Home Indole and Oxindoles 480-91-1
480-91-1,MFCD03085939
Catalog No.:AA0034Z2

480-91-1 | 2,3-Dihydroisoindol-1-one

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250mg
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1g
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5g
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$21.00   $15.00
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10g
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25g
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100g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0034Z2
Chemical Name:
2,3-Dihydroisoindol-1-one
CAS Number:
480-91-1
Molecular Formula:
C8H7NO
Molecular Weight:
133.1473
MDL Number:
MFCD03085939
SMILES:
O=C1NCc2c1cccc2
NSC Number:
3689
Properties
Properties
 
BP:
380.6°C at 760 mmHg  
Form:
Solid  
MP:
149.0 to 153.0 °C  
Refractive Index:
1.5282 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
155  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.8  

Literature

Title: 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models.

Journal: Journal of medicinal chemistry 20120809

Title: Rhodium-catalyzed synthesis of branched amines by direct addition of benzamides to imines.

Journal: Organic letters 20120504

Title: (E)-Methyl 3-(3,4-dimeth-oxy-phen-yl)-2-[(1,3-dioxoisoindolin-2-yl)meth-yl]acrylate.

Journal: Acta crystallographica. Section E, Structure reports online 20120401

Title: Rh(I)-catalyzed asymmetric synthesis of 3-substituted isoindolinones through CO gas-free aminocarbonylation.

Journal: The Journal of organic chemistry 20120316

Title: Pharmacokinetics, metabolism and excretion of [(14)C]-lenalidomide following oral administration in healthy male subjects.

Journal: Cancer chemotherapy and pharmacology 20120301

Title: Synthesis of extended, π-conjugated isoindolin-1-ones.

Journal: The Journal of organic chemistry 20120203

Title: Daldinan A, a novel isoindolinone antioxidant from the ascomycete Daldinia concentrica.

Journal: The Journal of antibiotics 20120201

Title: Clitocybin A, a novel isoindolinone, from the mushroom Clitocybe aurantiaca, inhibits cell proliferation through G1 phase arrest by regulating the PI3K/Akt cascade in vascular smooth muscle cells.

Journal: Journal of pharmacological sciences 20120101

Title: Synthesis of a library of tricyclic azepinoisoindolinones.

Journal: Beilstein journal of organic chemistry 20120101

Title: New heteroannulation reactions of N-alkoxybenzamides by Pd(II) catalyzed C-H activation.

Journal: Organic letters 20111007

Title: MDM2-p53 protein-protein interaction inhibitors: a-ring substituted isoindolinones.

Journal: Bioorganic & medicinal chemistry letters 20111001

Title: Assembly of the isoindolinone core of muironolide A by asymmetric intramolecular Diels-Alder cycloaddition.

Journal: Organic letters 20110805

Title: Nickel(0)-catalyzed cyclization of N-benzoylaminals for isoindolinone synthesis.

Journal: Organic letters 20110701

Title: Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity.

Journal: Bioorganic & medicinal chemistry 20110701

Title: Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.

Journal: Chemical biology & drug design 20110501

Title: The identification of synthetic organic pigments in modern paints and modern paintings using pyrolysis-gas chromatography-mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20110501

Title: Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.

Journal: Journal of medicinal chemistry 20110310

Title: 10-Hydr-oxy-2-aza-penta-cyclo-[10.8.0.0.0.0]icosa-1(12),4(9),5,7,13,15(20),16,18-octa-ene-3,11-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20110301

Title: Synthesis and blocking activities of isoindolinone- and isobenzofuranone-containing phenoxylalkylamines as potent α(1)-adrenoceptor antagonists.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal.

Journal: Advances in pharmacological sciences 20110101

Title: Drug discovery opportunities and challenges at g protein coupled receptors for long chain free Fatty acids.

Journal: Frontiers in endocrinology 20110101

Title: Synthesis and nootropic activity of some 2,3-dihydro-1H-isoindol-1-one derivatives structurally related with piracetam.

Journal: Chemistry & biodiversity 20101101

Title: Design, synthesis, and preliminary biological evaluation of pyrrolo[3,4-c]quinolin-1-one and oxoisoindoline derivatives as aggrecanase inhibitors.

Journal: ChemMedChem 20100503

Title: Inadvertent polychlorinated biphenyls in commercial paint pigments.

Journal: Environmental science & technology 20100415

Title: 2-(4-Hydroxy-biphenyl-3-yl)isoindolin-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20100201

Title: Cardiovascular responses to intravenous injection of a novel isoindolin-1-one derivate in conscious rats.

Journal: Brain research 20091201

Title: Clitocybins, novel isoindolinone free radical scavengers, from mushroom Clitocybe aurantiaca inhibit apoptotic cell death and cellular senescence.

Journal: Biological & pharmaceutical bulletin 20091001

Title: Lenalidomide, an antineoplastic drug, and its hemihydrate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20091001

Title: 3-Eth-oxy-2-(1,3-thia-zol-2-yl)isoindolin-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20091001

Title: Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders.

Journal: Bioorganic & medicinal chemistry letters 20090915

Title: Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction.

Journal: Journal of the American Chemical Society 20081126

Title: Syntheses of substituted 3-methyleneisoindolin-1-ones by a palladium-catalyzed Sonogashira coupling-carbonylation-hydroamination sequence in phosphonium salt-based ionic liquids.

Journal: Organic letters 20081120

Title: Antinociceptive property of intrathecal and intraperitoneal administration of a novel water-soluble isoindolin-1-one derivative, JM 1232 (-) in rats.

Journal: European journal of pharmacology 20081031

Title: Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade reaction.

Journal: Organic letters 20080821

Title: Sterenin A, B, C and D, novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitors from Stereum sp. SANK 21205.

Journal: The Journal of antibiotics 20080301

Title: Raman identification of yellow synthetic organic pigments in modern and contemporary paintings: reference spectra and case studies.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080201

Title: Novel water-soluble sedative-hypnotic agents: isoindolin-1-one derivatives.

Journal: Chemical & pharmaceutical bulletin 20071201

Title: A concise first total synthesis of narceine imide.

Journal: Organic & biomolecular chemistry 20070507

Title: Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.

Journal: Journal of medicinal chemistry 20061019

Title: RAF modulators and methods of use.

Journal: Expert opinion on therapeutic patents 20060701

Title: Comparative study on the use of ortho-phthalaldehyde, naphthalene-2,3-dicarboxaldehyde and anthracene-2,3-dicarboxaldehyde reagents for alpha-amino acids followed by the enantiomer separation of the formed isoindolin-1-one derivatives using quinine-type chiral stationary phases.

Journal: Journal of chromatography. A 20050812

Title: Synthesis of 4-(1-oxo-isoindoline) and 4-(5,6-dimethoxy-1-oxo-isoindoline)-substituted phenoxypropanolamines and their beta1-, beta2-adrenergic receptor binding studies.

Journal: Bioorganic chemistry 20050801

Title: Isoindolinone ureas: a novel class of KDR kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20040906

Title: Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor.

Journal: The Journal of pharmacology and experimental therapeutics 20040801

Title: Synthesis and duplex DNA recognition studies of oligonucleotides containing a ureido isoindolin-1-one homo-N-nucleoside. A comparison of host-guest and DNA recognition studies.

Journal: Bioorganic & medicinal chemistry 20040315

Title: The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

Journal: Bioorganic & medicinal chemistry letters 20040105

Title: Synthesis and SAR studies for the inhibition of TNF-alpha production. Part 2. 2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-substituted-1-isoindolinone derivatives.

Journal: Archives of pharmacal research 20020401

Title: cis-6-Phenyl-4bH,6H,11H,13H-isoindolo[1,2-c]benz[2,4]oxazepin-13-one.

Journal: Acta crystallographica. Section C, Crystal structure communications 20010601

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Tags:480-91-1 Molecular Formula|480-91-1 MDL|480-91-1 SMILES|480-91-1 2,3-Dihydroisoindol-1-one