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Home Other Building Blocks 4611-05-6
4611-05-6,MFCD00058400
Catalog No.:AA00DENS

4611-05-6 | Ophiobolin a

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Purity
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1mg
≥95%
in stock  
$393.00   $275.00
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5mg
≥95%
in stock  
$1,172.00   $820.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DENS
Chemical Name:
Ophiobolin a
CAS Number:
4611-05-6
Molecular Formula:
C25H36O4
Molecular Weight:
400.5509
MDL Number:
MFCD00058400
SMILES:
O=CC1=CC[C@@H]2[C@](C[C@H]3[C@@H]1C(=O)C[C@@]3(C)O)(C)CC[C@]12O[C@H](C[C@@H]1C)C=C(C)C
Properties
Computed Properties
 
Complexity:
778  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
3.5  

Literature

Title: Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity.

Journal: Cell death & disease 20130301

Title: Screening and identification of insertion mutants from Bipolaris eleusines by mutagenesis based on restriction enzyme-mediated integration.

Journal: FEMS microbiology letters 20120501

Title: Convergent total synthesis of (+)-ophiobolin A.

Journal: Angewandte Chemie (International ed. in English) 20110926

Title: Calcium depletion and calmodulin inhibition affect the import of nuclear-encoded proteins into plant mitochondria.

Journal: The Plant journal : for cell and molecular biology 20090501

Title: Stimulation of seed germination of Orobanche species by ophiobolin A and fusicoccin derivatives.

Journal: Journal of agricultural and food chemistry 20080924

Title: Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20061201

Title: Pharmacological characterization of protease activated receptor-1 by a serum responsive element-dependent reporter gene assay: major role of calmodulin.

Journal: Biochemical pharmacology 20060514

Title: Herbicidal potential of ophiobolins produced by Drechslera gigantea.

Journal: Journal of agricultural and food chemistry 20060308

Title: Calcium regulation of chloroplast protein import.

Journal: The Plant journal : for cell and molecular biology 20050601

Title: Analysis of posttranslational regulations in the Neurospora circadian clock.

Journal: Methods in enzymology 20050101

Title: FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation.

Journal: The EMBO journal 20030901

Title: Calmodulin antagonists differentially affect capacitation-associated protein tyrosine phosphorylation of mouse sperm components.

Journal: Journal of cell science 20030515

Title: Integrins regulate neuronal neurotrophin gene expression through effects on voltage-sensitive calcium channels.

Journal: Neuroscience 20030101

Title: Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis.

Journal: The EMBO journal 20020801

Title: Leung PC, et al. Ophiobolin A. A natural product inhibitor of calmodulin. J Biol Chem. 1984 Mar 10;259(5):2742-7

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