[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2009/34133,2009,A1Locationinpatent:Page/Pagecolumn20
Title: Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.
Journal: The international journal of neuropsychopharmacology 20140101
Title: Selective orexin receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters 20130901
Title: Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist.
Journal: Journal of psychopharmacology (Oxford, England) 20120801
Title: Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120401
Title: Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.
Journal: Bioorganic & medicinal chemistry letters 20110915
Title: Disposition and metabolism of [14C]SB-649868, an orexin 1 and 2 receptor antagonist, in humans.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201
Title: Di Fabio R, et al. Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2receptor antagonist useful for treatment of sleep disorders. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5562-7.
Title: Faedo S, et al. Functional and binding kinetic studies make a distinction between OX1 and OX2 orexin receptorantagonists. Eur J Pharmacol. 2012 Oct 5;692(1-3):1-9.
