[1]Sun,Qun;Tafesse,Laykea;Islam,Khondaker;Zhou,Xiaoming;Victory,SamF.;Zhang,Chongwu;Hachicha,Mohamed;Schmid,LoriA.;Patel,Aniket;Rotshteyn,Yakov;Valenzano,KennethJ.;Kyle,DonaldJ.[BioorganicandMedicinalChemistryLetters,2003,vol.13,#20,p.3611-3616]
[1]Sun,Qun;Tafesse,Laykea;Islam,Khondaker;Zhou,Xiaoming;Victory,SamF.;Zhang,Chongwu;Hachicha,Mohamed;Schmid,LoriA.;Patel,Aniket;Rotshteyn,Yakov;Valenzano,KennethJ.;Kyle,DonaldJ.[BioorganicandMedicinalChemistryLetters,2003,vol.13,#20,p.3611-3616]
Title: The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel.
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Title: Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists.
Journal: Bioorganic & medicinal chemistry 20131101
Title: Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice.
Journal: Laboratory investigation; a journal of technical methods and pathology 20120501
Title: Ocular dryness excites two classes of corneal afferent neurons implicated in basal tearing in rats: involvement of transient receptor potential channels.
Journal: Journal of neurophysiology 20120215
Title: Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors.
Journal: The Journal of biological chemistry 20120127
Title: Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC.
Journal: European journal of pharmacology 20120105
Title: TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction.
Journal: Journal of cellular physiology 20110601
Title: Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist.
Journal: Life sciences 20110314
Title: Pharmacological and functional properties of TRPM8 channels in prostate tumor cells.
Journal: Pflugers Archiv : European journal of physiology 20110101
Title: TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons.
Journal: Molecular neurodegeneration 20110101
Title: Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea.
Journal: Nature medicine 20101201
Title: Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.
Journal: European journal of pharmacology 20100901
Title: Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis.
Journal: Experimental dermatology 20100901
Title: Acid-induced CGRP release from the stomach does not depend on TRPV1 or ASIC3.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100601
Title: Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay.
Journal: The Journal of pharmacology and experimental therapeutics 20100201
Title: TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100120
Title: Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.
Journal: Bioorganic & medicinal chemistry letters 20091201
Title: Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: role of CGRP and TRPV1 receptors.
Journal: European journal of pharmacology 20090801
Title: Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20090801
Title: Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone.
Journal: American journal of physiology. Heart and circulatory physiology 20090601
Title: TRPV1 controls acid- and heat-induced calcitonin gene-related peptide release and sensitization by bradykinin in the isolated mouse trachea.
Journal: The European journal of neuroscience 20090501
Title: TRPV1 is activated by both acidic and basic pH.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090107
Title: TRPM8, a versatile channel in human sperm.
Journal: PloS one 20090101
Title: Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.
Journal: Molecular pain 20090101
Title: TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice.
Journal: PloS one 20090101
Title: Human lung epithelial cells express a functional cold-sensing TRPM8 variant.
Journal: American journal of respiratory cell and molecular biology 20081001
Title: Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Journal: Bioorganic & medicinal chemistry 20080915
Title: Studies on somnolence in the daytime caused by drugs used for neuropathic pain.
Journal: Journal of pharmacological sciences 20080701
Title: The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons.
Journal: The Journal of clinical investigation 20080201
Title: Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
Journal: Behavioural pharmacology 20080201
Title: TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20080101
Title: The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.
Journal: Journal of medicinal chemistry 20070531
Title: Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors.
Journal: The Journal of physiology 20070515
Title: Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia.
Journal: The Journal of pharmacy and pharmacology 20070501
Title: Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig.
Journal: Cough (London, England) 20070101
Title: Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20061129
Title: Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo.
Journal: Biochemical and biophysical research communications 20061110
Title: Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles.
Journal: Journal of medicinal chemistry 20060615
Title: Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine.
Journal: European journal of pharmacology 20060113
Title: Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats.
Journal: Neuropharmacology 20051201
Title: Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1.
Journal: Molecular pharmacology 20051201
Title: Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.
Journal: Molecular pharmacology 20050801
Title: Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1).
Journal: European journal of pharmacology 20050418
Title: 4-(2-Pyridyl)piperazine-1-benzimidazoles as potent TRPV1 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20050201
Title: Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20041115
Title: Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse?
Journal: Journal of medicinal chemistry 20040520
Title: Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.
Journal: British journal of pharmacology 20040201
Title: 4-(2-pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20031020
Title: N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain.
Journal: The Journal of pharmacology and experimental therapeutics 20030701
Title: N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.
Journal: The Journal of pharmacology and experimental therapeutics 20030701
Title: Cytochrome c interaction with membranes. Absorption and emission spectra and binding characteristics of iron-free cytochrome c.
Journal: European journal of biochemistry 19751201
Title: Liu T, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016 Jan;11(1):182-188.
Title: Pomonis JD, et al. N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflamm
Title: Valenzano KJ, et al. N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic pro
