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37686-84-3,MFCD00242729
Catalog No.:AA00BY08

37686-84-3 | S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA

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5mg
≥98%
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$415.00   $290.00
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25mg
≥98%
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$1,441.00   $1,009.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BY08
Chemical Name:
S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA
CAS Number:
37686-84-3
Molecular Formula:
C20H28N4O
Molecular Weight:
340.4625
MDL Number:
MFCD00242729
SMILES:
CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(C1)c1cccc3c1c(C2)c[nH]3)CC
Properties
Computed Properties
 
Complexity:
494  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
2.5  

Literature

Title: Pathways in pulmonary arterial hypertension: the future is here.

Journal: European respiratory review : an official journal of the European Respiratory Society 20121201

Title: Modeling of bias for the analysis of receptor signaling in biochemical systems.

Journal: Biochemistry 20120214

Title: Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20120201

Title: [Pharmacology of antipsychotics at human dopamine D2 and D3 receptors].

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20120201

Title: Terguride for pulmonary arterial hypertension.

Journal: Expert opinion on therapeutic targets 20111101

Title: Partial agonists in schizophrenia--why some work and others do not: insights from preclinical animal models.

Journal: The international journal of neuropsychopharmacology 20111001

Title: Serotonergic involvement in methamphetamine-induced locomotor activity: a detailed pharmacological study.

Journal: Behavioural brain research 20110620

Title: Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.

Journal: The European respiratory journal 20110501

Title: New perspectives for the treatment of pulmonary hypertension.

Journal: British journal of pharmacology 20110501

Title: Pharmacological and physiological characterization of the tremulous jaw movement model of parkinsonian tremor: potential insights into the pathophysiology of tremor.

Journal: Frontiers in systems neuroscience 20110101

Title: Can ropinirole modulate reinforcing subjective effects of cocaine in humans?

Journal: Frontiers in psychiatry 20110101

Title: 5-HT(1A) receptor activation improves anti-cataleptic effects of levodopa in 6-hydroxydopamine-lesioned rats.

Journal: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101

Title: The dopamine D(2) partial agonist and antagonist terguride decreases heroin self-administration on fixed- and progressive-ratio schedules.

Journal: Pharmacology, biochemistry, and behavior 20101201

Title: Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention.

Journal: Thorax 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Development and application of an LC-MS/MS method for measuring the effect of (partial) agonists on cAMP accumulation in vitro.

Journal: Journal of neuroscience methods 20100430

Title: LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor.

Journal: Psychopharmacology 20100201

Title: Evaluation of the efficacy and safety of terguride in patients with fibromyalgia syndrome: results of a twelve-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study.

Journal: Arthritis and rheumatism 20100101

Title: Co-administration of the partial dopamine D2 agonist terguride with L-dopa attenuates L-dopa-induced locomotor sensitization in hemiparkinsonian mice.

Journal: Behavioural brain research 20090914

Title: Dopamine receptor subtypes contribution to Homer1a induction: insights into antipsychotic molecular action.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20090801

Title: Recognition properties and competitive assays of a dual dopamine/serotonin selective molecularly imprinted polymer.

Journal: International journal of molecular sciences 20081201

Title: Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors.

Journal: European journal of pharmacology 20081112

Title: The effect of terguride in carbon tetrachloride-induced liver fibrosis in rat.

Journal: Experimental biology and medicine (Maywood, N.J.) 20081101

Title: Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling.

Journal: Neuropharmacology 20080601

Title: Effects of aripiprazole and terguride on dopamine synthesis in the dorsal striatum and medial prefrontal cortex of preweanling rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20080101

Title: Pharmacological properties of a wide array of ergolines at functional alpha(1)-adrenoceptor subtypes.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080101

Title: [A case of ruptured internal carotid artery aneurysm mimicking pituitary apoplexy].

Journal: No shinkei geka. Neurological surgery 20071201

Title: Long-term serotonin effects in the rat are prevented by terguride.

Journal: Regulatory peptides 20071004

Title: In vitro functional characteristics of dopamine D2 receptor partial agonists in second and third messenger-based assays of cloned human dopamine D2Long receptor signalling.

Journal: Journal of psychopharmacology (Oxford, England) 20070801

Title: In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist.

Journal: Synapse (New York, N.Y.) 20061215

Title: Pre- and postsynaptic actions of a partial D2 receptor agonist in reserpinized young rats: longevity of agonistic effects.

Journal: Brain research 20061208

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: The partial dopamine D2-like receptor agonist terguride functions as an agonist in preweanling rats after a 5-day reserpine regimen.

Journal: Psychopharmacology 20060301

Title: Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat.

Journal: Pharmacology, biochemistry, and behavior 20060301

Title: Effects of a partial D2-like receptor agonist on striatal dopamine autoreceptor functioning in preweanling rats.

Journal: Brain research 20060216

Title: Aripiprazole's low intrinsic activities at human dopamine D2L and D2S receptors render it a unique antipsychotic.

Journal: European journal of pharmacology 20050516

Title: Influence of steric hindrance on enantioseparation of Dns-amino acids and pesticides on terguride based chiral selectors in capillary electrophoresis.

Journal: Journal of separation science 20050501

Title: Agonism at 5-HT2B receptors is not a class effect of the ergolines.

Journal: European journal of pharmacology 20050425

Title: A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.

Journal: Journal of medicinal chemistry 20050421

Title: The partial D2-like dopamine receptor agonist terguride acts as a functional antagonist in states of high and low dopaminergic tone: evidence from preweanling rats.

Journal: Psychopharmacology 20050401

Title: Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050101

Title: In vitro antiplasmodial activities of semisynthetic N,N'-spacer-linked oligomeric ergolines.

Journal: Bioorganic & medicinal chemistry 20040215

Title: Pergolide, terguride and N,N'-spacer-linked oligomers of both interact with 5-HT2A receptors of rat tail artery.

Journal: Physiological research 20040101

Title: Effects of terguride treatment on glucose abnormalities induced by ischemic brain damage in SHR/N-cp lean Koletsky strain and in rats of Wistar strain.

Journal: Bratislavske lekarske listy 20040101

Title: Management of restless legs syndrome by the partial D2-agonist terguride.

Journal: Sleep medicine 20030901

Title: Effects of a partial dopamine D2-like agonist on the cocaine-induced behavioral sensitization of preweanling rats.

Journal: Pharmacology, biochemistry, and behavior 20030801

Title: [Pharmacokinetic/pharmacodynamic analysis of anti-hyperprolactinemic effect of terguride based on dopamine D2 receptor occupancy].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20030401

Title: Suppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeys.

Journal: Psychopharmacology 20030301

Title: Inhibition of growth hormone excess reduces insulin resistance and ovarian dysfunction in a lean case of polycystic ovary syndrome with a growth-hormone-producing pituitary adenoma.

Journal: Hormone research 20030101

Title: [Arrest of lactation after 2nd trimester abortion with a single dose of cabergoline in comparison with 10-day administration of teguride].

Journal: Ceska gynekologie 20030101

Title: [Results of treatment for male prolactinomas].

Journal: No shinkei geka. Neurological surgery 20021201

Title: Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor.

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT(1) and 5-HT(2), receptor subtypes.

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: Terguride treatment attenuated prolactin release and enhanced insulin receptor affinity and GLUT 4 content in obese spontaneously hypertensive female, but not male rats.

Journal: Annals of the New York Academy of Sciences 20020601

Title: Clustered ergot alkaloids modulate cell-mediated cytotoxicity.

Journal: Bioorganic & medicinal chemistry 20020201

Title: Atypical kinetics for a series of putative dopamine antagonists to reverse the low-magnitude Ca2+ phase in the dopamine-bound D2short receptor state.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020101

Title: Dopamine partial agonist reverses amphetamine withdrawal in rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011101

Title: Reinforcing effects of D2 dopamine receptor agonists and partial agonists in rhesus monkeys.

Journal: Drug and alcohol dependence 20011001

Title: Effects of dopamine d2 receptor agonists in a pituitary transplantation-induced hyperprolactinaemia/anovulation model in rats.

Journal: Clinical and experimental pharmacology & physiology 20010801

Title: A dopamine partial agonist and antagonist block amphetamine self-administration in a progressive ratio schedule.

Journal: Pharmacology, biochemistry, and behavior 20010401

Title: Clinical features and medical treatment of male prolactinomas.

Journal: Acta neurochirurgica 20010101

Title: Nonlinear analysis of partial dopamine agonist effects on cAMP in C6 glioma cells.

Journal: Journal of pharmacological and toxicological methods 20010101

Title: Atypical polypoid adenomyoma in a patient with hyperprolactinemia.

Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20010101

Title: Terguride attenuates prolactin levels and ameliorates insulin sensitivity and insulin binding in obese spontaneously hypertensive rats.

Journal: Physiological research 20010101

Title: Pharmacological effects of BAM-1120, a novel ergoline derivative, on central dopaminergic functions in rats.

Journal: Methods and findings in experimental and clinical pharmacology 19980901

Title: Effects of terguride on anterior pituitary function in parkinsonian patients treated with L-dopa: a double-blind study versus placebo.

Journal: Clinical neuropharmacology 19960201

Title: Effects of several partial dopamine D2 receptor agonists in Cebus apella monkeys previously treated with haloperidol.

Journal: European journal of pharmacology 19930624

Title: Effects of terguride, a partial D2 agonist, on MPTP-lesioned parkinsonian cynomolgus monkeys.

Journal: Annals of neurology 19930501

Title: Partial dopamine agonist therapy of levodopa-induced dyskinesias.

Journal: Neurology 19920601

Title: Effect of D1 and D2 agonists and antagonists on dyskinesia produced by L-dopa in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 19911001

Title: Antagonist effect of terguride in Parkinson's disease.

Journal: Clinical neuropharmacology 19911001

Title: Behavioural profile of partial D2 dopamine receptor agonists. 1. Atypical inhibition of d-amphetamine-induced locomotor hyperactivity and stereotypy.

Journal: Psychopharmacology 19910101

Title: Transdihydrolisuride in parkinsonism.

Journal: Clinical neuropharmacology 19870101

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Tags:37686-84-3 Molecular Formula|37686-84-3 MDL|37686-84-3 SMILES|37686-84-3 S(+)-N,N-DIETHYL-N'([8ALPHA]-6-METHYLERGOLIN-8-YL)UREA