Pharmacological characterization of spinal alpha adrenoceptors related to blood pressure control in rats.

Journal: The Journal of pharmacology and experimental therapeutics 19870101

Title: Imidazole has similar behavioural effects to yohimbine.

Journal: Psychopharmacology 19860101

Title: Behavioural pharmacology of imidazole, a potential antidepressant agent.

Journal: Archives internationales de pharmacodynamie et de therapie 19851001

Title: Ricci and Taira Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen.Pharmacol. (1999)32 29.

Title: Eur J Pharmacol. 1997 May 1;325(2-3):137-44.

Title: Kohno Y, Fukuzaki K, Kitahara K, Koja T.Anti-tremor activity of talipexole produced by selective dopamine D2 receptor stimulation in cynomolgus monkeys with unilateral lesions in the ventromedial tegmentum.Eur J Pharmacol. 1997 Jan 29;319(2-3):197-205.

Title: Momiyama T, Sasa M, Takaori S.Inhibition by talipexole, a thiazolo-azepine derivative, of dopaminergic neurons in the ventral tegmental area.Life Sci. 1991;49(7):535-43.

Title: Nishikawa T, Yamada S, Tsuda A, Tanaka M, Koga I, Uchida Y.Chronic treatment with talipexole dihydrochloride on abnormal involuntary movement in humans.Clin Neuropharmacol. 1990 Jun;13(3):259-63.

Title: Robertson, G.S., et al., In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. J Pharmacol Exp Ther, 1993. 264(3): p. 1344-51.

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Tags:36085-73-1 Molecular Formula|36085-73-1 MDL|36085-73-1 SMILES|36085-73-1 B-HT 920 DIHYDROCHLORIDE