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495-40-9,MFCD00009397
Catalog No.:AA003OJS

495-40-9 | Butyrophenone

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25g
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100g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003OJS
Chemical Name:
Butyrophenone
CAS Number:
495-40-9
Molecular Formula:
C10H12O
Molecular Weight:
148.2017
MDL Number:
MFCD00009397
SMILES:
CCCC(=O)c1ccccc1
NSC Number:
8463
Properties
Properties
 
BP:
228.5°C at 760 mmHg  
Form:
Liquid  
MP:
11-13 °C(lit.)  
Refractive Index:
n20/D 1.520(lit.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
123  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.5  

Literature

Title: Role of haloperidol in palliative medicine: an update.

Journal: The American journal of hospice & palliative care 20120601

Title: Butyrophenone on O-TiO2(110): one-dimensional motion in a weakly confined potential well.

Journal: ACS nano 20120424

Title: Evidence of Haldol (haloperidol) long-term intoxication.

Journal: Forensic science international 20120210

Title: Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.

Journal: Bioorganic & medicinal chemistry 20120201

Title: The psychopharmacology of agitation: consensus statement of the american association for emergency psychiatry project Beta psychopharmacology workgroup.

Journal: The western journal of emergency medicine 20120201

Title: Update on the role of antipsychotics in the treatment of Tourette syndrome.

Journal: Neuropsychiatric disease and treatment 20120101

Title: Synthesis and evaluation of a series of 2-substituted-5-thiopropylpiperazine (piperidine)-1,3,4-oxadiazoles derivatives as atypical antipsychotics.

Journal: PloS one 20120101

Title: Auditing clinical outcomes after introducing off-licence prescribing of atypical antipsychotic melperone for patients with treatment refractory schizophrenia.

Journal: TheScientificWorldJournal 20120101

Title: Photochemistry of 2-diphenylmethoxyacetophenone. Direct detection of a long-lived enol from a Norrish Type II photoreaction.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110901

Title: [Loss of visual acuity after treatment with pipamperone].

Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20110801

Title: Haloperidol disrupts opioid-antinociceptive tolerance and physical dependence.

Journal: The Journal of pharmacology and experimental therapeutics 20110701

Title: Are butyrophenones effective for the treatment of primary headache in the emergency department?

Journal: CJEM 20110301

Title: An extraction technique for analytical sample preparation in aqueous solution based on controlling dispersion of ionic surfactant assemblies in isotachophoretic migration.

Journal: Journal of chromatography. A 20110107

Title: New thoughts on thought disorders in Parkinson's disease: review of current research strategies and challenges.

Journal: Parkinson's disease 20110101

Title: Neuroprotective effects of alpha lipoic Acid on haloperidol-induced oxidative stress in the rat brain.

Journal: Cell & bioscience 20110101

Title: Parkinson's disease and anaesthesia.

Journal: Indian journal of anaesthesia 20110101

Title: Prescribing patterns in dementia: a multicentre observational study in a German network of CAM physicians.

Journal: BMC neurology 20110101

Title: Olfactory cues from plants infected by powdery mildew guide foraging by a mycophagous ladybird beetle.

Journal: PloS one 20110101

Title: Differential changes in QTc duration during in-hospital haloperidol use.

Journal: PloS one 20110101

Title: Treating nausea and vomiting in palliative care: a review.

Journal: Clinical interventions in aging 20110101

Title: Diagnostic dilemma in a child with tuberculous meningitis on haloperidol therapy.

Journal: Toxicology international 20110101

Title: Current concepts in the management of postoperative nausea and vomiting.

Journal: Anesthesiology research and practice 20110101

Title: Are prescribing doctors sensitive to the price that their patients have to pay in the Spanish National Health System?

Journal: BMC health services research 20110101

Title: Droperidol for treatment of nausea and vomiting in palliative care patients.

Journal: The Cochrane database of systematic reviews 20101006

Title: The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome.

Journal: Anesthesia and analgesia 20100901

Title: Antagonist-D2S-dopamine receptor interactions in intact recombinant Chinese hamster ovary cells [corrected].

Journal: Fundamental & clinical pharmacology 20100601

Title: Effect of alkyl substituents on photorelease from butyrophenone derivatives.

Journal: The Journal of organic chemistry 20100305

Title: MDMA-evoked changes in the binding of dopamine D(2) receptor ligands in striatum of rats with unilateral serotonin depletion.

Journal: Synapse (New York, N.Y.) 20100101

Title: Acute gastroenteritis: from guidelines to real life.

Journal: Clinical and experimental gastroenterology 20100101

Title: 4-(4-Chloro-phen-yl)-1-[3-(4-fluoro-benzo-yl)prop-yl]-4-hydroxy-piperidin-1-ium 2,4,6-trinitro-phenolate (haloperidol picrate).

Journal: Acta crystallographica. Section E, Structure reports online 20091001

Title: [Pharmaco-therapeutic evaluation of medical treatments of adult autistics and multi-handicapped patients in a public mental health unit].

Journal: L'Encephale 20090901

Title: Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics.

Journal: Human psychopharmacology 20090701

Title: Automated on-line in-tube solid-phase microextraction coupled with HPLC/MS/MS for the determination of butyrophenone derivatives in human plasma.

Journal: Analytical and bioanalytical chemistry 20090601

Title: The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice.

Journal: Brain research bulletin 20090429

Title: Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway.

Journal: BMC pharmacology 20090101

Title: Determination of gaseous organic compounds in Hyogo Prefecture, Japan.

Journal: The Southeast Asian journal of tropical medicine and public health 20081101

Title: Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.

Journal: Bioorganic & medicinal chemistry 20080801

Title: Antagonist-radioligand binding to D2L-receptors in intact cells.

Journal: Biochemical pharmacology 20080601

Title: Chemotherapy-and cancer-related nausea and vomiting.

Journal: Current oncology (Toronto, Ont.) 20080101

Title: Rational design, synthesis and evaluation of (6aR( *),11bS( *))-1-(4-fluorophenyl)-4-{7-[4-(4-fluorophenyl)-4-oxobutyl]1,2,3,4,6,6a,7,11b,12,12a(RS)-decahydropyrazino[2',1':6,1]pyrido[3,4-b]indol-2-yl}-butan-1-one as a potential neuroleptic agent.

Journal: Bioorganic & medicinal chemistry 20071201

Title: A prototypical Sigma-1 receptor antagonist protects against brain ischemia.

Journal: Brain research 20071121

Title: Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.

Journal: Bioorganic & medicinal chemistry letters 20070901

Title: Pesticides in surface drinking-water supplies of the northern Great Plains.

Journal: Environmental health perspectives 20070801

Title: Fifty years chlorpromazine: a historical perspective.

Journal: Neuropsychiatric disease and treatment 20070801

Title: Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity.

Journal: Neurochemistry international 20070601

Title: Effects of haloperidol and its pyridinium metabolite on plasma membrane permeability and fluidity in the rat brain.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070509

Title: Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20070501

Title: Methyl chloroacetate as an extraction solvent for coupling liquid-liquid semimicroextraction with micellar electrokinetic chromatography through on-capillary decomposition for the separation of neutral compounds with concentration enhancement.

Journal: Journal of chromatography. A 20070413

Title: Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401

Title: Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones.

Journal: Journal of enzyme inhibition and medicinal chemistry 20070201

Title: Trends in hospital admissions for adverse drug reactions in England: analysis of national hospital episode statistics 1998-2005.

Journal: BMC clinical pharmacology 20070101

Title: Forty years of antipsychotic Drug research--from haloperidol to paliperidone--with Dr. Paul Janssen.

Journal: Arzneimittel-Forschung 20070101

Title: Systematic review of antipsychotics for the treatment of hospital-associated delirium in medically or surgically ill patients.

Journal: The Annals of pharmacotherapy 20061101

Title: QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine.

Journal: Neuropharmacology 20060801

Title: Successful treatment of six patients with neuroleptic malignant syndrome associated with myoglobulinemic acute renal failure.

Journal: Renal failure 20060101

Title: Synthesis, neutron structure, and reactivity of the bis(dihydrogen) complex RuH2(eta(2)-H2)2(PCyp3)2 stabilized by two tricyclopentylphosphines.

Journal: Journal of the American Chemical Society 20051221

Title: Haloperidol: an alternative butyrophenone for nausea and vomiting prophylaxis in anesthesia.

Journal: AANA journal 20050801

Title: Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives.

Journal: Bioorganic & medicinal chemistry letters 20050701

Title: Benperidol for schizophrenia.

Journal: The Cochrane database of systematic reviews 20050418

Title: Safety of haloperidol and penfluridol in pregnancy: a multicenter, prospective, controlled study.

Journal: The Journal of clinical psychiatry 20050301

Title: Factors related to prescription dosage in Japanese psychiatric hospitals.

Journal: Psychiatry and clinical neurosciences 20050201

Title: The haloperidol story.

Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20050101

Title: Haloperidol: towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors.

Journal: Bioorganic & medicinal chemistry letters 20041206

Title: [Butyrophenone derivatives].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20041201

Title: Multiresidue method for the detection of tranquillisers, xylazine, and a beta-blocker in animal production by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20041029

Title: Droperidol for acute psychosis.

Journal: The Cochrane database of systematic reviews 20041018

Title: A review of drugs and techniques used for sedation and anaesthesia in captive rhinoceros species.

Journal: Australian veterinary journal 20040901

Title: Antipsychotics and the risk of sudden cardiac death.

Journal: Archives of internal medicine 20040628

Title: Rhodium-catalyzed addition/ring-opening reaction of arylboronic acids with cyclobutanones.

Journal: Organic letters 20040415

Title: [Injection anesthesia administered in the mid-anesthesia period after ether induction in laboratory rats].

Journal: Ceskoslovenska fysiologie 20031201

Title: The evolving management of migraine.

Journal: Current opinion in neurology 20030601

Title: Droperidol, QT prolongation, and sudden death: what is the evidence?

Journal: Annals of emergency medicine 20030401

Title: The effect of melperone, an atypical antipsychotic drug, on cognitive function in schizophrenia.

Journal: Schizophrenia research 20030101

Title: Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine.

Journal: Pharmacopsychiatry 20030101

Title: Functional cooperation between neurosteroids and D2 dopamine antagonists on KCl-evoked [3H]noradrenaline release: modulation by calcium channel blockers.

Journal: Journal of neuroendocrinology 20021201

Title: Metabolism and excretion of centbutindole (neuroleptic) in rats after oral administration.

Journal: The Journal of pharmacy and pharmacology 20021201

Title: Platelet serotonin transporter in schizophrenic patients with and without neuroleptic treatment.

Journal: Neurochemistry international 20021001

Title: Antipsychotics: impact on prolactin levels.

Journal: Expert opinion on pharmacotherapy 20021001

Title: A hybrid microdevice for electrophoresis and electrochromatography using UV detection.

Journal: Electrophoresis 20021001

Title: Antipsychotic and antidepressant drug use in the elderly and the risk of venous thromboembolism.

Journal: Thrombosis and haemostasis 20020801

Title: Differential inhibition of T-type calcium channels by neuroleptics.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020115

Title: Benperidol for schizophrenia.

Journal: The Cochrane database of systematic reviews 20020101

Title: Relations of clinical features, subgroups and medication to serum monoamines in schizophrenia.

Journal: Human psychopharmacology 20020101

Title: Comparative efficacy of centbutindole & risperidone in schizophrenia.

Journal: Indian journal of psychiatry 20020101

Title: Dopamine receptors in the brains of schizophrenia patients: a meta-analysis of the findings.

Journal: Behavioural pharmacology 20010901

Title: Effect of hyperprolactinemia induced by pituitary grafts or castration on porphyrin content of the mouse Harderian gland.

Journal: The Journal of toxicological sciences 20010801

Title: Use of olanzapine in non-psychotic psychiatric disorders.

Journal: Expert opinion on pharmacotherapy 20010401

Title: Suspected induction of a pyoderma gangrenosum-like eruption due to sulpiride treatment.

Journal: Cutis 20010301

Title: Droperidol for acute psychosis.

Journal: The Cochrane database of systematic reviews 20010101

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