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41941-56-4,MFCD00153938
Catalog No.:AA00BZH3

41941-56-4 | 8-CHLORO-CAMP

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1mg
99%
1 week  
$1,003.00   $702.00
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5mg
99%
1 week  
$2,241.00   $1,569.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BZH3
Chemical Name:
8-CHLORO-CAMP
CAS Number:
41941-56-4
Molecular Formula:
C10H11ClN5O6P
Molecular Weight:
363.6510
MDL Number:
MFCD00153938
SMILES:
O[C@@H]1[C@@H]2OP(=O)(O)OC[C@H]2O[C@H]1n1c(Cl)nc2c1ncnc2N
Properties
Properties
 
Storage:
2-8℃;Light sensitive;  

Computed Properties
 
Complexity:
532  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
-1.6  

Literature

Title: cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation.

Journal: FEBS letters 20120120

Title: 8-Phenylthio-adenines stimulate the expression of steroid hydroxylases, Cav3.2 Ca²⁺ channels, and cortisol synthesis by a cAMP-independent mechanism.

Journal: American journal of physiology. Endocrinology and metabolism 20111101

Title: 8-Chloro-cyclic AMP and protein kinase A I-selective cyclic AMP analogs inhibit cancer cell growth through different mechanisms.

Journal: PloS one 20110101

Title: Purine analogs sensitize the multidrug resistant cell line (NCI-H460/R) to doxorubicin and stimulate the cell growth inhibitory effect of verapamil.

Journal: Investigational new drugs 20100801

Title: 8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells.

Journal: Journal of molecular endocrinology 20100601

Title: Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.

Journal: The Journal of biological chemistry 20100312

Title: 8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors.

Journal: The Journal of clinical endocrinology and metabolism 20091001

Title: Involvement of AMP-activated protein kinase and p38 mitogen-activated protein kinase in 8-Cl-cAMP-induced growth inhibition.

Journal: Journal of cellular physiology 20090101

Title: Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implications of CRP and lipid peroxides.

Journal: Cell division 20090101

Title: Cytogenetic effects of 8-Cl-cAMP on human and animal chromosomes.

Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20090101

Title: The combination of gamma ionizing radiation and 8-Cl-cAMP induces synergistic cell growth inhibition and induction of apoptosis in human prostate cancer cells.

Journal: Investigational new drugs 20080801

Title: A study on the genotoxic effects of 8-Cl-cAMP on human lymphocytes in vitro.

Journal: Genetika 20080501

Title: Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine.

Journal: The Journal of clinical endocrinology and metabolism 20080301

Title: Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: relationship with cell proliferation.

Journal: Experimental cell research 20080101

Title: [Apoptosis of multiple myeloma cells induced by 8-Cl-cAMP in vitro].

Journal: Zhongguo shi yan xue ye xue za zhi 20071201

Title: Deregulated sequential motion of centromeres induced by antitumor agents may lead to genome instability in human peripheral blood lymphocytes.

Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20070101

Title: Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells.

Journal: Journal of cellular physiology 20061201

Title: The combination of sulfinosine and 8-Cl-cAMP induces synergistic cell growth inhibition of the human neuroblastoma cell line in vitro.

Journal: Investigational new drugs 20060101

Title: Tumor reversion: protein kinase A isozyme switching.

Journal: Annals of the New York Academy of Sciences 20051101

Title: 8-Chloro-cyclic AMP-induced growth inhibition and apoptosis is mediated by p38 mitogen-activated protein kinase activation in HL60 cells.

Journal: Cancer research 20050601

Title: The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival.

Journal: Cell cycle (Georgetown, Tex.) 20050201

Title: Inhibition of B16 mouse melanoma cell growth and induction of apoptotic cell death with 8-chloroadenosine-3',5'-monophosphate and tiazofurin.

Journal: Annals of the New York Academy of Sciences 20041201

Title: 8-Cl-cAMP and its metabolite, 8-Cl-adenosine induce growth inhibition in mouse fibroblast DT cells through the same pathways: protein kinase C activation and cyclin B down-regulation.

Journal: Journal of cellular physiology 20041101

Title: Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy.

Journal: British journal of cancer 20040705

Title: PKA- and PKC-dependent regulation of angiopoietin 2 mRNA in human granulosa lutein cells.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040201

Title: A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

Journal: Nature cell biology 20021101

Title: Anti-proliferative effects of 8-chloro-cAMP and other cAMP analogs are unrelated to their effects on protein kinase A regulatory subunit expression.

Journal: Journal of cellular physiology 20020801

Title: Genome-wide expression profiling of 8-chloroadenosine- and 8-chloro-cAMP-treated human neuroblastoma cells using radioactive human cDNA microarray.

Journal: Experimental & molecular medicine 20020731

Title: Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy.

Journal: Annals of the New York Academy of Sciences 20020601

Title: 8-Cl-cAMP affects glioma cell-cycle kinetics and selectively induces apoptosis.

Journal: Cancer investigation 20020101

Title: 8-Chloro-cAMP-related changes on mice uteri.

Journal: TheScientificWorldJournal 20020101

Title: 8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs.

Journal: Cancer chemotherapy and pharmacology 20011201

Title: 8-Cl-adenosine induces growth arrest without differentiation of primary mouse epidermal keratinocytes.

Journal: The Journal of investigative dermatology 20011201

Title: The influence of the protein kinase A system in differentiation of HL-60-Eo cells to eosinophils induced by histamine.

Journal: Japanese journal of pharmacology 20011101

Title: Cyclic AMP-dependent protein kinase isoenzymes in human myeloid leukemia (HL60) and breast tumor (MCF-7) cells.

Journal: Archives of biochemistry and biophysics 20010801

Title: 8-chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells.

Journal: Cancer research 20010715

Title: 8-Cl-cAMP induces cell cycle-specific apoptosis in human cancer cells.

Journal: International journal of cancer 20010701

Title: 8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFalpha-induced apoptosis is via inactivation of NF-kappaB.

Journal: Leukemia research 20010501

Title: 8-Chloro-cAMP modulates apoptosis of thymocytes and thymocyte hybridoma.

Journal: Transplantation proceedings 20010501

Title: 8-Cl-adenosine induces differentiation in LS174T cells.

Journal: Digestive diseases and sciences 20010401

Title: Determination of 8-chloroadenosine 3',5'-monophosphate in dog plasma by capillary electrophoresis.

Journal: Journal of pharmaceutical and biomedical analysis 20010301

Title: Synthesis and antitumor and antiviral activities of a series of 1-beta-D-ribofuranosyl-5-halocytosine (5-halocytidine) cyclic 3',5'-monophosphates.

Journal: Journal of medicinal chemistry 19850401

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Tags:41941-56-4 Molecular Formula|41941-56-4 MDL|41941-56-4 SMILES|41941-56-4 8-CHLORO-CAMP