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415697-08-4,MFCD06798326
Catalog No.:AA00C08Y

415697-08-4 | 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER

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Purity
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Price(USD)
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1mg
98%
in stock  
$15.00   $11.00
- +
5mg
98%
in stock  
$36.00   $25.00
- +
10mg
98%
in stock  
$54.00   $38.00
- +
25mg
98%
in stock  
$90.00   $63.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C08Y
Chemical Name:
2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER
CAS Number:
415697-08-4
Molecular Formula:
C20H22N2O5S
Molecular Weight:
402.4641
MDL Number:
MFCD06798326
SMILES:
CCOC(=O)C1CSC(N1)Cc1ccc(cc1)OCc1ccc(cc1)[N+](=O)[O-]
Properties
Computed Properties
 
Complexity:
513  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
2  
XLogP3:
4  

Literature

Title: Chronic nicotine exposure selectively activates a carrier-mediated release of endogenous glutamate and aspartate from rat hippocampal synaptosomes.

Journal: Neurochemistry international 20120501

Title: High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943.

Journal: British journal of pharmacology 20120401

Title: Vasopressin and oxytocin excite MCH neurons, but not other lateral hypothalamic GABA neurons.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20120401

Title: Na+-independent, nifedipine-resistant rat afferent arteriolar Ca2+ responses to noradrenaline: possible role of TRPC channels.

Journal: Acta physiologica (Oxford, England) 20101101

Title: The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels.

Journal: Molecular pharmacology 20090901

Title: A key role for dense granule secretion in potentiation of the Ca2+ signal arising from store-operated calcium entry in human platelets.

Journal: Cell calcium 20090501

Title: The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction.

Journal: Journal of neurophysiology 20090301

Title: Characterization of SN-6, a novel Na+/Ca2+ exchange inhibitor in guinea pig cardiac ventricular myocytes.

Journal: European journal of pharmacology 20071114

Title: Involvement of Na+/H+ exchangers in induction of cyclooxygenase-2 by vacuolar-type (H+)-ATPase inhibitors in RAW 264 cells.

Journal: FEBS letters 20071002

Title: Endoplasmic reticulum is a key organella in bradykinin-triggered ATP release from cultured smooth muscle cells.

Journal: Journal of pharmacological sciences 20070901

Title: Inhibitory mechanism of SN-6, a novel benzyloxyphenyl Na+/Ca2+ exchange inhibitor.

Journal: Annals of the New York Academy of Sciences 20070301

Title: Electrophysiological effects of SN-6, a novel Na+/Ca2+ exchange inhibitor on membrane currents in guinea pig ventricular myocytes.

Journal: Annals of the New York Academy of Sciences 20070301

Title: YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.

Journal: Molecular pharmacology 20061201

Title: The influence of sodium-calcium exchange inhibitors on rabbit lens ion balance and transparency.

Journal: Experimental eye research 20061101

Title: [Characterization of SN-6, a novel exchange inhibitor and its renal protective effect].

Journal: Clinical calcium 20040801

Title: The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative.

Journal: Molecular pharmacology 20040701

Title: Iwamoto T, et al. The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 --(4-nitrobenzyloxy)benzylthiazolidine-4-carboxylic acid ethyl ester, a novel benzyloxyphenyl derivative. Mol Pharmacol. 2004 Jul;66(1):45-55.

Title: Niu CF, et al. Electrophysiological effects of SN-6, a novel Na+/Ca2+ exchange inhibitor on membrane currents in guinea pig ventricular myocytes. Ann N Y Acad Sci. 2007 Mar;1099:534-9.

Title: Kita S, et al. Inhibitory mechanism of SN-6, a novel benzyloxyphenyl Na+/Ca2+ exchange inhibitor. Ann N Y Acad Sci. 2007 Mar;1099:529-33.

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Tags:415697-08-4 Molecular Formula|415697-08-4 MDL|415697-08-4 SMILES|415697-08-4 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER