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4431-00-9,MFCD00011663
Catalog No.:AA003NUZ

4431-00-9 | 5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoic acid)

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1g
>85%powder
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5g
>85%powder
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003NUZ
Chemical Name:
5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoic acid)
CAS Number:
4431-00-9
Molecular Formula:
C22H14O9
Molecular Weight:
422.3412
MDL Number:
MFCD00011663
SMILES:
OC(=O)C1=CC(=C(c2ccc(c(c2)C(=O)O)O)c2ccc(c(c2)C(=O)O)O)C=CC1=O
Properties
Properties
 
BP:
759.6°C at 760 mmHg  
Form:
Solid  
MP:
300 °C(lit.)  
Refractive Index:
1.6230 (estimate)  
Solubility:
1  M NH4OH: 10 mg/mL  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
841  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
4.3  

Literature

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Journal: ACS chemical biology 20151016

Title: The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.

Journal: The Journal of biological chemistry 20150116

Title: Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP.

Journal: Biochemistry 20130910

Title: Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex.

Journal: Neurobiology of aging 20121001

Title: Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies.

Journal: Journal of molecular modeling 20120401

Title: First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.

Journal: ACS chemical biology 20120316

Title: Anomalous inhibition of c-Met by the kinesin inhibitor aurintricarboxylic acid.

Journal: International journal of cancer 20120301

Title: Electrophoretic deposition of TiO2 nanoparticles using organic dyes.

Journal: Journal of colloid and interface science 20120301

Title: Small molecule inhibition of RISC loading.

Journal: ACS chemical biology 20120217

Title: Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase.

Journal: Bioorganic & medicinal chemistry 20120115

Title: Quantization of bovine serum albumin by fluorescence enhancement effects and corresponding binding of macrocyclic host-protein assembly.

Journal: Journal of photochemistry and photobiology. B, Biology 20120105

Title: Arabidopsis serine decarboxylase mutants implicate the roles of ethanolamine in plant growth and development.

Journal: International journal of molecular sciences 20120101

Title: Novel optical PVC probes for on-site detection/determination of fluoroquinolones in a solid/liquid interface: application to the determination of Norfloxacin in aquaculture water.

Journal: Biosensors & bioelectronics 20120101

Title: Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor.

Journal: Advances in protein chemistry and structural biology 20120101

Title: Mechanisms of xenogeneic baboon platelet aggregation and phagocytosis by porcine liver sinusoidal endothelial cells.

Journal: PloS one 20120101

Title: Aurintricarboxylic acid promotes the conversion of naive CD4+CD25- T cells into Foxp3-expressing regulatory T cells.

Journal: International immunology 20110901

Title: Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.

Journal: PLoS pathogens 20110501

Title: Aurintricarboxylic acid inhibits the nuclear factor-κB-dependent expression of intercellular cell adhesion molecule-1 and endothelial cell selectin on activated human endothelial cells.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110301

Title: Investigations on the interactions of aurintricarboxylic acid with bovine serum albumin: Steady state/time resolved spectroscopic and docking studies.

Journal: Journal of photochemistry and photobiology. B, Biology 20110110

Title: The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures.

Journal: Medicinal research reviews 20110101

Title: Comparative functional genomic analysis of Solanum glandular trichome types.

Journal: Plant physiology 20110101

Title: Neuroprotection in glaucoma.

Journal: Indian journal of ophthalmology 20110101

Title: An immunohistochemical analysis of the neuroprotective effects of memantine, hyperbaric oxygen therapy, and brimonidine after acute ischemia reperfusion injury.

Journal: Molecular vision 20110101

Title: Identification of tissue-specific, abiotic stress-responsive gene expression patterns in wine grape (Vitis vinifera L.) based on curation and mining of large-scale EST data sets.

Journal: BMC plant biology 20110101

Title: First transcriptome of the testis-vas deferens-male accessory gland and proteome of the spermatophore from Dermacentor variabilis (Acari: Ixodidae).

Journal: PloS one 20110101

Title: Effect of five common anticonvulsant drugs on naloxone-precipitated morphine withdrawal in mice.

Journal: Research in pharmaceutical sciences 20110101

Title: Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus.

Journal: BMC bioinformatics 20110101

Title: Cosalane and its analogues: a unique class of anti-HIV agents.

Journal: Mini reviews in medicinal chemistry 20100901

Title: New evidences on Tau-DNA interactions and relevance to neurodegeneration.

Journal: Neurochemistry international 20100801

Title: Lack of efficacy of aurintricarboxylic acid and ethacrynic acid against vaccinia virus respiratory infections in mice.

Journal: Antiviral chemistry & chemotherapy 20100414

Title: Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid.

Journal: The Journal of antimicrobial chemotherapy 20100401

Title: N-acetylcysteine impairs survival of luteal cells through mitochondrial dysfunction.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20100401

Title: In vitro reconstitution of SARS-coronavirus mRNA cap methylation.

Journal: PLoS pathogens 20100401

Title: Nelfinavir, an HIV-1 protease inhibitor, induces oxidative stress-mediated, caspase-independent apoptosis in Leishmania amastigotes.

Journal: PLoS neglected tropical diseases 20100301

Title: Tumors induced in mice by direct inoculation of plasmid DNA expressing both activated H-ras and c-myc.

Journal: International journal of biological sciences 20100101

Title: Interaction of aurintricarboxylic acid (ATA) with four nucleic acid binding proteins DNase I, RNase A, reverse transcriptase and Taq polymerase.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20091201

Title: Simultaneous trace multielement determination by ICP-OES after solid phase extraction with modified octadecyl silica gel.

Journal: Journal of hazardous materials 20091015

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Characterization of aurintricarboxylic acid as a potent hepatitis C virus replicase inhibitor.

Journal: Antiviral chemistry & chemotherapy 20090925

Title: Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.

Journal: ChemMedChem 20090803

Title: Single-strand DNA translation initiation step analyzed by Isothermal Titration Calorimetry.

Journal: Biochemical and biophysical research communications 20090731

Title: Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20090324

Title: Aurintricarboxylic acid inhibits influenza virus neuraminidase.

Journal: Antiviral research 20090201

Title: Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin.

Journal: The Journal of biological chemistry 20090123

Title: Landscape changes influence the occurrence of the melioidosis bacterium Burkholderia pseudomallei in soil in northern Australia.

Journal: PLoS neglected tropical diseases 20090101

Title: Citrate-mediated release of aurintricarboxylic acid from a calcium alginate complex: implications for intravaginal HIV chemoprophylaxis and related applications.

Journal: Pharmaceutical development and technology 20090101

Title: Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.

Journal: PloS one 20090101

Title: Antagonistic actions of boron against inhibitory effects of aluminum toxicity on growth, CO2 assimilation, ribulose-1,5-bisphosphate carboxylase/oxygenase, and photosynthetic electron transport probed by the JIP-test, of Citrus grandis seedlings.

Journal: BMC plant biology 20090101

Title: Optimization and comparison of different methods for RNA isolation for cDNA library construction from the reindeer lichen Cladonia rangiferina.

Journal: BMC research notes 20090101

Title: Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases.

Journal: PloS one 20090101

Title: Aluminum granuloma after administration of the quadrivalent human papillomavirus vaccine. Report of a case.

Journal: The American Journal of dermatopathology 20081201

Title: In vitro and in vivo activity of aurintricarboxylic acid preparations against Cryptosporidium parvum.

Journal: The Journal of antimicrobial chemotherapy 20081101

Title: Selection of an effective red-pigment producing Monascus pilosus by efficient transformation with aurintricarboxylic acid.

Journal: Bioscience, biotechnology, and biochemistry 20081101

Title: Posttreatment with the Ca(2+)-Mg(2+)-dependent endonuclease inhibitor aurintricarboxylic acid abolishes genotoxic agent-induced nuclear condensation and DNA fragmentation and decreases death of astrocytes.

Journal: Journal of neuroscience research 20081001

Title: A new binding assay of von Willebrand factor and glycoprotein Ib using solid-phase biotinylated platelets.

Journal: Journal of pharmacological sciences 20081001

Title: Apoptosis of mesenchymal cells during the pseudoglandular stage of lung development affects branching morphogenesis.

Journal: Experimental lung research 20081001

Title: Aurintricarboxylic acid upregulates the thrombomodulin expression of endothelial cells and peripheral blood monocytes.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20080901

Title: Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.

Journal: Journal of medicinal chemistry 20080814

Title: A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors.

Journal: ACS chemical biology 20080718

Title: Functional circularity of legitimate Qbeta replicase templates.

Journal: Journal of molecular biology 20080606

Title: Platelet GPIb complex as a target for anti-thrombotic drug development.

Journal: Thrombosis and haemostasis 20080301

Title: Gene expression-based screening for inhibitors of PDGFR signaling.

Journal: Genome biology 20080101

Title: Tear lipocalin is the major endonuclease in tears.

Journal: Molecular vision 20080101

Title: Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression.

Journal: BMC structural biology 20080101

Title: Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A.

Journal: PloS one 20080101

Title: Aurintricarboxylic acid inhibits endothelial activation, complement activation, and von Willebrand factor secretion in vitro and attenuates hyperacute rejection in an ex vivo model of pig-to-human pulmonary xenotransplantation.

Journal: Xenotransplantation 20080101

Title: A novel bioluminescent protease assay using engineered firefly luciferase.

Journal: Current chemical genomics 20080101

Title: Identification and characterization of UK-201844, a novel inhibitor that interferes with human immunodeficiency virus type 1 gp160 processing.

Journal: Antimicrobial agents and chemotherapy 20071001

Title: Apoptosis as a therapeutic target in heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20070901

Title: A sensitive stain for aluminum in undecalcified cancellous bone.

Journal: Journal of inorganic biochemistry 20070901

Title: A new evidence for DNA nicking property of amyloid beta-peptide (1-42): relevance to Alzheimer's disease.

Journal: Archives of biochemistry and biophysics 20070715

Title: Biodegradable magnesium scaffolds: Part 1: appropriate inflammatory response.

Journal: Journal of biomedical materials research. Part A 20070601

Title: Salmonella SPI1 effector SipA persists after entry and cooperates with a SPI2 effector to regulate phagosome maturation and intracellular replication.

Journal: Cell host & microbe 20070315

Title: Rapid, high-quality and epidermal-specific isolation of RNA from human skin.

Journal: Experimental dermatology 20070301

Title: Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes: effect of serum on thrombomodulin expression in the THP-1 monocytic cell line.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070301

Title: Aurintricarboxylic acid inhibits protein synthesis independent, sanguinarine-induced apoptosis and oncosis.

Journal: Toxicologic pathology 20070201

Title: Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells.

Journal: Toxicology 20070105

Title: Inhibition of K+ efflux prevents mitochondrial dysfunction, and suppresses caspase-3-, apoptosis-inducing factor-, and endonuclease G-mediated constitutive apoptosis in human neutrophils.

Journal: Cellular signalling 20061201

Title: Cortisol promotes survival and regeneration of axotomised retinal ganglion cells and enhances effects of aurintricarboxylic acid.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20061101

Title: Oral gene delivery: design of polymeric carrier systems shielding toward intestinal enzymatic attack.

Journal: Biopolymers 20061101

Title: Influence of the SCGE protocol on the amount of basal DNA damage detected in the Mediterranean mussel, Mytilus galloprovincialis.

Journal: Environmental and molecular mutagenesis 20061001

Title: Sodium selenite induces apoptosis in cultured cortical neurons with special concomitant changes in expression of the apoptosis-related genes.

Journal: Neurotoxicology 20060701

Title: Fibrosarcoma with typical features of postinjection sarcoma at site of microchip implant in a dog: histologic and immunohistochemical study.

Journal: Veterinary pathology 20060701

Title: Biological evaluation, chelation, and molecular modeling studies of novel metal-chelating inhibitors of NF-kappaB-DNA binding: structure activity relationships.

Journal: Journal of medicinal chemistry 20060615

Title: Post-treatment with the Ca(2+)-Mg(2+)-endonuclease inhibitor aurintricarboxylic acid prevents peroxynitrite-induced DNA damage and death of murine astrocytes.

Journal: Biochemical and biophysical research communications 20060609

Title: Oral gene delivery: Strategies to improve stability of pDNA towards intestinal digestion.

Journal: Journal of drug targeting 20060601

Title: Potential antivirals and antiviral strategies against SARS coronavirus infections.

Journal: Expert review of anti-infective therapy 20060401

Title: Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress.

Journal: The Journal of biological chemistry 20060310

Title: Fusion and differentiation of murine C2C12 skeletal muscle cells that express Trichinella spiralis p43 protein.

Journal: Experimental parasitology 20060201

Title: Paradoxical effects of aurintricarboxylic acid and RG-13577: acute thrombosis and in-stent stenosis in a passive-coated stent.

Journal: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 20060201

Title: Dendritic supermolecules--towards controllable nanomaterials.

Journal: Chemical communications (Cambridge, England) 20060107

Title: Microtubules regulate disassembly of epithelial apical junctions.

Journal: BMC cell biology 20060101

Title: Salt is necessary for nucleosomal DNA fragmentation induced by caspase.

Journal: Biotechnology letters 20051201

Title: Barriers to productive transfection of trabecular meshwork cells.

Journal: Molecular vision 20051026

Title: Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.

Journal: Biochemical pharmacology 20050715

Title: ATR-IR spectroscopy as applied to nucleic acid films.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050701

Title: Structural analysis of inhibition mechanisms of aurintricarboxylic acid on SARS-CoV polymerase and other proteins.

Journal: Computational biology and chemistry 20050601

Title: Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol-1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase.

Journal: The Journal of biological chemistry 20050408

Title: Use of the nuclease inhibitor aurintricarboxylic acid (ATA) for improved non-viral intratumoral in vivo gene transfer by jet-injection.

Journal: The journal of gene medicine 20050401

Title: Activation of porcine endothelium in response to xenogeneic serum causes thrombosis independently of platelet activation.

Journal: Xenotransplantation 20050301

Title: Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1c.

Journal: Journal of cell science 20050215

Title: Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20050201

Title: p66ShcA and ageing: modulation by longevity-promoting agent aurintricarboxylic acid.

Journal: Mechanisms of ageing and development 20050201

Title: Coordinate involvement of cysteine protease and nuclease in the executive phase of plant apoptosis.

Journal: FEBS letters 20041217

Title: Green tea polyphenol (-)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20041101

Title: Induction of apoptosis by benzamide and its inhibition by aurin tricarboxylic acid (ATA) in Chinese hamster V79 cells.

Journal: Mutation research 20041004

Title: Aurintricarboxylic acid translocates across the plasma membrane, inhibits protein tyrosine phosphatase and prevents apoptosis in PC12 cells.

Journal: Molecules and cells 20040831

Title: Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid.

Journal: Biochemical and biophysical research communications 20040806

Title: [Neuroprotection and regeneration after traumatic lesion of the optic nerve].

Journal: Klinische Monatsblatter fur Augenheilkunde 20040801

Title: Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.

Journal: Journal of the National Cancer Institute 20040602

Title: Programmed cell death is not a necessary prerequisite for fusion of the fetal mouse palate.

Journal: The International journal of developmental biology 20040201

Title: Novel shift of Jak/Stat signalling characterizes the protective effect of aurintricarboxylic acid (ATA) from tumor necrosis factor-alpha toxicity in human B lymphocytes.

Journal: International journal of immunopathology and pharmacology 20040101

Title: Enhanced systemic transgene expression after nonviral salivary gland transfection using a novel endonuclease inhibitor/DNA formulation.

Journal: Gene therapy 20031201

Title: RNA degradation in cell extracts: real-time monitoring by fluorescence resonance energy transfer.

Journal: Journal of the American Chemical Society 20031126

Title: Mitigation of tumor necrosis factor alpha cytotoxicity by aurintricarboxylic acid in human peripheral B lymphocytes.

Journal: Biochemical pharmacology 20031115

Title: CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.

Journal: Oncogene 20031113

Title: Qbeta replicase discriminates between legitimate and illegitimate templates by having different mechanisms of initiation.

Journal: The Journal of biological chemistry 20031107

Title: Aurintricarboxylic acid blocks in vitro and in vivo activity of YopH, an essential virulent factor of Yersinia pestis, the agent of plague.

Journal: The Journal of biological chemistry 20031024

Title: Ca(2+)-dependent and caspase-3-independent apoptosis caused by damage in Golgi apparatus due to 2,4,5,7-tetrabromorhodamine 123 bromide-induced photodynamic effects.

Journal: Photochemistry and photobiology 20030901

Title: Nuclear factor kappa B: a potential target for anti-HIV chemotherapy.

Journal: Current medicinal chemistry 20030801

Title: Fibrosarcomas at presumed sites of injection in dogs: characteristics and comparison with non-vaccination site fibrosarcomas and feline post-vaccinal fibrosarcomas.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20030801

Title: Pharmacologic platelet anesthesia by glycoprotein IIb/IIIa complex antagonist and argatroban during in vitro extracorporeal circulation.

Journal: The Journal of thoracic and cardiovascular surgery 20030801

Title: Inhibition of myocardial apoptosis reduces infarct size and improves regional contractile dysfunction during reperfusion.

Journal: Cardiovascular research 20030701

Title: Diethyldithiocarbamate-induced cytotoxicity and apoptosis in leukemia cell lines.

Journal: Biological & pharmaceutical bulletin 20030701

Title: Transient reporter gene (GUS) expression in creeping bentgrass (Agrostis palustris) is affected by in vivo nucleolytic activity.

Journal: Biotechnology letters 20030601

Title: Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells.

Journal: The Journal of biological chemistry 20030509

Title: Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury.

Journal: Transplantation 20030415

Title: Is platelet aggregation a more important contributor than platelet adhesion to the overall platelet-related primary haemostasis measured by PFA-100?

Journal: Thrombosis research 20030315

Title: [Resonance light scattering of aurintricarboxylic acid].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20030201

Title: Enhanced transport of a novel anti-HIV agent--cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers.

Journal: International journal of pharmaceutics 20030102

Title: Görög Thrombosis Test: a global in-vitro test of platelet function and thrombolysis.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030101

Title: Spontaneous DNA fragmentation in swim-up selected human spermatozoa during long term incubation.

Journal: Journal of andrology 20030101

Title: Non-classic characteristics define prominent DNase activities from the intestine and other tissues of Haemonchus contortus.

Journal: Experimental parasitology 20030101

Title: Combined addition of glutathione and iron chelators for decrease of intracellular level of reactive oxygen species and death of Chinese hamster ovary cells.

Journal: Journal of bioscience and bioengineering 20030101

Title: Repeated addition of insulin for dynamic control of apoptosis in serum-free culture of Chinese hamster ovary cells.

Journal: Journal of bioscience and bioengineering 20030101

Title: Inhibition of cytokine-induced JAK-STAT signalling pathways by an endonuclease inhibitor aurintricarboxylic acid.

Journal: British journal of pharmacology 20021201

Title: Alteration of intrinsic biological rhythms during interferon treatment and its possible mechanism.

Journal: Molecular pharmacology 20021201

Title: Polymorphisms of glycoprotein Ib affect the inhibition by aurintricarboxylic acid of the von Willebrand factor dependent platelet aggregation.

Journal: Journal of molecular medicine (Berlin, Germany) 20021201

Title: Electroporation in combination with a plasmid vector containing SV40 enhancer elements results in increased and persistent gene expression in mouse muscle.

Journal: Biochemical and biophysical research communications 20021108

Title: CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor.

Journal: Virology 20021025

Title: Aurintricarboxylic acid attenuates intimal thickening after balloon injury of the rabbit aorta.

Journal: Thrombosis and haemostasis 20021001

Title: Development of nonradioactive microtiter plate assays for nuclease activity.

Journal: Analytical biochemistry 20021001

Title: Aluminum deposition in the bone of patients with chronic renal failure--detection of aluminum accumulation without signs of aluminum toxicity in bone using acid solochrome azurine.

Journal: Clinical nephrology 20021001

Title: Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in macrophages by decreasing inducible nitric-oxide synthase induction via IkappaB kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase inhibition.

Journal: Molecular pharmacology 20020701

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: DNase I-like endonuclease in rat kidney cortex that is activated during ischemia/reperfusion injury.

Journal: Journal of the American Society of Nephrology : JASN 20020401

Title: Aurintricarboxylic acid induces a distinct activation of the IGF-I receptor signaling within MDA-231 cells.

Journal: Endocrinology 20020301

Title: Etoposide-induced apoptosis in lymphoblastoid leukaemic MOLT-4 cells: evidence that chromatin condensation, loss of phosphatidylserine asymmetry and apoptotic body formation can occur independently.

Journal: Apoptosis : an international journal on programmed cell death 20020201

Title: Modulation of apoptosis by mitochondrial uncouplers: apoptosis-delaying features despite intrinsic cytotoxicity.

Journal: Biochemical pharmacology 20020201

Title: Intestinal absorption and biodistribution of cosalane and its amino acid conjugates: novel anti-HIV agents.

Journal: International journal of pharmaceutics 20020114

Title: Stable genetic transformation of garlic plants using particle bombardment.

Journal: Cellular & molecular biology letters 20020101

Title: DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor.

Journal: The journal of gene medicine 20020101

Title: [RNA, unlike DNA, binds to aurintricarboxylic acid via covalent bonds: molecular-biological and spectroscopic evidence].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20020101

Title: Purification and characterization of a Bacillus subtilis 168 nuclease, YokF, involved in chromosomal DNA degradation and cell death caused by thermal shock treatments.

Journal: The Journal of biological chemistry 20011214

Title: Effects of fibrinogen receptor antagonist GR144053F and aurintricarboxylic acid on platelet activation and degranulation.

Journal: Biochemical pharmacology 20011115

Title: Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments.

Journal: Bioorganic & medicinal chemistry 20011101

Title: Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress.

Journal: Blood 20010915

Title: Perforated microelectrode arrays implanted in the regenerating adult central nervous system.

Journal: Experimental neurology 20010901

Title: Activation of the insulin-like growth factor 1 signaling pathway by the antiapoptotic agents aurintricarboxylic acid and evans blue.

Journal: Endocrinology 20010701

Title: Binding of cosalane--a novel highly lipophilic anti-HIV agent--to albumin and glycoprotein.

Journal: Journal of pharmaceutical sciences 20010501

Title: Preparation of bacterial RNA.

Journal: Current protocols in molecular biology 20010501

Title: Alcohol enhances oxysterol-induced apoptosis in human endothelial cells by a calcium-dependent mechanism.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20010301

Title: Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores.

Journal: Journal of medicinal chemistry 20010301

Title: Pharmacological interventions of cyanide-induced cytotoxicity and DNA damage in isolated rat thymocytes and their protective efficacy in vivo.

Journal: Toxicology letters 20010203

Title: Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis.

Journal: Biochemistry 20010109

Title: Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds.

Journal: Bioorganic & medicinal chemistry letters 20010108

Title: Reconsidering the importance of long-term low-level aluminum exposure in renal failure patients.

Journal: Seminars in dialysis 20010101

Title: Ca2+-sensitive cytosolic nucleases prevent efficient delivery to the nucleus of injected plasmids.

Journal: The journal of gene medicine 20010101

Title: [Aluminum and uremic bone disease. Diagnostic utility of serum aluminum and the deferoxamine (DFO) test ].

Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20010101

Title: Aurintricarboxylic acid decreases proliferative potential of SKOV3 and MCF7 human carcinoma cells.

Journal: Anticancer research 20010101

Title: Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8.

Journal: Reviews in medical virology 20010101

Title: Aurintricarboxylic acid exerts insulin-like growth stimulating effects on Chinese hamster ovary cells under serum-free conditions.

Journal: Journal of bioscience and bioengineering 20010101

Title: Anti-HIV activity of a series of cosalane amino acid conjugates.

Journal: Bioorganic & medicinal chemistry letters 20001120

Title: Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates.

Journal: Bioorganic & medicinal chemistry letters 20000918

Title: Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain.

Journal: Bioorganic & medicinal chemistry 20000101

Title: Selective activity of various antiviral compounds against HHV-7 infection.

Journal: Antiviral research 19990801

Title: N-Nitrosodimethylamine-mediated cytotoxicity in a cell line expressing P450 2E1: evidence for apoptotic cell death.

Journal: Toxicology and applied pharmacology 19990601

Title: The toxicity of 6-hydroxydopamine on PC12 and P19 cells.

Journal: Brain research. Molecular brain research 19990521

Title: Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.

Journal: Journal of medicinal chemistry 19990520

Title: Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent.

Journal: Bioorganic & medicinal chemistry letters 19980407

Title: Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues.

Journal: Bioorganic & medicinal chemistry 19961001

Title: Synthesis and biological evaluation of certain alkenyldiarylmethanes as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors.

Journal: Journal of medicinal chemistry 19960802

Title: Correlation of anti-HIV potency with lipophilicity in a series of cosalane analogs having normal alkenyl and phosphodiester chains as cholestane replacements.

Journal: Journal of medicinal chemistry 19960119

Title: Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.

Journal: Journal of medicinal chemistry 19950203

Title: Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction.

Journal: Journal of medicinal chemistry 19940916

Title: Infection by HIV-1 blocked by binding of dextrin 2-sulphate to the cell surface of activated human peripheral blood mononuclear cells and cultured T-cells.

Journal: British journal of pharmacology 19940901

Title: Three-dimensional structure-activity analysis of a series of porphyrin derivatives with anti-HIV-1 activity targeted to the V3 loop of the gp120 envelope glycoprotein of the human immunodeficiency virus type 1.

Journal: Journal of medicinal chemistry 19940415

Title: Inhibition of HIV-1 integration protein by aurintricarboxylic acid monomers, monomer analogs, and polymer fractions.

Journal: Biochemical and biophysical research communications 19920529

Title: [The anti-HIV activity of beta-glycyrrhizic acid].

Journal: Voprosy virusologii 19920101

Title: Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight.

Journal: Journal of medicinal chemistry 19910101

Title: Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds.

Journal: Journal of medicinal chemistry 19910101

Title: Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation.

Journal: Journal of medicinal chemistry 19891001

Title: Aurintricarboxylic acid and Evans Blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virus.

Journal: Biochemical and biophysical research communications 19860414

Title: Influence of twenty potentially antiviral substances on in vitro multiplication of hepatitis A virus.

Journal: Antiviral research 19860301

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Tags:4431-00-9 Molecular Formula|4431-00-9 MDL|4431-00-9 SMILES|4431-00-9 5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene)bis(2-hydroxybenzoic acid)