Title: Tenofovir Alafenamide.
Journal: The Annals of pharmacotherapy 20161101
Title: Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus.
Journal: Antiviral research 20160101
Title: PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer.
Journal: European journal of medicinal chemistry 20140506
Title: Metabolism and antiretroviral activity of tenofovir alafenamide in CD4+ T-cells and macrophages from demographically diverse donors.
Journal: Antiviral therapy 20140101
Title: Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity.
Journal: Antiviral therapy 20140101
Title: Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults.
Journal: Journal of acquired immune deficiency syndromes (1999) 20130801
Title: Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro.
Journal: Antimicrobial agents and chemotherapy 20121001
Title: Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.
Journal: Bioorganic & medicinal chemistry 20100515
Title: Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors.
Journal: Journal of medicinal chemistry 20080724
Title: Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.
Journal: Molecular pharmacology 20080701
Title: Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
Journal: Antimicrobial agents and chemotherapy 20080201
Title: Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.
Journal: Antimicrobial agents and chemotherapy 20070201
Title: Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus.
Journal: Journal of acquired immune deficiency syndromes (1999) 20060901
Title: Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.
Journal: Antimicrobial agents and chemotherapy 20050501
Title: Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.
Journal: Antimicrobial agents and chemotherapy 20030701
Title: Purification of PMPA amidate prodrugs by SMB chromatography and x-ray crystallography of the diastereomerically pure GS-7340.
Journal: Nucleosides, nucleotides & nucleic acids 20010101
Title: Metabolism of GS-7340, a novel phenyl monophosphoramidate intracellular prodrug of PMPA, in blood.
Journal: Nucleosides, nucleotides & nucleic acids 20010101
Title: Practical synthesis, separation, and stereochemical assignment of the PMPA pro-drug GS-7340.
Journal: Nucleosides, nucleotides & nucleic acids 20010101
Title: Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10(2):459-66.
Title: Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55.