Home Nitro Compounds 504-88-1
504-88-1,MFCD00007406
Catalog No.:AA003JR2

504-88-1 | 3-Nitropropionic acid

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250mg
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5g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003JR2
Chemical Name:
3-Nitropropionic acid
CAS Number:
504-88-1
Molecular Formula:
C3H5NO4
Molecular Weight:
119.0761
MDL Number:
MFCD00007406
SMILES:
[O-][N+](=O)CCC(=O)O
NSC Number:
64266
UN Number:
2811
Properties
Properties
 
BP:
222.3°C (rough estimate)  
Form:
Solid  
MP:
68-70 °C(lit.)  
Refractive Index:
1.4940 (estimate)  
Solubility:
alcohol: 100 mg/mL, may be light yellow  
Storage:
2-8℃;Light sensitive;Keep in dry area;  

Computed Properties
 
Complexity:
104  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
-0.5  

Downstream Synthesis Route

[1]Greshametal.[JournaloftheAmericanChemicalSociety,1952,vol.74,p.1323]Hassetal.[JournaloftheAmericanChemicalSociety,1951,vol.73,p.1858]

[1]Lewkowitsch[JournalfurpraktischeChemie(Leipzig1954),1879,vol.<2>20,p.169]

[1]Locationinpatent:experimentalpartChapelon,Anne-Sophie;Giorgi,Michel;Ollivier,Cyril;Santelli,Maurice[SyntheticCommunications,2010,vol.40,#1,p.87-103]

[2]Locationinpatent:experimentalpartCueva,JuanPablo;Nichols,DavidE.[Synthesis,2009,#5,p.715-720]

[3]CurrentPatentAssignee:HANMIPHARMCOLTD-WO2007/55513,2007,A1Locationinpatent:Page/Pagecolumn27

[4]Barger;Tutin[BiochemicalJournal,1918,vol.12,p.405]

[5]Seebach,D.etal.[AngewandteChemie,1977,vol.89,p.334-335]

[6]CurrentPatentAssignee:MAPIPHARMALTD.;MIZHIRITSKIIMICAEL-WO2012/56458,2012,A2Locationinpatent:Page/Pagecolumn23

[1]Carter[JournaloftheSocietyofChemicalIndustry,1943,vol.62,p.238]

[2]Carter[JournaloftheSocietyofChemicalIndustry,1943,vol.62,p.238]

504-88-1   
3-1-hydroxy-3-(4-nitro-phenyl)-triazenyl-propionicacid 

[1]Bamberger;Renauld[ChemischeBerichte,1897,vol.30,p.2288]

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Title: Kainic acid and 3-Nitropropionic acid induced expression of laminin in vascular elements of the rat brain.

Journal: Brain research 20100917

Title: Androgens selectively protect against apoptosis in hippocampal neurones.

Journal: Journal of neuroendocrinology 20100901

Title: Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.

Journal: EMBO molecular medicine 20100901

Title: The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging.

Journal: Aging 20100901

Title: The role of mitochondria in brain aging and the effects of melatonin.

Journal: Current neuropharmacology 20100901

Title: Assessment of 3-nitropropionic acid-evoked peripheral neuropathy in rats: neuroprotective effects of acetyl-l-carnitine and resveratrol.

Journal: Neuroscience letters 20100816

Title: Regulation of GSK-3beta by calpain in the 3-nitropropionic acid model.

Journal: Hippocampus 20100801

Title: Complex I: inhibitors, inhibition and neurodegeneration.

Journal: Experimental neurology 20100801

Title: Delayed pre-conditioning by 3-nitropropionic acid prevents 3,4-methylenedioxymetamphetamine-induced 5-HT deficits.

Journal: Journal of neurochemistry 20100801

Title: 5-Nitro-2-furoic acid hydrazones: design, synthesis and in vitro antimycobacterial evaluation against log and starved phase cultures.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage.

Journal: Aging 20100801

Title: Protective effect of sesamol against 3-nitropropionic acid-induced cognitive dysfunction and altered glutathione redox balance in rats.

Journal: Basic & clinical pharmacology & toxicology 20100701

Title: Identification of novel 1,4-benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration.

Journal: Journal of neuroscience research 20100701

Title: Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors.

Journal: Journal of neurochemistry 20100701

Title: Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription.

Journal: Experimental neurology 20100701

Title: Mechanisms underlying striatal vulnerability to 3-nitropropionic acid.

Journal: Journal of neurochemistry 20100701

Title: Brain region-specific vulnerability of astrocytes in response to 3-nitropropionic acid is mediated by cytochrome c oxidase isoform expression.

Journal: Cell and tissue research 20100701

Title: Neuroprotective mechanisms of brain-derived neurotrophic factor against 3-nitropropionic acid toxicity: therapeutic implications for Huntington's disease.

Journal: Annals of the New York Academy of Sciences 20100701

Title: Lithium reduces apoptosis and autophagy after neonatal hypoxia-ischemia.

Journal: Cell death & disease 20100701

Title: Prophylaxis with Centella asiatica confers protection to prepubertal mice against 3-nitropropionic-acid-induced oxidative stress in brain.

Journal: Phytotherapy research : PTR 20100601

Title: FoxO1 is involved in the antineoplastic effect of calorie restriction.

Journal: Aging cell 20100601

Title: Geranylgeranylacetone ameliorates acute cochlear damage caused by 3-nitropropionic acid.

Journal: Neurotoxicology 20100601

Title: Mitochondrial matters of the brain: the role in Huntington's disease.

Journal: Journal of bioenergetics and biomembranes 20100601

Title: Dysregulation of CREB activation and histone acetylation in 3-nitropropionic acid-treated cortical neurons: prevention by BDNF and NGF.

Journal: Neurotoxicity research 20100501

Title: Balance dysfunction resulting from acute inner ear energy failure is caused primarily by vestibular hair cell damage.

Journal: Journal of neuroscience research 20100501

Title: Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.

Journal: Neurobiology of disease 20100501

Title: Nitric oxide mechanism in the protective effect of antidepressants against 3-nitropropionic acid-induced cognitive deficit, glutathione and mitochondrial alterations in animal model of Huntington's disease.

Journal: Behavioural pharmacology 20100501

Title: Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy.

Journal: Neuroreport 20100421

Title: Opening of the mitoKATP channel and decoupling of mitochondrial complex II and III contribute to the suppression of myocardial reperfusion hyperoxygenation.

Journal: Molecular and cellular biochemistry 20100401

Title: Mitochondrial-dependent apoptosis in Huntington's disease human cybrids.

Journal: Experimental neurology 20100401

Title: Hypoxia sensing in the fetal chicken femoral artery is mediated by the mitochondrial electron transport chain.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100401

Title: Mitochondrial quality control and neurological disease: an emerging connection.

Journal: Expert reviews in molecular medicine 20100401

Title: HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease.

Journal: Antioxidants & redox signaling 20100215

Title: 3-nitropropionic acid-induced mitochondrial permeability transition: comparative study of mitochondria from different tissues and brain regions.

Journal: Journal of neuroscience research 20100215

Title: 3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington's disease: past, present and future.

Journal: Molecules (Basel, Switzerland) 20100210

Title: Systemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes.

Journal: Neurochemistry international 20100201

Title: Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid.

Journal: Neurochemistry international 20100201

Title: Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide.

Journal: Behavioural brain research 20100105

Title: Trolox ameliorates 3-nitropropionic acid-induced neurotoxicity in rats.

Journal: Neurotoxicology and teratology 20100101

Title: Protective effect of tert-butylhydroquinone on the quinolinic-acid-induced toxicity in rat striatal slices: role of the Nrf2-antioxidant response element pathway.

Journal: Neuro-Signals 20100101

Title: Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats.

Journal: Neurochemistry international 20100101

Title: Promethazine protects against 3-nitropropionic acid-induced neurotoxicity.

Journal: Neurochemistry international 20100101

Title: Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression.

Journal: The Journal of biological chemistry 20100101

Title: Antioxidant strategy to rescue synaptosomes from oxidative damage and energy failure in neurotoxic models in rats: protective role of S-allylcysteine.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20100101

Title: Electrophysiological actions of zonisamide on striatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction.

Journal: Experimental neurology 20100101

Title: Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review.

Journal: Lipids in health and disease 20100101

Title: Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.

Journal: Journal of neuroinflammation 20100101

Title: Preconditioning-induced ischemic tolerance: a window into endogenous gearing for cerebroprotection.

Journal: Experimental & translational stroke medicine 20100101

Title: Time-course correlation of early toxic events in three models of striatal damage: modulation by proteases inhibition.

Journal: Neurochemistry international 20100101

Title: Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline.

Journal: PloS one 20100101

Title: Genetic mouse models of Huntington's disease: focus on electrophysiological mechanisms.

Journal: ASN neuro 20100101

Title: The bright and the dark sides of DNA repair in stem cells.

Journal: Journal of biomedicine & biotechnology 20100101

Title: Uncoupling oxidative/energy metabolism with low sub chronic doses of 3-nitropropionic acid or iodoacetate in vivo produces striatal cell damage.

Journal: International journal of biological sciences 20100101

Title: Cyclosporine A attenuates 3-nitropropionic acid-induced Huntington-like symptoms in rats: possible nitric oxide mechanism.

Journal: International journal of toxicology 20100101

Title: Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease.

Journal: ASN neuro 20100101

Title: Oxidative stress induced in rat brain by a combination of 3-nitropropionic acid and global ischemia.

Journal: International journal of clinical and experimental medicine 20100101

Title: Effects of mitochondrial dysfunction on the immunological properties of microglia.

Journal: Journal of neuroinflammation 20100101

Title: Mitochondrial preconditioning: a potential neuroprotective strategy.

Journal: Frontiers in aging neuroscience 20100101

Title: PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration.

Journal: Cell communication and signaling : CCS 20100101

Title: Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder.

Journal: International journal of tryptophan research : IJTR 20100101

Title: An investigation of the neuroprotective effects of Curcumin in a model of Homocysteine - induced oxidative stress in the rat's brain.

Journal: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101

Title: Delayed onset of the diurnal melatonin rise in patients with Huntington's disease.

Journal: Journal of neurology 20091201

Title: Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum.

Journal: Journal of neuroscience research 20091201

Title: Protective effects of epigallocatechin gallate following 3-nitropropionic acid-induced brain damage: possible nitric oxide mechanisms.

Journal: Psychopharmacology 20091201

Title: Altered open field behavior in rats induced by acute administration of 3-nitropropionic acid: possible glutamatergic and dopaminergic involvement.

Journal: Acta biologica Hungarica 20091201

Title: Cyclopiazonic acid biosynthesis of Aspergillus flavus and Aspergillus oryzae.

Journal: Toxins 20091201

Title: Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity.

Journal: Life sciences 20091104

Title: Cytochrome c oxidase isoform IV-2 is involved in 3-nitropropionic acid-induced toxicity in striatal astrocytes.

Journal: Glia 20091101

Title: Striatal dopamine level contributes to hydroxyl radical generation and subsequent neurodegeneration in the striatum in 3-nitropropionic acid-induced Huntington's disease in rats.

Journal: Neurochemistry international 20091101

Title: CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease.

Journal: Neurobiology of disease 20091101

Title: Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.

Journal: Neurobiology of disease 20091101

Title: An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis.

Journal: PLoS pathogens 20091101

Title: Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment.

Journal: Neuroscience 20091020

Title: Preconditioning with 4-aminopyridine protects cerebellar granule neurons against excitotoxicity.

Journal: Brain research 20091019

Title: Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases.

Journal: Human molecular genetics 20091015

Title: Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: a novel nitric oxide mechanism.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091001

Title: Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord.

Journal: The Journal of comparative neurology 20091001

Title: Kaempferol protects against rat striatal degeneration induced by 3-nitropropionic acid.

Journal: Journal of neurochemistry 20091001

Title: Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons.

Journal: Journal of neurochemistry 20091001

Title: ROS scavenging capacity and neuroprotective effect of alpha-mangostin against 3-nitropropionic acid in cerebellar granule neurons.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20090901

Title: Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy.

Journal: Journal of neuroscience research 20090901

Title: BDNF regulates BIM expression levels in 3-nitropropionic acid-treated cortical neurons.

Journal: Neurobiology of disease 20090901

Title: Involvement of nitric oxide in 3-nitropropionic acid-induced depression of spinal reflexes in neonatal rat spinal cord in vitro.

Journal: European journal of pharmacology 20090901

Title: Anaerobic central metabolic pathways active during polyhydroxyalkanoate production in uncultured cluster 1 Defluviicoccus enriched in activated sludge communities.

Journal: FEMS microbiology letters 20090901

Title: Induction of membrane permeability in Escherichia coli mediated by lysis protein of the ColE7 operon.

Journal: FEMS microbiology letters 20090901

Title: Protective role of sertraline against 3-nitropropionic acid-induced cognitive dysfunction and redox ratio in striatum, cortex and hippocampus of rat brain.

Journal: Indian journal of experimental biology 20090901

Title: Neuroprotective effect of carvedilol and melatonin on 3-nitropropionic acid-induced neurotoxicity in neuroblastoma.

Journal: Journal of physiology and biochemistry 20090901

Title: Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS).

Journal: Aging 20090901

Title: Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity.

Journal: Current neuropharmacology 20090901

Title: In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents.

Journal: Neurochemical research 20090801

Title: Protective effect of rivastigmine against 3-nitropropionic acid-induced Huntington's disease like symptoms: possible behavioural, biochemical and cellular alterations.

Journal: European journal of pharmacology 20090801

Title: Early nerve ending rescue from oxidative damage and energy failure by L: -carnitine as post-treatment in two neurotoxic models in rat: recovery of antioxidant and reductive capacities.

Journal: Experimental brain research 20090801

Title: Sonic hedgehog mediates BDNF-induced neuroprotection against mitochondrial inhibitor 3-nitropropionic acid.

Journal: Biochemical and biophysical research communications 20090717

Title: In vivo dopamine release and uptake impairments in rats treated with 3-nitropropionic acid.

Journal: Neuroscience 20090707

Title: Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington's disease.

Journal: Neurochemical research 20090701

Title: Protective effects of brain-derived neurotrophic factor against neurotoxicity of 3-nitropropionic acid in rat cortical neurons.

Journal: Neurotoxicology 20090701

Title: The brain uncoupling protein UCP4 attenuates mitochondrial toxin-induced cell death: role of extracellular signal-regulated kinases in bioenergetics adaptation and cell survival.

Journal: Neurotoxicity research 20090701

Title: Heme oxygenase-1 induction prevents neuronal damage triggered during mitochondrial inhibition: role of CO and bilirubin.

Journal: The international journal of biochemistry & cell biology 20090601

Title: A mouse model for degeneration of the spiral ligament.

Journal: Journal of the Association for Research in Otolaryngology : JARO 20090601

Title: Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway.

Journal: Cell death and differentiation 20090601

Title: Whole body hyperthermia reduces oxidative stress in the striatum of rats in an animal model of mitochondrial toxicity with 3-nitropropionic acid.

Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20090601

Title: Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases.

Journal: Journal of neurochemistry 20090601

Title: Site-directed mutagenesis, kinetic and inhibition studies of aspartate ammonia lyase from Bacillus sp. YM55-1.

Journal: The FEBS journal 20090601

Title: Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunction in an animal model of Huntington's disease.

Journal: Journal of medicinal food 20090601

Title: Targeting oxidative/nitrergic stress ameliorates motor impairment, and attenuates synaptic mitochondrial dysfunction and lipid peroxidation in two models of Huntington's disease.

Journal: Behavioural brain research 20090516

Title: Antioxidant effects of different extracts from Melissa officinalis, Matricaria recutita and Cymbopogon citratus.

Journal: Neurochemical research 20090501

Title: Effects of nitrocompounds on uric acid-utilizing microorganisms, nitrogen retention, and microbial community in laying hen manure.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20090501

Title: GABAergic striatal neurons exhibit caspase-independent, mitochondrially mediated programmed cell death.

Journal: Journal of neurochemistry 20090501

Title: Mitochondria and energetic depression in cell pathophysiology.

Journal: International journal of molecular sciences 20090501

Title: No spatial memory deficit exists in Kunming mice that recently recovered from motor defects following 3-nitropropionic acid intoxication.

Journal: Neuroscience bulletin 20090401

Title: Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease.

Journal: Brain : a journal of neurology 20090401

Title: p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum.

Journal: Autophagy 20090401

Title: [Model of Huntington's disease induced with 3-nitropropionic acid].

Journal: Revista de neurologia 20090401

Title: Neuroprotective effect of cyclosporine and FK506 against 3-nitropropionic acid induced cognitive dysfunction and glutathione redox in rat: possible role of nitric oxide.

Journal: Neuroscience research 20090401

Title: N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity.

Journal: Neurochemical research 20090301

Title: Targeting the progression of Parkinson's disease.

Journal: Current neuropharmacology 20090301

Title: 5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp.

Journal: Bioorganic & medicinal chemistry letters 20090215

Title: Evidence of calpain/cdk5 pathway inhibition by lithium in 3-nitropropionic acid toxicity in vivo and in vitro.

Journal: Neuropharmacology 20090201

Title: Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease.

Journal: Diabetes 20090201

Title: Impaired mitochondria-dependent vasodilation in cerebral arteries of Zucker obese rats with insulin resistance.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090201

Title: Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20090201

Title: The natural xanthone alpha-mangostin reduces oxidative damage in rat brain tissue.

Journal: Nutritional neuroscience 20090201

Title: Mitochondrial dysfunction disrupts trafficking of Kir4.1 in spiral ganglion satellite cells.

Journal: Journal of neuroscience research 20090101

Title: Old mice present increased levels of succinate dehydrogenase activity and lower vulnerability to dyskinetic effects of 3-nitropropionic acid.

Journal: Pharmacology, biochemistry, and behavior 20090101

Title: Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington's disease.

Journal: DNA repair 20090101

Title: Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes.

Journal: Journal of molecular and cellular cardiology 20090101

Title: Blood-brain barrier disruption in the striatum of rats treated with 3-nitropropionic acid.

Journal: Neurotoxicology 20090101

Title: Normal aging modulates the neurotoxicity of mutant huntingtin.

Journal: PloS one 20090101

Title: Both systemic and local application of granulocyte-colony stimulating factor (G-CSF) is neuroprotective after retinal ganglion cell axotomy.

Journal: BMC neuroscience 20090101

Title: Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.

Journal: PloS one 20090101

Title: IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.

Journal: PloS one 20090101

Title: Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.

Journal: PloS one 20090101

Title: Sesamol attenuate 3-nitropropionic acid-induced Huntington-like behavioral, biochemical, and cellular alterations in rats.

Journal: Journal of Asian natural products research 20090101

Title: A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis.

Journal: BMC systems biology 20090101

Title: Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease.

Journal: Molecular brain 20090101

Title: Does neuroinflammation fan the flame in neurodegenerative diseases?

Journal: Molecular neurodegeneration 20090101

Title: Coenzyme Q10 effects in neurodegenerative disease.

Journal: Neuropsychiatric disease and treatment 20090101

Title: Dopamine D2 receptor stimulation potentiates PolyQ-Huntingtin-induced mouse striatal neuron dysfunctions via Rho/ROCK-II activation.

Journal: PloS one 20090101

Title: Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.

Journal: Neuron 20081226

Title: Galantamine reduces striatal degeneration in 3-nitropropionic acid model of Huntington's disease.

Journal: Neuroscience letters 20081219

Title: 3-Nitropropionic acid-induced depression of spinal reflexes involves mechanisms different from ischemia-induced depression.

Journal: Brain research bulletin 20081216

Title: Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress.

Journal: Neuroscience letters 20081212

Title: 3-Nitropropionic acid-induced depression of spinal reflexes does not involve 5-hydroxytryptaminergic system in contrast to ischemia-induced depression in neonatal rat spinal cord in vitro.

Journal: Neuroscience letters 20081203

Title: Bcl-2 upregulation after 3-nitropropionic acid preconditioning in warm rat liver ischemia.

Journal: Shock (Augusta, Ga.) 20081201

Title: Effects of select nitrocompounds on in vitro ruminal fermentation during conditions of limiting or excess added reductant.

Journal: Bioresource technology 20081201

Title: Mechanism of 3-nitropropionic acid-induced membrane permeability transition of isolated mitochondria and its suppression by L-carnitine.

Journal: Cell biochemistry and function 20081201

Title: Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?

Journal: Neurotoxicity research 20081201

Title: 3-Nitropropionic acid depresses spinal reflexes involving GABAergic and glycinergic transmission in neonatal rat spinal cord in vitro.

Journal: Life sciences 20081121

Title: Effect of Centella asiatica leaf powder on oxidative markers in brain regions of prepubertal mice in vivo and its in vitro efficacy to ameliorate 3-NPA-induced oxidative stress in mitochondria.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20081101

Title: Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20081101

Title: Neurotoxicological effects of 3-nitropropionic acid on the neonatal rat.

Journal: Neurotoxicology 20081101

Title: Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid induced oxidative stress and mitochondrial dysfunctions in brain regions of prepubertal mice.

Journal: Neurotoxicology 20081101

Title: Scalarane sesterterpenes from the sponge Smenospongia sp.

Journal: Journal of natural products 20081101

Title: A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.

Journal: PLoS genetics 20081101

Title: A pharmacological MRI assessment of dizocilpine (MK-801) in the 3-nitroproprionic acid-lesioned rat.

Journal: Neuroscience letters 20081017

Title: Inhibition of Candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge Dysidea sp.

Journal: Bioorganic & medicinal chemistry letters 20081015

Title: Increased glucose metabolism and ATP level in brain tissue of Huntington's disease transgenic mice.

Journal: The FEBS journal 20081001

Title: The mechanism of the late preconditioning effect of 3-nitropropionic acid.

Journal: Archives of pharmacal research 20081001

Title: Lipid peroxidation, mitochondrial dysfunction and neurochemical and behavioural deficits in different neurotoxic models: protective role of S-allylcysteine.

Journal: Free radical research 20081001

Title: Brain adaptation to stressful stimuli: a new perspective on potential therapeutic approaches based on BDNF and NMDA receptors.

Journal: CNS & neurological disorders drug targets 20081001

Title: Miscellaneous.

Journal: Indian journal of pharmacology 20081001

Title: Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080917

Title: Melatonin combats molecular terrorism at the mitochondrial level.

Journal: Interdisciplinary toxicology 20080901

Title: Preconditioning with NMDA protects against toxicity of 3-nitropropionic acid or glutamate in cultured cerebellar granule neurons.

Journal: Neuroscience letters 20080808

Title: Depressive-like behavior in mice recently recovered from motor disorders after 3-nitropropionic acid intoxication.

Journal: Neuroscience bulletin 20080801

Title: Current approaches to the treatment of Parkinson's disease.

Journal: Neuropsychiatric disease and treatment 20080801

Title: Modulation of SIRT1 expression in different neurodegenerative models and human pathologies.

Journal: Neuroscience 20080717

Title: Resistance to kynurenic acid of the NMDA receptor-dependent toxicity of 3-nitropropionic acid and cyanide in cerebellar granule neurons.

Journal: Brain research 20080618

Title: Responses of differentiated MC3T3-E1 osteoblast-like cells to reactive oxygen species.

Journal: European journal of pharmacology 20080610

Title: Chemical hypoxia facilitates alternative splicing of EAAT2 in presymptomatic APP23 transgenic mice.

Journal: Neurochemical research 20080601

Title: Neuroprotection of lamotrigine on hypoxic-ischemic brain damage in neonatal rats: Relations to administration time and doses.

Journal: Biologics : targets & therapy 20080601

Title: Altered striatal vulnerability to 3-nitropropionic acid in rats due to sex hormone levels during late phase of brain development.

Journal: Neuroscience letters 20080516

Title: Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

Journal: Human molecular genetics 20080515

Title: Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine.

Journal: Journal of neurochemistry 20080501

Title: Sensory motor mismatch within the supplementary motor area in the dystonic monkey.

Journal: Neurobiology of disease 20080501

Title: Chemical preconditioning effect of 3-nitropropionic acid in anesthetized rat heart.

Journal: Life sciences 20080423

Title: NF-kB/NOS cross-talk induced by mitochondrial complex II inhibition: implications for Huntington's disease.

Journal: Neuroscience letters 20080404

Title: Rasagiline is neuroprotective in a transgenic model of multiple system atrophy.

Journal: Experimental neurology 20080401

Title: Tiagabine, a GABA uptake inhibitor, attenuates 3-nitropropionic acid-induced alterations in various behavioral and biochemical parameters in rats.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080401

Title: Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats.

Journal: Environmental health perspectives 20080401

Title: Effect of 17beta-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats.

Journal: Neuropsychiatric disease and treatment 20080401

Title: Application of multipotent mesenchymal stromal cells from human adipose tissue for compensation of neurological deficiency induced by 3-nitropropionic Acid in rats.

Journal: Bulletin of experimental biology and medicine 20080401

Title: Differential involvement of cell cycle reactivation between striatal and cortical neurons in cell death induced by 3-nitropropionic acid.

Journal: The Journal of biological chemistry 20080307

Title: Atorvastatin attenuates mitochondrial toxin-induced striatal degeneration, with decreasing iNOS/c-Jun levels and activating ERK/Akt pathways.

Journal: Journal of neurochemistry 20080301

Title: Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques.

Journal: Psychopharmacology 20080301

Title: Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production.

Journal: Neurotoxicology 20080301

Title: Cytoplasmic calcium mediates oxidative damage in an excitotoxic /energetic deficit synergic model in rats.

Journal: The European journal of neuroscience 20080301

Title: Preconditioning paradigms and pathways in the brain.

Journal: Cleveland Clinic journal of medicine 20080301

Title: Regional susceptibility to domoic acid in primary astrocyte cells cultured from the brain stem and hippocampus.

Journal: Marine drugs 20080301

Title: Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity.

Journal: Toxicology 20080227

Title: Granulocyte-colony stimulating factor attenuates striatal degeneration with activating survival pathways in 3-nitropropionic acid model of Huntington's disease.

Journal: Brain research 20080215

Title: The impact of mitochondrial energetic dysfunction on apoptosis in outer hair cells of the cochlea following exposure to intense noise.

Journal: Hearing research 20080201

Title: Induction of apoptosis signal-regulating kinase 1 and oxidative stress mediate age-dependent vulnerability to 3-nitropropionic acid in the mouse striatum.

Journal: Neuroscience letters 20080110

Title: Caspase inhibitor facilitates recovery of hearing by protecting the cochlear lateral wall from acute cochlear mitochondrial dysfunction.

Journal: Journal of neuroscience research 20080101

Title: Mitochondrial NAD+-linked State 3 respiration and complex-I activity are compromised in the cerebral cortex of 3-nitropropionic acid-induced rat model of Huntington's disease.

Journal: Journal of neurochemistry 20080101

Title: Neural stem/progenitor cells initiate the formation of cellular networks that provide neuroprotection by growth factor-modulated antioxidant expression.

Journal: Stem cells (Dayton, Ohio) 20080101

Title: Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease.

Journal: Journal of neuroinflammation 20080101

Title: Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation.

Journal: PloS one 20080101

Title: Proteomic modeling for HIV-1 infected microglia-astrocyte crosstalk.

Journal: PloS one 20080101

Title: Ototoxic interaction of kanamycin and 3-nitropropionic acid.

Journal: Acta oto-laryngologica 20080101

Title: PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence.

Journal: PloS one 20080101

Title: Protective efficiacy of taurine against pulmonary edema progression: experimental study.

Journal: Journal of cardiothoracic surgery 20080101

Title: Prolonged pretreatment with carvedilol prevents 3-nitropropionic acid-induced behavioral alterations and oxidative stress in rats.

Journal: Pharmacological reports : PR 20080101

Title: Reaction of chromium(III) with 3,4-dihydroxybenzoic acid: kinetics and mechanism in weak acidic aqueous solutions.

Journal: Bioinorganic chemistry and applications 20080101

Title: Inflammatory and neurochemical changes associated with 3-nitropropionic Acid neurotoxicity.

Journal: Toxicology mechanisms and methods 20080101

Title: Citicoline is not protective in experimental models of Huntington's disease.

Journal: Neurobiology of aging 20071201

Title: Catecholamine exocytosis is diminished in R6/2 Huntington's disease model mice.

Journal: Journal of neurochemistry 20071201

Title: Neurotoxic effects of repetitive inhibition of oxidative phosphorylation in young adults surfacing with deficits of spatial learning in old age.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20071201

Title: Cannabinoids in health and disease.

Journal: Dialogues in clinical neuroscience 20071201

Title: IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats.

Journal: Neuroscience letters 20071002

Title: Memantine reduces neuronal dysfunctions triggered by in vitro ischemia and 3-nitropropionic acid.

Journal: Experimental neurology 20071001

Title: Commonly used tropical medicinal plants exhibit distinct in vitro antioxidant activities against hepatotoxins in rat liver.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20070801

Title: Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina.

Journal: Experimental brain research 20070801

Title: The role of mitochondria in protection of the heart by preconditioning.

Journal: Biochimica et biophysica acta 20070801

Title: Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors.

Journal: The European journal of neuroscience 20070801

Title: Co-localization and functional cross-talk between A1 and P2Y1 purine receptors in rat hippocampus.

Journal: The European journal of neuroscience 20070801

Title: Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism.

Journal: PLoS genetics 20070801

Title: Changes in opioid receptor proteins during mitochondrial impairment in differentiated SK-N-SH cells.

Journal: Neuroscience letters 20070718

Title: Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070718

Title: Creatine treatment promotes differentiation of GABA-ergic neuronal precursors in cultured fetal rat spinal cord.

Journal: Journal of neuroscience research 20070701

Title: Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes.

Journal: The American journal of pathology 20070701

Title: 3-Nitropropionic acid activates calpain/cdk5 pathway in rat striatum.

Journal: Neuroscience letters 20070621

Title: Exacerbation of excitotoxic neuronal death induced during mitochondrial inhibition in vivo: relation to energy imbalance or ATP depletion?

Journal: Neuroscience 20070608

Title: Ubiquitin-proteasome system alterations in a striatal cell model of Huntington's disease.

Journal: Journal of neuroscience research 20070601

Title: Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells.

Journal: Journal of neuroscience research 20070601

Title: Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms.

Journal: Fundamental & clinical pharmacology 20070601

Title: Mutant SOD1G93A in bone marrow-derived cells exacerbates 3-nitropropionic acid induced striatal damage in mice.

Journal: Neuroscience letters 20070517

Title: Neurturin gene therapy improves motor function and prevents death of striatal neurons in a 3-nitropropionic acid rat model of Huntington's disease.

Journal: Neurobiology of disease 20070501

Title: Effect of testosterone on oxidative stress and cell damage induced by 3-nitropropionic acid in striatum of ovariectomized rats.

Journal: Life sciences 20070306

Title: Gender- and region-specific expression of insulin receptor protein in mouse brain: effect of mild inhibition of oxidative phosphorylation.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20070301

Title: Cerebellar granule neurons are more vulnerable to transient transport-mediated glutamate release than to glutamate uptake blockade. correlation with excitatory amino acids levels.

Journal: Neurochemical research 20070301

Title: Effects of 3-nitropropionic acid administration on memory and hippocampal lipid peroxidation in sleep-deprived mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070130

Title: Pharmacological MRI of stem cell transplants in the 3-nitropropionic acid-damaged striatum.

Journal: Neuroscience 20070105

Title: Transglutaminase 2 ablation leads to defective function of mitochondrial respiratory complex I affecting neuronal vulnerability in experimental models of extrapyramidal disorders.

Journal: Journal of neurochemistry 20070101

Title: Mitochondrial toxins and neurodegenerative diseases.

Journal: Frontiers in bioscience : a journal and virtual library 20070101

Title: Integrative hypothesis for Huntington's disease: a brief review of experimental evidence.

Journal: Physiological research 20070101

Title: Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage.

Journal: Mitochondrion 20070101

Title: Proteasome activator enhances survival of Huntington's disease neuronal model cells.

Journal: PloS one 20070101

Title: Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity.

Journal: Methods and findings in experimental and clinical pharmacology 20070101

Title: Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA.

Journal: BMC biology 20070101

Title: Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain.

Journal: PloS one 20070101

Title: Hyperglycemia enhances the inhibitory effect of mitochondrial toxins and D,L-homocysteine on the brain production of kynurenic acid.

Journal: Pharmacological reports : PR 20070101

Title: Early energy deficit in Huntington disease: identification of a plasma biomarker traceable during disease progression.

Journal: PloS one 20070101

Title: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Journal: BMC infectious diseases 20070101

Title: The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation.

Journal: International journal of biological sciences 20070101

Title: Animal models of Huntington's disease.

Journal: ILAR journal 20070101

Title: The functional genome of CA1 and CA3 neurons under native conditions and in response to ischemia.

Journal: BMC genomics 20070101

Title: Developmental stage of oligodendrocytes determines their response to activated microglia in vitro.

Journal: Journal of neuroinflammation 20070101

Title: Polyphasic taxonomy of Aspergillus section Candidi based on molecular, morphological and physiological data.

Journal: Studies in mycology 20070101

Title: MEK inhibition exacerbates ischemic calcium imbalance and neuronal cell death in rat cortical cultures.

Journal: European journal of pharmacology 20061228

Title: Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine.

Journal: Neuroscience letters 20061213

Title: Deficits of glutamate transmission in the striatum of toxic and genetic models of Huntington's disease.

Journal: Neuroscience letters 20061213

Title: NR2B-containing NMDA receptors promote the neurotoxic effects of 3-nitropropionic acid but not of rotenone in the striatum.

Journal: Experimental neurology 20061201

Title: Acute administration of 3-nitropropionic acid, a reactive oxygen species generator, boosts ethanol-induced locomotor stimulation. New support for the role of brain catalase in the behavioural effects of ethanol.

Journal: Neuropharmacology 20061201

Title: Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease.

Journal: Neurobiology of disease 20061201

Title: Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease.

Journal: Brain research 20061106

Title: D-beta-hydroxybutyrate protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease.

Journal: Journal of neuroscience research 20061101

Title: Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.

Journal: Cell metabolism 20061101

Title: Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20061101

Title: Infant mice with glutaric acidaemia type I have increased vulnerability to 3-nitropropionic acid toxicity.

Journal: Journal of inherited metabolic disease 20061001

Title: Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells.

Journal: Mitochondrion 20061001

Title: Involvement of nitric oxide in 3-nitropropionic acid-induced striatal toxicity in rats.

Journal: Brain research 20060907

Title: Increased 'vigilance' of antioxidant mechanisms in neural stem cells potentiates their capability to resist oxidative stress.

Journal: Stem cells (Dayton, Ohio) 20060901

Title: S-Allylcysteine prevents the rat from 3-nitropropionic acid-induced hyperactivity, early markers of oxidative stress and mitochondrial dysfunction.

Journal: Neuroscience research 20060901

Title: Effect of transcranial magnetic stimulation on oxidative stress induced by 3-nitropropionic acid in cortical synaptosomes.

Journal: Neuroscience research 20060901

Title: Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms.

Journal: Behavioural pharmacology 20060901

Title: Differential effects of impaired mitochondrial energy production on the function of mu and delta opioid receptors in neuronal SK-N-SH cells.

Journal: Neuroscience letters 20060814

Title: Effects of L-carnitine pretreatment in methamphetamine and 3-nitropropionic acid-induced neurotoxicity.

Journal: Annals of the New York Academy of Sciences 20060801

Title: The stamp of ancestry: roots of behavioral and neuronal impairment in adulthood.

Journal: Experimental neurology 20060701

Title: Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development.

Journal: Fungal genetics and biology : FG & B 20060701

Title: Mitochondrial inhibition prior to oxygen-withdrawal facilitates the occurrence of hypoxia-induced spreading depression in rat hippocampal slices.

Journal: Journal of neurophysiology 20060701

Title: Ischemic tolerance in chemical preconditioning: possible role of astrocytic glutamine synthetase buffering glutamate-mediated neurotoxicity.

Journal: Journal of neuroscience research 20060701

Title: Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060701

Title: Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.

Journal: The Journal of biological chemistry 20060616

Title: Longevity in mice: is stress resistance a common factor?

Journal: Age (Dordrecht, Netherlands) 20060601

Title: Caspase-dependent and -independent cell death induced by 3-nitropropionic acid in rat cortical neurons.

Journal: Journal of cellular biochemistry 20060501

Title: The role of peroxynitrite in chemical preconditioning with 3-nitropropionic acid in rat hearts.

Journal: Cardiovascular research 20060501

Title: Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3-nitropropionic model of Huntington's disease.

Journal: Journal of neurochemistry 20060501

Title: Brain mitochondrial defects amplify intracellular [Ca2+] rise and neurodegeneration but not Ca2+ entry during NMDA receptor activation.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity.

Journal: The European journal of neuroscience 20060501

Title: Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons.

Journal: Neurobiology of disease 20060401

Title: 17 beta-Estradiol may affect vulnerability of striatum in a 3-nitropropionic acid-induced experimental model of Huntington's disease in ovariectomized rats.

Journal: Neurochemistry international 20060401

Title: Endotoxin preconditioning protects neurones from in vitro ischemia: role of endogenous IL-1beta and TNF-alpha.

Journal: Journal of neuroimmunology 20060401

Title: Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells.

Journal: The European journal of neuroscience 20060401

Title: [The research of the pathogen responsible for Pleurocybella porrigens related encephalopathy: investigation of 3-nitropropionic acid hypothesis].

Journal: No to shinkei = Brain and nerve 20060401

Title: Lactate dehydrogenase activity is inhibited by methylmalonate in vitro.

Journal: Neurochemical research 20060401

Title: 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.

Journal: The Journal of biological chemistry 20060303

Title: Mice lacking alpha-synuclein are resistant to mitochondrial toxins.

Journal: Neurobiology of disease 20060301

Title: Metabolic insights into the hepatoprotective role of N-acetylcysteine in mouse liver.

Journal: Hepatology (Baltimore, Md.) 20060301

Title: Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools.

Journal: Biochemical pharmacology 20060214

Title: Mechanisms of hypoxic tolerance in presymptomatic APP23 transgenic mice.

Journal: Mechanisms of ageing and development 20060201

Title: [Aristolochic acid nephropathy and acute encephalopathy related to Pleurocybella porrigens (Sugihiratake)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060201

Title: Protective effect of S-allylcysteine on 3-nitropropionic acid-induced lipid peroxidation and mitochondrial dysfunction in rat brain synaptosomes.

Journal: Brain research bulletin 20060130

Title: Alterations in the cortical and peripheral somatosensory evoked activity of rats treated with 3-nitropropionic acid.

Journal: Toxicology letters 20060125

Title: UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060101

Title: Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease.

Journal: Neurochemistry international 20060101

Title: Growth inhibition by nitrocompounds of selected uric acid-utilizing microorganisms isolated from poultry manure.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20060101

Title: The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report.

Journal: BMC cancer 20060101

Title: Preservation of striatal tissue and behavioral function after neural stem cell transplantation in a rat model of Huntington's disease.

Journal: Neuroscience 20060101

Title: [Hairy root induction and plant regeneration of crownvetch (Coronilla varia L.) transformed by Agrobacterium rhizogenes].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20060101

Title: Delayed postconditionig initiates additive mechanism necessary for survival of selectively vulnerable neurons after transient ischemia in rat brain.

Journal: Cellular and molecular neurobiology 20060101

Title: Melatonin in Alzheimer's disease and other neurodegenerative disorders.

Journal: Behavioral and brain functions : BBF 20060101

Title: The changes in endogenous antioxidant enzyme activity after postconditioning.

Journal: Cellular and molecular neurobiology 20060101

Title: Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices.

Journal: Respiratory research 20060101

Title: Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets.

Journal: Theoretical biology & medical modelling 20060101

Title: 3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism.

Journal: Hippocampus 20060101

Title: Involvement of calpain activation in neurodegenerative processes.

Journal: CNS drug reviews 20060101

Title: Genetic analysis of the GRIK2 modifier effect in Huntington's disease.

Journal: BMC neuroscience 20060101

Title: Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics.

Journal: Journal of biomedicine & biotechnology 20060101

Title: Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function.

Journal: BMC neuroscience 20060101

Title: Cerebral ischemic tolerance induced by 3-nitropropionic acid is associated with increased expression of erythropoietin in rats.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

Title: The acute effects of 3-nitropropionic acid on the behavior and spontaneous cortical electrical activity of rats.

Journal: Acta neurobiologiae experimentalis 20060101

Title: Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.

Journal: BMC neuroscience 20060101

Title: Inhibition of mitochondrial complex II affects dopamine metabolism and decreases its uptake into striatal synaptosomes.

Journal: Folia neuropathologica 20060101

Title: Mitochondrial toxins in Basal Ganglia disorders: from animal models to therapeutic strategies.

Journal: Current neuropharmacology 20060101

Title: Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival.

Journal: The Journal of biological chemistry 20051209

Title: 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.

Journal: Journal of neurochemistry 20051201

Title: Effects of 3-nitropropionic acid in rats: general toxicity and functional neurotoxicity.

Journal: Arhiv za higijenu rada i toksikologiju 20051201

Title: Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype.

Journal: Pharmacology, biochemistry, and behavior 20051101

Title: Evidence for a role of second pathophysiological stress in prevention of delayed neuronal death in the hippocampal CA1 region.

Journal: Neurochemical research 20051101

Title: Effects of mitochondrial toxins on the brain amino acid concentrations.

Journal: Neurochemical research 20051101

Title: Behavioral alterations in Lewis rats following two-day continuous 3-nitropropionic acid administration.

Journal: Neurotoxicity research 20051101

Title: Differential effects of sublethal ischemia and chemical preconditioning with 3-nitropropionic acid on protein expression in gerbil hippocampus.

Journal: Life sciences 20051021

Title: The histaminergic signaling system exerts a neuroprotective role against neurodegenerative-induced processes in the hamster.

Journal: The Journal of pharmacology and experimental therapeutics 20051001

Title: Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain.

Journal: Neuropharmacology 20051001

Title: Effects of creatine treatment on survival and differentiation of GABA-ergic neurons in cultured striatal tissue.

Journal: Journal of neurochemistry 20051001

Title: [Animal models of parkinsonism].

Journal: Revue neurologique 20051001

Title: Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats.

Journal: Brain research bulletin 20050930

Title: A potential role for beta- and gamma-crystallins in the vascular remodeling of the eye.

Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20050901

Title: Depressant effect of mitochondrial respiratory complex inhibitors on proteasome inhibitor-induced mitochondrial dysfunction and cell death in PC12 cells.

Journal: Neurochemical research 20050901

Title: Mitochondrial regulation of insulin production in rat pancreatic islets.

Journal: Diabetologia 20050801

Title: Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity.

Journal: Journal of neurochemistry 20050801

Title: Identification of rat hippocampal mRNAs altered by the mitochondrial toxicant, 3-NPA.

Journal: Annals of the New York Academy of Sciences 20050801

Title: L-carnitine and neuroprotection in the animal model of mitochondrial dysfunction.

Journal: Annals of the New York Academy of Sciences 20050801

Title: Effects of metabolic modifiers such as carnitines, coenzyme Q10, and PUFAs against different forms of neurotoxic insults: metabolic inhibitors, MPTP, and methamphetamine.

Journal: Annals of the New York Academy of Sciences 20050801

Title: Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria.

Journal: Brain research bulletin 20050730

Title: The critical threshold of 3-nitropropionic acid-induced ischemic tolerance in the rat.

Journal: Brain research 20050719

Title: Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease.

Journal: Brain research 20050719

Title: Crystal structure of mitochondrial respiratory membrane protein complex II.

Journal: Cell 20050701

Title: Inducible neuronal expression of transgenic TGF-beta1 in vivo: dissection of short-term and long-term effects.

Journal: The European journal of neuroscience 20050701

Title: 3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: is 3-NPA in some plants produced by endophytes?

Journal: Journal of natural products 20050701

Title: The differential JunB responses to inhibition of succinate dehydrogenase in rat hippocampus and liver.

Journal: Neuroscience letters 20050624

Title: Altered distribution of striatal activity-dependent synaptic plasticity in the 3-nitropropionic acid model of Huntington's disease.

Journal: Brain research 20050621

Title: Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo.

Journal: The Journal of biological chemistry 20050617

Title: Melatonin protects against neuronal damage induced by 3-nitropropionic acid in rat striatum.

Journal: Brain research 20050607

Title: Treatment with dehydroepiandrosterone prevents oxidative stress induced by 3-nitropropionic acid in synaptosomes.

Journal: Pharmacology 20050601

Title: Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence.

Journal: Nature medicine 20050601

Title: Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade.

Journal: Purinergic signalling 20050601

Title: The nature of the stimulus and of the fumarate binding site of the fumarate sensor DcuS of Escherichia coli.

Journal: The Journal of biological chemistry 20050527

Title: Effects of riluzole on combined MPTP + 3-nitropropionic acid-induced mild to moderate striatonigral degeneration in mice.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20050501

Title: Induction of hypoxia inducible factor-1 attenuates metabolic insults induced by 3-nitropropionic acid in rat C6 glioma cells.

Journal: Journal of neurochemistry 20050501

Title: Protective effects of ginseng components in a rodent model of neurodegeneration.

Journal: Annals of neurology 20050501

Title: Grafted neural stem cells shield the host environment from oxidative stress.

Journal: Annals of the New York Academy of Sciences 20050501

Title: Functional neurotoxic effects in rats elicited by 3-nitropropionic acid in acute and subacute administration.

Journal: Environmental toxicology and pharmacology 20050501

Title: Susceptibility to excitotoxic and metabolic striatal neurodegeneration in the mouse is genotype dependent.

Journal: Brain research 20050408

Title: Regional selectivity of amyloid mRNA expression and neurotrophins on repetitive inhibition of oxidative phosphorylation.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20050401

Title: Protective effects of ginseng saponins on 3-nitropropionic acid-induced striatal degeneration in rats.

Journal: Neuropharmacology 20050401

Title: Toxicity and metabolism of the conjugates of 3-nitropropanol and 3-nitropropionic acid in forages poisonous to livestock.

Journal: Journal of agricultural and food chemistry 20050323

Title: Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy.

Journal: The American journal of pathology 20050301

Title: Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons.

Journal: Brain research 20050221

Title: 3-nitropropionic acid-induced hydrogen peroxide, mitochondrial DNA damage, and cell death are attenuated by Bcl-2 overexpression in PC12 cells.

Journal: Brain research. Molecular brain research 20050218

Title: Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat.

Journal: Brain research. Molecular brain research 20050218

Title: Minocycline in phenotypic models of Huntington's disease.

Journal: Neurobiology of disease 20050201

Title: Acute effects of pulsed microwaves and 3-nitropropionic acid on neuronal ultrastructure in the rat caudate-putamen.

Journal: Bioelectromagnetics 20050201

Title: Paradoxical increase in 3-nitropropionic acid neurotoxicity by alpha-phenyl-tert-butyl-nitrone, a spin-trapping agent.

Journal: Chang Gung medical journal 20050201

Title: Scope and limitations of the nitro-Mannich reaction for the stereoselective synthesis of 1,2-diamines.

Journal: The Journal of organic chemistry 20050121

Title: 3-nitropropionic acid model of metabolic stress: assessment by magnetic resonance imaging.

Journal: Methods in molecular medicine 20050101

Title: Adenosine A1 receptors and the anticonvulsant potential of drugs effective in the model of 3-nitropropionic acid-induced seizures in mice.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050101

Title: A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities.

Journal: Experimental neurology 20050101

Title: Neurotrophic factor expression after focal brain ischemia preceded by different preconditioning strategies.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20050101

Title: Permanent threshold shift caused by acute cochlear mitochondrial dysfunction is primarily mediated by degeneration of the lateral wall of the cochlea.

Journal: Audiology & neuro-otology 20050101

Title: Gait dynamics in mouse models of Parkinson's disease and Huntington's disease.

Journal: Journal of neuroengineering and rehabilitation 20050101

Title: Overexpression of Bcl-xl protects septal neurons from prolonged hypoglycemia and from acute ischemia-like stress.

Journal: Neuroscience 20050101

Title: Chemical preconditioning by 3-nitropropionic acid reduces ischemia-reperfusion injury in rat heart.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

Title: FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures.

Journal: Neurobiology of disease 20041201

Title: Nicotinic receptor modulation for neuroprotection and enhancement of functional recovery following brain injury or disease.

Journal: Annals of the New York Academy of Sciences 20041201

Title: Effect of nicotine on 3-nitropropionic acid-induced oxidative stress in synaptosomes.

Journal: European journal of pharmacology 20041119

Title: The mitochondrial toxin, 3-nitropropionic acid, induces extracellular Zn2+ accumulation in rat hippocampus slices.

Journal: Neuroscience letters 20041111

Title: A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo.

Journal: Neurobiology of disease 20041101

Title: Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease.

Journal: Journal of pineal research 20041101

Title: Potential involvement of cannabinoid receptors in 3-nitropropionic acid toxicity in vivo.

Journal: Neuroreport 20041025

Title: Creatine protects against 3-nitropropionic acid-induced cell death in murine corticostriatal slice cultures.

Journal: Brain research 20041022

Title: Menadione reduces rotenone-induced cell death in cerebellar granule neurons.

Journal: Neuroreport 20041005

Title: Influence of chemical and ischemic preconditioning on cytokine expression after focal brain ischemia.

Journal: Journal of neuroscience research 20041001

Title: Increased Alix (apoptosis-linked gene-2 interacting protein X) immunoreactivity in the degenerating striatum of rats chronically treated by 3-nitropropionic acid.

Journal: Neuroscience letters 20040930

Title: Neuroprotective effect of L-carnitine in the 3-nitropropionic acid (3-NPA)-evoked neurotoxicity in rats.

Journal: Neuroscience letters 20040902

Title: Mitochondrial permeability transition in neuronal damage promoted by Ca2+ and respiratory chain complex II inhibition.

Journal: Journal of neurochemistry 20040901

Title: Antioxidant effects of taurine, vitamin C, and vitamin E on oxidative damage in hippocampus caused by the administration of 3-nitropropionic acid in rats.

Journal: The International journal of neuroscience 20040901

Title: Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury.

Journal: The Journal of biological chemistry 20040813

Title: The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism.

Journal: Journal of neurochemistry 20040801

Title: Strain dependence of receptor regulation on chemical preconditioning in mice hippocampus.

Journal: Neuroscience letters 20040729

Title: A novel animal model of acute cochlear mitochondrial dysfunction.

Journal: Neuroreport 20040719

Title: Nitrification by plants that also fix nitrogen.

Journal: Nature 20040701

Title: Altered oxidative stress response of the long-lived Snell dwarf mouse.

Journal: Biochemical and biophysical research communications 20040611

Title: 3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy.

Journal: Journal of neurochemistry 20040601

Title: Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease.

Journal: Neurobiology of disease 20040601

Title: Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease.

Journal: The European journal of neuroscience 20040601

Title: Protective effects of S-nitrosoglutathione against neurotoxicity of 3-nitropropionic acid in rat.

Journal: Neuroscience letters 20040527

Title: Induction of corticostriatal LTP by 3-nitropropionic acid requires the activation of mGluR1/PKC pathway.

Journal: Neuropharmacology 20040501

Title: Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway.

Journal: Human molecular genetics 20040401

Title: Production of toxic metabolites in Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei: justification of mycotoxin testing in food grade enzyme preparations derived from the three fungi.

Journal: Regulatory toxicology and pharmacology : RTP 20040401

Title: Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history.

Journal: Neurobiology of disease 20040401

Title: Effect of glucocorticoids on 3-nitropropionic acid-induced oxidative stress in synaptosomes.

Journal: European journal of pharmacology 20040319

Title: Inhibition of mitochondrial complex II alters striatal expression of genes involved in glutamatergic and dopaminergic signaling: possible implications for Huntington's disease.

Journal: Neurobiology of disease 20040301

Title: Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.

Journal: Journal of neurochemistry 20040301

Title: Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid.

Journal: Journal of neurochemistry 20040301

Title: Genetic and pharmacological inactivation of the adenosine A2A receptor attenuates 3-nitropropionic acid-induced striatal damage.

Journal: Journal of neurochemistry 20040201

Title: Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms.

Journal: Neurobiology of disease 20040201

Title: Magnetic resonance imaging and spectroscopy in assessing 3-nitropropionic acid-induced brain lesions: an animal model of Huntington's disease.

Journal: Progress in neurobiology 20040201

Title: Chronic intoxication with 3-nitropropionic acid in rats induces the loss of striatal dopamine terminals without affecting nigral cell viability.

Journal: Neuroscience letters 20040116

Title: MPTP potentiates 3-nitropropionic acid-induced striatal damage in mice: reference to striatonigral degeneration.

Journal: Experimental neurology 20040101

Title: Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease.

Journal: Molecular and cellular neurosciences 20040101

Title: Sertoli cell grafts for Huntington's disease. An opinion.

Journal: Neurotoxicity research 20040101

Title: Chronic memantine does not block 3-nitropropionic acid-delayed ischaemic tolerance in rat hippocampal slices ex vivo.

Journal: Neurotoxicity research 20040101

Title: Involvement of apoptosis in 3-nitropropionic acid-induced ischemic tolerance to transient focal cerebral ischemia in rats.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101

Title: Differential depression of spinal synaptic transmission in vitro by different hypoxic insults.

Journal: Indian journal of experimental biology 20040101

Title: Pharmacological preconditioning in global cerebral ischemia.

Journal: Acta neurochirurgica. Supplement 20040101

Title: Hypoxic increase in nitric oxide generation of rat sensory neurons requires activation of mitochondrial complex II and voltage-gated calcium channels.

Journal: Neuroscience 20040101

Title: Inhibition of caspase-3 activation and apoptosis is involved in 3-nitropropionic acid-induced ischemic tolerance to transient focal cerebral ischemia in rats.

Journal: Journal of molecular neuroscience : MN 20040101

Title: Neurotoxins and neurotoxic species implicated in neurodegeneration.

Journal: Neurotoxicity research 20040101

Title: Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease.

Journal: Brain research 20031219

Title: Glutamate uptake inhibitor L-trans-pyrrolidine 2,4-dicarboxylate becomes neurotoxic in the presence of subthreshold concentrations of mitochondrial toxin 3-nitropropionate: involvement of mitochondrial reducing activity and ATP production.

Journal: Journal of neuroscience research 20031215

Title: Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs.

Journal: American journal of respiratory cell and molecular biology 20031201

Title: Bcl-2 prevents loss of cell viability and caspase activation induced by 3-nitropropionic acid in GT1-7 cells.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons.

Journal: Journal of neurochemistry 20031101

Title: In vivo calpain/caspase cross-talk during 3-nitropropionic acid-induced striatal degeneration: implication of a calpain-mediated cleavage of active caspase-3.

Journal: The Journal of biological chemistry 20031031

Title: 3-Nitropropionic acid increases frataxin expression in human lymphoblasts and in transgenic rat PC12 cells.

Journal: Neuroscience letters 20031030

Title: Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20031015

Title: Neuroprotection and neuronal dysfunction upon repetitive inhibition of oxidative phosphorylation.

Journal: Experimental neurology 20031001

Title: Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption?

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030924

Title: Chemical preconditioning prevents paradoxical increase in glutamate release during ischemia by activating ATP-dependent potassium channels in gerbil hippocampus.

Journal: Experimental neurology 20030901

Title: Type I glutaric aciduria, part 2: a model of acute striatal necrosis.

Journal: American journal of medical genetics. Part C, Seminars in medical genetics 20030815

Title: Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy).

Journal: Acta neuropathologica 20030801

Title: Differential responsiveness of rat striatal nerve endings to the mitochondrial toxin 3-nitropropionic acid: implications for Huntington's disease.

Journal: The European journal of neuroscience 20030801

Title: Influence of cytosolic and mitochondrial Ca2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid.

Journal: Neurochemistry international 20030701

Title: Alpha-synuclein protects naive but not dbcAMP-treated dopaminergic cell types from 1-methyl-4-phenylpyridinium toxicity.

Journal: Journal of neurochemistry 20030701

Title: GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insults.

Journal: The Journal of comparative neurology 20030630

Title: Calpain is a major cell death effector in selective striatal degeneration induced in vivo by 3-nitropropionate: implications for Huntington's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615

Title: A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615

Title: The effect on motor cortical neuronal development of focal lesions to the sub-cortical white matter in the neonatal rat: a model for periventricular leukomalacia.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20030601

Title: Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF.

Journal: Experimental neurology 20030601

Title: 1,3-Dinitrobenzene inhibits mitochondrial complex II in rat and mouse brainstem and cortical astrocytes.

Journal: Neurotoxicology 20030601

Title: Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid.

Journal: Mechanisms of ageing and development 20030601

Title: Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology.

Journal: Journal of neuropathology and experimental neurology 20030601

Title: Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030501

Title: Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030501

Title: Possible mechanism for the neuroprotective effects of L-carnitine on methamphetamine-evoked neurotoxicity.

Journal: Annals of the New York Academy of Sciences 20030501

Title: Neuroprotective effects of L-carnitine in induced mitochondrial dysfunction.

Journal: Annals of the New York Academy of Sciences 20030501

Title: 3-nitropropionic acid inhibition of succinate dehydrogenase (complex II) activity in cultured Chinese hamster ovary cells: antagonism by L-carnitine.

Journal: Annals of the New York Academy of Sciences 20030501

Title: Opening of mitochondrial ATP-sensitive potassium channels is a trigger of 3-nitropropionic acid-induced tolerance to transient focal cerebral ischemia in rats.

Journal: Stroke 20030401

Title: Quantitative on-line monitoring of hippocampus glucose and lactate metabolism in organotypic cultures using biosensor technology.

Journal: Journal of neurochemistry 20030401

Title: Neuroprotective effects of (+/-)-huprine Y on in vitro and in vivo models of excitoxicity damage.

Journal: Experimental neurology 20030401

Title: Knockout of p75NTR does not alter the viability of striatal neurons following a metabolic or excitotoxic injury.

Journal: Journal of molecular neuroscience : MN 20030401

Title: Differential regulation of 5' splice variants of the glutamate transporter EAAT2 in an in vivo model of chemical hypoxia induced by 3-nitropropionic acid.

Journal: Journal of neuroscience research 20030315

Title: Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice.

Journal: Human molecular genetics 20030301

Title: Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.

Journal: Journal of neurochemistry 20030301

Title: Microglial activation and cell death induced by the mitochondrial toxin 3-nitropropionic acid: in vitro and in vivo studies.

Journal: Neurobiology of disease 20030301

Title: Mitochondrial complex inhibitors preferentially damage substantia nigra dopamine neurons in rat brain slices.

Journal: Experimental neurology 20030101

Title: Polycyclic phenols, estrogens and neuroprotection: a proposed mitochondrial mechanism.

Journal: Experimental gerontology 20030101

Title: Homocysteine-induced brain lipid peroxidation: effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition.

Journal: Neurotoxicity research 20030101

Title: FK506 attenuates 1-methyl-4-phenylpyridinium- and 3-nitropropionic acid-evoked inhibition of kynurenic acid synthesis in rat cortical slices.

Journal: Acta neurobiologiae experimentalis 20030101

Title: Mitochondrial complex II is essential for hypoxia-induced ROS generation and vasoconstriction in the pulmonary vasculature.

Journal: Advances in experimental medicine and biology 20030101

Title: Mitochondrial complex I inhibition produces selective damage to hippocampal subfield CA1 in organotypic slice cultures.

Journal: Neurotoxicity research 20030101

Title: Effects of Sertoli cell transplants in a 3-nitropropionic acid model of early Huntington's disease: a preliminary study.

Journal: Neurotoxicity research 20030101

Title: Dystonia is predictive of subsequent altered dopaminergic responsiveness in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine+3-nitropropionic acid model of striatonigral degeneration in monkeys.

Journal: Neuroscience letters 20021219

Title: Estrogen blocks 3-nitropropionic acid-induced Ca2+i increase and cell damage in cultured rat cerebral endothelial cells.

Journal: Brain research 20021122

Title: Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons.

Journal: The Journal of biological chemistry 20021018

Title: The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20021015

Title: 1-Methyl-4-phenylpyridinium and 3-nitropropionic acid diminish cortical synthesis of kynurenic acid via interference with kynurenine aminotransferases in rats.

Journal: Neuroscience letters 20020913

Title: Analysis of mitochondrial free radical generation in animal models of neuronal disease.

Journal: Free radical biology & medicine 20020901

Title: The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid.

Journal: Mechanisms of ageing and development 20020901

Title: Effect of 3-nitropropionic acid on kynurenine aminotransferase in the rat brain.

Journal: Experimental neurology 20020901

Title: 3-Nitropropionic acid induces cell death and mitochondrial dysfunction in rat corticostriatal slice cultures.

Journal: Neuroscience letters 20020823

Title: Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020801

Title: Striatal and cortical neurochemical changes induced by chronic metabolic compromise in the 3-nitropropionic model of Huntington's disease.

Journal: Neurobiology of disease 20020801

Title: Decreased TCA cycle rate in the rat brain after acute 3-NP treatment measured by in vivo 1H-[13C] NMR spectroscopy.

Journal: Journal of neurochemistry 20020801

Title: Reduction of Alamar Blue, a novel redox indicator, is dependent on both the glycolytic and oxidative metabolism of glucose in rat cultured neurons.

Journal: Neuroscience letters 20020705

Title: The differential vulnerability of striatal projection neurons in 3-nitropropionic acid-treated rats does not match that typical of adult-onset Huntington's disease.

Journal: Experimental neurology 20020701

Title: beta-Amyloid neurotoxicity is exacerbated during glycolysis inhibition and mitochondrial impairment in the rat hippocampus in vivo and in isolated nerve terminals: implications for Alzheimer's disease.

Journal: Experimental neurology 20020701

Title: 3-Nitropropionic acid neurotoxicity in hippocampal slice cultures: developmental and regional vulnerability and dependency on glucose.

Journal: Experimental neurology 20020701

Title: Mice overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid.

Journal: Experimental neurology 20020701

Title: Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020701

Title: Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degeneration.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020601

Title: Dopamine transporter knock-out mice are hypersensitive to 3-nitropropionic acid-induced striatal damage.

Journal: The European journal of neuroscience 20020601

Title: A method to assay glyoxylate cycle inhibitors for antifungals.

Journal: The Journal of antibiotics 20020601

Title: 3-nitropropionic acid-induced changes in bilayer fluidity in synaptosomal membranes: implications for Huntington's disease.

Journal: Neurochemical research 20020601

Title: Chemical preconditioning with 3-nitropropionic acid: lack of induction of neuronal tolerance in gerbil hippocampus subjected to transient forebrain ischemia.

Journal: Brain research bulletin 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Mitochondrial toxin inhibition of [(3)H]dopamine uptake into rat striatal synaptosomes.

Journal: Biochemical pharmacology 20020415

Title: Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.

Journal: Synapse (New York, N.Y.) 20020401

Title: Gender-dependent hypoxic tolerance mediated via gender-specific mechanisms.

Journal: Journal of neuroscience research 20020401

Title: [Huntington disease].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020401

Title: Coenzyme Q10 as a possible treatment for neurodegenerative diseases.

Journal: Free radical research 20020401

Title: Evaluation of 3-nitrotyrosine as a marker for 3-nitropropionic acid-induced oxidative stress in Lewis and Wistar rats and strain-specific whole brain spheroid cultures.

Journal: Brain research 20020322

Title: Excitotoxic and metabolic damage to the rodent striatum: role of the P75 neurotrophin receptor and glial progenitors.

Journal: The Journal of comparative neurology 20020318

Title: The mitochondrial toxin 3-nitropropionic acid induces striatal neurodegeneration via a c-Jun N-terminal kinase/c-Jun module.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020315

Title: Modulation of apoptotic regulatory proteins and early activation of cytochrome C following systemic 3-nitropropionic acid administration.

Journal: Brain research bulletin 20020315

Title: ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus.

Journal: Neuroscience letters 20020301

Title: Hypoxic tolerance induction in rat brain slices following 3-nitropropionic acid pretreatment as revealed by dynamic changes in glucose metabolism.

Journal: Neuroscience letters 20020215

Title: Immediate-early gene response to methamphetamine, haloperidol, and quinolinic acid is not impaired in Huntington's disease transgenic mice.

Journal: Journal of neuroscience research 20020201

Title: The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020201

Title: Partial ablations of the flocculus and ventral paraflocculus in monkeys cause linked deficits in smooth pursuit eye movements and adaptive modification of the VOR.

Journal: Journal of neurophysiology 20020201

Title: Evaluation of neuronal cell death by laser scanning cytometry.

Journal: Brain research. Brain research protocols 20020201

Title: A simple method to measure stride length as an index of nigrostriatal dysfunction in mice.

Journal: Journal of neuroscience methods 20020130

Title: Behavioral and morphological comparison of two nonhuman primate models of Huntington's disease.

Journal: Neurosurgery 20020101

Title: The mechanisms of neuronal death produced by mitochondrial toxin 3-nitropropionic acid: the roles of N-methyl-D-aspartate glutamate receptors and mitochondrial calcium overload.

Journal: Neuroscience 20020101

Title: Acute and chronic alterations in calcium homeostasis in 3-nitropropionic acid-treated human NT2-N neurons.

Journal: Neuroscience 20020101

Title: Impaired hypoxic tolerance and altered protein binding of NADH in presymptomatic APP23 transgenic mice.

Journal: Neuroscience 20020101

Title: Subacute systemic 3-nitropropionic acid intoxication induces a distinct motor disorder in adult C57Bl/6 mice: behavioural and histopathological characterisation.

Journal: Neuroscience 20020101

Title: Increased neuronal hypoxic tolerance induced by repetitive chemical hypoxia.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20020101

Title: Neuroprotective role of L-carnitine in the 3-nitropropionic acid induced neurotoxicity.

Journal: Toxicology letters 20011215

Title: Elucidation of the quantitative significance of pyruvate carboxylation in cultured cerebellar neurons and astrocytes.

Journal: Journal of neuroscience research 20011201

Title: Excretion of miserotoxin and detoxification of the aglycone by grasshoppers (Orthoptera: Acrididae).

Journal: Phytochemistry 20011101

Title: Perseverative behavior underlying attentional set-shifting deficits in rats chronically treated with the neurotoxin 3-nitropropionic acid.

Journal: Experimental neurology 20011101

Title: Inhibition of glutamate uptake into synaptic vesicles from rat brain by 3-nitropropionic acid in vitro.

Journal: Experimental neurology 20011101

Title: Concentrations of different sterols in the striatum and serum of 3-nitropropionic acid-treated Wistar and Lewis rats.

Journal: Neurochemical research 20011101

Title: A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease.

Journal: Experimental neurology 20011001

Title: Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice.

Journal: The American journal of pathology 20011001

Title: Fluoro-Jade and silver methods: application to the neuropathology of scrapie, a transmissible spongiform encephalopathy.

Journal: Brain research. Brain research protocols 20011001

Title: Phospholipid fatty acids and neurotoxicity in human neuroblastoma SH-SY5Y cells.

Journal: Neuroscience letters 20010831

Title: In vivo hydroxyl radical formation after quinolinic acid infusion into rat corpus striatum.

Journal: Neuroreport 20010828

Title: Taurine increases rat survival and reduces striatal damage caused by 3-nitropropionic acid.

Journal: The International journal of neuroscience 20010801

Title: Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease.

Journal: Neuroreport 20010720

Title: Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010715

Title: Topological analysis of striatal lesions induced by 3-nitropropionic acid in the Lewis rat.

Journal: Neuroreport 20010613

Title: Protective effect of adenosine receptor agonists in a new model of epilepsy--seizures evoked by mitochondrial toxin, 3-nitropropionic acid, in mice.

Journal: Neuroscience letters 20010608

Title: Effect of L-carnitine pretreatment on 3-nitropropionic acid-induced inhibition of rat brain succinate dehydrogenase activity.

Journal: Annals of the New York Academy of Sciences 20010601

Title: Biomarkers of 3-nitropropionic acid (3-NPA)-induced mitochondrial dysfunction as indicators of neuroprotection.

Journal: Annals of the New York Academy of Sciences 20010601

Title: Strategies for neuroprotection against L-trans-2,4-pyrrolidine dicarboxylate-induced neuronal damage during energy impairment in vitro.

Journal: Journal of neuroscience research 20010515

Title: Manganese toxicity is associated with mitochondrial dysfunction and DNA fragmentation in rat primary striatal neurons.

Journal: Brain research bulletin 20010515

Title: Chemical preconditioning with 3-nitropropionic acid in hearts: role of mitochondrial K(ATP) channel.

Journal: American journal of physiology. Heart and circulatory physiology 20010501

Title: Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells.

Journal: Journal of neurochemistry 20010501

Title: Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPTP and 3-nitropropionic acid.

Journal: Experimental neurology 20010401

Title: N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.

Journal: Journal of neurochemistry 20010401

Title: Glucose deprivation and chemical hypoxia: neuroprotection by P2 receptor antagonists.

Journal: Neurochemistry international 20010301

Title: [Neuroprotective effect of a neurotoxin, 3-nitropropionic acid, against hypoxic damage to the gerbil hippocampus: neuroprotection after the onset of hypoxic depolarization].

Journal: No to shinkei = Brain and nerve 20010301

Title: Contamination of food with mycotoxins and human health.

Journal: Arhiv za higijenu rada i toksikologiju 20010301

Title: White matter damage following systemic injection of the mitochondrial inhibitor 3-nitropropionic acid in rat.

Journal: Brain research 20010223

Title: Chemical preconditioning in mice is not mediated by upregulation of nitric oxide synthase isoforms.

Journal: Neuroscience letters 20010216

Title: 'Chemical preconditioning' by 3-nitropropionate reduces ischemia-reperfusion injury in cardiac-arrested rat lungs.

Journal: Transplantation 20010215

Title: Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo.

Journal: British journal of pharmacology 20010201

Title: Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum.

Journal: Neurobiology of disease 20010201

Title: The mitochondrial toxin 3-nitropropionic acid induces differential expression patterns of apoptosis-related markers in rat striatum.

Journal: Neuropathology and applied neurobiology 20010201

Title: Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010101

Title: Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.

Journal: Experimental neurology 20010101

Title: On the mechanisms of neuroprotection by creatine and phosphocreatine.

Journal: Journal of neurochemistry 20010101

Title: No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy).

Journal: Neuroscience 20010101

Title: Behavioural correlates of striatal glial fibrillary acidic protein in the 3-nitropropionic acid rat model: disturbed walking pattern and spatial orientation.

Journal: Neuroscience 20010101

Title: Neurotoxicity of glutamate uptake inhibition in vivo: correlation with succinate dehydrogenase activity and prevention by energy substrates.

Journal: Neuroscience 20010101

Title: Neuronal ectopic expression of tyrosine hydroxylase in the mouse striatum by combined administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 3-nitropropionic acid.

Journal: Neuroscience 20010101

Title: Neurotoxicology of the brain barrier system: new implications.

Journal: Journal of toxicology. Clinical toxicology 20010101

Title: Effect of adenosine receptor agonists on neurodegenerative and convulsive activity of mitochondrial toxin, 3-nitropropionic acid.

Journal: Polish journal of pharmacology 20010101

Title: Brain tolerance and preconditioning.

Journal: Polish journal of pharmacology 20010101

Title: Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition.

Journal: Journal of neurochemistry 20001201

Title: Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease.

Journal: Journal of molecular neuroscience : MN 20000801

Title: Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.

Journal: Annals of tropical medicine and parasitology 19961201

Title: [Studies on the potentiation of the antibiotics contained in Prednobiotad].

Journal: DTW. Deutsche tierarztliche Wochenschrift 19760105

Title: Huang LS, et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J Biol Chem. 2006 Mar 3;281(9):5965-72.

Title: Chomcheon P, et al. 3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: is 3-NPA in some plants produced by endophytes? J Nat Prod. 2005 Jul;68(7):1103-5.

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