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36861-47-9,MFCD00209662
Catalog No.:AA003DOQ

36861-47-9 | 4-Methylbenzylidene camphor

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250mg
98%
in stock  
$6.00   $4.00
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1g
98%
in stock  
$7.00   $5.00
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5g
95%
in stock  
$18.00   $13.00
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25g
98%
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003DOQ
Chemical Name:
4-Methylbenzylidene camphor
CAS Number:
36861-47-9
Molecular Formula:
C18H22O
Molecular Weight:
254.3667
MDL Number:
MFCD00209662
SMILES:
Cc1ccc(cc1)/C=C/1\C(=O)C2(C(C1CC2)(C)C)C
Properties
Properties
 
BP:
371.9°C at 760 mmHg  
Form:
Solid  
MP:
66-68°C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
423  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
1  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
2  
XLogP3:
4.5  

Downstream Synthesis Route
1.2.2-trimethyl-3-<β-oxy-β-p-tolyl-ethyl>-cyclopentane-carboxylicacid-(1) 
  36861-47-9 

[1]ComptesRendusHebdomadairesdesSeancesdel'AcademiedesSciences,1912,vol.154,p.744

[1]JournaloftheBrazilianChemicalSociety,2010,vol.21,p.1377-1383

Literature

Title: Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine.

Journal: International journal of environmental research and public health 20160601

Title: Simultaneous determination of ultraviolet filters in aqueous samples by plunger-in-needle solid-phase microextraction with graphene-based sol-gel coating as sorbent coupled with gas chromatography-mass spectrometry.

Journal: Analytica chimica acta 20120912

Title: Degradation of UV filters in sewage sludge and 4-MBC in liquid medium by the ligninolytic fungus Trametes versicolor.

Journal: Journal of environmental management 20120815

Title: Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters.

Journal: International journal of andrology 20120601

Title: Ionic liquid based hollow fiber supported liquid phase microextraction of ultraviolet filters.

Journal: Journal of chromatography. A 20120316

Title: Impact of 4-methylbenzylidene camphor, daidzein, and estrogen on intact and osteotomized bone in osteopenic rats.

Journal: The Journal of endocrinology 20111101

Title: Acute and chronic toxicity of four frequently used UV filter substances for Desmodesmus subspicatus and Daphnia magna.

Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20110101

Title: Vertical flow soil filter for the elimination of micro pollutants from storm and waste water.

Journal: Chemosphere 20091101

Title: Impact of 4-methylbenzylidene-camphor (4-MBC) during embryonic and fetal development in the neuroendocrine regulation of testicular axis in prepubertal and peripubertal male rats.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20091001

Title: Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20090731

Title: Effect of daidzein, 4-methylbenzylidene camphor or estrogen on gastrocnemius muscle of osteoporotic rats undergoing tibia healing period.

Journal: The Journal of endocrinology 20090501

Title: Female sexual behavior, estrous cycle and gene expression in sexually dimorphic brain regions after pre- and postnatal exposure to endocrine active UV filters.

Journal: Neurotoxicology 20090301

Title: Co-loading of a photostabilizer with the sunscreen agent, butyl methoxydibenzoylmethane in solid lipid microparticles.

Journal: Drug development and industrial pharmacy 20090201

Title: Possible environmental effects of sunscreen run-off.

Journal: Journal of the American Academy of Dermatology 20081101

Title: Region-specific growth effects in the developing rat prostate following fetal exposure to estrogenic ultraviolet filters.

Journal: Environmental health perspectives 20080701

Title: Developmental toxicity of UV filters and environmental exposure: a review.

Journal: International journal of andrology 20080401

Title: Sunscreens in human plasma and urine after repeated whole-body topical application.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20080401

Title: Endocrine modulation and toxic effects of two commonly used UV screens on the aquatic invertebrates Potamopyrgus antipodarum and Lumbriculus variegatus.

Journal: Environmental pollution (Barking, Essex : 1987) 20080301

Title: Development of a method for the determination of UV filters in water samples using stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20080201

Title: Influence of solid lipid microparticle carriers on skin penetration of the sunscreen agent, 4-methylbenzylidene camphor.

Journal: The Journal of pharmacy and pharmacology 20071201

Title: Estrogen sensitivity of target genes and expression of nuclear receptor co-regulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor.

Journal: Environmental health perspectives 20071201

Title: Occurrence and behavior of four of the most used sunscreen UV filters in a wastewater reclamation plant.

Journal: Water research 20070801

Title: Risk assessment of topically applied products.

Journal: Toxicology 20070701

Title: Complexation of the sunscreen agent, 4-methylbenzylidene camphor with cyclodextrins: effect on photostability and human stratum corneum penetration.

Journal: Journal of pharmaceutical and biomedical analysis 20070509

Title: Sunscreens and thyroid function in humans after short-term whole-body topical application: a single-blinded study.

Journal: The British journal of dermatology 20070501

Title: Sexually dimorphic gene regulation in brain as a target for endocrine disrupters: developmental exposure of rats to 4-methylbenzylidene camphor.

Journal: Toxicology and applied pharmacology 20070115

Title: A validated method for the determination of traces of UV filters in fish using LC-MS/MS.

Journal: Analytical and bioanalytical chemistry 20061101

Title: Toxicokinetics and biotransformation of 3-(4-methylbenzylidene)camphor in rats after oral administration.

Journal: Toxicology and applied pharmacology 20061015

Title: Kinetics of 3-(4-methylbenzylidene)camphor in rats and humans after dermal application.

Journal: Toxicology and applied pharmacology 20061015

Title: Comparison of effects of estradiol with those of octylmethoxycinnamate and 4-methylbenzylidene camphor on fat tissue, lipids and pituitary hormones.

Journal: Toxicology and applied pharmacology 20060701

Title: Occurrence of UV filters 4-methylbenzylidene camphor and octocrylene in fish from various Swiss rivers with inputs from wastewater treatment plants.

Journal: Environmental science & technology 20060301

Title: Comparison of effects of estradiol (E2) with those of octylmethoxycinnamate (OMC) and 4-methylbenzylidene camphor (4MBC)--2 filters of UV light - on several uterine, vaginal and bone parameters.

Journal: Toxicology and applied pharmacology 20060201

Title: Concentrations and specific loads of UV filters in sewage sludge originating from a monitoring network in Switzerland.

Journal: Chemosphere 20060201

Title: Evaluation of the photostability of different UV filter combinations in a sunscreen.

Journal: International journal of pharmaceutics 20060113

Title: Enantioselective separation of the sunscreen agent 3-(4-methylbenzylidene)-camphor by electrokinetic chromatography: Quantitative analysis in cosmetic formulations.

Journal: Electrophoresis 20051001

Title: Estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor.

Journal: Endocrinology 20050501

Title: Shining a light on sunscreens.

Journal: Endocrinology 20050501

Title: Stereoisomer composition of the chiral UV filter 4-methylbenzylidene camphor in environmental samples.

Journal: Environmental science & technology 20050501

Title: Estrogen-like effects of ultraviolet screen 3-(4-methylbenzylidene)-camphor (Eusolex 6300) on cell proliferation and gene induction in mammalian and amphibian cells.

Journal: Environmental research 20050301

Title: Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss Lakes.

Journal: Environmental science & technology 20050215

Title: Estrogenic activity and estrogen receptor beta binding of the UV filter 3-benzylidene camphor. Comparison with 4-methylbenzylidene camphor.

Journal: Toxicology 20040701

Title: Assessment of hormonal activity of UV filters in tadpoles of frog Xenopus laevis at environmental concentrations.

Journal: Marine environmental research 20040101

Title: Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes).

Journal: Toxicology 20031215

Title: Confirmation of uterotrophic activity of 3-(4-methylbenzylidine)camphor in the immature rat.

Journal: Environmental health perspectives 20020501

Title: Confirmation of uterotrophic activity for 4-MBC in the immature rat.

Journal: Environmental health perspectives 20011101

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