[1]Meselhy,MeselhyR.;Kadota,Shigetoshi;Tsubono,Koji;Hattori,Masao;Namba,Tsuneo[Tetrahedron,1994,vol.50,#10,p.3081-3098]
517-89-5
[1]Ahn;Baik;Kweon;Lim;Hwang[JournalofMedicinalChemistry,1995,vol.38,#6,p.1044-1047]
517-89-5
[1]Ahn;Baik;Kweon;Lim;Hwang[JournalofMedicinalChemistry,1995,vol.38,#6,p.1044-1047]
[1]Han,Xuan-zhen;Liu,Xinhua;Shen,Xiao-bao;Sheng,Liang-quan;Wang,Yang;Wu,Fu-fang[JournalofEnzymeInhibitionandMedicinalChemistry,2020,vol.35,#1,p.773-785]
[2]Locationinpatent:experimentalpartZhou,Wen;Peng,Ying;Li,Shao-Shun[EuropeanJournalofMedicinalChemistry,2010,vol.45,#12,p.6005-6011]
[1]Locationinpatent:experimentalpartRao,Zhen;Liu,Xin;Zhou,Wen;Yi,Jing;Li,Shao-Shun[EuropeanJournalofMedicinalChemistry,2011,vol.46,#9,p.3934-3941]
[2]Locationinpatent:experimentalpartZhou,Wen;Zhang,Xu;Xiao,Ling;Ding,Jing;Liu,Quan-Hua;Li,Shao-Shun[EuropeanJournalofMedicinalChemistry,2011,vol.46,#8,p.3420-3427]
Title: Assessment of the inhibition risk of shikonin on cytochrome P450 via cocktail inhibition assay.
Journal: Toxicology letters 20171105
Title: Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1α signaling.
Journal: Chemico-biological interactions 20170825
Title: Functional and mechanistic investigation of Shikonin in scarring.
Journal: Chemico-biological interactions 20150225
Title: Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells.
Journal: Chemico-biological interactions 20141205
Title: Shikonin time-dependently induced necrosis or apoptosis in gastric cancer cells via generation of reactive oxygen species.
Journal: Chemico-biological interactions 20140325
Title: The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells.
Journal: Chemico-biological interactions 20130925
Title: Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway.
Journal: Toxicology 20130607
Title: Shikonin induces programmed necrosis-like cell death through the formation of receptor interacting protein 1 and 3 complex.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130501
Title: In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma.
Journal: Journal of ethnopharmacology 20121121
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry 20121115
Title: Addition of β-lactoglobulin produces water-soluble shikonin.
Journal: Journal of agricultural and food chemistry 20121031
Title: Novel multiple apoptotic mechanism of shikonin in human glioma cells.
Journal: Annals of surgical oncology 20120901
Title: Shikonin and its derivatives: a patent review.
Journal: Expert opinion on therapeutic patents 20120901
Title: Ionization of shikonin derivatives using negative-ion electrospray mass spectrometry: [M-H]- versus [M + e]•-.
Journal: Journal of mass spectrometry : JMS 20120501
Title: [Antitumor effect research progress of shikonin and its derivatives].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120501
Title: Theoretical investigation of the radical scavenging activity of shikonin and acylshikonin derivatives.
Journal: Journal of molecular modeling 20120401
Title: Selective and slow-binding inhibition of shikonin derivatives isolated from Lithospermum erythrorhizon on glycosyl hydrolase 33 and 34 sialidases.
Journal: Bioorganic & medicinal chemistry 20120301
Title: [Compare the composition and content of Arnebiae radix and the stem residues].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120301
Title: Synthesis and human telomeric G-quadruplex DNA-binding activity of glucosaminosides of shikonin/alkannin.
Journal: Bioorganic & medicinal chemistry letters 20120215
Title: [Effects of shikonin on the proliferation and apoptosis of HL-60 cells].
Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120201
Title: Chimeric advanced drug delivery nano systems (chi-aDDnSs) for shikonin combining dendritic and liposomal technology.
Journal: International journal of pharmaceutics 20120117
Title: Shikonin derivatives protect immune organs from damage and promote immune responses in vivo in tumour-bearing mice.
Journal: Phytotherapy research : PTR 20120101
Title: Compounds from Arnebia euchroma and their related anti-HCV and antibacterial activities.
Journal: Planta medica 20120101
Title: Chemical inducers of heat shock proteins derived from medicinal plants and cytoprotective genes response.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20120101
Title: Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES.
Journal: Journal of biomedical science 20120101
Title: Nec-1 enhances shikonin-induced apoptosis in leukemia cells by inhibition of RIP-1 and ERK1/2.
Journal: International journal of molecular sciences 20120101
Title: The critical role of redox homeostasis in shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway.
Journal: Oxidative medicine and cellular longevity 20120101
Title: Inhibitory effect of Shikonin on Candida albicans growth.
Journal: Biological & pharmaceutical bulletin 20120101
Title: Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma.
Journal: Free radical biology & medicine 20111215
Title: Structure/antileishmanial activity relationship study of naphthoquinones and dependency of the mode of action on the substitution patterns.
Journal: Planta medica 20111201
Title: Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.
Journal: Journal of medical microbiology 20111201
Title: Glutathione-S-transferase enhances proliferation-migration and protects against shikonin-induced cell death in breast cancer cells.
Journal: The Kaohsiung journal of medical sciences 20111101
Title: Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.
Journal: Oncogene 20111020
Title: Comparative study on enantiomeric excess of main akannin/shikonin derivatives isolated from the roots of three endemic Boraginaceae plants in China.
Journal: Biomedical chromatography : BMC 20111001
Title: Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction.
Journal: Life sciences 20110912
Title: Semi-synthesis and antitumor activity of 6-isomers of 5, 8-O-dimethyl acylshikonin derivatives.
Journal: European journal of medicinal chemistry 20110801
Title: [Rationality for dynamic detection of shikonin of Arnerbia euchroma in industrial process].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110701
Title: Determination of the active constituents in Arnebia euchroma (Royle) Johnst. by ionic liquid-based ultrasonic-assisted extraction high-performance liquid chromatography.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110615
Title: Modeling of hyperbranched polyesters as hosts for the multifunctional bioactive agent Shikonin.
Journal: Physical chemistry chemical physics : PCCP 20110614
Title: Electrospun fiber mats containing shikonin and derivatives with potential biomedical applications.
Journal: International journal of pharmaceutics 20110516
Title: Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition.
Journal: European journal of pharmacology 20110511
Title: Shikonin inhibits tumor invasion via down-regulation of NF-κB-mediated MMP-9 expression in human ACC-M cells.
Journal: Oral diseases 20110501
Title: [Study on dynamic changes and stability of effective components of Arnerbia euchroma].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110401
Title: LeERF-1, a novel AP2/ERF family gene within the B3 subcluster, is down-regulated by light signals in Lithospermum erythrorhizon.
Journal: Plant biology (Stuttgart, Germany) 20110301
Title: Shikonin inhibits adipogenesis by modulation of the WNT/β-catenin pathway.
Journal: Life sciences 20110214
Title: Physico-chemical factors influencing the shikonin derivatives production in cell suspension cultures of Arnebia euchroma (Royle) Johnston, a medicinally important plant species.
Journal: Cell biology international 20110201
Title: Assessment of shikonin for potential estrogenic activity by dual-luciferase reporter based bioluminescent measurements in vitro.
Journal: Die Pharmazie 20110201
Title: Tigloylshikonin, a new minor Shikonin derivative, from the roots and the commercial root extract of lithospermum erythrorhizon.
Journal: Chemical & pharmaceutical bulletin 20110101
Title: DNA damage induced by shikonin in the presence of Cu(II) ions: potential mechanism of its activity to apoptotic cell death.
Journal: Journal of Asian natural products research 20110101
Title: Anti-adenovirus activities of shikonin, a component of Chinese herbal medicine in vitro.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Evaluation of the effectiveness of an ointment based on Alkannins/Shikonins on second intention wound healing in the dog.
Journal: Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20110101
Title: Detailed investigations on the solid cell culture and antimicrobial activities of the Iranian Arnebia euchroma.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto-Kakizaki rats.
Journal: PloS one 20110101
Title: Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthma.
Journal: British journal of pharmacology 20101201
Title: Semi-synthesis and anti-tumor activity of 5,8-O-dimethyl acylshikonin derivatives.
Journal: European journal of medicinal chemistry 20101201
Title: Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells.
Journal: Canadian journal of physiology and pharmacology 20101201
Title: Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer.
Journal: Breast cancer research and treatment 20101101
Title: Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity.
Journal: European journal of pharmacology 20100925
Title: [Simultaneous determination of five active components in compound preparation of Dangguishuan by high-performance liquid chromatography].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100901
Title: Synthesis and antitumor activity of new shikonin glycosides.
Journal: European journal of medicinal chemistry 20100701
Title: Solid-phase extraction for purification of alkannin/shikonin samples and isolation of monomeric and dimeric fractions.
Journal: Analytical and bioanalytical chemistry 20100701
Title: A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells.
Journal: Breast cancer research and treatment 20100501
Title: Shikonin reduces oedema induced by phorbol ester by interfering with IkappaBalpha degradation thus inhibiting translocation of NF-kappaB to the nucleus.
Journal: British journal of pharmacology 20100501
Title: Shikonin inhibits fat accumulation in 3T3-L1 adipocytes.
Journal: Phytotherapy research : PTR 20100301
Title: Targeting tumor proteasome with traditional Chinese medicine.
Journal: Current drug discovery technologies 20100301
Title: [Role of NF-kappaB pathway in shikonin induced apoptosis in oral squamous cell carcinoma Tca-8113 cells].
Journal: Shanghai kou qiang yi xue = Shanghai journal of stomatology 20100201
Title: Shikonin directly inhibits nitric oxide synthases: possible targets that affect thoracic aorta relaxation response and nitric oxide release from RAW 264.7 macrophages.
Journal: Journal of pharmacological sciences 20100101
Title: Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling.
Journal: BMC genomics 20100101
Title: Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston].
Journal: BMC molecular biology 20100101
Title: Electrospun shikonin-loaded PCL/PTMC composite fiber mats with potential biomedical applications.
Journal: International journal of pharmaceutics 20091201
Title: [Shikonin down-regulates CXCR4 expression and inhibits CXCL12-induced migratory responses in colorectal carcinoma cell line SW480].
Journal: Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 20091101
Title: Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells.
Journal: Cancer letters 20091018
Title: Simultaneous densitometric determination of shikonin, acetylshikonin, and beta-acetoxyisovaleryl-shikonin in ultrasonic-assisted extracts of four Arnebia species using reversed-phase thin layer chromatography.
Journal: Journal of separation science 20090901
Title: Effects of shikonin isolated from zicao on lupus nephritis in NZB/W F1 mice.
Journal: Biological & pharmaceutical bulletin 20090901
Title: Bothriodumin, a shikonin derivative from Bothriospermum secundum Maxim.
Journal: Die Pharmazie 20090901
Title: Dual role of shikonin in early and late stages of collagen type II arthritis.
Journal: Molecular biology reports 20090701
Title: Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo.
Journal: International journal of cancer 20090515
Title: Identification of shikonin and its ester derivatives from the roots of Echium italicum L.
Journal: Journal of chromatography. A 20090410
Title: Synthesis and antitumor activity of 6- and 2-(1-substituted-thio-4-methylpent-3-enyl)-5,8-dimethoxynaphthalene-1,4-diones.
Journal: European journal of medicinal chemistry 20090401
Title: Naturally-occurring shikonin analogues--a class of necroptotic inducers that circumvent cancer drug resistance.
Journal: Cancer letters 20090218
Title: Preparative isolation and purification of alkannin/shikonin derivatives from natural products by high-speed counter-current chromatography.
Journal: Biomedical chromatography : BMC 20090201
Title: Synthesis and biological activity of novel shikonin analogues.
Journal: Bioorganic & medicinal chemistry letters 20090201
Title: Mechanism of inhibition of tumor angiogenesis by beta-hydroxyisovalerylshikonin.
Journal: Cancer science 20090201
Title: Nitric oxide regulates shikonin formation in suspension-cultured Onosma paniculatum cells.
Journal: Plant & cell physiology 20090101
Title: Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-kappaB signaling.
Journal: Journal of ethnopharmacology 20081120
Title: Shikonin, acetylshikonin, and isobutyroylshikonin inhibit VEGF-induced angiogenesis and suppress tumor growth in lewis lung carcinoma-bearing mice.
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20081101
Title: Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications.
Journal: Neuropharmacology 20081001
Title: Shikonin inhibits IgE-mediated histamine release by human basophils and Syk kinase activity.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20081001
Title: Expression analysis of light-regulated genes isolated from a full-length-enriched cDNA library of Onosma paniculatum cell cultures.
Journal: Journal of plant physiology 20080929
Title: Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells.
Journal: Cell research 20080801
Title: Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.
Journal: European journal of medicinal chemistry 20080601
Title: [Shikonin inhibits the proliferation of human airway smooth muscle cells].
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080501
Title: Alkannin/shikonin mixture from roots of Onosma echioides (L.) L.: extraction method study and quantification.
Journal: Journal of separation science 20080401
Title: Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappaB pathway.
Journal: Phytotherapy research : PTR 20080301
Title: Simultaneous determination of monomeric and oligomeric alkannins and shikonins by high-performance liquid chromatography-diode array detection-mass spectrometry.
Journal: Biomedical chromatography : BMC 20080201
Title: Shikonin analogue (SA) 93/637 induces apoptosis by activation of caspase-3 in U937 cells.
Journal: Frontiers in bioscience : a journal and virtual library 20080101
Title: Red pigment from Lithospermum erythrorhizon by supercritical CO2 extraction.
Journal: Journal of cosmetic science 20080101
Title: Alkannins and shikonins: a new class of wound healing agents.
Journal: Current medicinal chemistry 20080101
Title: Microencapsulation of extract containing shikonin using gelatin-acacia coacervation method: a formaldehyde-free approach.
Journal: Colloids and surfaces. B, Biointerfaces 20070801
Title: Inhibition of tumor necrosis factor-alpha through selective blockade of Pre-mRNA splicing by shikonin.
Journal: Molecular pharmacology 20070601
Title: Shikonin circumvents cancer drug resistance by induction of a necroptotic death.
Journal: Molecular cancer therapeutics 20070501
Title: A new EGFR inhibitor induces apoptosis in colon cancer cells.
Journal: Biochemical and biophysical research communications 20070309
Title: Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon.
Journal: Bioorganic & medicinal chemistry letters 20070215
Title: DMNQ S-64 induces apoptosis via caspase activation and cyclooxygenase-2 inhibition in human nonsmall lung cancer cells.
Journal: Annals of the New York Academy of Sciences 20070101
Title: Shikonin-induced apoptosis involves caspase-3 activity in a human bladder cancer cell line (T24).
Journal: In vivo (Athens, Greece) 20070101
Title: Effect of shikonin on human breast cancer cells proliferation and apoptosis in vitro.
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061201
Title: The shikonin derivatives and pyrrolizidine alkaloids in hairy root cultures of Lithospermum canescens (Michx.) Lehm.
Journal: Plant cell reports 20061001
Title: SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor.
Journal: International journal of cancer 20060901
Title: A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases.
Journal: Molecular pharmacology 20060901
Title: Cell growth and shikonin production of Arnebia euchroma in a periodically submerged airlift bioreactor.
Journal: Biotechnology letters 20060401
Title: Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma leptantha.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20060301
Title: [Antitumor effect and mechanism of shikonin derivative SYUNZ-7].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20051201
Title: Structure determination of oligomeric alkannin and shikonin derivatives.
Journal: Biomedical chromatography : BMC 20050901
Title: Presence of peroxyradicals in cigarette smoke and the scavenging effect of shikonin, a naphthoquinone pigment.
Journal: Chemical & pharmaceutical bulletin 20050701
Title: [Effect of shikonin, a phytocompound from Lithospermum erythrorhizon, on rat vascular smooth muscle cells proliferation and apoptosis in vitro].
Journal: Zhonghua yi xue za zhi 20050608
Title: Phosphorylated extracellular signal-regulated kinase up-regulated p53 expression in shikonin-induced HeLa cell apoptosis.
Journal: Chinese medical journal 20050420
Title: [Determination of shikonin derivatives in gromwell by reversed-phase high performance liquid chromatography].
Journal: Se pu = Chinese journal of chromatography 20050301
Title: Ethylene induced shikonin biosynthesis in shoot culture of Lithospermum erythrorhizon.
Journal: Plant physiology and biochemistry : PPB 20050201
Title: [Cytochrome P450 enzymes in biosyntheses of some plant secondary metabolites].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050101
Title: [Biosynthesis of naphthoquinoine pigments in plants from Boraginaceae family in nature and in vitro culture].
Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20050101
Title: Study on the enantiomeric ratio of the pharmaceutical substances alkannin and shikonin.
Journal: Biomedical chromatography : BMC 20041201
Title: Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells.
Journal: Journal of agricultural and food chemistry 20041006
Title: Study on isohexenylnaphthazarins polymerization in alkaline media.
Journal: Biomedical chromatography : BMC 20041001
Title: Study on polymerization of the pharmaceutical substances isohexenylnaphthazarins.
Journal: Biomedical chromatography : BMC 20041001
Title: Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis.
Journal: Journal of Asian natural products research 20040901
Title: Immunomodulatory effect of shikonin derivatives isolated from Lithospermum canescens on cellular and humoral immunity in Balb/c mice.
Journal: Die Pharmazie 20040801
Title: Encapsulation of isohexenylnaphthazarins in cyclodextrins.
Journal: Biomedical chromatography : BMC 20040501
Title: [Production of shikonin by cell cultures of Lithospermum erythrorhizon].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040501
Title: Evans Blue and other dyes as protein tyrosine phosphatase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20040419
Title: Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo.
Journal: The Journal of biological chemistry 20040213
Title: p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells.
Journal: Journal of pharmacological sciences 20040201
Title: Preparative high-speed counter-current chromatography for purification of shikonin from the Chinese medicinal plant Lithospermum erythrorhizon.
Journal: Journal of chromatography. A 20040109
Title: Impairment of vascular function of rat thoracic aorta in an endothelium-dependent manner by shikonin/alkannin and derivatives isolated from roots of Macrotomia euchroma.
Journal: Planta medica 20040101
Title: The inhibition of N-acetyltransferase activity and gene expression in human bladder cancer cells (T24) by shikonin.
Journal: In vivo (Athens, Greece) 20040101
Title: Shikonin inhibits the growth and N-acetylation of 2-aminofluorene in Helicobacter pylori from ulcer patients.
Journal: Anticancer research 20040101
Title: Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Journal: Biological & pharmaceutical bulletin 20031201
Title: Involvement of reactive oxygen species, but not mitochondrial permeability transition in the apoptotic induction of human SK-Hep-1 hepatoma cells by shikonin.
Journal: Planta medica 20031201
Title: Shikonin modulates cell proliferation by inhibiting epidermal growth factor receptor signaling in human epidermoid carcinoma cells.
Journal: Cancer letters 20031028
Title: Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives.
Journal: Antimicrobial agents and chemotherapy 20030901
Title: Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation.
Journal: Phytotherapy research : PTR 20030501
Title: Molecular cloning and characterization of a cDNA encoding a novel apoplastic protein preferentially expressed in a shikonin-producing callus strain of Lithospermum erythrorhizon.
Journal: Plant & cell physiology 20030401
Title: Synthesis and release studies of shikonin-containing microcapsules prepared by the solvent evaporation method.
Journal: Journal of microencapsulation 20030101
Title: Antimicrobial activities of naphthazarins from Arnebia euchroma.
Journal: Journal of natural products 20021201
Title: Regulation of lithospermic acid B and shikonin production in Lithospermum erythrorhizon cell suspension cultures.
Journal: Chemical & pharmaceutical bulletin 20020801
Title: High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon.
Journal: Plant & cell physiology 20020801
Title: Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases.
Journal: Japanese journal of cancer research : Gann 20020801
Title: Direct reaction between shikonin and thiols induces apoptosis in HL60 cells.
Journal: Biological & pharmaceutical bulletin 20020701
Title: Alkannin and shikonin: effect on free radical processes and on inflammation - a preliminary pharmacochemical investigation.
Journal: Archiv der Pharmazie 20020601
Title: Shikonin derivatives: synthesis and inhibition of human telomerase.
Journal: Bioorganic & medicinal chemistry letters 20020520
Title: Cellular pharmacology studies of shikonin derivatives.
Journal: Phytotherapy research : PTR 20020501
Title: Enhancement of shikonin production in single- and two-phase suspension cultures of Lithospermum erythrorhizon cells using low-energy ultrasound.
Journal: Biotechnology and bioengineering 20020405
Title: Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway.
Journal: Biochemical and biophysical research communications 20020405
Title: Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase.
Journal: Phytotherapy research : PTR 20020301
Title: Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis.
Journal: The Journal of biological chemistry 20020222
Title: Granulomatous tissue formation of shikon and shikonin by air pouch method.
Journal: Biological & pharmaceutical bulletin 20010601
Title: Shikonin production by p-fluorophenylalanine resistant cells of Lithospermum erythrorhizon.
Journal: Fitoterapia 20010501
Title: A novel dark-inducible protein, LeDI-2, and its involvement in root-specific secondary metabolism in Lithospermum erythrorhizon.
Journal: Plant physiology 20010401
Title: Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription.
Journal: Journal of biomolecular screening 20010401
Title: Shikonin, a component of antiinflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1.
Journal: International immunopharmacology 20010201
Title: Jiang Y et al. Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea. Front Pharmacol. 2016 Aug 23;7:270.
Title: Li W, et al. Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation. PLoS One. 2015 May 11;10(5):e0126459.
Title: Yan Y, et al. Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-κB Translocation via Proteasome Inhibition In Vitro. Chin Med J (Engl). 2015 Aug 20;128(16):2228-33.
Title: Zhang FY, et al. Shikonin Inhibits the Migration and Invasion of Human Glioblastoma Cells by Targeting Phosphorylated β-Catenin and Phosphorylated PI3K/Akt: A Potential Mechanism for the Anti-Glioma Efficacy of a Traditional Chinese Herbal Medicine. Int J Mol Sci. 2015 Oct 9;16(10):23823-48.
Title: Fu D, et al. Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis. Exp Ther Med. 2016 Oct;12(4):2735-2740.
Title: Kathleen M McAndrews, et al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18(1):52.
Title: Jernej Zorman, et al. Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1. PLoS One. 2016 Jul 28;11(7):e0159826.
