Home Pyridines 3811-73-2
3811-73-2,MFCD01941547
Catalog No.:AA00I7FK

3811-73-2 | 2-Mercaptopyridine N-oxide sodium salt

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98%(HPLC)powder
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5g
98%(HPLC)powder
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25g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I7FK
Chemical Name:
2-Mercaptopyridine N-oxide sodium salt
CAS Number:
3811-73-2
Molecular Formula:
C5H4NNaOS
Molecular Weight:
149.1461
MDL Number:
MFCD01941547
SMILES:
[S-]c1cccc[n+]1[O-].[Na+]
Properties
Computed Properties
 
Complexity:
162  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  

Downstream Synthesis Route

[1]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1976,vol.14,p.756-758

[1]Hay,BenjaminP.;Beckwith,AthelstanL.J.[JournalofOrganicChemistry,1989,vol.54,#18,p.4330-4334]

[1]Newcomb,Martin;Sanchez,RobertM.;Kaplan,Jere[JournaloftheAmericanChemicalSociety,1987,vol.109,#4,p.1195-1199]

[1]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1982,vol.21,p.1115-1117

[1]Tetrahedron,1992,vol.48,p.1627-1636

Literature

Title: Species sensitivity distribution approach to primary risk analysis of the metal pyrithione photodegradation product, 2,2'-dipyridyldisulfide in the Inland Sea and induction of notochord undulation in fish embryos.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20120815

Title: The versatile binding mode of transition-state analogue inhibitors of tyrosinase towards dicopper(II) model complexes: experimental and theoretical investigations.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20111125

Title: Single-substance and mixture toxicity of five pharmaceuticals and personal care products to marine periphyton communities.

Journal: Environmental toxicology and chemistry 20110901

Title: Dense fouling in acid transfer pipelines by an acidophilic rubber degrading fungus.

Journal: Biofouling 20110701

Title: Precursors and formation of pyrithione and other pyridyl-containing sulfur compounds in drumstick onion, Allium stipitatum.

Journal: Journal of agricultural and food chemistry 20110525

Title: Direct observation of the β-carotene reaction with hydroxyl radical.

Journal: The journal of physical chemistry. B 20110310

Title: Zinc is a potential therapeutic for chemoresistant ovarian cancer.

Journal: Journal of experimental therapeutics & oncology 20110101

Title: Activation of the orphan receptor tyrosine kinase ALK by zinc.

Journal: Biochemical and biophysical research communications 20100806

Title: Zinc signals promote IL-2-dependent proliferation of T cells.

Journal: European journal of immunology 20100501

Title: K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport.

Journal: Respiratory research 20100101

Title: Leaching of hydrophobic Cu and Zn from discarded marine antifouling paint residues: evidence for transchelation of metal pyrithiones.

Journal: Environmental pollution (Barking, Essex : 1987) 20091201

Title: Metal ionophores - an emerging class of anticancer drugs.

Journal: IUBMB life 20091101

Title: Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight into its mechanism of action.

Journal: Journal of inorganic biochemistry 20091001

Title: Pyrithione and 8-hydroxyquinolines transport lead across erythrocyte membranes.

Journal: Translational research : the journal of laboratory and clinical medicine 20090901

Title: Molecular mechanism underlying Akt activation in zinc-induced cardioprotection.

Journal: American journal of physiology. Heart and circulatory physiology 20090801

Title: Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20090519

Title: Aryl-bridged 1-hydroxypyridin-2-one: sensitizer ligands for Eu(III).

Journal: Inorganic chemistry 20080721

Title: Synthesis and anticancer properties of water-soluble zinc ionophores.

Journal: Cancer research 20080701

Title: Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080601

Title: In vitro-refolding of a single-chain Fv fragment in the presence of heteroaromatic thiols.

Journal: Journal of biotechnology 20080430

Title: Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.

Journal: American journal of physiology. Cell physiology 20080301

Title: Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons.

Journal: Biochemical and biophysical research communications 20080201

Title: Thioperoxy derivative generated by UV-induced transformation of N-hydroxypyridine-2(1H)-thione isolated in low-temperature matrixes.

Journal: The journal of physical chemistry. A 20080117

Title: NADPH-dependent coenzyme Q reductase is the main enzyme responsible for the reduction of non-mitochondrial CoQ in cells.

Journal: BioFactors (Oxford, England) 20080101

Title: Overexpression of DSCR1 blocks zinc-induced neuronal cell death through the formation of nuclear aggregates.

Journal: Molecular and cellular neurosciences 20070801

Title: Automated laser scanning cytometry: a powerful tool for multi-parameter analysis of drug-induced apoptosis.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20070201

Title: Zinc induces cell death in immortalized embryonic hippocampal cells via activation of Akt-GSK-3beta signaling.

Journal: Experimental cell research 20070115

Title: Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis.

Journal: Molecular bioSystems 20070101

Title: Zinc induces ERK-dependent cell death through a specific Ras isoform.

Journal: Apoptosis : an international journal on programmed cell death 20061101

Title: Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation.

Journal: Journal of neuroscience research 20060101

Title: Product pharmacology and medical actives in achieving therapeutic benefits.

Journal: The journal of investigative dermatology. Symposium proceedings 20051201

Title: A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.

Journal: The journal of investigative dermatology. Symposium proceedings 20051201

Title: S100A9 deficiency alters adenosine-5'-triphosphate induced calcium signalling but does not generally interfere with calcium and zinc homeostasis in murine neutrophils.

Journal: The international journal of biochemistry & cell biology 20050601

Title: Activation of caspase-3 in HL-60 cells treated with pyrithione and zinc.

Journal: Biological & pharmaceutical bulletin 20050401

Title: Effect of Zn2+ ions on ryanodine binding to sarcoplasmic reticulum of striated muscles in the presence of pyrithione.

Journal: Acta pharmacologica Sinica 20041201

Title: Chromatographic behavior of pyrithiones.

Journal: Journal of chromatography. A 20041015

Title: Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia.

Journal: Journal of neurobiology 20040915

Title: Characterisation of zinc uptake into rat cultured cerebrocortical oligodendrocyte progenitor cells.

Journal: Neuroscience letters 20031204

Title: Blocking NF-kappaB activation may be an effective strategy in the fever therapy.

Journal: The Japanese journal of physiology 20031001

Title: Role of lipid-soluble complexes in targeted tumor therapy.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030801

Title: Nuclear factor-kappaB inhibitors abolish hypoxic vasoconstriction in sheep-isolated pulmonary arteries.

Journal: European journal of pharmacology 20030101

Title: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells.

Journal: European journal of biochemistry 20021201

Title: Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20021201

Title: Zinc is involved in the expression of a nuclear-encoded alternative oxidase gene in the yeast Hansenula anomala.

Journal: Bioscience, biotechnology, and biochemistry 20021201

Title: One-electron oxidation of 'photo-Fenton' reagents and inhibition of lipid peroxidation.

Journal: Biochemical and biophysical research communications 20021122

Title: Studies on cytotoxic and genotoxic effects of N-hydroxypyridine-2-thione (Omadine) in L5178Y mouse lymphoma cells.

Journal: Toxicology letters 20021115

Title: Delayed diagnosis of occupational contact dermatitis from sodium pyrithione in a metalworking fluid.

Journal: Contact dermatitis 20021001

Title: The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020715

Title: Antimicrobial susceptibility changes and T-OMP shifts in pyrithione-passaged planktonic cultures of Pseudomonas aeruginosa PAO1.

Journal: Journal of applied microbiology 20020101

Title: Elevated intracellular zinc and altered proton homeostasis in forebrain neurons.

Journal: Neuroscience 20020101

Title: Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells.

Journal: Journal of neurochemistry 20010801

Title: Allergic contact dermatitis from sodium pyrithione in metalworking fluid.

Journal: Contact dermatitis 20010701

Title: Debora L Campos, et al. Bactericidal Effect of pyridine-2-thiol 1-oxide Sodium Salt and Its Complex With Iron Against Resistant Clinical Isolates of Mycobacterium Tuberculosis. J Antibiot (Tokyo). 2020 Feb;73(2):120-124.

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