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371-86-8,MFCD00801119
Catalog No.:AA00CZ6K

371-86-8 | N,N'-Diisopropylphosphorodiamidic fluoride

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500mg
95%
2 weeks  
$674.00   $472.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00CZ6K
Chemical Name:
N,N'-Diisopropylphosphorodiamidic fluoride
CAS Number:
371-86-8
Molecular Formula:
C6H16FN2OP
Molecular Weight:
182.1762
MDL Number:
MFCD00801119
SMILES:
CC(NP(=O)(NC(C)C)F)C
NSC Number:
8924
Properties
Computed Properties
 
Complexity:
147  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
1  

Literature

Title: Phenyl valerate esterase activity of human butyrylcholinesterase.

Journal: Archives of toxicology 20171001

Title: High concentration of trichlorfon (1mM) disrupts axonal cytoskeleton and decreases the expression of plasticity-related proteins in SH-SY5Y cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20170301

Title: Butyrylcholinesterase identification in a phenylvalerate esterase-enriched fraction sensitive to low mipafox concentrations in chicken brain.

Journal: Archives of toxicology 20170201

Title: Effects of mipafox, paraoxon, chlorpyrifos and its metabolite chlorpyrifos-oxon on the expression of biomarker genes of differentiation in D3 mouse embryonic stem cells.

Journal: Chemico-biological interactions 20161125

Title: Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches.

Journal: Archives of toxicology 20160301

Title: Further studies toward a mouse model for biochemical assessment of neuropathic potential of organophosphorus compounds.

Journal: Journal of applied toxicology : JAT 20141201

Title: Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox.

Journal: International journal of molecular sciences 20140101

Title: Kinetics of the inhibitory interaction of organophosphorus neuropathy inducers and non-inducers in soluble esterases in the avian nervous system.

Journal: Toxicology and applied pharmacology 20111101

Title: Motor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.

Journal: Toxicology letters 20101110

Title: Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.

Journal: Toxicology letters 20100701

Title: Effect of inhibition of neuropathy target esterase in mouse nervous tissues in vitro on phosphatidylcholine and lysophosphatidylcholine homeostasis.

Journal: International journal of toxicology 20090101

Title: Molecular cloning and expression of the C-terminal domain of mouse NTE-related esterase.

Journal: Molecular and cellular biochemistry 20071201

Title: Molecular cloning and expression of chicken neuropathy target esterase activity domain.

Journal: Toxicology letters 20071101

Title: Biosensor assay of neuropathy target esterase in whole blood as a new approach to OPIDN risk assessment: review of progress.

Journal: Human & experimental toxicology 20070401

Title: The search of the target of promotion: Phenylbenzoate esterase activities in hen peripheral nerve.

Journal: Toxicology and applied pharmacology 20070301

Title: Mechanism of aging of mipafox-inhibited butyrylcholinesterase.

Journal: Chemical research in toxicology 20070301

Title: Over-expression of neuropathy target esterase activity in bovine chromaffin cell cultures by adenovirus-mediated gene transfer.

Journal: Toxicology letters 20070205

Title: Recovery of neuropathy target esterase activity after inhibition with mipafox and O-hexyl O-2,5-dichlorophenyl phosphoramidate in bovine chromaffin cell cultures.

Journal: Chemico-biological interactions 20070130

Title: Comparison of chromaffin cells from several animal sources for their use as an in vitro model to study the mechanism of organophosphorous toxicity.

Journal: Toxicology letters 20060910

Title: Degradation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH).

Journal: Journal of toxicology and environmental health. Part A 20060801

Title: Aging of mipafox-inhibited human acetylcholinesterase proceeds by displacement of both isopropylamine groups to yield a phosphate adduct.

Journal: Chemical research in toxicology 20060201

Title: Reduction of neuropathy target esterase does not affect neuronal differentiation, but moderate expression induces neuronal differentiation in human neuroblastoma (SK-N-SH) cell line.

Journal: Brain research. Molecular brain research 20051118

Title: Effects of organophosphorus compounds on ATP production and mitochondrial integrity in cultured cells.

Journal: Neurotoxicity research 20050101

Title: Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride.

Journal: Journal of applied toxicology : JAT 20050101

Title: Neurofilament 200 as an indicator of differences between mipafox and paraoxon sensitivity in Sy5Y neuroblastoma cells.

Journal: Journal of toxicology and environmental health. Part A 20040709

Title: Bovine chromaffin cell cultures as model to study organophosporus neurotoxicity.

Journal: Toxicology letters 20040615

Title: The inhibition of the high sensitive peripheral nerve soluble esterases by mipafox. A new mathematical processing for the kinetics of inhibition of esterases by organophosphorus compounds.

Journal: Toxicology letters 20040615

Title: Lysophospholipase inhibition by organophosphorus toxicants.

Journal: Toxicology and applied pharmacology 20040501

Title: The mipafox-inhibited catalytic domain of human neuropathy target esterase ages by reversible proton loss.

Journal: Biochemistry 20040330

Title: In vitro protection of plasma cholinesterases by metoclopramide from inhibition by mipafox.

Journal: Journal of applied toxicology : JAT 20040101

Title: Relative inhibitory potencies of chlorpyrifos oxon, chlorpyrifos methyl oxon, and mipafox for acetylcholinesterase versus neuropathy target esterase.

Journal: Journal of toxicology and environmental health. Part A 20030627

Title: Neurotoxicity of polycyclic aromatic hydrocarbons and simple chemical mixtures.

Journal: Journal of toxicology and environmental health. Part A 20030523

Title: Properties of phenyl valerate esterase activities from chicken serum are comparable with soluble esterases of peripheral nerves in relation with organophosphorus compounds inhibition.

Journal: Toxicology letters 20030430

Title: Biosensor detection of neuropathy target esterase in whole blood as a biomarker of exposure to neuropathic organophosphorus compounds.

Journal: Journal of toxicology and environmental health. Part A 20030411

Title: Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds.

Journal: Toxicology and applied pharmacology 20030115

Title: In vitro protection of red blood cell acetylcholinesterase by metoclopramide from inhibition by organophosphates (paraoxon and mipafox).

Journal: Journal of applied toxicology : JAT 20030101

Title: Inhibition of carboxylesterases in SH-SY5Y human and NB41A3 mouse neuroblastoma cells by organophosphorus esters.

Journal: Journal of toxicology and environmental health. Part A 19980313

Title: Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19970701

Title: Potentiation of organophosphorus-induced delayed neurotoxicity following phenyl saligenin phosphate exposures in 2-, 5-, and 8-week-old chickens.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19970501

Title: Subacute neurotoxicity induced in mice by potent organophosphorus neuropathy target esterase inhibitors.

Journal: Toxicology and applied pharmacology 19960701

Title: Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19950101

Title: Interactions between neuropathy target esterase and its inhibitors and the development of polyneuropathy.

Journal: Toxicology and applied pharmacology 19931001

Title: Biochemical properties and possible toxicological significance of various forms of NTE.

Journal: Chemico-biological interactions 19930601

Title: Delayed neurotoxic effect of sarin in mice after repeated inhalation exposure.

Journal: Journal of applied toxicology : JAT 19930101

Title: Comparative evolution of mipafox-induced delayed neuropathy in rats and hens.

Journal: Neurotoxicology 19920101

Title: Comparative dose-response studies of organophosphorus ester-induced delayed neuropathy in rats and hens administered mipafox.

Journal: Neurotoxicology 19920101

Title: Age sensitivity to organophosphate-induced delayed polyneuropathy. Biochemical and toxicological studies in developing chicks.

Journal: Biochemical pharmacology 19910515

Title: The correlation between neurotoxic esterase inhibition and mipafox-induced neuropathic damage in rats.

Journal: Neurotoxicology 19860101

Title: Phenylmethylsulfonyl fluoride protects rats from Mipafox-induced delayed neuropathy.

Journal: Toxicology and applied pharmacology 19851101

Title: Striatal neurochemical changes and motor dysfunction in mipafox-treated animals.

Journal: Methods and findings in experimental and clinical pharmacology 19850201

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Tags:371-86-8 Molecular Formula|371-86-8 MDL|371-86-8 SMILES|371-86-8 N,N'-Diisopropylphosphorodiamidic fluoride