[1]Chmielewska;Cieslak[Bulletindel'AcademiePolonaisedesSciences,SeriedesSciencesChimiques,1953,vol.<III>1,p.257]
[1]Borsche;Blount[ChemischeBerichte,1932,vol.65,p.820,827]
[1]Bacardit,R.;Moreno-Manas,M.;Pleixats,R.[JournalofHeterocyclicChemistry,1982,vol.19,p.157-160]
[1]Lygo,Barry[Tetrahedron,1995,vol.51,#47,p.12859-12868]
Title: Yangonin protects against cholestasis and hepatotoxity via activation of farnesoid X receptor in vivo and in vitro.
Journal: Toxicology and applied pharmacology 20180601
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry 20121115
Title: Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit.
Journal: Journal of pharmacological sciences 20120101
Title: Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20111201
Title: Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro.
Journal: Phytotherapy research : PTR 20110301
Title: Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.
Journal: PloS one 20110101
Title: Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract.
Journal: International journal of toxicology 20090101
Title: Permeability studies of Kavalactones using a Caco-2 cell monolayer model.
Journal: Journal of clinical pharmacy and therapeutics 20070601
Title: Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum).
Journal: Journal of agricultural and food chemistry 20060208
Title: Kavalactones fail to inhibit alcohol dehydrogenase in vitro.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20060201
Title: Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.
Journal: Journal of AOAC International 20050101
Title: Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones.
Journal: Phytochemical analysis : PCA 20050101
Title: In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040501
Title: Kava does not display metabolic toxicity in a homogeneous cellular assay.
Journal: Planta medica 20040401
Title: Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20040101
Title: Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum).
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20030501
Title: Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20020401
Title: Interaction of various Piper methysticum cultivars with CNS receptors in vitro.
Journal: Planta medica 20010601
Title: Ligresti A, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB1 receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9.
Title: Ma J, et al. Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci. 2012;118(4):447-54.
Title: Wruck CJ, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95.
