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379270-37-8,MFCD23843796
Catalog No.:AA00C6G9

379270-37-8 | GS-7340

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$8.00   $6.00
- +
5mg
98%
in stock  
$15.00   $11.00
- +
10mg
98%
in stock  
$19.00   $14.00
- +
50mg
98%(HPLC)
in stock  
$66.00   $46.00
- +
100mg
98%
in stock  
$66.00   $47.00
- +
250mg
98%
in stock  
$131.00   $92.00
- +
1g
98%
in stock  
$222.00   $156.00
- +
5g
98%
in stock  
$581.00   $407.00
- +
10g
98%
in stock  
$1,116.00   $781.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6G9
Chemical Name:
GS-7340
CAS Number:
379270-37-8
Molecular Formula:
C21H29N6O5P
Molecular Weight:
476.4659
MDL Number:
MFCD23843796
SMILES:
C[C@H](Cn1cnc2c1ncnc2N)OC[P@@](=O)(N[C@H](C(=O)OC(C)C)C)Oc1ccccc1
Properties
Computed Properties
 
Complexity:
680  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
12  
XLogP3:
1.9  

Literature

Title: Tenofovir Alafenamide.

Journal: The Annals of pharmacotherapy 20161101

Title: Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus.

Journal: Antiviral research 20160101

Title: PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer.

Journal: European journal of medicinal chemistry 20140506

Title: Metabolism and antiretroviral activity of tenofovir alafenamide in CD4+ T-cells and macrophages from demographically diverse donors.

Journal: Antiviral therapy 20140101

Title: Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity.

Journal: Antiviral therapy 20140101

Title: Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults.

Journal: Journal of acquired immune deficiency syndromes (1999) 20130801

Title: Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro.

Journal: Antimicrobial agents and chemotherapy 20121001

Title: Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.

Journal: Bioorganic & medicinal chemistry 20100515

Title: Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors.

Journal: Journal of medicinal chemistry 20080724

Title: Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.

Journal: Molecular pharmacology 20080701

Title: Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.

Journal: Antimicrobial agents and chemotherapy 20080201

Title: Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

Journal: Antimicrobial agents and chemotherapy 20070201

Title: Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus.

Journal: Journal of acquired immune deficiency syndromes (1999) 20060901

Title: Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.

Journal: Antimicrobial agents and chemotherapy 20050501

Title: Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.

Journal: Antimicrobial agents and chemotherapy 20030701

Title: Purification of PMPA amidate prodrugs by SMB chromatography and x-ray crystallography of the diastereomerically pure GS-7340.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Metabolism of GS-7340, a novel phenyl monophosphoramidate intracellular prodrug of PMPA, in blood.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Practical synthesis, separation, and stereochemical assignment of the PMPA pro-drug GS-7340.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10(2):459-66.

Title: Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55.

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SDS
Tags:379270-37-8 Molecular Formula|379270-37-8 MDL|379270-37-8 SMILES|379270-37-8 GS-7340