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41078-02-8,MFCD06357414
Catalog No.:AA00I7YO

41078-02-8 | Enprofylline

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10mg
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$46.00   $32.00
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25mg
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50mg
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$199.00   $139.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I7YO
Chemical Name:
Enprofylline
CAS Number:
41078-02-8
Molecular Formula:
C8H10N4O2
Molecular Weight:
194.1906
MDL Number:
MFCD06357414
SMILES:
CCCn1c(=O)[nH]c(=O)c2c1[nH]cn2
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
268  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
0.3  

Literature

Title: Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy.

Journal: Malaria journal 20120101

Title: Progress in the management of childhood asthma.

Journal: Asia Pacific allergy 20120101

Title: Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.

Journal: PloS one 20120101

Title: Mast cell adenosine receptors function: a focus on the a3 adenosine receptor and inflammation.

Journal: Frontiers in immunology 20120101

Title: Contraction-induced secretion of VEGF from skeletal muscle cells is mediated by adenosine.

Journal: American journal of physiology. Heart and circulatory physiology 20100901

Title: Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.

Journal: Bioorganic & medicinal chemistry letters 20100101

Title: Theophylline inhibits the differentiation of human monocyte into dendritic cell potentially via adenosine receptor antagonism.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201

Title: Allergen-induced airway inflammation and its therapeutic intervention.

Journal: Allergy, asthma & immunology research 20091001

Title: 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.

Journal: Journal of medicinal chemistry 20090709

Title: Progress in the discovery of selective, high affinity A(2B) adenosine receptor antagonists as clinical candidates.

Journal: Purinergic signalling 20090301

Title: Comparative diffusion of drugs through bronchial tissue.

Journal: International journal of pharmaceutics 20080605

Title: Possible involvement of organic anion and cation transporters in renal excretion of xanthine derivatives, 3-methylxanthine and enprofylline.

Journal: Life sciences 20070922

Title: P1 receptors and cytokine secretion.

Journal: Purinergic signalling 20070301

Title: Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.

Journal: Journal of medicinal chemistry 20060615

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Purinergic substances promote murine keratinocyte proliferation and enhance impaired wound healing in mice.

Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20060101

Title: The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma.

Journal: British journal of pharmacology 20050801

Title: Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1.

Journal: Molecular pharmacology 20050501

Title: Enprofylline protects motor neurons from in vitro excitotoxic challenge.

Journal: Neuro-degenerative diseases 20050101

Title: A putative osmoreceptor system that controls neutrophil function through the release of ATP, its conversion to adenosine, and activation of A2 adenosine and P2 receptors.

Journal: Journal of leukocyte biology 20040701

Title: Long-term hypothermic lung preservation: does adenosine A1 receptor antagonism have a role in ischemic preconditioning protection?

Journal: Interactive cardiovascular and thoracic surgery 20040301

Title: Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030601

Title: Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens.

Journal: European journal of pharmacology 20030124

Title: Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activities.

Journal: The Journal of biological chemistry 20021004

Title: Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.

Journal: Journal of medicinal chemistry 20020801

Title: Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.

Journal: Journal of medicinal chemistry 20020523

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Adenosine receptor antagonists and retinal neovascularization in vivo.

Journal: Investigative ophthalmology & visual science 20011201

Title: Antioxidant and radical scavenging properties of 8-oxo derivatives of xanthine drugs pentoxifylline and lisofylline.

Journal: Biochemical and biophysical research communications 20011116

Title: Adenosine A(2A) and A(2B) receptor activation of erythropoietin production.

Journal: American journal of physiology. Renal physiology 20011101

Title: Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2).

Journal: Biochemical pharmacology 20011101

Title: Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.

Journal: British journal of pharmacology 20011001

Title: Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells.

Journal: British journal of pharmacology 20010901

Title: Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation.

Journal: Investigative ophthalmology & visual science 20010801

Title: Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation.

Journal: Science (New York, N.Y.) 20010309

Title: Alkylxanthine-induced recovery of respiratory function following cervical spinal cord injury in adult rats.

Journal: Experimental neurology 20010301

Title: Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.

Journal: Molecular pharmacology 19991001

Title: Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.

Journal: Journal of medicinal chemistry 19931029

Title: Sleep disturbances in asthma: theophylline versus enprofylline.

Journal: Upsala journal of medical sciences 19910101

Title: Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.

Journal: Pharmacology, biochemistry, and behavior 19900801

Title: Comparative assessment of enprofylline and theophylline for chronic obstructive airways disease in the elderly.

Journal: Respiratory medicine 19900501

Title: Additive bronchodilator effects of terbutaline and enprofylline in asthma.

Journal: European journal of clinical pharmacology 19870101

Title: Enprofylline and theophylline slow-eroding tablets in the treatment of asthma: a comparison.

Journal: Respiration; international review of thoracic diseases 19860101

Title: Continuous treatment of asthmatic patients with enprofylline and theophylline.

Journal: European journal of respiratory diseases 19841001

Title: Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease.

Journal: European journal of clinical pharmacology 19820101

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