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37704-45-3,MFCD06655779
Catalog No.:AA00C6TB

37704-45-3 | Methyl 7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
>98%
in stock  
$258.00   $181.00
- +
250mg
>98%
in stock  
$354.00   $248.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C6TB
Chemical Name:
Methyl 7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate
CAS Number:
37704-45-3
Molecular Formula:
C10H11NO4
Molecular Weight:
209.1986
MDL Number:
MFCD06655779
SMILES:
COC(=O)c1c(O)cc(=O)n2c1CCC2
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
394  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
0.3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED-US2009/124595,2009,A1Locationinpatent:Page/Pagecolumn33

[2]Dannhardt;Meindl;Gussmann;Ajili;Kappe[EuropeanJournalofMedicinalChemistry,1987,vol.22,#6,p.505-510]

[1]Dannhardt;Meindl;Gussmann;Ajili;Kappe[EuropeanJournalofMedicinalChemistry,1987,vol.22,#6,p.505-510]

[1]Dannhardt;Meindl;Gussmann;Ajili;Kappe[EuropeanJournalofMedicinalChemistry,1987,vol.22,#6,p.505-510]

[2]Christoforow,Andreas;Wilke,Julian;Binici,Aylin;Pahl,Axel;Ostermann,Claude;Sievers,Sonja;Waldmann,Herbert[AngewandteChemie-InternationalEdition,2019,vol.58,#41,p.14715-14723][Angew.Chem.,2019,vol.131,#41,p.14857-14865,9]

[1]Dannhardt;Meindl;Gussmann;Ajili;Kappe[EuropeanJournalofMedicinalChemistry,1987,vol.22,#6,p.505-510]

Literature

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

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SDS
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Tags:37704-45-3 Molecular Formula|37704-45-3 MDL|37704-45-3 SMILES|37704-45-3 Methyl 7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate |Heterocyclic_Building_Blocks