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472-15-1,MFCD00009619
Catalog No.:AA003O3T

472-15-1 | Betulinic acid

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1g
98%(HPLC)
in stock  
$47.00   $33.00
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5g
≥ 98% (HPLC)
in stock  
$143.00   $100.00
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25g
≥ 98% (HPLC)
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$500.00   $350.00
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100g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003O3T
Chemical Name:
Betulinic acid
CAS Number:
472-15-1
Molecular Formula:
C30H48O3
Molecular Weight:
456.7003
MDL Number:
MFCD00009619
SMILES:
CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O
NSC Number:
677578
Properties
Properties
 
BP:
550°C at 760 mmHg  
Form:
Solid  
MP:
295-298 °C (dec.)(lit.)  
Refractive Index:
7.8 ° (C=0.9, Pyridine)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
861  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
8.2  

Literature

Title: Synthesis and biological investigation of new carbonic anhydrase IX (CAIX) inhibitors.

Journal: Chemico-biological interactions 20180325

Title: Intrinsic capabilities of Leptospermum javanicum in inducing apoptosis and suppressing the metastatic potential of human lung carcinoma cells.

Journal: Chemico-biological interactions 20170801

Title: Biological evaluation of a halogenated triterpenoid, 2α-bromo-dihydrobelulonic acid as inhibitor of human topoisomerase IIα and HeLa cell proliferation.

Journal: Chemico-biological interactions 20170425

Title: In vitro anticancer activity of Betulinic acid and derivatives thereof on equine melanoma cell lines from grey horses and in vivo safety assessment of the compound NVX-207 in two horses.

Journal: Chemico-biological interactions 20160225

Title: Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.

Journal: Bioorganic & medicinal chemistry letters 20160101

Title: Betulinyl Sulfamates as Anticancer Agents and Radiosensitizers in Human Breast Cancer Cells.

Journal: International journal of molecular sciences 20151101

Title: Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase.

Journal: Bioorganic & medicinal chemistry letters 20150815

Title: Combined effect of microRNA, nutraceuticals and drug on pancreatic cancer cell lines.

Journal: Chemico-biological interactions 20150525

Title: Synthesis and anti-HCV entry activity studies of β-cyclodextrin-pentacyclic triterpene conjugates.

Journal: ChemMedChem 20140501

Title: Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment.

Journal: Toxicology and applied pharmacology 20140301

Title: Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities.

Journal: Pathogens and disease 20130801

Title: Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.

Journal: Journal of medicinal chemistry 20130613

Title: Synthesis and biological evaluation of a new derivative of bevirimat that targets the Gag CA-SP1 cleavage site.

Journal: European journal of medicinal chemistry 20130401

Title: Quantitative purity-activity relationships of natural products: the case of anti-tuberculosis active triterpenes from Oplopanax horridus.

Journal: Journal of natural products 20130322

Title: GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death.

Journal: Cancer letters 20130201

Title: A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients.

Journal: Food chemistry 20130115

Title: Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L.

Journal: Food chemistry 20130115

Title: A novel one-step microbial transformation of betulin to betulinic acid catalysed by Cunninghamella blakesleeana.

Journal: Food chemistry 20130101

Title: Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity.

Journal: Food chemistry 20130101

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus.

Journal: Planta 20121101

Title: Antimycobacterial assessment of Salicylanilide benzoates including multidrug-resistant tuberculosis strains.

Journal: Molecules (Basel, Switzerland) 20121031

Title: Bioactive oleanane, lupane and ursane triterpene acid derivatives.

Journal: Molecules (Basel, Switzerland) 20121017

Title: Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana.

Journal: Bioorganic & medicinal chemistry letters 20121015

Title: Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues.

Journal: Molecules (Basel, Switzerland) 20121012

Title: Ionic derivatives of betulinic acid as novel HIV-1 protease inhibitors.

Journal: Journal of enzyme inhibition and medicinal chemistry 20121001

Title: A novel triterpene extract from mistletoe induces rapid apoptosis in murine B16.F10 melanoma cells.

Journal: Phytotherapy research : PTR 20121001

Title: Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20121001

Title: Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120929

Title: Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.

Journal: Journal of medicinal chemistry 20120927

Title: Mesua beccariana (Clusiaceae), a source of potential anti-cancer lead compounds in drug discovery.

Journal: Molecules (Basel, Switzerland) 20120910

Title: Investigation of the interactions of lupane type pentacyclic triterpenes with outer leaflet membrane phospholipids--Langmuir monolayer and synchrotron X-ray scattering study.

Journal: Journal of colloid and interface science 20120901

Title: Hepatoprotective potential of Tecomella undulata stem bark is partially due to the presence of betulinic acid.

Journal: Journal of ethnopharmacology 20120830

Title: Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.

Journal: Bioorganic & medicinal chemistry letters 20120815

Title: Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⁺ T-cell proliferation in human mononuclear cell cultures.

Journal: Phytotherapy research : PTR 20120801

Title: Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.

Journal: Cell death and differentiation 20120801

Title: Betulinic acid exerts immunoregulation and anti-tumor effect on cervical carcinoma (U14) tumor-bearing mice.

Journal: Die Pharmazie 20120801

Title: Betulin as an antitumor agent tested in vitro on A431, HeLa and MCF7, and as an angiogenic inhibitor in vivo in the CAM assay.

Journal: Natural product communications 20120801

Title: Exploration of the antiplatelet activity profile of betulinic acid on human platelets.

Journal: Journal of agricultural and food chemistry 20120718

Title: Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: Antiparasitic compounds from Cornus florida L. with activities against Plasmodium falciparum and Leishmania tarentolae.

Journal: Journal of ethnopharmacology 20120713

Title: Betulinic acid has an inhibitory effect on pancreatic lipase and induces adipocyte lipolysis.

Journal: Phytotherapy research : PTR 20120701

Title: Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.

Journal: Molecular cancer therapeutics 20120701

Title: [Chemical constituents contained in Macropanax rosthornii].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120701

Title: Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.

Journal: Bioorganic & medicinal chemistry letters 20120615

Title: Molecular dynamics simulation studies of betulinic acid with human serum albumin.

Journal: Journal of molecular modeling 20120601

Title: Effect on tumor necrosis factor-α production and antioxidant ability of black alder, as factors related to its anti-inflammatory properties.

Journal: Journal of medicinal food 20120601

Title: Orthoquinone and naphthalenone derivatives from Berrya ammonilla and their anti-inflammatory activity.

Journal: Planta medica 20120601

Title: Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid.

Journal: Bioorganic & medicinal chemistry 20120601

Title: NOXA as critical mediator for drug combinations in polychemotherapy.

Journal: Cell death & disease 20120601

Title: Betulinic acid induces Bax/Bak-independent cytochrome c release in human nasopharyngeal carcinoma cells.

Journal: Molecules and cells 20120531

Title: Effect of betulinic acid on neutrophil recruitment and inflammatory mediator expression in lipopolysaccharide-induced lung inflammation in rats.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512

Title: Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7.

Journal: Chest 20120501

Title: [Chemical constituents of Dolomiaea souliei].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

Title: Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo.

Journal: Journal of natural products 20120427

Title: Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi.

Journal: Journal of natural products 20120427

Title: Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption.

Journal: Journal of medicinal chemistry 20120412

Title: Preliminary study of the anticancer applications of mesoporous materials functionalized with the natural product betulinic acid.

Journal: ChemMedChem 20120401

Title: Rapid separation and determination of betulinic acid from a complex matrix using combination of TLC and RP-HPLC.

Journal: Pakistan journal of pharmaceutical sciences 20120401

Title: Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun.

Journal: Neuroscience 20120329

Title: Lupane-type pentacyclic triterpenes in Langmuir monolayers: a synchrotron radiation scattering study.

Journal: Langmuir : the ACS journal of surfaces and colloids 20120320

Title: alpha-Mangostin enhances betulinic acid cytotoxicity and inhibits cisplatin cytotoxicity on HCT 116 colorectal carcinoma cells.

Journal: Molecules (Basel, Switzerland) 20120308

Title: A comparison investigation on the solubilization of betulin and betulinic acid in cyclodextrin derivatives.

Journal: Natural product communications 20120301

Title: New ionic derivatives of betulinic acid as highly potent anti-cancer agents.

Journal: Bioorganic & medicinal chemistry letters 20120215

Title: The anti-fibrotic effect of betulinic acid is mediated through the inhibition of NF-κB nuclear protein translocation.

Journal: Chemico-biological interactions 20120205

Title: Does NAD(P)H oxidase-derived H2O2 participate in hypotonicity-induced insulin release by activating VRAC in β-cells?

Journal: Pflugers Archiv : European journal of physiology 20120201

Title: [Study on absorption kinetics of betulic acid in rat's intestines].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201

Title: The natural product betulinic acid inhibits C/EBP family transcription factors.

Journal: Chembiochem : a European journal of chemical biology 20120123

Title: Physico-chemical comparison of betulinic acid, betulin and birch bark extract and in vitro investigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines.

Journal: Natural product research 20120101

Title: Bioguided isolation of pentacyclic triterpenes from the leaves of Alstonia scholaris (Linn.) R. Br. growing in Egypt.

Journal: Natural product research 20120101

Title: A new triterpene from Barringtonia asiatica.

Journal: Natural product research 20120101

Title: A new fatty aldol ester from the aerial part of Mimosa invisa (Mimosaceae).

Journal: Natural product research 20120101

Title: Synthesis of bioactive 28-hydroxy-3-oxolup-20(29)-en-30-al with antileukemic activity.

Journal: Journal of Asian natural products research 20120101

Title: Bioactivity Evaluation of Plant Extracts Used in Indigenous Medicine against the Snail, Biomphalaria glabrata, and the Larvae of Aedes aegypti.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein.

Journal: Retrovirology 20120101

Title: Antiproliferative property of n-hexane and chloroform extracts of Anisomeles malabarica (L). R. Br. in HPV16-positive human cervical cancer cells.

Journal: Journal of pharmacology & pharmacotherapeutics 20120101

Title: New galloyl derivative from winged sumac (Rhus copallinum) fruit.

Journal: Natural product communications 20120101

Title: Triterpenes from Callicarpa integerrima Champ.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120101

Title: Ethanolic Extract of Vitis thunbergii Exhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Growth inhibition of human gynecologic and colon cancer cells by Phyllanthus watsonii through apoptosis induction.

Journal: PloS one 20120101

Title: Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer.

Journal: PloS one 20120101

Title: Notch, wnt, and hedgehog pathways in rhabdomyosarcoma: from single pathways to an integrated network.

Journal: Sarcoma 20120101

Title: Mitochondria: redox metabolism and dysfunction.

Journal: Biochemistry research international 20120101

Title: Antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants: a mini review.

Journal: Advances in pharmacological sciences 20120101

Title: Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Retigeric acid B exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo.

Journal: PloS one 20120101

Title: Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Radiation, inflammation, and immune responses in cancer.

Journal: Frontiers in oncology 20120101

Title: Antimicrobial Constituents of Artemisia afra Jacq. ex Willd. against Periodontal Pathogens.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Influence of betulinic acid on lymphocyte subsets and humoral immune response in mice.

Journal: Polish journal of veterinary sciences 20120101

Title: Lignans and triterpenes from the root of Pseuderanthemum carruthersii var. atropurpureum.

Journal: Chemical & pharmaceutical bulletin 20120101

Title: Betulinic Acid inhibits growth of cultured vascular smooth muscle cells in vitro by inducing g(1) arrest and apoptosis.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Betulinic acid inhibits superoxide anion-mediated impairment of endothelium-dependent relaxation in rat aortas.

Journal: Indian journal of pharmacology 20120101

Title: A new biphenyl and antimicrobial activity of extracts and compounds from Clusia burlemarxii.

Journal: Fitoterapia 20111201

Title: Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor-κB.

Journal: Biochimica et biophysica acta 20111201

Title: CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis.

Journal: Plant & cell physiology 20111201

Title: Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography.

Journal: Chemistry & biodiversity 20111201

Title: First self-assembly study of betulinic acid, a renewable nano-sized, 6-6-6-6-5 pentacyclic monohydroxy triterpenic acid.

Journal: Nanoscale 20111101

Title: Triterpenoid constituents from the roots of Paeonia rockii ssp. rockii.

Journal: Journal of natural products 20111028

Title: Two new xanthones from Calophyllum nodusum (Guttiferae).

Journal: Molecules (Basel, Switzerland) 20111025

Title: Efficient synthesis of lupane-type saponins via gold(I)-catalyzed glycosylation with glycosyl ortho-alkynylbenzoates as donors.

Journal: Organic letters 20111021

Title: Betulinic acid ameliorates endothelium-dependent relaxation in L-NAME-induced hypertensive rats by reducing oxidative stress.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20111009

Title: Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release.

Journal: Molecular carcinogenesis 20111001

Title: New betulinic acid derivatives as potent proteasome inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20111001

Title: A new furanoxanthone from the stem bark of Calophyllum inophyllum.

Journal: Journal of Asian natural products research 20111001

Title: In vitro effect of combined hybrid molecules from vitamin E analogues and betulinic acid on macrophage activity.

Journal: Bulletin of experimental biology and medicine 20111001

Title: Simultaneous qualitative and quantitative analysis of triterpenic acids, saponins and flavonoids in the leaves of two Ziziphus species by HPLC-PDA-MS/ELSD.

Journal: Journal of pharmaceutical and biomedical analysis 20110910

Title: An amphiphilic conjugate approach toward the design and synthesis of betulinic acid-polyphenol conjugates as inhibitors of the HIV-1 gp41 fusion core formation.

Journal: ChemMedChem 20110905

Title: Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling.

Journal: British journal of pharmacology 20110901

Title: Targeting Sp1 transcription factors in prostate cancer therapy.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20110901

Title: Identification and determination of carboxylic acids in food samples using 2-(2-(anthracen-10-yl)-1H-phenanthro[9,10-d]imidazol-1-yl)ethyl 4-methylbenzenesulfonate (APIETS) as labeling reagent by HPLC with FLD and APCI/MS.

Journal: Talanta 20110815

Title: Sp1 inhibition-mediated upregulation of VEGF 165 b induced by rh-endostatin enhances antiangiogenic and anticancer effect of rh-endostatin in A549.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20110801

Title: Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.

Journal: Cancer research 20110801

Title: Improvement of the cytotoxicity and tumor selectivity of glycyrrhetinic acid by derivatization with bifunctional amino acids.

Journal: Archiv der Pharmazie 20110801

Title: Up-regulation of cyclooxygenase-2-derived prostaglandin E(2) in colon cancer cells resistant to 5-fluorouracil.

Journal: Journal of the Korean Surgical Society 20110801

Title: [Study on the chemical constituents of Leptopus chineseis].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110801

Title: Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.

Journal: Molecules (Basel, Switzerland) 20110719

Title: Birch bark extract as therapy for chronic hepatitis C--a pilot study.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110715

Title: Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking.

Journal: Journal of molecular modeling 20110701

Title: A single polymorphism in HIV-1 subtype C SP1 is sufficient to confer natural resistance to the maturation inhibitor bevirimat.

Journal: Antimicrobial agents and chemotherapy 20110701

Title: Novel 3-oxo- and 3,24-dinor-2,4-secooleanane-type triterpenes from Terminalia ivorensis A. Chev.

Journal: Chemistry & biodiversity 20110701

Title: Constituents of the root of Anemone tomentosa.

Journal: Archives of pharmacal research 20110701

Title: New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells.

Journal: Biochimie 20110601

Title: Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.

Journal: Journal of natural products 20110527

Title: Betulinic acid protects against cerebral ischemia-reperfusion injury in mice by reducing oxidative and nitrosative stress.

Journal: Nitric oxide : biology and chemistry 20110430

Title: Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.

Journal: Bioorganic & medicinal chemistry letters 20110415

Title: Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits.

Journal: Journal of agricultural and food chemistry 20110413

Title: Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cells.

Journal: Investigational new drugs 20110401

Title: Betulinic acid prevention of d-galactosamine/lipopolysaccharide liver toxicity is triggered by activation of Bcl-2 and antioxidant mechanisms.

Journal: The Journal of pharmacy and pharmacology 20110401

Title: Antileukemic activity of the leaf extract of Bischofia javanica blume on human leukemic cell lines.

Journal: Indian journal of pharmacology 20110401

Title: Anti-angiogenic effects of betulinic acid administered in nanoemulsion formulation using chorioallantoic membrane assay.

Journal: Journal of biomedical nanotechnology 20110401

Title: Betulinic acid inhibits endotoxin-stimulated phosphorylation cascade and pro-inflammatory prostaglandin E(2) production in human peripheral blood mononuclear cells.

Journal: British journal of pharmacology 20110301

Title: Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity.

Journal: Anti-cancer drugs 20110301

Title: Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.

Journal: Oncotarget 20110301

Title: Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling.

Journal: Toxicology 20110227

Title: Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.).

Journal: Phytotherapy research : PTR 20110201

Title: Anxiolytic activity of a supercritical carbon dioxide extract of Souroubea sympetala (Marcgraviaceae).

Journal: Phytotherapy research : PTR 20110201

Title: In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa.

Journal: Inflammopharmacology 20110201

Title: Effect of culture conditions on synthesis of triterpenoids in suspension cultures of Lantana camara L.

Journal: Bioprocess and biosystems engineering 20110101

Title: Biotransformation optimization of betulin into betulinic acid production catalysed by cultured Armillaria luteo-virens Sacc ZJUQH100-6 cells.

Journal: Journal of applied microbiology 20110101

Title: Monolayer behavior of binary systems of betulinic acid and cardiolipin: thermodynamic analyses of Langmuir monolayers and AFM study of Langmuir-Blodgett monolayers.

Journal: Journal of colloid and interface science 20110101

Title: Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids.

Journal: Plant physiology 20110101

Title: Unexpected applications of secondary metabolites.

Journal: Biotechnology advances 20110101

Title: Synthesis, encapsulation and antitumor activity of new betulin derivatives.

Journal: Archiv der Pharmazie 20110101

Title: Antiapoptotic and Antioxidant Properties of Orthosiphon stamineus Benth (Cat's Whiskers): Intervention in the Bcl-2-Mediated Apoptotic Pathway.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Phenylpropanoids from the stem bark of Jacaranda mimosaefolia.

Journal: Natural product research 20110101

Title: Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae).

Journal: BMC complementary and alternative medicine 20110101

Title: 3-O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: Docking study of HIV-1 reverse transcriptase with phytochemicals.

Journal: Bioinformation 20110101

Title: Anti-inflammatory effects of seeds of the tropical fruit camu-camu (Myrciaria dubia).

Journal: Journal of nutritional science and vitaminology 20110101

Title: The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism.

Journal: BMC cancer 20110101

Title: Preparation of herbal tea as infusion or by maceration at room temperature using mistletoe tea as an example.

Journal: Scientia pharmaceutica 20110101

Title: Cell entry and trafficking of human adenovirus bound to blood factor X is determined by the fiber serotype and not hexon:heparan sulfate interaction.

Journal: PloS one 20110101

Title: Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains.

Journal: Annals of clinical microbiology and antimicrobials 20110101

Title: Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark.

Journal: Malaria journal 20110101

Title: Anticancer activity of 2α, 3α, 19β, 23β-Tetrahydroxyurs-12-en-28-oic acid (THA), a novel triterpenoid isolated from Sinojackia sarcocarpa.

Journal: PloS one 20110101

Title: Chemical analysis of Greek pollen - Antioxidant, antimicrobial and proteasome activation properties.

Journal: Chemistry Central journal 20110101

Title: Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells.

Journal: PloS one 20110101

Title: A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.

Journal: BMC cancer 20110101

Title: Safety of higher dosages of Viscum album L. in animals and humans--systematic review of immune changes and safety parameters.

Journal: BMC complementary and alternative medicine 20110101

Title: Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid.

Journal: The American journal of Chinese medicine 20110101

Title: Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions.

Journal: Radiation oncology (London, England) 20110101

Title: Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening.

Journal: Malaria journal 20110101

Title: Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative luciferase-Vpr packaging-based assay.

Journal: PloS one 20110101

Title: Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity.

Journal: BMC complementary and alternative medicine 20110101

Title: Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity.

Journal: International journal of nanomedicine 20110101

Title: The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles.

Journal: Retrovirology 20110101

Title: Morphogenesis of the Infectious HIV-1 Virion.

Journal: Frontiers in microbiology 20110101

Title: Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves.

Journal: Journal of parasitology research 20110101

Title: Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells.

Journal: Pharmacological reports : PR 20110101

Title: Prostate cancer cell lines under hypoxia exhibit greater stem-like properties.

Journal: PloS one 20110101

Title: Biological activities and medicinal properties of Cajanus cajan (L) Millsp.

Journal: Journal of advanced pharmaceutical technology & research 20110101

Title: Effects of newcastle disease virus strains AF2240 and V4-UPM on cytolysis and apoptosis of leukemia cell lines.

Journal: International journal of molecular sciences 20110101

Title: Bioactive constituents and medicinal importance of genus Alnus.

Journal: Pharmacognosy reviews 20110101

Title: The prospective role of plant products in radiotherapy of cancer: a current overview.

Journal: Frontiers in pharmacology 20110101

Title: Triterpenoids from Schleichera oleosa of Darjeeling Foothills and Their Antimicrobial Activity.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: Triterpenoid contents and anti-inflammatory properties of the methanol extracts of ligustrum species leaves.

Journal: Molecules (Basel, Switzerland) 20101223

Title: Betulinic acid inhibits high glucose-induced vascular smooth muscle cells proliferation and migration.

Journal: Journal of cellular biochemistry 20101215

Title: Redefining the TGR5 triterpenoid binding pocket at the C-3 position.

Journal: ChemMedChem 20101203

Title: Immunomodulatory effects of betulinic acid from the bark of white birch on mice.

Journal: Journal of veterinary science 20101201

Title: Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats.

Journal: Indian journal of pharmacology 20101201

Title: Zfra is a small wizard in the mitochondrial apoptosis.

Journal: Aging 20101201

Title: Extended longevity of Drosophila melanogaster by water and ethanol extracts of Stachys lavandulifolia.

Journal: Pharmaceutical biology 20101101

Title: Inhibition of insulin and T3-induced fatty acid synthase by hexanoate.

Journal: Lipids 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: [Influence of betulinic acid on proliferation, migration, cell cycle and apoptosis of pancreatic cancer cells].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

Title: [Advances in the study of structural modifications and biological activities of betulinic acids].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20101101

Title: 3β-Acet-oxy-lup-20(29)-en-28-yl 1H-1,2,4-tri-azole-1-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20101101

Title: Synthesis, cytotoxicity and liposome preparation of 28-acetylenic betulin derivatives.

Journal: Bioorganic & medicinal chemistry 20101015

Title: New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern).

Journal: Fitoterapia 20101001

Title: Antimicrobial and antioxidant effects of phenolic constituents from Klainedoxa gabonensis.

Journal: Pharmaceutical biology 20101001

Title: Antiinflammatory properties of Morus nigra leaves.

Journal: Phytotherapy research : PTR 20101001

Title: Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.

Journal: Toxins 20101001

Title: Synthesis, proapoptotic screening, and structure-activity relationships of novel aza-lupane triterpenoids.

Journal: Bioorganic & medicinal chemistry letters 20100915

Title: Two new flavones from Tridax procumbens Linn.

Journal: Molecules (Basel, Switzerland) 20100909

Title: Exploring the potential of Nelumbo nucifera rhizome on membrane stabilization, mast cell protection, nitric oxide synthesis, and expression of costimulatory molecules.

Journal: Immunopharmacology and immunotoxicology 20100901

Title: Conjugates of betulin derivatives with AZT as potent anti-HIV agents.

Journal: Bioorganic & medicinal chemistry 20100901

Title: [Betulinic acid ameliorates impairment of endothelium-dependent relaxation induced by oxidative stress in rat aorta].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100901

Title: Betulinic acid isolated from Bacopa monniera (L.) Wettst suppresses lipopolysaccharide stimulated interleukin-6 production through modulation of nuclear factor-kappaB in peripheral blood mononuclear cells.

Journal: International immunopharmacology 20100801

Title: Small structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer properties.

Journal: European journal of medicinal chemistry 20100801

Title: Modulation of apoptosis by natural products for cancer therapy.

Journal: Planta medica 20100801

Title: Antitumor effect of betulinic acid on human acute leukemia K562 cells in vitro.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20100801

Title: Synthesis and anticancer activity of novel betulinic acid and betulin derivatives.

Journal: Archiv der Pharmazie 20100801

Title: Last stop before exit - hepatitis C assembly and release as antiviral drug targets.

Journal: Viruses 20100801

Title: Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.

Journal: International journal of cancer 20100715

Title: Betulinic acid inhibits the expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in human endometrial adenocarcinoma cells.

Journal: Molecular and cellular biochemistry 20100701

Title: Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors.

Journal: Current diabetes reviews 20100701

Title: A new steroidal glycoside and fatty acid esters from the stem bark of Tectona grandis Linn.

Journal: Natural product research 20100701

Title: Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells.

Journal: Molecular carcinogenesis 20100701

Title: 3β-Hy-droxy-lup-20(29)-en-28-yl 1H-imidazole-1-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20100701

Title: Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.

Journal: British journal of cancer 20100629

Title: Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid.

Journal: Bioorganic & medicinal chemistry 20100615

Title: Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signals.

Journal: Journal of agricultural and food chemistry 20100609

Title: Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites.

Journal: DNA repair 20100604

Title: Anti-angiogenic and cytotoxicity studies of some medicinal plants.

Journal: Planta medica 20100601

Title: Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.

Journal: Pharmacological research 20100601

Title: Secondary plant substances in various extracts of the leaves, fruits, stem and bark of Caraipa densifolia Mart.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

Title: Carbamate derivatives of betulinic acid and betulin with selective cytotoxic activity.

Journal: Bioorganic & medicinal chemistry letters 20100601

Title: Acylated manoyl oxide diterpenes of Stemodia trifoliata.

Journal: Magnetic resonance in chemistry : MRC 20100601

Title: Nonsurgical innovations in the treatment of nonmelanoma skin cancer.

Journal: The Journal of clinical and aesthetic dermatology 20100601

Title: [Studies on the chemical constituents of Callicarpa kochiana].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601

Title: [Studies on the triterpenoids of Vitex trifolia].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601

Title: Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.

Journal: Journal of natural products 20100528

Title: Anti-leukemic activity of Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100501

Title: Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells.

Journal: Molecular cancer research : MCR 20100501

Title: In vitro anticancer studies of alpha- and beta-D-glucopyranose betulin anomers.

Journal: Chemico-biological interactions 20100429

Title: Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.

Journal: Journal of medicinal chemistry 20100422

Title: Antiprotozoal activity of betulinic acid derivatives.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100401

Title: Minor secondary metabolic products from the stem bark of Plumeria rubra Linn. displaying antimicrobial activities.

Journal: Planta medica 20100401

Title: Synthesis and biological evaluation of antitumor-active gamma-butyrolactone substituted betulin derivatives.

Journal: Bioorganic & medicinal chemistry 20100401

Title: A pentacyclic triterpene from Litchi chinensis.

Journal: Natural product communications 20100401

Title: Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

Journal: Journal of natural products 20100326

Title: Bioactivity-guided isolation of cytotoxic triterpenoids from the trunk of Berberis koreana.

Journal: Bioorganic & medicinal chemistry letters 20100315

Title: Betulinic acid protects against ischemia/reperfusion-induced renal damage and inhibits leukocyte apoptosis.

Journal: Phytotherapy research : PTR 20100301

Title: Anti-HIV-1 and anti-inflammatory lupanes from the leaves, twigs, and resin of Garcinia hanburyi.

Journal: Planta medica 20100301

Title: Betulinic acid, a natural compound with potent anticancer effects.

Journal: Anti-cancer drugs 20100301

Title: Anti-leishmanial activity of betulin derivatives.

Journal: The Journal of antibiotics 20100301

Title: Betulinic acid a radiosensitizer in head and neck squamous cell carcinoma cell lines.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20100301

Title: Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7.

Journal: Pharmaceutical biology 20100301

Title: Antiproliferative cardenolides from Pentopetia androsaemifolia Decne. from the Madagascar rain forest.

Journal: Indian journal of experimental biology 20100301

Title: Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives.

Journal: Bioorganic & medicinal chemistry 20100215

Title: Effects of triterpene derivatives from Maytenus rigida on VEGF-induced Kaposi's sarcoma cell proliferation.

Journal: Chemico-biological interactions 20100212

Title: Augmentation of expression of immunocytes' functions by seed extract of Ziziphus mauritiana (Lamk.).

Journal: Journal of ethnopharmacology 20100203

Title: Synthesis and biological evaluation of antitumour-active betulin derivatives.

Journal: Bioorganic & medicinal chemistry 20100201

Title: Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.

Journal: Journal of medicinal chemistry 20100114

Title: Synthesis of a molecularly imprinted polymer for the solid-phase extraction of betulin and betulinic acid from plane bark.

Journal: Phytochemical analysis : PCA 20100101

Title: Protective role of betulinic acid on TNF-alpha-induced cell adhesion molecules in vascular endothelial cells.

Journal: Biochemical and biophysical research communications 20100101

Title: Effect of betulinic acid on the regulation of Hiwi and cyclin B1 in human gastric adenocarcinoma AGS cells.

Journal: Acta pharmacologica Sinica 20100101

Title: Molecular interaction studies of trimethoxy flavone with human serum albumin.

Journal: PloS one 20100101

Title: Indigenous use and bio-efficacy of medicinal plants in the Rasuwa District, Central Nepal.

Journal: Journal of ethnobiology and ethnomedicine 20100101

Title: Effects of hydroxy pentacyclic triterpene acids from Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea pigs.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat.

Journal: Retrovirology 20100101

Title: Anticancer activity of 3-O-acylated betulinic acid derivatives obtained by enzymatic synthesis.

Journal: Bioscience, biotechnology, and biochemistry 20100101

Title: Possible fungistatic implications of betulin presence in betulaceae plants and their hymenochaetaceae parasitic fungi.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20100101

Title: Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells.

Journal: The American journal of Chinese medicine 20100101

Title: NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.

Journal: Molecular cancer 20100101

Title: Rapid validated HPTLC method for estimation of betulinic acid in Nelumbo nucifera (Nymphaeaceae) rhizome extract.

Journal: Phytochemical analysis : PCA 20100101

Title: Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation.

Journal: Experimental diabetes research 20100101

Title: Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death.

Journal: Parasites & vectors 20100101

Title: Baculovirus display of single chain antibody (scFv) using a novel signal peptide.

Journal: BMC biotechnology 20100101

Title: Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation.

Journal: PloS one 20100101

Title: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.

Journal: BMC cancer 20100101

Title: Traditional herbal medicine in far-west Nepal: a pharmacological appraisal.

Journal: Journal of ethnobiology and ethnomedicine 20100101

Title: Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel.

Journal: Journal of inflammation (London, England) 20100101

Title: Triterpenoids from Psidium guajava with Biocidal Activity.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Bioactivity of Syzygium jambos methanolic extracts: Antibacterial activity and toxicity.

Journal: Pharmacognosy research 20100101

Title: Diuretic and natriuretic activity of two mistletoe species in rats.

Journal: Pharmacognosy research 20100101

Title: Cameroonian medicinal plants: pharmacology and derived natural products.

Journal: Frontiers in pharmacology 20100101

Title: Ethnopharmacology and integrative medicine - Let the history tell the future.

Journal: Journal of Ayurveda and integrative medicine 20100101

Title: Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.

Journal: Journal of medicinal chemistry 20091210

Title: Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy.

Journal: Planta medica 20091201

Title: Bioactive constituents of the stem bark of Beilschmiedia zenkeri.

Journal: Journal of natural products 20091201

Title: Pharmacotherapy of actinic keratosis.

Journal: Expert opinion on pharmacotherapy 20091201

Title: The hunt for natural skin whitening agents.

Journal: International journal of molecular sciences 20091201

Title: Phytotoxic activity of Salvia x jamensis.

Journal: Natural product communications 20091201

Title: Triterpenoids as new promising anticancer drugs.

Journal: Anti-cancer drugs 20091101

Title: Cellular fingerprints: a novel approach using large-scale cancer cell line data for the identification of potential anticancer agents.

Journal: Chemical biology & drug design 20091101

Title: Betulin-derived compounds as inhibitors of alphavirus replication.

Journal: Journal of natural products 20091101

Title: A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta.

Journal: Bioscience, biotechnology, and biochemistry 20091101

Title: Anticancer agents derived from natural products.

Journal: Mini reviews in medicinal chemistry 20091101

Title: [Studies on the chemical constituents from the seed of Forsythia suspense].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20091101

Title: Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet.

Journal: Journal of agricultural and food chemistry 20091014

Title: Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells.

Journal: Bioorganic & medicinal chemistry letters 20091001

Title: Betulinic acid treatment promotes apoptosis in hepatoblastoma cells.

Journal: International journal of oncology 20091001

Title: [Effect of betulinic acid on inducing apoptosis of human multiple myeloma cell line RPMI-8226].

Journal: Zhongguo shi yan xue ye xue za zhi 20091001

Title: Recent developments in anti-inflammatory natural products.

Journal: Medicinal research reviews 20090901

Title: Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma.

Journal: Fitoterapia 20090901

Title: Mitochondrial membrane potential disruption pattern in human sperm.

Journal: Human reproduction (Oxford, England) 20090901

Title: Targeting mitochondrial apoptosis by betulinic acid in human cancers.

Journal: Drug discovery today 20090901

Title: Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity.

Journal: Bioorganic & medicinal chemistry 20090901

Title: Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors.

Journal: Journal of natural products 20090901

Title: Study on determination of pentacyclic triterpenoids in Chaenomeles by HPLC-ELSD.

Journal: Journal of chromatographic science 20090901

Title: Antifungal activity of Eugenia umbelliflora against dermatophytes.

Journal: Natural product communications 20090901

Title: [Chemical constituents from fruits of Ailanthus altissima].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090901

Title: [Studies on the chemical constituents of Coleus forskohlii].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090901

Title: Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo.

Journal: International journal of cancer 20090815

Title: Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells.

Journal: Bioorganic & medicinal chemistry letters 20090815

Title: Antimicrobial activity of the crude extract, fractions and compounds from stem bark of Ficus ovata (Moraceae).

Journal: Journal of ethnopharmacology 20090730

Title: High-performance liquid chromatography--two wavelength detection of triterpenoid acids from the fruits of Ziziphus jujuba containing various cultivars in different regions and classification using chemometric analysis.

Journal: Journal of pharmaceutical and biomedical analysis 20090712

Title: Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice.

Journal: Parasitology research 20090701

Title: Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents.

Journal: Bioorganic & medicinal chemistry letters 20090701

Title: Phytochemical analyses and gastroprotective effects of Eugenia umbelliflora (Myrtaceae) on experimental gastric ulcers.

Journal: Natural product communications 20090701

Title: A new lipid and other constituents from the rhizomes of Nelumbo nucifera.

Journal: Journal of Asian natural products research 20090701

Title: Triterpenoids from the roots of Pterospermum heterophyllum Hance.

Journal: Journal of Asian natural products research 20090701

Title: Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.

Journal: Molecules (Basel, Switzerland) 20090604

Title: Bioactive triterpenoids from Callistemon lanceolatus.

Journal: Archives of pharmacal research 20090601

Title: Curtisia dentata (Cornaceae) leaf extracts and isolated compounds inhibit motility of parasitic and free-living nematodes.

Journal: The Onderstepoort journal of veterinary research 20090601

Title: 2'-Methyl-pyrazolo[4',3':16,17]androst-5-en-3β-ol.

Journal: Acta crystallographica. Section E, Structure reports online 20090601

Title: Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.

Journal: Journal of medicinal chemistry 20090528

Title: Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound.

Journal: European journal of clinical investigation 20090501

Title: Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression.

Journal: The FEBS journal 20090501

Title: Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines.

Journal: Molecules (Basel, Switzerland) 20090424

Title: Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Synthesis and cytotoxicity of 2-cyano-28-hydroxy-lup-1-en-3-ones.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.

Journal: Bioorganic & medicinal chemistry 20090301

Title: Efficacy and mechanism of action of KHBJ-9B, a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit model of collagenase-induced osteoarthritis.

Journal: International immunopharmacology 20090201

Title: Acasiane A and B and farnesirane A and B, diterpene derivatives from the roots of Acacia farnesiana.

Journal: Planta medica 20090201

Title: Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion.

Journal: Apoptosis : an international journal on programmed cell death 20090201

Title: Anti-oxidative and anti-inflammatory activities of some isolated constituents from the stem bark of Allanblackia monticola Staner L.C (Guttiferae).

Journal: Inflammopharmacology 20090201

Title: Peltophorum africanum, a traditional South African medicinal plant, contains an anti HIV-1 constituent, betulinic acid.

Journal: The Tohoku journal of experimental medicine 20090201

Title: Identification and isolation of pharmacologically active triterpenes in Betuale cortex, Betula pendula Roth., Betulaceae.

Journal: Bosnian journal of basic medical sciences 20090201

Title: Antioxidative action of methanolic extract and buthanolic fraction of Vochysia tucanorum Mart. in the gastroprotection.

Journal: Journal of ethnopharmacology 20090130

Title: Enhancing the divergent activities of betulinic acid via neoglycosylation.

Journal: Organic letters 20090115

Title: Betulinic acid binding to human serum albumin: a study of protein conformation and binding affinity.

Journal: Journal of photochemistry and photobiology. B, Biology 20090109

Title: Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke.

Journal: Molecules (Basel, Switzerland) 20090108

Title: Uapaca genus (Euphorbiaceae), a good source of betulinic acid.

Journal: Fitoterapia 20090101

Title: Analysis of pentacyclic triterpenes by LC-MS. A comparative study between APCI and APPI.

Journal: Journal of mass spectrometry : JMS 20090101

Title: Betulinic acid: a natural product with anticancer activity.

Journal: Molecular nutrition & food research 20090101

Title: Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins.

Journal: Journal of natural products 20090101

Title: Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells.

Journal: Journal of translational medicine 20090101

Title: Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness.

Journal: PloS one 20090101

Title: [Drug discovery based on classic natural products].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090101

Title: Betulin is a potent anti-tumor agent that is enhanced by cholesterol.

Journal: PloS one 20090101

Title: Mechanism of betulinic acid inhibition of collagen biosynthesis in human endometrial adenocarcinoma cells.

Journal: Neoplasma 20090101

Title: Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research.

Journal: Journal of experimental & clinical cancer research : CR 20090101

Title: Antimalarial compounds from the stem bark of Vismia laurentii.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

Title: Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation.

Journal: PloS one 20090101

Title: Chemical composition of the stem bark and leaves of Ficus pandurata Hance.

Journal: Natural product research 20090101

Title: Prevention of atherosclerosis by interference with the vascular nitric oxide system.

Journal: Current pharmaceutical design 20090101

Title: Antimicrobial activity of pentacyclic triterpenes isolated from Acacia mellifera.

Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM 20090101

Title: Betulinic acid does not modulate the activity of P-gp/ABCB1 or MRP1/ABCC1 in a non-tumoral renal cell line: Possible utility in multidrug resistance cancer chemotherapy.

Journal: Molecular medicine reports 20090101

Title: Betulinic acid exhibits stronger cytotoxic activity on the normal melanocyte NHEM-neo cell line than on drug-resistant and drug-sensitive MeWo melanoma cell lines.

Journal: Molecular medicine reports 20090101

Title: Simultaneous determination of jujuboside A, B and betulinic acid in semen Ziziphi spinosae by high performance liquid chromatography-evaporative light scattering detection.

Journal: Journal of pharmaceutical and biomedical analysis 20081215

Title: Triterpene based compounds with potent anti-maturation activity against HIV-1.

Journal: Bioorganic & medicinal chemistry letters 20081215

Title: Enhanced analysis of triterpenes, flavonoids and phenolic compounds in Prunella vulgaris L. by capillary zone electrophoresis with the addition of running buffer modifiers.

Journal: Journal of chromatography. A 20081212

Title: Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells.

Journal: Molecular carcinogenesis 20081201

Title: Effect of hydrogen peroxide on secretory response, calcium mobilisation and caspase-3 activity in the isolated rat parotid gland.

Journal: Molecular and cellular biochemistry 20081201

Title: Effects of betulinic acid on proliferation and apoptosis in Jurkat cells and its in vitro mechanism.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081201

Title: Screening of Chinese medicinal plants for inhibition against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).

Journal: Journal of ethnopharmacology 20081120

Title: Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes.

Journal: Journal of ethnopharmacology 20081120

Title: Two novel triterpenoids with antiproliferative and apoptotic activities in human leukemia cells isolated from the resin of Garcinia hanburyi.

Journal: Planta medica 20081101

Title: Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.

Journal: Bioorganic & medicinal chemistry 20081101

Title: Study of antimalarial activity of chemical constituents from Diospyros quaesita.

Journal: Chemistry & biodiversity 20081101

Title: Determination of betulinic acid from Orthosiphon stamineus leaf extract in rat plasma.

Journal: Die Pharmazie 20081101

Title: Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice.

Journal: Pharmacology, biochemistry, and behavior 20081001

Title: Phytochemical composition and in vitro pharmacological activity of two rose hip (Rosa canina L.) preparations.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20081001

Title: Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.

Journal: Journal of natural products 20081001

Title: Four pentacyclic triterpenoids with antifungal and antibacterial activity from Curtisia dentata (Burm.f) C.A. Sm. leaves.

Journal: Journal of ethnopharmacology 20080926

Title: Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid.

Journal: The Journal of organic chemistry 20080919

Title: Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry letters 20080915

Title: Conventional and dense gas techniques for the production of liposomes: a review.

Journal: AAPS PharmSciTech 20080901

Title: Cancer is a preventable disease that requires major lifestyle changes.

Journal: Pharmaceutical research 20080901

Title: Comparison with various parts of Broussonetia papyrifera as to the antinociceptive and anti-inflammatory activities in rodents.

Journal: Bioscience, biotechnology, and biochemistry 20080901

Title: Identification of alpha amylase inhibitors from Syzygium cumini Linn seeds.

Journal: Indian journal of experimental biology 20080901

Title: Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al.

Journal: Journal of natural products 20080801

Title: [Studies on chemical constituents from stem barks of Fraxinus paxiana].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080801

Title: [Studies on chemical constituents from roots of Pterospermum heterophyllum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080801

Title: [Effect of betulinic acid on proliferation and apoptosis in Jurkat cells and its mechanism].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20080801

Title: In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.

Journal: British journal of cancer 20080722

Title: Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria.

Journal: Cellular signalling 20080701

Title: Nitric oxide induces caspase activity in boar spermatozoa.

Journal: Theriogenology 20080701

Title: Antibacterial activity of labdane diterpenoids from Stemodia foliosa.

Journal: Journal of natural products 20080701

Title: [Chemical constituents from herb of Gueldenstaedtia stenophylla].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701

Title: Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.

Journal: Journal of medicinal chemistry 20080626

Title: A new source of whitening agent from a Thai Mulberry plant and its betulinic acid quantitation.

Journal: Natural product research 20080615

Title: Fas receptor is not present on ejaculated human sperm.

Journal: Human reproduction (Oxford, England) 20080601

Title: Investigation of Indian diospyros species for antiplasmodial properties.

Journal: Evidence-based complementary and alternative medicine : eCAM 20080601

Title: Betulinic Acid for cancer treatment and prevention.

Journal: International journal of molecular sciences 20080601

Title: Synthesis of lupane-type saponins bearing mannosyl and 3,6-branched trimannosyl residues and their evaluation as anticancer agents.

Journal: Carbohydrate research 20080505

Title: alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus.

Journal: Journal of natural products 20080501

Title: A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta.

Journal: Archives of pharmacal research 20080501

Title: Inhibitors of DNA polymerase beta: activity and mechanism.

Journal: Bioorganic & medicinal chemistry 20080415

Title: [RP-HPLC determination of betulinic acid in Callicarpa macrophylla].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401

Title: Chemical constituents of radix Ranunculus ternati.

Journal: Natural product research 20080215

Title: Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity.

Journal: Investigational new drugs 20080201

Title: Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids.

Journal: Chemical & pharmaceutical bulletin 20080201

Title: Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum.

Journal: Chemical & pharmaceutical bulletin 20080201

Title: [Study on triterpenes from of Ligularia xanthotricha].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

Title: Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.

Journal: Antimicrobial agents and chemotherapy 20080101

Title: Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants.

Journal: Journal of natural products 20080101

Title: Silencing of GM3 synthase suppresses lung metastasis of murine breast cancer cells.

Journal: Breast cancer research : BCR 20080101

Title: Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity.

Journal: AIDS research and therapy 20080101

Title: PPARgamma: The Portrait of a Target Ally to Cancer Chemopreventive Agents.

Journal: PPAR research 20080101

Title: HA14-1 is able to reconstitute the impaired mitochondrial pathway of apoptosis in renal cell carcinoma cell lines.

Journal: Cellular oncology : the official journal of the International Society for Cellular Oncology 20080101

Title: The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain.

Journal: Virology journal 20080101

Title: Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death.

Journal: Cancer research 20071215

Title: Antielastase and free radical scavenging activities of compounds from the stems of Cornus kousa.

Journal: Phytotherapy research : PTR 20071201

Title: Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry letters 20071201

Title: Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum.

Journal: Phytotherapy research : PTR 20071101

Title: 2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells.

Journal: Carcinogenesis 20071101

Title: Cimicifuga foetida extract inhibits proliferation of hepatocellular cells via induction of cell cycle arrest and apoptosis.

Journal: Journal of ethnopharmacology 20071101

Title: Activation and inhibition of the proteasome by betulinic acid and its derivatives.

Journal: FEBS letters 20071016

Title: Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis (Ixonanthaceae).

Journal: Journal of ethnopharmacology 20071008

Title: Effect of betulinic acid on anticancer drug-resistant colon cancer cells.

Journal: Basic & clinical pharmacology & toxicology 20071001

Title: [Chemical constituents in the root of Cynanchum auriculatum].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071001

Title: Synthesis and structure-activity relationship study of cytotoxic germanicane- and lupane-type 3beta-O-monodesmosidic saponins starting from betulin.

Journal: Bioorganic & medicinal chemistry 20070915

Title: Inhibition of Escherichia coli heat-labile enterotoxin-induced diarrhea by Chaenomeles speciosa.

Journal: Journal of ethnopharmacology 20070905

Title: Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections?

Journal: Evidence-based complementary and alternative medicine : eCAM 20070901

Title: In vitro anti-Candida Activity of Zataria multiflora Boiss.

Journal: Evidence-based complementary and alternative medicine : eCAM 20070901

Title: Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.

Journal: Journal of medicinal chemistry 20070823

Title: Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.

Journal: Journal of natural products 20070801

Title: High-performance thin-layer chromatographic method for quantitative determination of 4alpha-methyl-24beta-ethyl-5alpha-cholesta-14,25-dien-3beta-ol, 24beta-ethylcholesta-5,9(11),22E-trien-3beta-ol, and betulinic acid in Clerodendrum inerme.

Journal: Journal of separation science 20070801

Title: Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

Journal: Molecular cancer therapeutics 20070701

Title: The constituents from the stems of Garcinia cowa Roxb. and their cytotoxic activities.

Journal: Die Pharmazie 20070701

Title: Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types.

Journal: Cancer letters 20070618

Title: Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE).

Journal: Biological & pharmaceutical bulletin 20070601

Title: Antiviral triterpenoids from the medicinal plant Schefflera heptaphylla.

Journal: Phytotherapy research : PTR 20070501

Title: In vitro evaluation of the cytotoxic and trypanocidal activities of Ampelozizyphus amazonicus (Rhamnaceae).

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070501

Title: Triterpenoid pyrazines and benzopyrazines with cytotoxic activity.

Journal: Journal of natural products 20070401

Title: Two new triterpenoids and a steroidal glycoside from the aerial parts of Ocimum basilicum.

Journal: Chemical & pharmaceutical bulletin 20070401

Title: Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.

Journal: Cancer research 20070315

Title: Triterpenoids from Eugenia grandis: structure elucidation by NMR spectroscopy.

Journal: Magnetic resonance in chemistry : MRC 20070301

Title: Biotransformation of betulinic and betulonic acids by fungi.

Journal: Phytochemistry 20070301

Title: alpha-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae).

Journal: Phytochemistry 20070301

Title: Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives.

Journal: Bioorganic & medicinal chemistry letters 20070301

Title: Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae).

Journal: Chemical & pharmaceutical bulletin 20070301

Title: Two new flavanone glycosides of Jasminum lanceolarium and their anti-oxidant activities.

Journal: Chemical & pharmaceutical bulletin 20070301

Title: [Studies on chemical constituents in fruits of Eucalyptus globulus].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070301

Title: Simultaneous determination of betulin and betulinic acid in white birch bark using RP-HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20070219

Title: A new multiparameter flow cytometric method for human semen analysis.

Journal: Human reproduction (Oxford, England) 20070201

Title: Antidermatophytic triterpenoids from Syzygium jambos (L.) Alston (Myrtaceae).

Journal: Phytotherapy research : PTR 20070201

Title: [Biological activity tests of chemical constituents from two Brazilian Labiatae plants].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070201

Title: Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L.

Journal: Planta medica 20070201

Title: New developments in natural products-based anti-AIDS research.

Journal: Medicinal research reviews 20070101

Title: Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine.

Journal: Journal of ethnobiology and ethnomedicine 20070101

Title: Phytochemical investigation of Perovskia abrotanoides.

Journal: Planta medica 20070101

Title: Betulin binds to melanocortin receptors and antagonizes alpha-melanocyte stimulating hormone induced cAMP generation in mouse melanoma cells.

Journal: Cell biochemistry and function 20070101

Title: New flavonoids and other constituents from Lespedeza cuneata.

Journal: Journal of Asian natural products research 20070101

Title: Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.

Journal: PloS one 20070101

Title: The oncoprotein H-RasV12 increases mitochondrial metabolism.

Journal: Molecular cancer 20070101

Title: [Effect of nitrogen-containing derivatives of the plant triterpenes betulin and glycyrrhetic acid on the growth of MT-4, MOLT-4, CEM, and Hep G2 tumor cells].

Journal: Bioorganicheskaia khimiia 20070101

Title: The 3-O-(3',3'-dimethylsuccinyl) derivative of betulinic acid (DSB) inhibits the assembly of virus-like particles in HIV-1 Gag precursor-expressing cells.

Journal: Antiviral therapy 20070101

Title: Targeting human immunodeficiency virus type 1 assembly, maturation and budding.

Journal: Drug target insights 20070101

Title: Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A.

Journal: Bioorganic & medicinal chemistry letters 20061215

Title: Determinants of activity of the HIV-1 maturation inhibitor PA-457.

Journal: Virology 20061201

Title: Physical, chemical and pharmacological characterization of a new oleogel-forming triterpene extract from the outer bark of birch (betulae cortex).

Journal: Planta medica 20061201

Title: Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens.

Journal: Planta medica 20061201

Title: Antihyperglycemic activity and chemical constituents of Eysenhardtia platycarpa.

Journal: Journal of natural products 20061201

Title: Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents.

Journal: Bioorganic & medicinal chemistry 20061001

Title: Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20061001

Title: Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.

Journal: Journal of medicinal chemistry 20060907

Title: Triterpenic and other lipophilic components from industrial cork byproducts.

Journal: Journal of agricultural and food chemistry 20060906

Title: Pharmacological properties of the ubiquitous natural product betulin.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060901

Title: [Studies on triterpenoids from Potentilla chinensis].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060901

Title: Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae.

Journal: Bioorganic & medicinal chemistry 20060815

Title: A new assault on HIV.

Journal: Scientific American 20060601

Title: 3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro.

Journal: Journal of virology 20060601

Title: Loading of erythrocyte membrane with pentacyclic triterpenes inhibits Plasmodium falciparum invasion.

Journal: Planta medica 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Betulinic acid derivatives as anticancer agents: structure activity relationship.

Journal: Anti-cancer agents in medicinal chemistry 20060501

Title: Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry 20060401

Title: Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana.

Journal: Chemical & pharmaceutical bulletin 20060401

Title: Two new 18-en-oleane derivatives from marine mangrove plant, Barringtonia racemosa.

Journal: Die Pharmazie 20060401

Title: Signalling responses linked to betulinic acid-induced apoptosis are antagonized by MEK inhibitor U0126 in adherent or 3D spheroid melanoma irrespective of p53 status.

Journal: International journal of cancer 20060301

Title: Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.

Journal: Journal of natural products 20060301

Title: Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia.

Journal: Archives of pharmacal research 20060301

Title: Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships.

Journal: Journal of agricultural and food chemistry 20060208

Title: Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ.

Journal: Biological & pharmaceutical bulletin 20060201

Title: [Treatment of actinic keratoses with birch bark extract: a pilot study].

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20060201

Title: Inhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta.

Journal: Planta medica 20060201

Title: [Studies on chemical constituents of hairy root of Cassia obtusifolia].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

Title: Betulinic acid, a natural cytotoxic agent, fails to trigger apoptosis in human Burkitt's lymphoma-derived B-cell lines.

Journal: International journal of cancer 20060101

Title: Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

Journal: Medicinal research reviews 20060101

Title: [Antimitochondrial agents: a new class of anticancer agents].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20060101

Title: Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine.

Journal: BMC cell biology 20060101

Title: [Biological activity and pharmacological prospects of lupane terpenoids: I. Natural lupane derivatives].

Journal: Bioorganicheskaia khimiia 20060101

Title: Dereplication of pentacyclic triterpenoids in plants by GC-EI/MS.

Journal: Phytochemical analysis : PCA 20060101

Title: Chemical study of triterpenoid resinous materials in archaeological findings by means of direct exposure electron ionisation mass spectrometry and gas chromatography/mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Is translational research compatible with preclinical publication strategies?

Journal: Radiation oncology (London, England) 20060101

Title: Activation of apoptosis by derivatives of betulinic acid in human tumor cells in vitro.

Journal: Doklady. Biochemistry and biophysics 20060101

Title: A disease epidemic on Zizyphus mucronata in the Kruger National Park caused by Coniodictyum chevalieri.

Journal: Studies in mycology 20060101

Title: Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles.

Journal: The Journal of biological chemistry 20051223

Title: A new bisabolane sesquiterpenoid from Euphorbia chrysocoma.

Journal: Journal of Asian natural products research 20051201

Title: Lupane-triterpenes from Bupleurum flavum.

Journal: Natural product research 20051201

Title: [Studies on the chemical constituents in root of Coleus forskohlii].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051101

Title: Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy.

Journal: Oncogene 20051020

Title: Antibacterial triterpenes from Syzygium guineense (Myrtaceae).

Journal: Journal of ethnopharmacology 20051003

Title: Betulinic acid induces apoptosis in skin cancer cells and differentiation in normal human keratinocytes.

Journal: Experimental dermatology 20051001

Title: Phospholipid nanosomes.

Journal: Current drug delivery 20051001

Title: [Chemical constituents from the mangrove plant Ceriops tagal].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20051001

Title: Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats.

Journal: Journal of ethnopharmacology 20050914

Title: Characterization of the ATPase activity of topoisomerase II from Leishmania donovani and identification of residues conferring resistance to etoposide.

Journal: The Biochemical journal 20050901

Title: Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.

Journal: International journal of oncology 20050901

Title: Combination of betulinic acid with cisplatin--different cytotoxic effects in two head and neck cancer cell lines.

Journal: Oncology reports 20050901

Title: [Mitochondrial damage in human sperm caused by the antineoplastic agent betulinic acid].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20050801

Title: Resistance of human astrocytoma cells to apoptosis induced by mitochondria-damaging agents: possible implications for anticancer therapy.

Journal: The Journal of pharmacology and experimental therapeutics 20050801

Title: Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.

Journal: Journal of natural products 20050801

Title: Antibacterial constituents from fruit bodies of ascomyce Bulgaria inquinans.

Journal: Archives of pharmacal research 20050801

Title: [Chemical investingation of Chinese mangrove Sonneratia apetala II].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050801

Title: Lupane triterpenoids from Maytenus species.

Journal: Journal of natural products 20050701

Title: The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV.

Journal: Expert opinion on investigational drugs 20050601

Title: Chemical constituents and antioxidant activity of Mallotus roxburghianus leaves.

Journal: Chemistry & biodiversity 20050601

Title: Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity.

Journal: Bioorganic & medicinal chemistry 20050516

Title: Prenylated anthronoid antioxidants from the stem bark of Harungana madagascariensis.

Journal: Phytochemistry 20050501

Title: Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica.

Journal: Chemistry & biodiversity 20050501

Title: Caspase activation in human spermatozoa in response to physiological and pathological stimuli.

Journal: Fertility and sterility 20050401

Title: Betulinic acid induces apoptosis in human chronic myelogenous leukemia (CML) cell line K-562 without altering the levels of Bcr-Abl.

Journal: Toxicology letters 20050315

Title: Effect of water and temperature stress on the content of active constituents of Hypericum brasiliense Choisy.

Journal: Plant physiology and biochemistry : PPB 20050301

Title: Three new triterpenes from Nerium oleander and biological activity of the isolated compounds.

Journal: Journal of natural products 20050201

Title: Sensitization for anticancer drug-induced apoptosis by betulinic Acid.

Journal: Neoplasia (New York, N.Y.) 20050201

Title: The chemical constituents of Rhododendron ovatum Planch.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050201

Title: Four new prenylated isoflavonoids in Tadehagi triquetrum.

Journal: Journal of agricultural and food chemistry 20050126

Title: Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L.

Journal: The Journal of pharmacy and pharmacology 20050101

Title: Betulinic acid derivatives as HIV-1 antivirals.

Journal: Trends in molecular medicine 20050101

Title: Betulinic acid and its derivatives: a review on their biological properties.

Journal: Current medicinal chemistry 20050101

Title: Bioactive triterpenoids from Vochysia pacifica interact with cyclic nucleotide phosphodiesterase isozyme PDE4.

Journal: Phytotherapy research : PTR 20050101

Title: Quantitative analysis of 23-hydroxybetulinic acid in mouse plasma using electrospray liquid chromatography/mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: [Synthesis and antitumor activity of cyclopropane derivatives of betulinic and betulonic acids].

Journal: Bioorganicheskaia khimiia 20050101

Title: Protective effects of betulin and betulinic acid against ethanol-induced cytotoxicity in HepG2 cells.

Journal: Pharmacological reports : PR 20050101

Title: Quantitative structure-cytotoxicity relationship analysis of betulinic acid and its derivatives by semi-empirical molecular-orbital method.

Journal: Anticancer research 20050101

Title: Purification of betulinic acid from Eugenia florida (Myrtaceae) by high-speed counter-current chromatography.

Journal: Phytochemical analysis : PCA 20050101

Title: Chemosensitization and radiosensitization of tumors by plant polyphenols.

Journal: Antioxidants & redox signaling 20050101

Title: 3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents.

Journal: Bioorganic & medicinal chemistry letters 20041206

Title: A new flavone from Hypericum wightianum.

Journal: Journal of Asian natural products research 20041201

Title: Protection of Ewing's sarcoma family tumor (ESFT) cell line SK-N-MC from betulinic acid induced apoptosis by alpha-DL-tocopherol.

Journal: Toxicology letters 20041102

Title: Anti-complementary activity of triterpenoides from fruits of Zizyphus jujuba.

Journal: Biological & pharmaceutical bulletin 20041101

Title: Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents.

Journal: Cancer research 20041015

Title: Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells.

Journal: Oncogene 20041007

Title: From chemoprevention to chemotherapy: common targets and common goals.

Journal: Expert opinion on investigational drugs 20041001

Title: Cytotoxic saponins from Schefflera rotundifolia.

Journal: Planta medica 20041001

Title: Immobilized betulinic acid column and its interactions with phospholipase A2 and snake venom proteins.

Journal: Journal of separation science 20041001

Title: Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line.

Journal: European journal of pharmacology 20040913

Title: Constituents of Senecio chionophilus with potential antitubercular activity.

Journal: Journal of natural products 20040901

Title: Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors.

Journal: Phytotherapy research : PTR 20040901

Title: Synthesis and cytotoxic activity of 3-O-acyl/3-hydrazine /2-bromo/20,29-dibromo betulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry letters 20040802

Title: Betulinic acid-induced apoptosis in leukemia cells.

Journal: Leukemia 20040801

Title: [Inhibitory effects of some traditional medicines on proliferation of HIV-1 and its protease].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801

Title: Rapid analysis of triterpenic acids by liquid chromatography using porous graphitic carbon and evaporative light scattering detection.

Journal: Journal of separation science 20040801

Title: Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells.

Journal: Acta neurochirurgica 20040701

Title: Betulinic acid enhances 1alpha,25-dihydroxyvitamin D3-induced differentiation in human HL-60 promyelocytic leukemia cells.

Journal: Anti-cancer drugs 20040701

Title: Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra.

Journal: Biological & pharmaceutical bulletin 20040701

Title: Synthesis of A-seco derivatives of betulinic acid with cytotoxic activity.

Journal: Journal of natural products 20040701

Title: Synthesis of 3-O-acyl/3-benzylidene/3-hydrazone/3-hydrazine/17-carboxyacryloyl ester derivatives of betulinic acid as anti-angiogenic agents.

Journal: Bioorganic & medicinal chemistry letters 20040621

Title: Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil.

Journal: Journal of agricultural and food chemistry 20040602

Title: Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.

Journal: Journal of natural products 20040601

Title: New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.

Journal: Journal of natural products 20040601

Title: Antitubercular constituents of Valeriana laxiflora.

Journal: Planta medica 20040601

Title: Betulinic acid and its derivatives as anti-angiogenic agents.

Journal: Bioorganic & medicinal chemistry letters 20040503

Title: Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice.

Journal: British journal of cancer 20040419

Title: Marmenol: a 7-geranyloxycoumarin from the leaves of Aegle marmelos Corr.

Journal: Natural product research 20040401

Title: Betulinic acid: a promising anticancer candidate.

Journal: IDrugs : the investigational drugs journal 20040401

Title: Cytotoxic lupane-type triterpenoids from Acacia mellifera.

Journal: Phytochemistry 20040401

Title: Lipoxygenase inhibition by anadanthoflavone, a new flavonoid from the aerial parts of Anadenanthera colubrina.

Journal: Planta medica 20040301

Title: Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.

Journal: Antimicrobial agents and chemotherapy 20040201

Title: Apoptosis-modulating agents in combination with radiotherapy-current status and outlook.

Journal: International journal of radiation oncology, biology, physics 20040201

Title: Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea.

Journal: Phytotherapy research : PTR 20040201

Title: Antiplasmodial constituents of Cajanus cajan.

Journal: Phytotherapy research : PTR 20040201

Title: Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase.

Journal: Archives of pharmacal research 20040201

Title: Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues.

Journal: Bioorganic & medicinal chemistry 20040102

Title: Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection.

Journal: Medicinal research reviews 20040101

Title: New prenylated isoflavanones and other constituents of Lespedeza bicolor.

Journal: Fitoterapia 20040101

Title: Role of the ectodomain of the gp41 transmembrane envelope protein of human immunodeficiency virus type 1 in late steps of the membrane fusion process.

Journal: Journal of virology 20040101

Title: Steroids and triterpenes from Eleocharis acutangula and E. sellowiana (Cyperaceae).

Journal: Phytochemical analysis : PCA 20040101

Title: The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid.

Journal: Retrovirology 20040101

Title: Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKBR3 cells with: cis -platin, Tamoxifen, Melphalan, Betulinic acid, L-PDMP, L-PPMP, and GD3 ganglioside.

Journal: Glycoconjugate journal 20040101

Title: Constituents of Quinchamalium majus with potential antitubercular activity.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

Title: New lupane derived compounds with pro-apoptotic activity in cancer cells: synthesis and structure-activity relationships.

Journal: Journal of medicinal chemistry 20031204

Title: Immunomodulatory activity of betulinic acid by producing pro-inflammatory cytokines and activation of macrophages.

Journal: Archives of pharmacal research 20031201

Title: News from the bench.

Journal: GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20031201

Title: [Studies on the constituents from the stems of Spatholobus suberectus].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031201

Title: Antitumor-promoting constituents from Chaenomeles sinensis KOEHNE and their activities in JB6 mouse epidermal cells.

Journal: Chemical & pharmaceutical bulletin 20031101

Title: A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta.

Journal: Journal of natural products 20031101

Title: Cytotoxic triterpenoids from the fruits of Zizyphus jujuba.

Journal: Planta medica 20031101

Title: Lupane triterpenes and derivatives with antiviral activity.

Journal: Bioorganic & medicinal chemistry letters 20031020

Title: Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry letters 20031006

Title: Antiplasmodial triterpenes from twigs of Gardenia saxatilis.

Journal: Journal of ethnopharmacology 20031001

Title: Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030915

Title: A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents.

Journal: Mini reviews in medicinal chemistry 20030901

Title: Betulinic acid: a new cytotoxic compound against malignant head and neck cancer cells.

Journal: Head & neck 20030901

Title: Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.

Journal: Journal of natural products 20030901

Title: Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses.

Journal: Fitoterapia 20030701

Title: Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030701

Title: A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells.

Journal: Molecular pharmacology 20030601

Title: Broncho-vasodilatory activity of fractions and pure constituents isolated from Bacopa monniera.

Journal: Journal of ethnopharmacology 20030501

Title: A new acylglycosyl sterol from Quisqualis Fructus.

Journal: Archives of pharmacal research 20030401

Title: New ursolic and betulinic derivatives as potential cytotoxic agents.

Journal: Journal of enzyme inhibition and medicinal chemistry 20030401

Title: New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata.

Journal: Journal of natural products 20030301

Title: Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L.

Journal: Phytotherapy research : PTR 20030201

Title: Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.

Journal: Journal of natural products 20030201

Title: Constituents of antibacterial extract of Caesalpinia paraguariensis Burk.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

Title: [Epimerization of hydroxyl group in the lupan series of triterpenes].

Journal: Bioorganicheskaia khimiia 20030101

Title: Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy.

Journal: Molecular medicine (Cambridge, Mass.) 20030101

Title: [Synthesis and antiviral activity of hydrazides and substituted benzalhydrazides of betulinic acid and its derivatives].

Journal: Bioorganicheskaia khimiia 20030101

Title: Differential effect of betulin and betulinic acid on cytokine production in human whole blood cell cultures.

Journal: Polish journal of pharmacology 20030101

Title: Quantitative analysis of betulinic acid in mouse, rat and dog plasma using electrospray liquid chromatography/mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: [Synthesis and antiviral activity of ureides and carbamates of betulinic acid and its derivatives].

Journal: Bioorganicheskaia khimiia 20030101

Title: Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay.

Journal: Planta medica 20021201

Title: Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis.

Journal: Journal of natural products 20021201

Title: Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.

Journal: Journal of natural products 20021201

Title: Structure and spasmolytic activity of eucalyptanoic acid from Eucalyptus camaldulensis var. obtusa and synthesis of its active derivative from oleanolic acid.

Journal: Journal of natural products 20021201

Title: Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance.

Journal: Molecular medicine (Cambridge, Mass.) 20021201

Title: 23-Hydroxybetulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 Cells.

Journal: Life sciences 20021122

Title: Effect of three triterpenoids, lupeol, betulin, and betulinic acid on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils.

Journal: Clinica chimica acta; international journal of clinical chemistry 20021101

Title: Ursolic acid as a trypanocidal constituent in rosemary.

Journal: Biological & pharmaceutical bulletin 20021101

Title: Pentacyclic triterpenoids from Ilex macropoda.

Journal: Archives of pharmacal research 20021001

Title: Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities.

Journal: Journal of agricultural and food chemistry 20020925

Title: Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.

Journal: Journal of medicinal chemistry 20020912

Title: Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I.

Journal: The Biochemical journal 20020901

Title: [Study on chemical constituents of rhizome of Anemone raddeana].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020901

Title: [Studies on chemical constituents in fruit of Eucalyptus globulus].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020801

Title: Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20020701

Title: Preparation of a 24-nor-1,4-dien-3-one triterpene derivative from betulin: a new route to 24-nortriterpene analogues.

Journal: The Journal of organic chemistry 20020503

Title: Synthesis of combinatorial libraries based on terpenoid scaffolds.

Journal: Combinatorial chemistry & high throughput screening 20020501

Title: Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line.

Journal: Journal of natural products 20020501

Title: Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells.

Journal: Japanese journal of cancer research : Gann 20020401

Title: [Studies on flavoniod constituents of Hedysarum multijugum].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020301

Title: Mitochondrial involvement in tracheary element programmed cell death.

Journal: Cell death and differentiation 20020201

Title: Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells.

Journal: Cancer letters 20020110

Title: Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.

Journal: Planta medica 20020101

Title: Betulinic acid sensitization of low pH adapted human melanoma cells to hyperthermia.

Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20020101

Title: Determination of the triterpenoid, betulinic acid, in Doliocarpus schottianus by HPLC.

Journal: Phytochemical analysis : PCA 20020101

Title: [Are mitochondria targets of anticancer drugs responsible for apoptosis?].

Journal: Annales de biologie clinique 20020101

Title: Review on phytochemical and medicinal aspects of jussiaea suferuticosa linn.

Journal: Ancient science of life 20020101

Title: New developments in anti-HIV chemotherapy.

Journal: Current medicinal chemistry 20011101

Title: Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A(2) inhibitors.

Journal: Phytochemistry 20011101

Title: Antimycobacterial plant terpenoids.

Journal: Planta medica 20011101

Title: Development of C-20 modified betulinic acid derivatives as antitumor agents.

Journal: Bioorganic & medicinal chemistry letters 20010903

Title: A small-molecule antagonist of virion assembly.

Journal: Expert opinion on investigational drugs 20010901

Title: The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis.

Journal: The Journal of investigative dermatology 20010801

Title: Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase.

Journal: Lipids 20010501

Title: Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturation.

Journal: Antimicrobial agents and chemotherapy 20010401

Title: Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent.

Journal: Melanoma research 20010401

Title: Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, Betulinic acid.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20010301

Title: p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.

Journal: Experimental cell research 20010115

Title: Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564.

Journal: Antimicrobial agents and chemotherapy 20010101

Title: [Studies on chemical constituents from Buddleja lindleyana Fert].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010101

Title: Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives.

Journal: Journal of natural products 20001201

Title: Synthesis and anti-HIV activity of 3-alkylamido-3-deoxy-betulinic acid derivatives.

Journal: Chemical & pharmaceutical bulletin 20000901

Title: Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha.

Journal: Molecular pharmacology 20000701

Title: Inhibitory effects of constituents from Cynomorium songaricum and related triterpene derivatives on HIV-1 protease.

Journal: Chemical & pharmaceutical bulletin 19990201

Title: Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.

Journal: Journal of medicinal chemistry 19981105

Title: Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives.

Journal: Bioorganic & medicinal chemistry letters 19980519

Title: Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.

Journal: Bioorganic & medicinal chemistry 19971201

Title: Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

Journal: Cancer research 19971101

Title: Triterpenes as potential dimerization inhibitors of HIV-1 protease.

Journal: Biochemical and biophysical research communications 19961014

Title: Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.

Journal: Journal of medicinal chemistry 19960301

Title: Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action.

Journal: Journal of medicinal chemistry 19960301

Title: Betulinic acid derivatives: a new class of specific inhibitors of human immunodeficiency virus type 1 entry.

Journal: Journal of medicinal chemistry 19960301

Title: Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19940426

Title: Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.

Journal: Journal of natural products 19940201

Title: Chowdhury AR, et al. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Med Sci Monit. 2002 Jul;8(7):BR254-65.

Title: Gao Y, et al. Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. 2018 Jan-Feb;42(1):49-54.

Title: Kalra J, et al. Betulinic acid alleviates dextran sulfate sodium-induced colitis and visceral pain in mice. Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec 26.

Title: Hashimoto F, et al. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. Bioorg Med Chem. 1997 Dec;5(12):2133-43.

Title: Kasperczyk H, et al. Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy. Oncogene. 2005 Oct 20;24(46):6945-56.

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Tags:472-15-1 Molecular Formula|472-15-1 MDL|472-15-1 SMILES|472-15-1 Betulinic acid