Home Other Building Blocks 486-60-2
486-60-2,MFCD00210479
Catalog No.:AA003LG0

486-60-2 | Bergaptol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$43.00   $30.00
- +
5mg
≥95%
in stock  
$138.00   $96.00
- +
10mg
≥95%
in stock  
$255.00   $178.00
- +
50mg
95%
in stock  
$314.00   $220.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003LG0
Chemical Name:
Bergaptol
CAS Number:
486-60-2
Molecular Formula:
C11H6O4
Molecular Weight:
202.1629
MDL Number:
MFCD00210479
SMILES:
O=c1ccc2c(o1)cc1c(c2O)cco1
NSC Number:
341958
Properties
Properties
 
Form:
Solid  
MP:
>178°C (dec.)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
312  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
XLogP3:
2  

Literature

Title: Biotransformations of 6',7'-dihydroxybergamottin and 6',7'-epoxybergamottin by the citrus-pathogenic fungi diminish cytochrome P450 3A4 inhibitory activity.

Journal: Bioorganic & medicinal chemistry letters 20120315

Title: Major furocoumarins in grapefruit juice II: phototoxicity, photogenotoxicity, and inhibitory potency vs. cytochrome P450 3A4 activity.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

Title: Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.

Journal: Bioorganic & medicinal chemistry 20120115

Title: Characterization of coumarin-specific prenyltransferase activities in Citrus limon peel.

Journal: Bioscience, biotechnology, and biochemistry 20120101

Title: Major furocoumarins in grapefruit juice I: levels and urinary metabolite(s).

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111201

Title: Construction of a model to estimate the CYP3A inhibitory effect of grapefruit juice.

Journal: Die Pharmazie 20110701

Title: Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.

Journal: Journal of natural products 20110624

Title: Effect of maturity, processing, and storage on the furanocoumarin composition of grapefruit and grapefruit juice.

Journal: Journal of food science 20110501

Title: Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines.

Journal: BMC biochemistry 20110101

Title: Phytophotodermatitis due to chinese herbal medicine decoction.

Journal: Indian journal of dermatology 20110101

Title: Sulfur fumigation processing of traditional chinese medicinal herbs: beneficial or detrimental?

Journal: Frontiers in pharmacology 20110101

Title: Coumarins from Seseli hartvigii.

Journal: Natural product communications 20100701

Title: Differentiation of four pairs of furocoumarin isomers by electrospray ionization tandem mass spectrometry.

Journal: European journal of mass spectrometry (Chichester, England) 20100101

Title: Notopterygium forbesii Boiss extract and its active constituent phenethyl ferulate attenuate pro-inflammatory responses to lipopolysaccharide in RAW 264.7 macrophages. A 'protective' role for oxidative stress?

Journal: Chemical research in toxicology 20090801

Title: Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures.

Journal: Plant cell reports 20090201

Title: Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.

Journal: Bioorganic & medicinal chemistry 20090101

Title: [Studies on chemical constituents in roots and rhizomes of Notopterygium incisum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081201

Title: Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action.

Journal: Chemical research in toxicology 20081201

Title: White and colored grapefruit juice produce similar pharmacokinetic interactions.

Journal: Die Pharmazie 20080801

Title: [Contents of furanocoumarins in grapefruit juice and health foods].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20080801

Title: Aspergillus niger metabolism of citrus furanocoumarin inhibitors of human cytochrome P450 3A4.

Journal: Applied microbiology and biotechnology 20080201

Title: Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins.

Journal: Journal of food science 20071001

Title: [A new coumarin glycoside from Glehnia littoralis].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20071001

Title: Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae).

Journal: Journal of ethnopharmacology 20070725

Title: Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit.

Journal: Bioorganic & medicinal chemistry 20070601

Title: The use of heat treatment to eliminate drug interactions due to grapefruit juice.

Journal: Biological & pharmaceutical bulletin 20061101

Title: Metabolism of bergamottin by cytochromes P450 2B6 and 3A5.

Journal: The Journal of pharmacology and experimental therapeutics 20060901

Title: UV-irradiated grapefruit juice loses pharmacokinetic interaction with nifedipine in rats.

Journal: Biological & pharmaceutical bulletin 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Comprehensive determination of furanocoumarin derivatives in citrus juice by high performance liquid chromatography].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20051101

Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Journal: Current drug metabolism 20051001

Title: Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.

Journal: European journal of biochemistry 20040301

Title: Effects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats.

Journal: Pharmaceutical research 20010201

Title: Basavaraj Girennavar et al. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorganic & Medicinal Chemistry.June 2007, Pages 3684-3691

Title: Yucheng Zhao et al. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. Front Plant Sci, 2016, 7: 722.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:486-60-2 Molecular Formula|486-60-2 MDL|486-60-2 SMILES|486-60-2 Bergaptol