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4773-96-0,MFCD28139337
Catalog No.:AA00I8M4

4773-96-0 | Mangiferin

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250mg
98%
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$12.00   $8.00
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1g
98%
in stock  
$21.00   $15.00
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5g
98%
in stock  
$25.00   $18.00
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25g
98%
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$78.00   $55.00
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100g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00I8M4
Chemical Name:
Mangiferin
CAS Number:
4773-96-0
Molecular Formula:
C19H18O11
Molecular Weight:
422.3396
MDL Number:
MFCD28139337
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)c1c(O)cc2c(c1O)c(=O)c1c(o2)cc(c(c1)O)O
Properties
Computed Properties
 
Complexity:
646  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
2  
XLogP3:
-0.4  

Downstream Synthesis Route

[1]Chemicalandpharmaceuticalbulletin,1984,vol.32,p.2676-2686

[2]Chemicalandpharmaceuticalbulletin,1984,vol.32,p.2676-2686

[1]Chemicalandpharmaceuticalbulletin,1984,vol.32,p.2676-2686

6′-O-acetylmangiferin 
  4773-96-0 

[1]Phytochemistry,1980,vol.19,p.415

[1]ChemistryofNaturalCompounds,1980,vol.16,p.145-149    KhimiyaPrirodnykhSoedinenii,1980,p.190-195

[2]OrganicPreparationsandProceduresInternational,2018,vol.50,p.91-94

[3]Patent:KR2019/55918,2019,A.Locationinpatent:Paragraph0032-0087

Literature

Title: Isolated mangiferin and naringenin exert antidiabetic effect via PPAR(γ)/GLUT4 dual agonistic action with strong metabolic regulation.

Journal: Chemico-biological interactions 20180125

Title: Harmonization of Mangiferin on methylmercury engendered mitochondrial dysfunction.

Journal: Environmental toxicology 20170201

Title: Anti-inflammatory effects of 6'-O-acetyl mangiferin from Iris rossii Baker via NF-κb signal blocking in lipopolysaccharide-stimulated RAW 264.7 cells.

Journal: Chemico-biological interactions 20160925

Title: Mangiferin attenuates DSS colitis in mice: Molecular docking and in vivo approach.

Journal: Chemico-biological interactions 20160625

Title: Mangiferin induces apoptosis in multiple myeloma cell lines by suppressing the activation of nuclear factor kappa B-inducing kinase.

Journal: Chemico-biological interactions 20160505

Title: Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A:diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: a link to amelioration of fatty liver.

Journal: Toxicology and applied pharmacology 20141015

Title: [Relationship between endothelial damage and p120-catenin in paraquat intoxication and the protective effect of mangiferin].

Journal: Zhonghua wei zhong bing ji jiu yi xue 20140601

Title: Mangiferin has an additive effect on the apoptotic properties of hesperidin in Cyclopia sp. tea extracts.

Journal: PloS one 20140101

Title: Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats.

Journal: European journal of pharmacology 20131205

Title: Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson's disease mice.

Journal: Chemico-biological interactions 20131125

Title: Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and β-catenin signaling pathway.

Journal: Toxicology and applied pharmacology 20131001

Title: Peripheral antinociceptive action of mangiferin in mouse models of experimental pain: role of endogenous opioids, K(ATP)-channels and adenosine.

Journal: Pharmacology, biochemistry, and behavior 20130901

Title: Mangifera indica L. extract and mangiferin modulate cytochrome P450 and UDP-glucuronosyltransferase enzymes in primary cultures of human hepatocytes.

Journal: Phytotherapy research : PTR 20130501

Title: Mangiferin and its traversal into the brain.

Journal: Advances in experimental medicine and biology 20130101

Title: Mangiferin, a natural xanthone, protects murine liver in Pb(II) induced hepatic damage and cell death via MAP kinase, NF-κB and mitochondria dependent pathways.

Journal: PloS one 20130101

Title: Protective nature of mangiferin on oxidative stress and antioxidant status in tissues of streptozotocin-induced diabetic rats.

Journal: ISRN pharmacology 20130101

Title: Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20121101

Title: Nanostructured lipid carriers as novel ophthalmic delivery system for mangiferin: improving in vivo ocular bioavailability.

Journal: Journal of pharmaceutical sciences 20121001

Title: A UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: application to a comparative pharmacokinetic study in normal and insomnic rats.

Journal: Journal of mass spectrometry : JMS 20121001

Title: Mangiferin decreases inflammation and oxidative damage in rat brain after stress.

Journal: European journal of nutrition 20120901

Title: Evaluation of genotoxicity and DNA protective effects of mangiferin, a glucosylxanthone isolated from Mangifera indica L. stem bark extract.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

Title: Reducing effect of mangiferin on serum uric acid levels in mice.

Journal: Pharmaceutical biology 20120901

Title: Inhibition of UVB-induced wrinkle formation and MMP-9 expression by mangiferin isolated from Anemarrhena asphodeloides.

Journal: European journal of pharmacology 20120815

Title: Mangiferin aglycone attenuates radiation-induced damage on human intestinal epithelial cells.

Journal: Journal of cellular biochemistry 20120801

Title: A survey of mangiferin and hydroxycinnamic acid ester accumulation in coffee (Coffea) leaves: biological implications and uses.

Journal: Annals of botany 20120801

Title: Mangiferin, a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism.

Journal: World journal of gastroenterology 20120707

Title: Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells: involvement of PI3K/Akt and MAPK signaling pathways.

Journal: Pharmacological research 20120701

Title: Neuropharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease.

Journal: European journal of pharmacology 20120515

Title: Chitosan-based luminescent/magnetic hybrid nanogels for insulin delivery, cell imaging, and antidiabetic research of dietary supplements.

Journal: International journal of pharmaceutics 20120510

Title: Perspectives on medicinal properties of mangiferin.

Journal: Mini reviews in medicinal chemistry 20120501

Title: Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFκB pathways.

Journal: Toxicology and applied pharmacology 20120401

Title: Development and application of an enzyme-linked immunosorbent assay for specific detection of mangiferin content in various cultivars of Mangifera indica leaves using anti-mangiferin polyclonal antibody.

Journal: Journal of food science 20120401

Title: Mangiferin glucuronidation: important hepatic modulation of antioxidant activity.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

Title: Mangiferin, a dietary xanthone protects against mercury-induced toxicity in HepG2 cells.

Journal: Environmental toxicology 20120201

Title: D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-κB and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a polyphenol xanthone, mangiferin.

Journal: Free radical research 20120201

Title: Anti-diabetic effects of TongGuanWan, a Chinese traditional herbal formula, in C57BL/KsJ-db/db mice.

Journal: Planta medica 20120101

Title: Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases.

Journal: Cancer research 20120101

Title: Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK.

Journal: PloS one 20120101

Title: Cardioprotective effect of mangiferin on left ventricular remodeling in rats.

Journal: Pharmacology 20120101

Title: Combination of mangiferin and dipeptidyl peptidase-4 inhibitor sitagliptin improves impaired glucose tolerance in streptozotocin-diabetic rats.

Journal: Pharmacology 20120101

Title: Antioxidation and the hypoxic ventilatory response.

Journal: Advances in experimental medicine and biology 20120101

Title: Mangiferin ameliorates 6-hydroxydopamine-induced cytotoxicity and oxidative stress in ketamine model of schizophrenia.

Journal: Pharmacological reports : PR 20120101

Title: Quantification and purification of mangiferin from Chinese Mango (Mangifera indica L.) cultivars and its protective effect on human umbilical vein endothelial cells under H(2)O(2)-induced stress.

Journal: International journal of molecular sciences 20120101

Title: Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters.

Journal: Molecular nutrition & food research 20111201

Title: Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic.

Journal: Asian Pacific journal of tropical medicine 20111101

Title: Mangifera indica L. extract (Vimang) and mangiferin reduce the airway inflammation and Th2 cytokines in murine model of allergic asthma.

Journal: The Journal of pharmacy and pharmacology 20111001

Title: Phenolic compounds from the whole plants of Gentiana rhodantha (Gentianaceae).

Journal: Chemistry & biodiversity 20111001

Title: Mangiferin attenuates methylmercury induced cytotoxicity against IMR-32, human neuroblastoma cells by the inhibition of oxidative stress and free radical scavenging potential.

Journal: Chemico-biological interactions 20110905

Title: Polysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents.

Journal: Journal of medicinal chemistry 20110811

Title: Structure elucidation of in vivo and in vitro metabolites of mangiferin.

Journal: Journal of pharmaceutical and biomedical analysis 20110715

Title: [Effects of mangiferin on MAPK signaling pathway in chronic inflammation].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110701

Title: Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes.

Journal: Journal of ethnopharmacology 20110614

Title: A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides.

Journal: Journal of enzyme inhibition and medicinal chemistry 20110601

Title: Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells.

Journal: Cancer letters 20110601

Title: Mangiferin, an anti-HIV-1 agent targeting protease and effective against resistant strains.

Journal: Molecules (Basel, Switzerland) 20110524

Title: Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice.

Journal: Journal of photochemistry and photobiology. B, Biology 20110503

Title: [Effects of mangiferin on cytokines in rats with chronic bronchitis and expression of macrophage COX-2 in mice].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110501

Title: Mangiferin: a possible strategy for periodontal disease to therapy.

Journal: Medical hypotheses 20110401

Title: Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells.

Journal: Archives of pharmacal research 20110301

Title: [Determination of mangiferin in rat plasma and aqueous humor by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301

Title: Investigation on a host-guest inclusion system by β-cyclodextrin derivative and its analytical application.

Journal: Bioorganic & medicinal chemistry letters 20110215

Title: [Metabolism of mangiferin by human intestinal bacteria in vitro].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110201

Title: The Ayurvedic Medicine Salacia oblonga Attenuates Diabetic Renal Fibrosis in Rats: Suppression of Angiotensin II/AT1 Signaling.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Mangiferin attenuates osteoclastogenesis, bone resorption, and RANKL-induced activation of NF-κB and ERK.

Journal: Journal of cellular biochemistry 20110101

Title: Mangiferin: A xanthone attenuates mercury chloride induced cytotoxicity and genotoxicity in HepG2 cells.

Journal: Journal of biochemical and molecular toxicology 20110101

Title: Introgression of Swertia mussotii gene into Bupleurum scorzonerifolium via somatic hybridization.

Journal: BMC plant biology 20110101

Title: Modulating effects of rooibos and honeybush herbal teas on the development of esophageal papillomas in rats.

Journal: Nutrition and cancer 20110101

Title: Effect of mangiferin, a naturally occurring glucoxylxanthone, on fear memory in rats.

Journal: Arzneimittel-Forschung 20110101

Title: Inhibition of matrix metalloproteinase-1 induced by oxidative stress in human keratinocytes by mangiferin isolated from Anemarrhena asphodeloides.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: Combination treatment with oxaliplatin and mangiferin causes increased apoptosis and downregulation of NFκB in cancer cell lines.

Journal: African journal of traditional, complementary, and alternative medicines : AJTCAM 20110101

Title: Application of a liquid chromatography/tandem mass spectrometry method to pharmacokinetic study of mangiferin in rats.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101215

Title: A Mangifera indica L. extract could be used to treat neuropathic pain and implication of mangiferin.

Journal: Molecules (Basel, Switzerland) 20101209

Title: [Effect of three penetration enhancers on corneal permeability of mangiferin in vitro].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101201

Title: Radioprotective activity of Gentiana lutea extract and mangiferin.

Journal: Phytotherapy research : PTR 20101101

Title: [Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20101001

Title: Establishment of a novel model for studying the effects of extracts of Chinese herb medicine on human type II 5alpha-reductase in vitro.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100901

Title: Synthesis of mangiferin, isomangiferin, and homomangiferin.

Journal: The Journal of organic chemistry 20100820

Title: In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica.

Journal: Chemico-biological interactions 20100805

Title: Determination of mangiferin in rat eyes and pharmacokinetic study in plasma after oral administration of mangiferin-hydroxypropyl-beta-cyclodextrin inclusion.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20100801

Title: [Determination of chlorogenic acid and mangiferin in Folium Pyrrosiae from different habitats and species by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801

Title: Simultaneous determination of active xanthone glycosides, timosaponins and alkaloids in rat plasma after oral administration of Zi-Shen Pill extract for the pharmacokinetic study by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100701

Title: Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats.

Journal: European journal of pharmacology 20100610

Title: Mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats.

Journal: Phytotherapy research : PTR 20100601

Title: Antigenotoxic effect of mangiferin and changes in antioxidant enzyme levels of Swiss albino mice treated with cadmium chloride.

Journal: Human & experimental toxicology 20100501

Title: Study on interaction of mangiferin to insulin and glucagon in ternary system.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100501

Title: The phenolic acids from bacterial degradation of the mangiferin aglycone are quantified in the feces of pigs after oral ingestion of an extract of Cyclopia genistoides (honeybush tea).

Journal: Nutrition research (New York, N.Y.) 20100501

Title: Mango extracts and the mango component mangiferin promote endothelial cell migration.

Journal: Journal of agricultural and food chemistry 20100428

Title: ICH guidance in practice: validated reversed-phase HPLC method for the determination of active mangiferin from extracts of Mangifera indica Linn.

Journal: Journal of chromatographic science 20100201

Title: Determination of mangiferin in rat plasma by liquid-liquid extraction with UPLC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20100105

Title: Preparative isolation of neomangiferin and mangiferin from Rhizoma anemarrhenae by high-speed countercurrent chromatography using ionic liquids as a two-phase solvent system modifier.

Journal: Journal of separation science 20100101

Title: Biological factors influencing production of xanthones in Aphloia theiformis.

Journal: Chemistry & biodiversity 20100101

Title: The effect of ultrasound on lipase-catalyzed regioselective acylation of mangiferin in non-aqueous solvents.

Journal: Journal of Asian natural products research 20100101

Title: [Effects of mangiferin on cell cycle status and CDC2/Cyclin B1 expression of HL-60 cells].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100101

Title: Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice.

Journal: Bioscience, biotechnology, and biochemistry 20100101

Title: Pharmacokinetic study of mangiferin in rat plasma and retina using high-performance liquid chromatography.

Journal: Molecular vision 20100101

Title: Influences of harvest date and location on the levels of beta-carotene, ascorbic acid, total phenols, the in vitro antioxidant capacity, and phenolic profiles of five commercial varieties of mango (Mangifera indica L.).

Journal: Journal of agricultural and food chemistry 20091125

Title: Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: role of mangiferin.

Journal: Clinical nutrition (Edinburgh, Scotland) 20091001

Title: Mangiferin inhibits passive cutaneous anaphylaxis reaction and pruritus in mice.

Journal: Planta medica 20091001

Title: [A new trincallane derivative from Salacia hainanensis Chun et How].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20091001

Title: Spectroscopic investigation of interaction between mangiferin and bovine serum albumin.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090901

Title: Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition.

Journal: Bioorganic & medicinal chemistry letters 20090901

Title: Assessment of systemic interaction between Swertia chirata extract and its Bioactive constituents in rabbits.

Journal: Phytotherapy research : PTR 20090701

Title: Miscibility characterization in relation to phase morphology of poly(ether sulfone)/poly(vinyl pyrrolidone) blends containing a phytochemical.

Journal: The journal of physical chemistry. B 20090625

Title: Mechanism of protective action of mangiferin on suppression of inflammatory response and lysosomal instability in rat model of myocardial infarction.

Journal: Phytotherapy research : PTR 20090601

Title: Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling.

Journal: Chemico-biological interactions 20090515

Title: Isolation of isomangiferin from honeybush (Cyclopia subternata) using high-speed counter-current chromatography and high-performance liquid chromatography.

Journal: Journal of chromatography. A 20090508

Title: Characterization of the mangiferin-human serum albumin complex by spectroscopic and molecular modeling approaches.

Journal: Journal of pharmaceutical and biomedical analysis 20090405

Title: Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols.

Journal: Cell calcium 20090401

Title: Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata.

Journal: Bioorganic & medicinal chemistry 20090401

Title: Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors.

Journal: Bioorganic & medicinal chemistry 20090315

Title: Polyphenols with antiulcerogenic action from aqueous decoction of mango leaves (Mangifera indica L.).

Journal: Molecules (Basel, Switzerland) 20090310

Title: Cytoprotective and antigenotoxic potential of Mangiferin, a glucosylxanthone against cadmium chloride induced toxicity in HepG2 cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090301

Title: Rapid identification of polyphenol C-glycosides from Swertia franchetiana by HPLC-ESI-MS-MS.

Journal: Journal of chromatographic science 20090301

Title: Mangiferin ameliorates scopolamine-induced learning deficits in mice.

Journal: Biological & pharmaceutical bulletin 20090201

Title: Mechanisms of blood glucose-lowering effect of aqueous extract from stems of Kothala himbutu (Salacia reticulata) in the mouse.

Journal: Journal of ethnopharmacology 20090121

Title: The variation in cytoplasmic distribution of mouse peritoneal macrophage during phagocytosis modulated by mangiferin, an immunomodulator.

Journal: Immunobiology 20090101

Title: In vitro cultures of Cyclopia plants (honeybush) as a source of bioactive xanthones and flavanones.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

Title: Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract.

Journal: Nutrition research (New York, N.Y.) 20081201

Title: Antioxidant C-glucosylxanthones from the leaves of Arrabidaea patellifera.

Journal: Journal of natural products 20081101

Title: Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells.

Journal: Archives of biochemistry and biophysics 20080915

Title: Cytoprotective effect of mangiferin on benzo(a)pyrene-induced lung carcinogenesis in swiss albino mice.

Journal: Basic & clinical pharmacology & toxicology 20080801

Title: Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.).

Journal: Journal of agricultural and food chemistry 20080723

Title: Salacia oblonga root decreases cardiac hypertrophy in Zucker diabetic fatty rats: inhibition of cardiac expression of angiotensin II type 1 receptor.

Journal: Diabetes, obesity & metabolism 20080701

Title: Protective role of mangiferin against Benzo(a)pyrene induced lung carcinogenesis in experimental animals.

Journal: Biological & pharmaceutical bulletin 20080601

Title: Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice.

Journal: Natural product research 20080520

Title: Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms.

Journal: Journal of agricultural and food chemistry 20080514

Title: Mangifera indica L. extract (Vimang) and its main polyphenol mangiferin prevent mitochondrial oxidative stress in atherosclerosis-prone hypercholesterolemic mouse.

Journal: Pharmacological research 20080501

Title: Studies on the constituents from the fruits of Phaleria macrocarpa.

Journal: Journal of natural medicines 20080401

Title: Modulation of P450 enzymes by Cuban natural products rich in polyphenolic compounds in rat hepatocytes.

Journal: Chemico-biological interactions 20080310

Title: Effect of species variation and processing on phenolic composition and in vitro antioxidant activity of aqueous extracts of Cyclopia spp. (Honeybush Tea).

Journal: Journal of agricultural and food chemistry 20080213

Title: High-performance liquid chromatography as a tool for the chemical standardisation of Triphala--an Ayurvedic formulation.

Journal: Phytochemical analysis : PCA 20080101

Title: Evaluation of spectrophotometric methods for screening of green rooibos (Aspalathus linearis) and green honeybush (Cyclopia genistoides) extracts for high levels of Bio-active compounds.

Journal: Phytochemical analysis : PCA 20080101

Title: Protective effects of Mangifera indica L extract (Vimang), and its major component mangiferin, on iron-induced oxidative damage to rat serum and liver.

Journal: Pharmacological research 20080101

Title: Identification and determination of four metabolites of mangiferin in rat urine.

Journal: Journal of pharmaceutical and biomedical analysis 20071221

Title: Novel screening assay for antioxidant protection against peroxyl radical-induced loss of protein function.

Journal: Journal of pharmaceutical sciences 20071101

Title: Simultaneous estimation of mangiferin and four secoiridoid glycosides in rat plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study of herbal preparation.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015

Title: Gastroprotective effect of mangiferin, a xanthonoid from Mangifera indica, against gastric injury induced by ethanol and indomethacin in rodents.

Journal: Planta medica 20071001

Title: Mangiferin identified in a screening study guided by neuraminidase inhibitory activity.

Journal: Planta medica 20070901

Title: [Determination of three glycosides from herbs of Swertia punicea by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

Title: Mangiferin protects against 1-methyl-4-phenylpyridinium toxicity mediated by oxidative stress in N2A cells.

Journal: Neuroscience letters 20070517

Title: On-line purity monitoring in high-speed counter-current chromatography: application of HSCCC-HPLC-DAD for the preparation of 5-HMF, neomangiferin and mangiferin from Anemarrhena asphodeloides Bunge.

Journal: Journal of pharmaceutical and biomedical analysis 20070509

Title: [The effect of mangiferin on telomerase activity and apoptosis in leukemic K562 cells].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070301

Title: [Investigation on the technology of processing Anemarrhena asphodeloides Bge. without hair by water].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070301

Title: Fe(III) shifts the mitochondria permeability transition-eliciting capacity of mangiferin to protection of organelle.

Journal: The Journal of pharmacology and experimental therapeutics 20070201

Title: Efficacy of mangiferin on serum and heart tissue lipids in rats subjected to isoproterenol induced cardiotoxicity.

Journal: Toxicology 20061207

Title: High-performance liquid chromatographic method for the determination of mangiferin in rat plasma and urine.

Journal: Biomedical chromatography : BMC 20061201

Title: [Simultaneous determination of six main constituents in Swertia of Qinghai Province and Sichuan Province by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

Title: Fe(III) improves antioxidant and cytoprotecting activities of mangiferin.

Journal: European journal of pharmacology 20061010

Title: Temperature and solvent dependent NMR studies on mangiferin and complete NMR spectral assignments of its acyl and methyl derivatives.

Journal: Magnetic resonance in chemistry : MRC 20060901

Title: Effects of a natural extract from Mangifera indica L, and its active compound, mangiferin, on energy state and lipid peroxidation of red blood cells.

Journal: Biochimica et biophysica acta 20060901

Title: Role of mangiferin on biochemical alterations and antioxidant status in isoproterenol-induced myocardial infarction in rats.

Journal: Journal of ethnopharmacology 20060811

Title: Neuroprotection by two polyphenols following excitotoxicity and experimental ischemia.

Journal: Neurobiology of disease 20060801

Title: Use of NIRS for quantification of mangiferin and hesperidin contents of dried green honeybush (Cyclopia genistoides) plant material.

Journal: Journal of agricultural and food chemistry 20060726

Title: UV/vis, 1H, and 13C NMR spectroscopic studies to determine mangiferin pKa values.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060701

Title: Efficacy of mangiferin against Cryptosporidium parvum in a neonatal mouse model.

Journal: Parasitology research 20060701

Title: Effect of mangiferin on mitochondrial energy production in experimentally induced myocardial infarcted rats.

Journal: Vascular pharmacology 20060601

Title: Protective effects of a standard extract of Mangifera indica L. (VIMANG) against mouse ear edemas and its inhibition of eicosanoid production in J774 murine macrophages.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20060601

Title: Dual mechanism of mangiferin protection against iron-induced damage to 2-deoxyribose and ascorbate oxidation.

Journal: Pharmacological research 20060301

Title: Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin.

Journal: The Journal of pharmacy and pharmacology 20060301

Title: Cardioprotective effect of mangiferin on isoproterenol induced myocardial infarction in rats.

Journal: Indian journal of experimental biology 20060301

Title: Using LC/MS/MS to determine matrine, oxymatrine, ferulic acid, mangiferin, and glycyrrhizin in the Chinese medicinal preparations Shiau-feng-saan and Dang-guei-nian-tong-tang.

Journal: Journal of pharmaceutical and biomedical analysis 20060213

Title: Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: activation of PPAR-alpha.

Journal: Toxicology and applied pharmacology 20060201

Title: Vimang (Mangifera indica L. extract) induces permeability transition in isolated mitochondria, closely reproducing the effect of mangiferin, Vimang's main component.

Journal: Chemico-biological interactions 20060201

Title: Differential oxidative stress in oligodendrocytes and neurons after excitotoxic insults and protection by natural polyphenols.

Journal: Glia 20060115

Title: Chemical constituents from Mahkota dewa.

Journal: Journal of Asian natural products research 20060101

Title: Immunotherapeutic effects of mangiferin mediated by the inhibition of oxidative stress to activated lymphocytes, neutrophils and macrophages.

Journal: Toxicology 20051105

Title: Capillary electrophoresis analysis of mangiferin extracted from Mangifera indica L. bark and Mangifera persiciformis C.Y. Wu et T.L. Ming leaves.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051105

Title: Two proteins, Mn2+, and low molecular cofactor are required for C-glucosyl-cleavage of mangiferin.

Journal: Biological & pharmaceutical bulletin 20051101

Title: Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C-glucosyl bond.

Journal: Biological & pharmaceutical bulletin 20050901

Title: Mangiferin, a natural occurring glucosyl xanthone, increases susceptibility of rat liver mitochondria to calcium-induced permeability transition.

Journal: Archives of biochemistry and biophysics 20050715

Title: Effect of mangiferin on radiation-induced micronucleus formation in cultured human peripheral blood lymphocytes.

Journal: Environmental and molecular mutagenesis 20050701

Title: Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate.

Journal: European journal of pharmacology 20050418

Title: Variation of active constituents of an important Tibet folk medicine Swertia mussotii Franch. (Gentianaceae) between artificially cultivated and naturally distributed.

Journal: Journal of ethnopharmacology 20050408

Title: Analgesic and antioxidant activity of mangiferin and its derivatives: the structure activity relationship.

Journal: Biological & pharmaceutical bulletin 20050401

Title: Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats.

Journal: Journal of ethnopharmacology 20050321

Title: Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20050301

Title: Pharmacokinetics of mangiferin in rat plasma after oral administration of a single dose of suanzaoren decoction.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050201

Title: [Studies on chemical constituents of the roots of Salacia hainanensis].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050101

Title: [CML cell line K562 cell apoptosis induced by mangiferin].

Journal: Zhongguo shi yan xue ye xue za zhi 20041001

Title: Insulin secretion is stimulated by ethanol extract of Anemarrhena asphodeloides in isolated islet of healthy Wistar and diabetic Goto-Kakizaki Rats.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20041001

Title: Vascular effects of the Mangifera indica L. extract (Vimang).

Journal: European journal of pharmacology 20040924

Title: Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese Zucker rats.

Journal: Life sciences 20040820

Title: beta-D-Glucoside suppresses tumor necrosis factor-induced activation of nuclear transcription factor kappaB but potentiates apoptosis.

Journal: The Journal of biological chemistry 20040806

Title: In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG).

Journal: Pharmacological research 20040801

Title: Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (VIMANG). Role of mangiferin isolated from the extract.

Journal: Pharmacological research 20040801

Title: An Anacardiaceae preparation reduces the expression of inflammation-related genes in murine macrophages.

Journal: International immunopharmacology 20040801

Title: Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines.

Journal: Free radical biology & medicine 20040615

Title: Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin.

Journal: International immunopharmacology 20040601

Title: In vitro effects of the polyphenols resveratrol, mangiferin and (-)-epigallocatechin-3-gallate on the scuticociliate fish pathogen Philasterides dicentrarchi.

Journal: Diseases of aquatic organisms 20040505

Title: Determination of mangiferin, jateorrhizine, palmatine, berberine, cinnamic acid, and cinnamaldehyde in the traditional Chinese medicinal preparation Zi-Shen pill by high-performance liquid chromatography.

Journal: Journal of chromatographic science 20040401

Title: High-performance liquid chromatographic method for the determination and pharmacokinetic study of mangiferin in plasma of rats having taken the traditional Chinese medicinal preparation Zi-Shen pill.

Journal: Journal of chromatographic science 20040201

Title: Antiviral effect of chinonin against herpes simplex virus.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101

Title: Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses.

Journal: Phytotherapy research : PTR 20031201

Title: Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin.

Journal: Phytotherapy research : PTR 20031201

Title: Isolation of mangiferin from Bombax malabaricum and structure revision of shamimin.

Journal: Planta medica 20031101

Title: New antioxidant C-glucosylxanthones from the stems of Arrabidaea samydoides.

Journal: Journal of natural products 20031001

Title: Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis.

Journal: Journal of natural products 20030901

Title: [RP-HPLC determination of mangiferin in the leafs of Folium mangiferae sampled in different months and regions].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030901

Title: Identification of flavonol and xanthone glycosides from mango (Mangifera indica L. Cv. 'Tommy Atkins') peels by high-performance liquid chromatography-electrospray ionization mass spectrometry.

Journal: Journal of agricultural and food chemistry 20030813

Title: In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-alpha and transforming growth factor-beta genes.

Journal: Biochemical pharmacology 20030415

Title: Pharmacokinetic study of free mangiferin in rats by microdialysis coupled with microbore high-performance liquid chromatography and tandem mass spectrometry.

Journal: Journal of chromatography. A 20030214

Title: Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats.

Journal: Toxicology 20020715

Title: Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin.

Journal: International immunopharmacology 20020501

Title: Isolation and quantitative analysis of phenolic antioxidants, free sugars, and polyols from mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as a nutritional supplement.

Journal: Journal of agricultural and food chemistry 20020213

Title: Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice.

Journal: Journal of ethnopharmacology 20011201

Title: Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside.

Journal: Biological & pharmaceutical bulletin 20010901

Title: The suppressive effect of mangiferin with exercise on blood lipids in type 2 diabetes.

Journal: Biological & pharmaceutical bulletin 20010901

Title: [Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010501

Title: Antidiabetic activity of a xanthone compound, mangiferin.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20010301

Title: The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats.

Journal: Cancer letters 20010226

Title: Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation.

Journal: Biochimica et biophysica acta 20000221

Title: Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20000101

Title: The effect of Kampo formulae on bone resorption in vitro and in vivo. I. Active constituents of Tsu-kan-gan.

Journal: Biological & pharmaceutical bulletin 19981201

Title: New antidiabetic compounds, mangiferin and its glucoside.

Journal: Biological & pharmaceutical bulletin 19981201

Title: Scavenging effect of Chinonin on NO and oxygen free radicals and its protective effect on the myocardium from the injury of ischemia-reperfusion.

Journal: Biochimica et biophysica acta 19960301

Title: Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone.

Journal: Chemotherapy 19960101

Title: [Pharmacological study of the anti-inflammatory agent glyderinine].

Journal: Farmakologiia i toksikologiia 19880101

Title: Zhang BP, et al. Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro. Acta Pharmacol Sin. 2014 Feb;35(2):257-66.

Title: Dilshara MG, et al. Mangiferin inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 expression and cellular invasion by suppressing nuclear factor-κB activity. BMB Rep. 2015 Oct;48(10):559-64.

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Tags:4773-96-0 Molecular Formula|4773-96-0 MDL|4773-96-0 SMILES|4773-96-0 Mangiferin