Home Carboxes 402-71-1
402-71-1,MFCD00000935
Catalog No.:AA00I7TF

402-71-1 | N-Tosyl-L-phenylalanine chloromethyl ketone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
≥98%
in stock  
$49.00   $34.00
- +
250mg
≥98%
in stock  
$92.00   $64.00
- +
500mg
≥98%
in stock  
$145.00   $101.00
- +
1g
≥98%
in stock  
$218.00   $152.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I7TF
Chemical Name:
N-Tosyl-L-phenylalanine chloromethyl ketone
CAS Number:
402-71-1
Molecular Formula:
C17H18ClNO3S
Molecular Weight:
351.8477
MDL Number:
MFCD00000935
SMILES:
ClCC(=O)[C@@H](NS(=O)(=O)c1ccc(cc1)C)Cc1ccccc1
NSC Number:
727365
Properties
Properties
 
BP:
509.9°C at 760 mmHg  
Form:
Solid  
MP:
106-108 °C(lit.)  
Refractive Index:
1.6100 (estimate)  
Solubility:
DMSO: >10 mg/mL stable for several months at 4°C.  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
475  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
3.6  

Literature

Title: Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma.

Journal: PloS one 20130101

Title: Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).

Journal: Bioorganic & medicinal chemistry 20121215

Title: Regulation of double-stranded RNA dependent protein kinase expression and attenuation of protein synthesis induced by bacterial toll-like receptors agonists in the absence of interferon.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20121001

Title: Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening.

Journal: The Journal of biological chemistry 20120921

Title: TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues.

Journal: FEBS letters 20120921

Title: Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea.

Journal: Bioorganic & medicinal chemistry letters 20120901

Title: Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.

Journal: Journal of medicinal chemistry 20120628

Title: Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.

Journal: Bioorganic & medicinal chemistry 20120401

Title: Creation of an artificial metalloprotein with a Hoveyda-Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin.

Journal: Chemical communications (Cambridge, England) 20120204

Title: Anti-inflammatory mechanism of 15,16-epoxy-3α-hydroxylabda-8,13(16),14-trien-7-one via inhibition of LPS-induced multicellular signaling pathways.

Journal: Journal of natural products 20120127

Title: Human foetal intestinal fibroblasts are hyper-responsive to lipopolysaccharide stimulation.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20120101

Title: Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets.

Journal: Bioorganic & medicinal chemistry 20120101

Title: Apolipoprotein A-I stimulates cholesteryl ester transfer protein and apolipoprotein E secretion from lipid-loaded macrophages; the role of NF-κB and PKA signaling pathways.

Journal: Biochemical and biophysical research communications 20111125

Title: Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells.

Journal: Chemico-biological interactions 20111115

Title: Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.

Journal: Bioorganic & medicinal chemistry 20111101

Title: Bortezomib: understanding the mechanism of action.

Journal: Molecular cancer therapeutics 20111101

Title: Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro.

Journal: Bioorganic & medicinal chemistry 20110815

Title: HMGB-1 induces IL-6 production in human synovial fibroblasts through c-Src, Akt and NF-κB pathways.

Journal: Journal of cellular physiology 20110801

Title: Experimental autoimmune encephalomyelitis: association with mutual regulation of RelA (p65)/NF-κB and phospho-IκB in the CNS.

Journal: Biochemical and biophysical research communications 20110729

Title: Nuclear factor kappa B plays a pivotal role in polyinosinic-polycytidylic acid-induced expression of human β-defensin 2 in intestinal epithelial cells.

Journal: Clinical and experimental immunology 20110701

Title: Expression of trypsin-like serine peptidases in pre-imaginal stages of Aedes aegypti (Diptera: Culicidae).

Journal: Archives of insect biochemistry and physiology 20110401

Title: Bioactive compounds from the fern Lepisorus contortus.

Journal: Journal of natural products 20110225

Title: Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284.

Journal: Journal of medicinal chemistry 20101223

Title: Caspase-3 triggers a TPCK-sensitive protease pathway leading to degradation of the BH3-only protein puma.

Journal: Apoptosis : an international journal on programmed cell death 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Collagenolytic activity in sonic extracts of Tannerella forsythia.

Journal: Archives of oral biology 20100801

Title: The classical NFkappaB pathway is required for phloroglucinol-induced activation of murine lymphocytes.

Journal: Biochimica et biophysica acta 20100701

Title: Trypsin and chymotrypsin are involved in the progesterone-induced acrosome reaction in canine spermatozoa.

Journal: Reproduction in domestic animals = Zuchthygiene 20100601

Title: TPCK targets elements of mitotic spindle and induces cell cycle arrest in prometaphase.

Journal: Biochemical and biophysical research communications 20100514

Title: High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance.

Journal: Cardiovascular research 20100401

Title: Cathepsin G-mediated enhanced TGF-beta signaling promotes angiogenesis via upregulation of VEGF and MCP-1.

Journal: Cancer letters 20100227

Title: Okadaic acid induces DNA fragmentation via caspase-3-dependent and caspase-3-independent pathways in Chinese hamster ovary (CHO)-K1 cells.

Journal: The FEBS journal 20100101

Title: Inflammatory responses in embryonal cardiomyocytes exposed to LPS challenge: an in vitro model of deciphering the effects of LPS on the heart.

Journal: Current pharmaceutical design 20100101

Title: N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1.

Journal: The Journal of biological chemistry 20091009

Title: TPCK-induced apoptosis and labelling of the largest subunit of RNA polymerase II in Jurkat cells.

Journal: Apoptosis : an international journal on programmed cell death 20091001

Title: N-tosyl-L-phenylalanine chloromethyl ketone inhibits NF-kappaB activation by blocking specific cysteine residues of IkappaB kinase beta and p65/RelA.

Journal: Biochemistry 20090804

Title: IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin.

Journal: The international journal of biochemistry & cell biology 20090701

Title: Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway.

Journal: Lung cancer (Amsterdam, Netherlands) 20090601

Title: The role of Bcl-xL and nuclear factor-kappaB in the effect of taxol on the viability of dendritic cells.

Journal: Journal of veterinary science 20090601

Title: Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant.

Journal: Bioorganic & medicinal chemistry 20090501

Title: Differential regulation of high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation in Müller cells by IL-1beta and IL-6.

Journal: Investigative ophthalmology & visual science 20090401

Title: Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.

Journal: Cancer research 20090401

Title: Nuclear factor-kappaB mediates cytoprotection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cells.

Journal: Clinical and experimental pharmacology & physiology 20090301

Title: Sodium deoxycholate causes nitric oxide mediated DNA damage in oesophageal cells.

Journal: Free radical research 20090301

Title: f-Met-Leu-Phe stimulates nitric oxide production in chick embryo neurons: the role of NF-kB.

Journal: Immunopharmacology and immunotoxicology 20090101

Title: Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) do not inhibit caspase-3 and caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli.

Journal: Journal of cellular biochemistry 20081215

Title: Transcriptional and post-translational regulation of Flip, an inhibitor of Fas-mediated apoptosis, in human gut inflammation.

Journal: Gut 20081201

Title: Treatment with N-tosyl-l-phenylalanine chloromethyl ketone after the onset of collagen-induced arthritis reduces joint erosion and NF-kappaB activation.

Journal: European journal of pharmacology 20081024

Title: Treatment of cells with n-alpha-tosyl-L-phenylalanine-chloromethyl ketone induces the proteolytic loss of STAT6 transcription factor.

Journal: Molecular immunology 20080901

Title: Na-Tosyl-Phe chloromethyl ketone prevents granule movement and mast cell synergistic degranulation elicited by costimulation of antigen and adenosine.

Journal: Life sciences 20080815

Title: Pentoxifylline downregulates alpha (I) collagen expression by the inhibition of Ikappabalpha degradation in liver stellate cells.

Journal: Cell biology and toxicology 20080801

Title: Development of a cell death-based method for the screening of nuclear factor-kappaB inhibitors.

Journal: Journal of immunological methods 20080601

Title: Rapidly alternating transmission mode electron-transfer dissociation and collisional activation for the characterization of polypeptide ions.

Journal: Analytical chemistry 20080501

Title: Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) are potent inhibitors of activated caspase proteases.

Journal: Journal of cellular biochemistry 20080401

Title: Effect of protease inhibitors on exflagellation in Plasmodium falciparum.

Journal: Molecular and biochemical parasitology 20080401

Title: Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo.

Journal: Archives of pharmacal research 20080401

Title: Myricetin down-regulates phorbol ester-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking activation of nuclear factor kappa B.

Journal: Journal of agricultural and food chemistry 20071114

Title: On-plate digestion of proteins using novel trypsin-immobilized magnetic nanospheres for MALDI-TOF-MS analysis.

Journal: Proteomics 20071001

Title: NF-kappaB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL-60 cells.

Journal: Journal of cellular biochemistry 20070801

Title: Probing the structure and activity of trypsin with amidination.

Journal: Analytical biochemistry 20070801

Title: Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events.

Journal: Molecular and cellular biochemistry 20070601

Title: Inhibition of human erythrocyte invasion by Babesia divergens using serine protease inhibitors.

Journal: Molecular and biochemical parasitology 20070501

Title: [Effect of N-tosyl-L-phenylalnylchloromethyl ketone and dexamethasone on expression of nuclear transcription factor-kappaB in childhood acute lymphoblastic leukemia and its significance].

Journal: Zhongguo shi yan xue ye xue za zhi 20070401

Title: N-tosyl-L-phenylalanyl-chloromethyl ketone reduces ceramide during hypoxic-ischemic brain injury in newborn rat.

Journal: European journal of pharmacology 20061203

Title: Macrophage-activating lipopeptide-2 induces cyclooxygenase-2 and prostaglandin E(2) via toll-like receptor 2 in human placental trophoblast cells.

Journal: Journal of reproductive immunology 20061201

Title: Nitric oxide-induced down-regulation of beta-catenin in colon cancer cells by a proteasome-independent specific pathway.

Journal: Gastroenterology 20061001

Title: Genetic and environmental influences on therapeutic and toxicity outcomes: studies with CYP2A6.

Journal: Current clinical pharmacology 20060901

Title: TNF-alpha-independent IL-8 expression: alterations in bacterial challenge dose cause differential human monocytic cytokine response.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060715

Title: Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells.

Journal: Vascular pharmacology 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Cross-interaction between PAR-activation and tyrosine kinase in the modulation of rat ileum smooth muscle contraction.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060401

Title: Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.

Journal: Journal of cellular biochemistry 20060201

Title: Differentiation and protease production in Micromonospora echinospora (ATCC 15837).

Journal: Antonie van Leeuwenhoek 20060101

Title: Plasmodium berghei: effect of protease inhibitors during gametogenesis and early zygote development.

Journal: Experimental parasitology 20051201

Title: Suppression of urokinase receptor expression by thalidomide is associated with inhibition of nuclear factor kappaB activation and subsequently suppressed ovarian cancer dissemination.

Journal: Cancer research 20051115

Title: 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK.

Journal: Toxicology and applied pharmacology 20051001

Title: Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells.

Journal: Clinical immunology (Orlando, Fla.) 20050901

Title: Characterization of a monolithic immobilized trypsin microreactor with on-line coupling to ESI-MS.

Journal: Journal of separation science 20050901

Title: Human immunodeficiency virus-1 Tat protein up-regulates interleukin-6 and interleukin-8 expression in human breast cancer cells.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050901

Title: Pancreatic trypsin activates human promatrix metalloproteinase-2.

Journal: Journal of molecular biology 20050722

Title: A biphasic role of nuclear transcription factor (NF)-kappaB in the islet beta-cell apoptosis induced by interleukin (IL)-1beta.

Journal: Journal of cellular physiology 20050701

Title: Can application of serine protease inhibitors TPCK and TLCK provide evidence for possible involvement of serine protease Omi/HtrA2 in imatinib mesylate-induced cell death of BCR-ABL-positive human leukemia cells?

Journal: Leukemia 20050601

Title: Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation.

Journal: The Journal of clinical endocrinology and metabolism 20050501

Title: Potential mechanism of blood vessel protection by resveratrol, a component of red wine.

Journal: Annals of the New York Academy of Sciences 20050501

Title: Direct effects of polymyxin B on human dendritic cells maturation. The role of IkappaB-alpha/NF-kappaB and ERK1/2 pathways and adhesion.

Journal: The Journal of biological chemistry 20050408

Title: Another biological effect of tosylphenylalanylchloromethane (TPCK): it prevents p47phox phosphorylation and translocation upon neutrophil stimulation.

Journal: The Biochemical journal 20050315

Title: Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050301

Title: Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.

Journal: Journal of leukocyte biology 20050301

Title: Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells.

Journal: Biochemical pharmacology 20050101

Title: alpha1-Adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.

Journal: Journal of immunotherapy (Hagerstown, Md. : 1997) 20050101

Title: Caspase-independent retinal ganglion cell death after target ablation in the neonatal rat.

Journal: The European journal of neuroscience 20050101

Title: Modulation of tryptase release from human tonsil mast cells by protease inhibitors.

Journal: Pharmacological reports : PR 20050101

Title: Pro- and anti-apoptotic effects of an inhibitor of chymotrypsin-like serine proteases.

Journal: Cell cycle (Georgetown, Tex.) 20041201

Title: Modulation of tryptase and histamine release from human lung mast cells by protease inhibitors.

Journal: Asian Pacific journal of allergy and immunology 20041201

Title: Expression of anti-apoptotic factors in cells parasitized by second-generation schizonts of Eimeria tenella and Eimeria necatrix.

Journal: Veterinary parasitology 20041110

Title: Do alkylating agents modify the histidine residue of the desensitized butyrylcholinesterase?

Journal: The protein journal 20041101

Title: L-ascorbic acid represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60.

Journal: Journal of cellular biochemistry 20041001

Title: Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor alpha and interleukin-8 expression.

Journal: Fertility and sterility 20041001

Title: Multiple effects of N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) on apoptotic pathways in human prostatic carcinoma cell lines.

Journal: Cancer biology & therapy 20040801

Title: On the trail of cell death pathways in prostate cancer.

Journal: Cancer biology & therapy 20040801

Title: Reactive oxygen species mediate chloroquine-induced expression of chemokines by human astroglial cells.

Journal: Glia 20040701

Title: A novel 'clip-and-link' activity of repeat in toxin (RTX) proteins from gram-negative pathogens. Covalent protein cross-linking by an Asp-Lys isopeptide bond upon calcium-dependent processing at an Asp-Pro bond.

Journal: The Journal of biological chemistry 20040611

Title: Proteinase inhibitors TPCK and TLCK prevent Entamoeba histolytica induced disturbance of tight junctions and microvilli in enteric cell layers in vitro.

Journal: International journal for parasitology 20040601

Title: Neuregulin signaling on glucose transport in muscle cells.

Journal: The Journal of biological chemistry 20040326

Title: A reporter-based assay for identifying hepatitis C virus inhibitors based on subgenomic replicon cells.

Journal: Journal of virological methods 20040301

Title: Poly(ethylene glycol)-supported enzyme inactivators. Efficient identification of the site of covalent attachment to alpha-chymotrypsin by PEG-TPCK.

Journal: Bioconjugate chemistry 20040101

Title: Possible role of NF-kappaB in Bcl-X(L) protection against hydrogen peroxide-induced PC12 cell death.

Journal: Redox report : communications in free radical research 20040101

Title: Effect of N-tosyl-L-phenylalanylchloromethyl ketone on tumor necrosis factor-alpha -induced NF-kappaB activation and apoptosis in U937 cell line.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101

Title: Toll-like receptor 4-dependent activation of macrophages by polysaccharide isolated from the radix of Platycodon grandiflorum.

Journal: International immunopharmacology 20031201

Title: Induction of RANTES/CCL5 by herpes simplex virus is regulated by nuclear factor kappa B and interferon regulatory factor 3.

Journal: The Journal of general virology 20030901

Title: Integrins induce expression of monocyte chemoattractant protein-1 via focal adhesion kinase in mesangial cells.

Journal: Kidney international 20030801

Title: The role of nuclear factor-kappa B in interleukin-8 expression by human adenoidal fibroblasts.

Journal: The Laryngoscope 20030801

Title: Dephosphorylation of p53 during cell death by N-alpha-tosyl-L-phenylalanyl chloromethyl ketone.

Journal: Biochemical and biophysical research communications 20030711

Title: Alcohol consumption decreases IL-2-induced NF-kappaB activity in enriched NK cells from C57BL/6 mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030501

Title: Effect of protease-activated receptors on guinea-pig ileum contraction in vitro.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030401

Title: Tumor necrosis factor-alpha-induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factor-kappa B activation: gonadotropin-releasing hormone agonist treatment reduced IL-8 expression.

Journal: The Journal of clinical endocrinology and metabolism 20030201

Title: Treatment of hypoxic-ischemic brain injury in newborn rats with TPCK 3 h after hypoxia decreases caspase-9 activation and improves neuropathologic outcome.

Journal: Developmental neuroscience 20030101

Title: Inhibitor of nuclear factor-Kappa B activation attenuates venular constriction, leukocyte rolling-adhesion and microvessel rupture induced by ethanol in intact rat brain microcirculation: relation to ethanol-induced brain injury.

Journal: Neuroscience letters 20021206

Title: Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension.

Journal: British journal of pharmacology 20021201

Title: Constitutively active NFkappa B is required for the survival of S-type neuroblastoma.

Journal: The Journal of biological chemistry 20021101

Title: N-tosyl-L-phenylalanyl-chloromethyl ketone eliminates the increase in caspase-3 and bcl-2 caused by brain injury in the newborn rat.

Journal: Pharmacology 20021101

Title: CancerB increases production of nitric oxide and tumor necrosis factor-alpha in peritoneal macrophages.

Journal: Clinica chimica acta; international journal of clinical chemistry 20020801

Title: PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorylation and cleavage in association with G2-M phase arrest and apoptosis.

Journal: Molecular cancer therapeutics 20020801

Title: NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020701

Title: Lipopolysaccharide down regulates both scavenger receptor B1 and ATP binding cassette transporter A1 in RAW cells.

Journal: Infection and immunity 20020601

Title: IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020601

Title: Indomethacin lowers the threshold thermal exposure for hyperthermic radiosensitization and heat-shock inhibition of ionizing radiation-induced activation of NF-kappaB.

Journal: International journal of radiation biology 20020601

Title: TLR4-dependent lipopolysaccharide signalling in epithelial cells is independent of extracellular protease activity.

Journal: Cellular microbiology 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Activation of chymotrypsin-like serine protease(s) during apoptosis detected by affinity-labeling of the enzymatic center with fluoresceinated inhibitor.

Journal: International journal of oncology 20020201

Title: MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020101

Title: Mutational analysis of the C-domain in nonribosomal peptide synthesis.

Journal: European journal of biochemistry 20020101

Title: Sequential activation of caspases and serine proteases (serpases) during apoptosis.

Journal: Cell cycle (Georgetown, Tex.) 20020101

Title: NF-kappaB activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells.

Journal: Biochemical and biophysical research communications 20011214

Title: Involvement of TLCK-sensitive serine protease in colchicine-induced cell death of sympathetic neurons in culture.

Journal: Journal of neuroscience research 20011115

Title: Digestive proteinases of red shrimp Pleoticus muelleri (Decapoda, Penaeoidea): partial characterization and relationship with molting.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20011001

Title: Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis.

Journal: Journal of neuroscience research 20010701

Title: High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells.

Journal: Cell death and differentiation 20010601

Title: Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone.

Journal: The Journal of biological chemistry 20010413

Title: Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.

Journal: Journal of neurochemistry 20010401

Title: Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia.

Journal: Journal of neurochemistry 20010401

Title: Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20010401

Title: Stromal cell-derived factor 1 alpha-induced chemotaxis in T cells is mediated by nitric oxide signaling pathways.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010301

Title: Cell transformation induced by hepatitis C virus NS3 serine protease.

Journal: Journal of viral hepatitis 20010301

Title: Prostaglandin levels in stimulated macrophages are controlled by phospholipase A2-activating protein and by activation of phospholipase C and D.

Journal: The Journal of biological chemistry 20010223

Title: Effect of serine protease inhibitors on posttraumatic brain injury and neuronal apoptosis.

Journal: Experimental neurology 20010201

Title: Relationship between NF-kappaB and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation.

Journal: Biochemical and biophysical research communications 20010112

Title: Effect of enzyme inhibitors on protein quaternary structure determined by on-line size exclusion chromatography-microelectrospray ionization mass spectrometry.

Journal: Journal of the American Society for Mass Spectrometry 20010101

Title: Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea.

Journal: Reproduction, fertility, and development 20010101

Title: Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB.

Journal: Inflammation 20001001

Title: Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB.

Journal: Brain research. Molecular brain research 20000414

Title: A role for serine proteases in mediating phorbol ester-induced differentiation of HL-60 cells.

Journal: Experimental cell research 20000410

Title: NF-kappa B modulates TNF-alpha production by alveolar macrophages in asymptomatic HIV-seropositive individuals.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20000201

Title: Effects of retinoic acid on N-glycosylation and mRNA stability of the liver/bone/kidney alkaline phosphatase in neuronal cells.

Journal: Journal of cellular physiology 20000101

Title: Effect of the serine protease inhibitor N-tosyl-l-phenylalanine-chloromethyl ketone (TPCK) on MCF-7 mammary tumour cells growth and differentiation.

Journal: Cell biology international 20000101

Title: Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation.

Journal: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 19991201

Title: Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells.

Journal: European journal of immunology 19991001

Title: Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA.

Journal: Oncogene 19990812

Title: The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma.

Journal: Cancer research 19990715

Title: N-acetylcysteine blocks apoptosis induced by N-alpha-tosyl-L-phenylalanine chloromethyl ketone in transformed T-cells.

Journal: Cell death and differentiation 19990401

Title: Evidence that non-caspase proteases are required for chromatin degradation during apoptosis.

Journal: Cell death and differentiation 19981201

Title: Distinct steps in DNA fragmentation pathway during camptothecin-induced apoptosis involved caspase-, benzyloxycarbonyl- and N-tosyl-L-phenylalanylchloromethyl ketone-sensitive activities.

Journal: Cancer research 19980715

Title: Proteolytic cleavage of HsRad51 during apoptosis.

Journal: FEBS letters 19980508

Title: Tyrosine phosphatase-dependent/tyrosine kinase-independent induction of nuclear factor-kappa B by tumor necrosis factor-alpha: effects on prostaglandin endoperoxide synthase-2 mRNA accumulation.

Journal: The Journal of pharmacology and experimental therapeutics 19980501

Title: Cryptosporidium parvum metalloaminopeptidase inhibitors prevent in vitro excystation.

Journal: Antimicrobial agents and chemotherapy 19961201

Title: Role of serine and ICE-like proteases in induction of apoptosis by etoposide in human leukemia HL-60 cells.

Journal: Leukemia 19960501

Title: Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B.

Journal: Molecular and cellular biochemistry 19950705

Title: Murine epidermal xanthine oxidase activity: correlation with degree of hyperplasia induced by tumor promoters.

Journal: Cancer research 19871201

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 402-71-1
Tags:402-71-1 Molecular Formula|402-71-1 MDL|402-71-1 SMILES|402-71-1 N-Tosyl-L-phenylalanine chloromethyl ketone