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51596-11-3,MFCD04972570
Catalog No.:AA006UQ9

51596-11-3 | Milbemycin A4

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Purity
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Quantity
  
1mg
≥85%
in stock  
$608.00   $425.00
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5mg
≥85%
in stock  
$1,663.00   $1,164.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006UQ9
Chemical Name:
Milbemycin A4
CAS Number:
51596-11-3
Molecular Formula:
C32H46O7
Molecular Weight:
542.7034
MDL Number:
MFCD04972570
SMILES:
CCC1OC2(CCC1C)CC1CC(O2)CC=C(C)CC(C)C=CC=C2C3(C(C(=O)O1)C=C(C)C(C3OC2)O)O
Properties
Computed Properties
 
Complexity:
1060  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
3  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
3.6  

Literature

Title: Identification of a nonsense mutation in feline ABCB1.

Journal: Journal of veterinary pharmacology and therapeutics 20151001

Title: Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance.

Journal: Veterinary parasitology 20150615

Title: Canine ocular thelaziosis caused by Thelazia callipaeda in Portugal.

Journal: Veterinary ophthalmology 20130701

Title: Moxidectin has a lower neurotoxic potential but comparable brain penetration in P-glycoprotein-deficient CF-1 mice compared to ivermectin.

Journal: Journal of veterinary pharmacology and therapeutics 20130601

Title: P-gp substrate-induced neurotoxicity in an Abcb1a knock-in/Abcb1b knock-out mouse model with a mutated canine ABCB1 targeted insertion.

Journal: Research in veterinary science 20130601

Title: Milbemycins: more than efflux inhibitors for fungal pathogens.

Journal: Antimicrobial agents and chemotherapy 20130201

Title: Efficacy of a spot on combination containing imidacloprid 10% and moxidectin 1% (Advocate(®)/Advantage(®) Multi, Bayer Animal Health) against Ancylostoma ceylanicum in cats.

Journal: Veterinary parasitology 20121123

Title: Isolation and characterization of degradation products of moxidectin using LC, LTQ FT-MS, H/D exchange and NMR.

Journal: Analytical and bioanalytical chemistry 20121101

Title: Evaluation of the comparative efficacy of a moxidectin plus triclabendazole pour-on solution against adult and immature liver fluke, Fasciola hepatica, in cattle.

Journal: Veterinary parasitology 20121026

Title: Efficacy of albendazole and moxidectin and resistance to ivermectin against Libyostrongylus douglassii and Libyostrongylus dentatus in ostriches.

Journal: Veterinary parasitology 20121026

Title: Use of a long acting injectable formulation of moxidectin to control the periparturient rise in faecal Teladorsagia circumcincta egg output of ewes.

Journal: Veterinary parasitology 20121026

Title: Assessing resistance against macrocyclic lactones in gastro-intestinal nematodes in cattle using the faecal egg count reduction test and the controlled efficacy test.

Journal: Veterinary parasitology 20121026

Title: Efficacy and safety of imidacloprid 10%/moxidectin 1% spot-on formulation in the treatment of feline infection by Capillaria aerophila.

Journal: Parasitology research 20121001

Title: Monthly application of 10 per cent moxidectin and 2.5 per cent imidacloprid spot-on to prevent relapses in generalised demodicosis: a pilot study.

Journal: The Veterinary record 20120915

Title: Efficacy of major anthelmintics against horse cyathostomins in France.

Journal: Veterinary parasitology 20120910

Title: Persistent efficacy of a long acting injectable formulation of moxidectin against natural infestations of the sheep nasal bot (Oestrus ovis) in Spain.

Journal: Veterinary parasitology 20120910

Title: Allergic dermatitis by Dirofilaria repens in a dog: clinical picture and treatment.

Journal: Parasitology research 20120701

Title: Pharmacological characterization of the Haemonchus contortus GABA-gated chloride channel, Hco-UNC-49: modulation by macrocyclic lactone anthelmintics and a receptor for piperazine.

Journal: Veterinary parasitology 20120430

Title: Comparative in vitro characterization of moxidectin and doramectin percutaneous absorption through bovine skin.

Journal: Journal of veterinary pharmacology and therapeutics 20120401

Title: An update on the therapy of canine demodicosis.

Journal: Compendium (Yardley, PA) 20120401

Title: Amino acid residues of both the extracellular and transmembrane domains influence binding of the antiparasitic agent milbemycin to Haemonchus contortus AVR-14B glutamate-gated chloride channels.

Journal: Biochemical and biophysical research communications 20120316

Title: Lethal and sublethal effects of avermectin/milbemycin parasiticides on the African malaria vector, Anopheles arabiensis.

Journal: Journal of medical entomology 20120301

Title: The effect of a high-fat breakfast on the pharmacokinetics of moxidectin in healthy male subjects: a randomized phase I trial.

Journal: The American journal of tropical medicine and hygiene 20120101

Title: Maize supplementation of Pelibuey sheep in a silvopastoral system: fodder selection, nutrient intake and resilience against gastrointestinal nematodes.

Journal: Animal : an international journal of animal bioscience 20120101

Title: Efficacy of a combination of 10% imidacloprid and 1% moxidectin against Caparinia tripilis in African pygmy hedgehog (Atelerix albiventris).

Journal: Parasites & vectors 20120101

Title: ABC transporters influence sensitivity of Brugia malayi to moxidectin and have potential roles in drug resistance.

Journal: Experimental parasitology 20111001

Title: Effect of prolonged status epilepticus as a result of intoxication on epileptogenesis in a UK canine population.

Journal: The Veterinary record 20111001

Title: Myiasis in a dog shelter in Greece: epidemiological and clinical features and therapeutic considerations.

Journal: Veterinary parasitology 20110927

Title: Nematode and ciliate nasal infection in captive archey's frogs (Leiopelma archeyi).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110901

Title: A comparison of the efficacy of subcutaneously administered ivermectin, doramectin, and moxidectin against naturally infected Toxocara vitulorum in calves.

Journal: Tropical animal health and production 20110801

Title: Evaluation of the therapeutic and preventive efficacy of 2.5 % moxidectin / 10 % imidacloprid (Advocate(®), Bayer animal health) in dogs naturally infected or at risk of natural infection by Dirofilaria repens.

Journal: Parasitology research 20110801

Title: Efficacy and safety of the combination imidacloprid 10 % / moxidectin 1.0 % spot-on (Advocate(®) spot-on for small cats and ferrets) in the treatment of ear mite infection (Otodectes cynotis) in ferrets.

Journal: Parasitology research 20110801

Title: Progress and challenges in the discovery of macrofilaricidal drugs.

Journal: Expert review of anti-infective therapy 20110801

Title: Pharmacokinetics of moxidectin in the southern hairy-nosed wombat (Lasiorhinus latifrons).

Journal: Journal of wildlife diseases 20110701

Title: Efficacy of a single administration of a spot-on solution containing imidacloprid 10%/moxidectin 2.5% in eliminating Dirofilaria repens microfilariae in naturally infected dogs.

Journal: Veterinary parasitology 20110630

Title: Reversal effects of two new milbemycin compounds on multidrug resistance in MCF-7/adr cells in vitro.

Journal: European journal of pharmacology 20110601

Title: Design, synthesis, and biological activities of milbemycin analogues.

Journal: Journal of agricultural and food chemistry 20110511

Title: Reduced activity of moxidectin and ivermectin on small strongyles in young horses on a farm (BC) in Central Kentucky in two field tests with notes on variable counts of eggs per gram of feces (EPGs).

Journal: Parasitology research 20110501

Title: Administration of a long-acting antiparasitic to pre-pubertal ewe-lambs in Greece results in earlier reproductive activity and improved reproductive performance.

Journal: Veterinary parasitology 20110419

Title: Efficacy and blood sera analysis of a long-acting formulation of moxidectin against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) on treated cattle.

Journal: Journal of medical entomology 20110301

Title: Combined moxidectin and environmental therapy do not eliminate Chorioptes bovis infestation in heavily feathered horses.

Journal: Veterinary dermatology 20110201

Title: Field tests demonstrating reduced activity of ivermectin and moxidectin against small strongyles in horses on 14 farms in Central Kentucky in 2007-2009.

Journal: Parasitology research 20110201

Title: Pharmacokinetics of moxidectin following topical administration to New Zealand rabbits.

Journal: Journal of veterinary pharmacology and therapeutics 20110201

Title: Efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 Ctenocephalides felis flea strain infesting cats.

Journal: Parasites & vectors 20110101

Title: Clinical, laboratory and pathological findings in dogs experimentally infected with Angiostrongylus vasorum.

Journal: Parasitology research 20101101

Title: Efficacy of a combination of imidacloprid 10%/moxidectin 2.5% spot-on (Advocate® for dogs) in the prevention of canine spirocercosis (Spirocerca lupi).

Journal: Parasitology research 20101101

Title: Critical tests evaluating efficacy of moxidectin against small strongyles in horses from a herd for which reduced activity had been found in field tests in Central Kentucky.

Journal: Parasitology research 20101101

Title: Shortened strongyle-type egg reappearance periods in naturally infected horses treated with moxidectin and failure of a larvicidal dose of fenbendazole to reduce fecal egg counts.

Journal: Veterinary parasitology 20101029

Title: Lymphatic filariasis and onchocerciasis.

Journal: Lancet (London, England) 20101002

Title: Teladorsagia circumcincta resistance to moxidectin and multiple anthelmintic groups in ewes following use of the persistent drug before lambing.

Journal: The Veterinary record 20101002

Title: Efficacy of a spot-on formulation of pyriprole on dogs infested with Sarcoptes scabiei.

Journal: The Veterinary record 20100918

Title: Reversal of P-glycoprotein-mediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7/adr) cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100901

Title: Cattle nematodes resistant to macrocyclic lactones: comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin.

Journal: Experimental parasitology 20100601

Title: Characterisation of milbemycin-, avermectin-, imidazothiazole- and benzimidazole-resistant Teladorsagia circumcincta from a sheep flock.

Journal: The Veterinary record 20100529

Title: Efficacy of moxidectin microsphere sustained release formulation for the prevention of subcutaneous filarial (Dirofilaria repens) infection in dogs.

Journal: Veterinary parasitology 20100528

Title: Experimental infection with Ancylostoma ceylanicum in dogs and efficacy of a spot on combination containing imidacloprid 10% and moxidectin 2.5% (Advocate/Advantage Multi, Bayer Animal Health).

Journal: Parasitology research 20100501

Title: Evaluation of topical application of 10% imidacloprid-1% moxidectin to prevent Bartonella henselae transmission from cat fleas.

Journal: Journal of the American Veterinary Medical Association 20100415

Title: Plasma dispositions of ivermectin, doramectin and moxidectin following subcutaneous administration in rabbits.

Journal: Laboratory animals 20100401

Title: Brugia malayi: in vitro effects of ivermectin and moxidectin on adults and microfilariae.

Journal: Experimental parasitology 20100401

Title: Onchodermatitis.

Journal: Current opinion in infectious diseases 20100401

Title: Role of P-glycoprotein in the disposition of macrocyclic lactones: A comparison between ivermectin, eprinomectin, and moxidectin in mice.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100401

Title: Elimination of Dirofilaria (syn. Nochtiella) repens microfilariae in dogs with monthly treatments of moxidectin 2.5%/imidacloprid 10% (Advocate, Bayer) spot-on.

Journal: Parasitology research 20100401

Title: Milbemectin resistance in Tetranychus urticae (Acari: Tetranychidae): selection, stability and cross-resistance to abamectin.

Journal: Experimental & applied acarology 20100301

Title: Evaluation of the persistent activity of moxidectin (10%) long-acting (LA) injectable formulation against Dictyocaulus viviparus, Haemonchus placei, Trichostrongylus axei and Oesophagostomum radiatum infections in cattle.

Journal: Veterinary parasitology 20100120

Title: Larvicidal effect of imidacloprid/moxidectin spot-on solution in dogs experimentally inoculated with Angiostrongylus vasorum.

Journal: Veterinary parasitology 20091223

Title: Licking induced changes to the pattern of moxidectin milk elimination after topical treatment in dairy cows.

Journal: Journal of veterinary pharmacology and therapeutics 20091201

Title: Transplacental exchange of moxidectin after maternal or fetal intravenous administration in sheep.

Journal: Journal of veterinary pharmacology and therapeutics 20091201

Title: A comparison of the effects of ivermectin and moxidectin on the nematode Caenorhabditis elegans.

Journal: Veterinary parasitology 20091028

Title: Comparative therapeutic effect of moxidectin, doramectin and ivermectin on psoroptes mites infestation in buffalo (Bubalus bubalis).

Journal: Tropical animal health and production 20091001

Title: Treatment of canine generalized demodicosis with a 'spot-on' formulation containing 10% moxidectin and 2.5% imidacloprid (Advocate, Bayer Healthcare).

Journal: Veterinary dermatology 20091001

Title: Treatment of canine-generalized demodicosis: a blind, randomized clinical trial comparing the efficacy of Advocate(Bayer Animal Health) with ivermectin.

Journal: Veterinary dermatology 20091001

Title: Efficacy of a single topical application of Advantage Multi (= Advocate) Topical Solution (10% imidocloprid + 2.5% moxidectin) in the treatment of dogs experimentally infected with Crenosoma vulpis.

Journal: Parasitology research 20090801

Title: Efficacy and safety of imidacloprid 10%/moxidectin 1% spot-on formulation in the treatment of feline aelurostrongylosis.

Journal: Parasitology research 20090801

Title: Comparative efficacy and safety of two treatment regimens with a topically applied combination of imidacloprid and moxidectin (Advocate) against generalised demodicosis in dogs.

Journal: Parasitology research 20090801

Title: Toxicity in three dogs from accidental oral administration of a topical endectocide containing moxidectin and imidacloprid.

Journal: Australian veterinary journal 20090801

Title: Efficacy of moxidectin against cyathostomins.

Journal: The Veterinary record 20090718

Title: Effects of faecal residues of moxidectin and doramectin on the activity of arthropods in cattle dung.

Journal: Ecotoxicology and environmental safety 20090701

Title: In vitro and in vivo interaction of moxidectin with BCRP/ABCG2.

Journal: Chemico-biological interactions 20090615

Title: Moxidectin toxicity in senescence-accelerated prone and resistant mice.

Journal: Comparative medicine 20090601

Title: Efficacy of moxidectin against cyathostomins after long-term use in a large herd of draught horses with a high stocking density.

Journal: The Veterinary record 20090523

Title: Moxidectin-resistant nematodes in cattle in Brazil.

Journal: Veterinary parasitology 20090512

Title: Comparative long-term efficacy of ivermectin and moxidectin over winter in Canadian horses treated at removal from pastures for winter housing.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20090501

Title: Import of Parafilaria bovicola in the Netherlands.

Journal: Veterinary parasitology 20090406

Title: Long-acting moxidectin for the control of trichostrongylid infections of sheep in south-eastern Australia.

Journal: Australian veterinary journal 20090401

Title: Moxidectin toxicosis in a puppy successfully treated with intravenous lipids.

Journal: Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) 20090401

Title: Investigations into the prevention of neonatal Ancylostoma caninum infections in puppies by application of imidacloprid 10% plus moxidectin 2.5% topical solution to the pregnant dog.

Journal: Zoonoses and public health 20090201

Title: Species-specific identification of equine cyathostomes resistant to fenbendazole and susceptible to oxibendazole and moxidectin by macroarray probing.

Journal: Experimental parasitology 20090101

Title: Thermal stability of antiparasitic macrocyclic lactones milk residues during industrial processing.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090101

Title: The effect of moxidectin 0,1% vs ivermectin 0,08% on milk production in sheep naturally infected by gastrointestinal nematodes.

Journal: BMC veterinary research 20090101

Title: Comparing therapeutic efficacy between ivermectin, selamectin, and moxidectin in canaries during natural infection with Dermanyssus gallinae.

Journal: Annals of the New York Academy of Sciences 20081201

Title: Plasma and milk kinetic of eprinomectin and moxidectin in lactating water buffaloes (Bubalus bubalis).

Journal: Veterinary parasitology 20081107

Title: A comparative kinetic study of doramectin and moxidectin in zebu Gobra cattle (Bos indicus).

Journal: Parasitology research 20081101

Title: Effects of strategic anthelmintic treatments on the milk production of dairy sheep naturally infected by gastrointestinal strongyles.

Journal: Veterinary parasitology 20081001

Title: Field efficacy and safety of a combination of moxidectin and imidacloprid for the prevention of feline heartworm (Dirofilaria immitis) infection.

Journal: Veterinary parasitology 20080614

Title: Efficacy of imidacloprid 10%/moxidectin 1% (Advocate/Advantage Multi) against fleas (Ctenocephalides felis felis) on ferrets (Mustela putorius furo).

Journal: Parasitology research 20080601

Title: Use of a formulation containing imidacloprid and moxidectin in the treatment of lice infestation in guinea pigs.

Journal: Veterinary dermatology 20080601

Title: Use of selamectin and moxidectin in the treatment of mouse fur mites.

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20080501

Title: Epidemiology of gastrointestinal nematode parasitism in a commercial sheep flock and its implications for control programmes.

Journal: The Veterinary record 20080426

Title: Patent Toxocara canis infections in previously exposed and in helminth-free dogs after infection with low numbers of embryonated eggs.

Journal: Veterinary parasitology 20080325

Title: Oral administration of moxidectin for treatment of murine acariosis due to Radfordia affinis.

Journal: Veterinary parasitology 20080214

Title: Moxidectin interference on sexual behavior, penile erection and hypothalamic GABA levels of male rats.

Journal: Research in veterinary science 20080201

Title: A nodular granulomatous posthitis caused by Halicephalobus sp. in a horse.

Journal: Veterinary dermatology 20080201

Title: The persistence of benzimidazole-resistant cyathostomes on horse farms in Ontario over 10 years and the effectiveness of ivermectin and moxidectin against these resistant strains.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20080101

Title: Endectocide residues affect insect attraction to dung from treated cattle: implications for toxicity tests.

Journal: Medical and veterinary entomology 20071201

Title: Economic efficacy of anthelmintic treatments in dairy sheep naturally infected by gastrointestinal strongyles.

Journal: Parassitologia 20071201

Title: First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy.

Journal: Parasitology research 20071101

Title: Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs.

Journal: Biopharmaceutics & drug disposition 20071101

Title: What is your diagnosis? Mange due to Trixacarus caviae infestation.

Journal: Lab animal 20071101

Title: Estimation of absolute oral bioavailability of moxidectin in dogs using a semi-simultaneous method: influence of lipid co-administration.

Journal: Journal of veterinary pharmacology and therapeutics 20071001

Title: Pharmacokinetics assessment of moxidectin long-acting formulation in cattle.

Journal: Veterinary parasitology 20070720

Title: Efficacy and safety of imidacloprid/moxidectin spot-on solution and fenbendazole in the treatment of dogs naturally infected with Angiostrongylus vasorum (Baillet, 1866).

Journal: Veterinary parasitology 20070720

Title: Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae.

Journal: Eukaryotic cell 20070701

Title: A novel approach for combining the use of in vitro and in vivo data to measure and detect emerging moxidectin resistance in gastrointestinal nematodes of goats.

Journal: International journal for parasitology 20070601

Title: Macrocyclic lactone-resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate.

Journal: Veterinary parasitology 20070430

Title: Efficacy of imidacloprid 10 per cent/moxidectin 2-5 per cent spot-on in the treatment of cheyletiellosis in dogs.

Journal: The Veterinary record 20070414

Title: The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure.

Journal: Analytica chimica acta 20070227

Title: Fecal egg count reductions and performance effect of Dectomax, Cydectin, and Cydectin plus Synanthic as used in feedlot steers.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Review of methodology for the determination of macrocyclic lactone residues in biological matrices.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061205

Title: Fumagillin, a new P-glycoprotein-interfering agent able to modulate moxidectin efflux in rat hepatocytes.

Journal: Journal of veterinary pharmacology and therapeutics 20061201

Title: Evidence that moxidectin is a greater risk factor than ivermectin in the development of resistance to macrocyclic lactones by Ostertagia spp in sheep in south eastern Australia.

Journal: New Zealand veterinary journal 20061201

Title: Influence of dyslipidemia on moxidectin distribution in plasma lipoproteins and on its pharmacokinetics.

Journal: Pharmaceutical research 20061101

Title: Clinical and therapeutic studies on mange in horses.

Journal: Veterinary parasitology 20061010

Title: Clinical presentation and management of moxidectin toxicity in two dogs.

Journal: The Journal of small animal practice 20061001

Title: Cyathostomes in horses in Canada resistant to pyrantel salts and effectively removed by moxidectin.

Journal: Veterinary parasitology 20060831

Title: Small strongyle infection: consequences of larvicidal treatment of horses with fenbendazole and moxidectin.

Journal: Veterinary parasitology 20060630

Title: Efficacy of moxidectin 2 per cent oral gel against cyathostomins, particularly third-stage inhibited larvae, in horses.

Journal: The Veterinary record 20060603

Title: Investigations into the prevention of prenatal and lactogenic Toxocara canis infections in puppies by application of moxidectin to the pregnant dog.

Journal: Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20060601

Title: Comparison of efficacy of moxidectin and ivermectin in the treatment of Strongyloides fulleborni infection in rhesus macaques.

Journal: Journal of medical primatology 20060601

Title: Dose determination of the persistent activity of moxidectin long-acting injectable formulations against various nematode species in cattle.

Journal: Veterinary parasitology 20060430

Title: Comparative effects of milbemycin oxime-based and febantel-pyrantel embonate-based anthelmintic tablets on Toxocara canis egg shedding in naturally infected pups.

Journal: Veterinary parasitology 20060430

Title: A multicenter evaluation of the effectiveness of Quest Gel (2% moxidectin) against parasites infecting equids.

Journal: Veterinary parasitology 20060415

Title: The interaction between moxidectin and MDR transporters in primary cultures of rat hepatocytes.

Journal: Journal of veterinary pharmacology and therapeutics 20060401

Title: Improving resilience against natural gastrointestinal nematode infections in browsing kids during the dry season in tropical Mexico.

Journal: Veterinary parasitology 20060130

Title: Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060101

Title: The efficacy of an imidacloprid/moxidectin combination against naturally acquired Sarcoptes scabiei infestations on dogs.

Journal: Australian veterinary journal 20060101

Title: A field trial evaluation of the effectiveness and benefit of cydectin long-acting injectable and ivomec injectable as used one time in grazing stocker cattle.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20060101

Title: Determination of abamectin, doramectin, emamectin, eprinomectin, ivermectin, and moxidectin in milk by liquid chromatography electrospray tandem mass specrometry.

Journal: Journal of AOAC International 20060101

Title: Further characterisation of a triple resistant field isolate of Teladorsagia from a Scottish lowland sheep farm.

Journal: Veterinary parasitology 20051210

Title: Efficacy of moxidectin 0.5% pour-on against naturally acquired nematode infections in cattle in the Mexican tropics.

Journal: Veterinary parasitology 20051125

Title: Six-month prophylactic efficacy of moxidectin sustained release (SR) injectable for dogs against experimental heartworm infection in growing puppies.

Journal: Veterinary parasitology 20051024

Title: Safety evaluation of moxidectin sustained-release injectable in 10-week-old puppies.

Journal: Veterinary parasitology 20051024

Title: Imidacloprid/moxidectin topical solution for the prevention of heartworm disease and the treatment and control of flea and intestinal nematodes of cats.

Journal: Veterinary parasitology 20051024

Title: Total synthesis of milbemycins: a synthesis of (6R)-6-hydroxy-3,4-dihydromilbemycin E.

Journal: Organic & biomolecular chemistry 20051021

Title: A total synthesis of milbemycin G: approaches to the C1-C10-fragment and completion of the synthesis.

Journal: Organic & biomolecular chemistry 20051021

Title: Moxidectin and ivermectin metabolic stability in sheep ruminal and abomasal contents.

Journal: Journal of veterinary pharmacology and therapeutics 20051001

Title: Safety of imidacloprid plus moxidectin topical solution applied to cats heavily infected with adult heartworms (Dirofilaria immitis).

Journal: Parasitology research 20051001

Title: Imidacloprid plus moxidectin topical solution for the prevention of heartworm disease (Dirofiloria immitis) in dogs.

Journal: Parasitology research 20051001

Title: Efficacy and safety of imidacloprid 10% plus moxidectin 2.5% spot-on in the treatment of sarcoptic mange and otoacariosis in dogs: results af a European field study.

Journal: Parasitology research 20051001

Title: Evaluation of the efficacy and safety of imidacloprid 10% plus moxidectin 2.5% spot-on in the treatment of generalized demodicosis in dogs: results of a European field study.

Journal: Parasitology research 20051001

Title: Efficacy of a combination of imidacloprid and moxidectin against parasites of reptiles and rodents: case reports.

Journal: Parasitology research 20051001

Title: Control of endoparasites in horses with a gel containing moxidectin and praziquantel.

Journal: The Veterinary record 20050625

Title: Efficacy of moxidectin injectable and pour-on formulations in a pilot control program against bovine hypodermosis in Southern Italy.

Journal: Preventive veterinary medicine 20050610

Title: Effect of moxidectin selection on the genetic variation within Cylicocyclus nassatus based on amplified fragment length polymorphism (AFLP).

Journal: International journal for parasitology 20050601

Title: Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein.

Journal: Journal of veterinary pharmacology and therapeutics 20050601

Title: Treatment of dog thelaziosis caused by Thelazia callipaeda (Spirurida, Thelaziidae) using a topical formulation of imidacloprid 10% and moxidectin 2.5%.

Journal: Veterinary parasitology 20050420

Title: Characterization of moxidectin resistant Trichostrongylus colubriformis and Haemonchus contortus.

Journal: Veterinary parasitology 20050310

Title: Efficacy of an injectable, sustained-release formulation of moxidectin in preventing experimental heartworm infection in mongrel dogs challenged 12 months after administration.

Journal: Veterinary parasitology 20050310

Title: Effects of three anthelmintic regimes on milk yield of ewes and growth of lambs.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20050301

Title: Failure of moxidectin to control benzimidazole-, levamisole- and ivermectin-resistant Teladorsagia circumcinda in a sheep flock.

Journal: The Veterinary record 20050122

Title: A single dose of topical moxidectin as an effective treatment for murine acariasis due to Myocoptes musculinus.

Journal: Contemporary topics in laboratory animal science 20050101

Title: Therapeutic and persistent efficacy of a single injection treatment of ivermectin and moxidectin against Boophilus microplus (Acari: Ixodidae) on infested cattle.

Journal: Experimental & applied acarology 20050101

Title: The use of sarmazenil in the treatment of a moxidectin intoxication in a foal.

Journal: Journal of veterinary internal medicine 20050101

Title: Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics.

Journal: Parasitology 20050101

Title: Effects of subcutaneous injections of a long acting moxidectin formulation in grazing beef cattle on parasite fecal egg reduction and animal weight gain.

Journal: Veterinary parasitology 20041215

Title: Evaluation of a single injection of a sustained-release formulation of moxidectin for prevention of experimental heartworm infection after 12 months in dogs.

Journal: American journal of veterinary research 20041101

Title: Comparative depletion of ivermectin and moxidectin milk residues in dairy sheep after oral and subcutaneous administration.

Journal: The Journal of dairy research 20041101

Title: Milk excretion of ivermectin and moxidectin in dairy sheep: assessment of drug residues during cheese elaboration and ripening period.

Journal: Journal of agricultural and food chemistry 20041006

Title: Enhancement of oral moxidectin bioavailability in rabbits by lipid co-administration.

Journal: Parasitology research 20041001

Title: Endectocide exchanges between grazing cattle after pour-on administration of doramectin, ivermectin and moxidectin.

Journal: International journal for parasitology 20041001

Title: Characterisation of two triple resistant field isolates of Teladorsagia from Scottish lowland sheep farms.

Journal: Veterinary parasitology 20040902

Title: Adverse drug event reports at the United States Food And Drug Administration Center for Veterinary Medicine.

Journal: Journal of the American Veterinary Medical Association 20040815

Title: Benzimidazole resistance in cyathostomin populations on horse farms in western Anatolia, Turkey.

Journal: Parasitology research 20040801

Title: The influence of parasitism on the pharmacokinetics of moxidectin in lambs.

Journal: Parasitology research 20040601

Title: Mutations in the extracellular domains of glutamate-gated chloride channel alpha3 and beta subunits from ivermectin-resistant Cooperia oncophora affect agonist sensitivity.

Journal: Journal of neurochemistry 20040601

Title: Amphids: the neuronal ultrastructure of macrocyclic-lactone-resistant Haemonchus contortus.

Journal: Parassitologia 20040601

Title: Dermal safety study with imidacloprid/moxidectin topical solution in the ivermectin-sensitive collie.

Journal: Veterinary parasitology 20040526

Title: Treatment of small lungworm infestation in sheep by using moxidectin.

Journal: Veterinary parasitology 20040526

Title: Therapeutic and persistent efficacy of moxidectin 1% nonaqueous injectable formulation against natural and experimentally induced lung and gastrointestinal nematodes in cattle.

Journal: Veterinary parasitology 20040415

Title: Evaluation of the chemoprophylactic efficacy of 10% long acting injectable moxidectin against gastrointestinal nematode infections in calves in Belgium.

Journal: Veterinary parasitology 20040415

Title: Treatment protocols for demodicosis: an evidence-based review.

Journal: Veterinary dermatology 20040401

Title: Current trends in the treatment of Sarcoptes, Cheyletiella and Otodectes mite infestations in dogs and cats.

Journal: Veterinary dermatology 20040401

Title: Persistent activity of moxidectin long-acting injectable formulations against natural and experimentally enhanced populations of lice infesting cattle.

Journal: Veterinary parasitology 20040325

Title: Agonist enhacement of macrocyclic lactone activity at a glutamate-gated chloride channel subunit from Haemonchus contortus.

Journal: Biochemical pharmacology 20040315

Title: Development of a novel self-medicating applicator for control of internal and external parasites of wild and domestic animals.

Journal: The Onderstepoort journal of veterinary research 20040301

Title: Field efficacy of moxidectin 1 per cent against Thelazia callipaeda in naturally infected dogs.

Journal: The Veterinary record 20040131

Title: Use of an injectable, sustained-release formulation of moxidectin to prevent canine subcutaneous dirofilariosis.

Journal: The Veterinary record 20040103

Title: Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep.

Journal: Parasitology research 20040101

Title: A detailed assessment of the pattern of moxidectin tissue distribution after pour-on treatment in calves.

Journal: Journal of veterinary pharmacology and therapeutics 20031201

Title: Treatment and follow-up of clinical cyathostominosis in horses.

Journal: Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20031201

Title: Multiresistant nematodes on a Devon farm.

Journal: The Veterinary record 20031108

Title: Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins.

Journal: Molecular and biochemical parasitology 20031001

Title: The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans.

Journal: Journal of clinical pharmacology 20031001

Title: The comparative serum disposition kinetics of subcutaneous administration of doramectin, ivermectin and moxidectin in the Australian Merino sheep.

Journal: Journal of veterinary pharmacology and therapeutics 20031001

Title: Fly larvicidal activity in the faeces of cattle and pigs treated with endectocide products.

Journal: Medical and veterinary entomology 20030901

Title: Resistance to prophylactic treatment with macrocyclic lactone anthelmintics in Teladorsagia circumcincta.

Journal: Veterinary parasitology 20030814

Title: [Analysis of moxidectin by LC/MS and determination of residues in adipose and muscle tissues in commercial beef].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20030801

Title: Evaluation of the efficacy of an imidacloprid 10%/moxidectin 1% spot-on against Otodectes cynotisin cats.

Journal: Parasitology research 20030701

Title: Larvicidal and persistent efficacy of an imidacloprid and moxidectin topical formulation against endoparasites in cats and dogs.

Journal: Parasitology research 20030701

Title: Evaluation of the efficacy of an imidacloprid 10%/moxidectin 2.5% spot-on against Sarcoptes scabieivar canison dogs.

Journal: Parasitology research 20030701

Title: Feline Advantage Heart (imidacloprid and moxidectin) topical solution as monthly treatment for prevention of heartworm infection (Dirofilaria immitis) and control of fleas (Ctenocephalides felis) on cats.

Journal: Parasitology research 20030701

Title: Evaluation of the efficacy of a combination of imidacloprid and moxidectin against immature Toxocara catiin cats.

Journal: Parasitology research 20030701

Title: The anthelmintic efficacy and the safety of a combination of imidacloprid and moxidectin spot-on in cats and dogs under field conditions in Europe.

Journal: Parasitology research 20030701

Title: The efficacy of two anthelmintics against ascarids and hookworms in naturally infected cats.

Journal: Parasitology research 20030701

Title: Dose confirmation of moxidectin 0.5% pour-on against adults and fourth-stage larvae of various Cooperia spp. and Trichostrongylus colubriformis in Louisiana.

Journal: Veterinary parasitology 20030625

Title: Anthelmintic treatment in horses: the extra-label use of products and the danger of under-dosing.

Journal: Journal of the South African Veterinary Association 20030601

Title: Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin.

Journal: Veterinary parasitology 20030325

Title: Effect of moxidectin against natural infestation of the cattle tick Boophilus microplus (Acarina: Ixodidae) in the Mexican tropics.

Journal: Veterinary parasitology 20030213

Title: Efficacy of ivermectin and moxidectin against Otostrongylus circumlitus and Parafilaroides gymnurus in harbour seals (Phoca vitulina).

Journal: The Veterinary record 20030201

Title: The effect of treatment with a 1% injectable formulation of moxidectin during the rainy season and at the beginning of the dry season on gastrointestinal nematodes in cattle from communal areas in Zimbabwe.

Journal: Tropical animal health and production 20030201

Title: The effect of anthelmintic capsules on the egg output and larval viability of drug-resistant parasites.

Journal: Veterinary research communications 20030201

Title: Simultaneous determination of residual antiparasitic lactones in bovine muscle and liver by liquid chromatography with fluorescence detection.

Journal: Journal of AOAC International 20030101

Title: Persistent efficacy of moxidectin canine sustained-release injectable against experimental infections of Ancylostoma caninum and Uncinaria stenocephala in dogs.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20030101

Title: Field evaluation of moxidectin/praziquantel oral gel in horses.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20030101

Title: Full season efficacy of moxidectin microsphere sustained release formulation for the prevention of heartworm (Dirofilaria immitis) infection in dogs.

Journal: Veterinary parasitology 20021211

Title: Reductions of non-pest insects in dung of cattle treated with endectocides: a comparison of four products.

Journal: Bulletin of entomological research 20021201

Title: Strategic use of moxidectin or closantel in combination with levamisole in the control of nematodes of sheep in the highlands of central Kenya.

Journal: Acta tropica 20021101

Title: Resistance to therapeutic treatment with macrocyclic lactone anthelmintics in Ostertagia circumcincta.

Journal: Veterinary parasitology 20021016

Title: Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs.

Journal: Biopharmaceutics & drug disposition 20021001

Title: Does the rate of fat deposition influence the pharmacokinetic disposition of subcutaneously administered moxidectin and ivermectin in pigs?

Journal: Journal of veterinary pharmacology and therapeutics 20021001

Title: Equine faecal egg counts and comparison of fenbendazole and moxidectin.

Journal: The Veterinary record 20020928

Title: Efficacy of macrocyclic lactone endectocides against Boophilus microplus (Acari: Ixodidae) infested cattle using different pour-on application treatment regimes.

Journal: Journal of medical entomology 20020901

Title: Determination of ivermectin and moxidecin residues in bovine milk and examination of the effects of these residues on acid fermentation of milk.

Journal: Food additives and contaminants 20020901

Title: Patterns of equine faecal egg counts following spring dosing with either fenbendazole or moxidectin.

Journal: The Veterinary record 20020831

Title: Dose confirmation studies of moxidectin 1% non-aqueous injectable and moxidectin 0.5% pour-on formulations against experimentally induced infections of larval and adult stage Oesophagostomum radiatum and Trichuris discolor in cattle.

Journal: Veterinary parasitology 20020830

Title: A review of moxidectin overdose cases in equines from 1998 through 2000.

Journal: Veterinary and human toxicology 20020801

Title: Liquid chromatographic assay of moxidectin in human plasma for application to pharmacokinetic studies.

Journal: Journal of pharmaceutical and biomedical analysis 20020731

Title: The effects of ivermectin and moxidectin on egg viability and larval development of ivermectin-resistant Haemonchus contortus.

Journal: Veterinary parasitology 20020729

Title: Efficacy of moxidectin 1% injectable and 0.2% oral drench against natural infection by Dictyocaulus filaria in sheep.

Journal: Veterinary parasitology 20020729

Title: Breed differences on the plasma availability of moxidectin administered pour-on to calves.

Journal: Veterinary journal (London, England : 1997) 20020701

Title: The effects of body composition on the pharmacokinetics of subcutaneously injected ivermectin and moxidectin in pigs.

Journal: Journal of veterinary pharmacology and therapeutics 20020601

Title: Persistent activity of moxidectin pour-on and injectable against sucking and biting louse infestations of cattle.

Journal: Veterinary parasitology 20020402

Title: Loperamide-induced enhancement of moxidectin availability in cattle.

Journal: Journal of veterinary pharmacology and therapeutics 20020401

Title: Use of moxidectin tablets in the control of canine subcutaneous dirofilariosis.

Journal: The Veterinary record 20020323

Title: A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand binding, and modulation of anthelmintic binding by glutamate.

Journal: Biochemical pharmacology 20020315

Title: Apparent resistance of Parascaris equorum to macrocylic lactones.

Journal: The Veterinary record 20020302

Title: Selection for resistance to macrocyclic lactones by Haemonchus contortus in sheep.

Journal: Veterinary parasitology 20020103

Title: Efficacy of moxidectin 6-month injectable and milbemycin oxime/lufenuron tablets against naturally acquired toxocara canis infections in dogs.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20020101

Title: Efficacy of moxidectin 6-month injectable and milbemycin oxime/lufenuron tablets against naturally acquired trichuris vulpis infections in dogs.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20020101

Title: Efficacy of moxidectin 1% injectable against natural infection of Sarcoptes scabiei in sheep.

Journal: Veterinary parasitology 20011203

Title: Reduced efficacy of ivermectin, abamectin and moxidectin against field isolates of Haemonchus contortus.

Journal: Australian veterinary journal 20011201

Title: Activity of an injectable, sustained-release formulation of moxidectin administered prophylactically to mixed-breed dogs to prevent infection with Dirofilaria immitis.

Journal: American journal of veterinary research 20011101

Title: Cyathostome fecal egg count trends in horses treated with moxidectin, ivermectin or fenbendazole.

Journal: Veterinary parasitology 20011031

Title: Evaluation of the persistent activity of injectable endectocides against Psoroptes ovis.

Journal: The Veterinary record 20011027

Title: Comparison of subcutaneous ivermectin and oral moxidectin for the treatment of notoedric acariasis in hamsters.

Journal: The Veterinary record 20010915

Title: Extraction and isolation of avermectins and milbemycins from liver samples using unmodified supercritical CO2 with in-line trapping on basic alumina.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010915

Title: Plasma pharmacokinetics and faecal excretion of ivermectin, doramectin and moxidectin following oral administration in horses.

Journal: Equine veterinary journal 20010901

Title: In vitro metabolism of moxidectin in Haemonchus contortus adult stages.

Journal: Parasitology research 20010901

Title: Efficacy of moxidectin for the prevention of adult heartworm (Dirofilaria immitis) infection in dogs.

Journal: Parassitologia 20010901

Title: A comparison of the development and survival of the dung beetle, Onthophagus taurus (Schreb.) when fed on the faeces of cattle treated with pour-on formulations of eprinomectin or moxidectin.

Journal: Veterinary parasitology 20010801

Title: Comparative efficacy, persistent effect, and treatment intervals of anthelmintic pastes in naturally infected horses.

Journal: Veterinary parasitology 20010731

Title: In vitro metabolism of 14C-moxidectin by hepatic microsomes from various species.

Journal: Veterinary research communications 20010701

Title: Cutaneous xanthomas with concurrent demodicosis and dermatophytosis in a cat.

Journal: Australian veterinary journal 20010701

Title: Resistance of Cooperia to ivermectin treatments in grazing cattle of the Humid Pampa, Argentina.

Journal: Veterinary parasitology 20010612

Title: Influence of verapamil on the efflux and metabolism of 14C moxidectin in cultured rat hepatocytes.

Journal: Journal of veterinary pharmacology and therapeutics 20010601

Title: Milk kinetics of moxidectin and doramectin in goats.

Journal: Research in veterinary science 20010601

Title: Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin/milbemycins.

Journal: International journal for parasitology 20010515

Title: Development and optimisation of an improved derivatisation procedure for the determination of avermectins and milbemycins in bovine liver.

Journal: The Analyst 20010501

Title: Persistent efficacy of doramectin and moxidectin against Cooperia oncophora infections in cattle.

Journal: Veterinary parasitology 20010419

Title: Pharmacokinetics of moxidectin and ivermectin following intravenous injection in pigs with different body compositions.

Journal: Journal of veterinary pharmacology and therapeutics 20010401

Title: Larvicidal activity of endectocides against pest flies in the dung of treated cattle.

Journal: Medical and veterinary entomology 20010301

Title: Efficacy of moxidectin 2 per cent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomes.

Journal: The Veterinary record 20010203

Title: Multi-residue analysis of avermectins and moxidectin by ion-trap LC-MSn.

Journal: The Analyst 20010201

Title: Efficacy of macrocyclic lactones for the control of larvae of the Old World screw-worm fly (Chrysomya bezziana).

Journal: Australian veterinary journal 20010201

Title: Faecal excretion profile of moxidectin and ivermectin after oral administration in horses.

Journal: Veterinary journal (London, England : 1997) 20010101

Title: Evaluation of a strategic deworming program in dairy heifers in Quebec based on the use of moxidectin, an endectocide with a long persistency.

Journal: The Canadian veterinary journal = La revue veterinaire canadienne 20010101

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Tags:51596-11-3 Molecular Formula|51596-11-3 MDL|51596-11-3 SMILES|51596-11-3 Milbemycin A4