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5171-37-9,MFCD03788766
Catalog No.:AA00D9Q2

5171-37-9 | UNCARINE E

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5mg
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$527.00   $369.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00D9Q2
Chemical Name:
UNCARINE E
CAS Number:
5171-37-9
Molecular Formula:
C21H24N2O4
Molecular Weight:
368.4263
MDL Number:
MFCD03788766
SMILES:
COC(=O)C1=CO[C@H]([C@H]2[C@@H]1C[C@@H]1N(C2)CC[C@]21C(=O)Nc1c2cccc1)C
Properties
Computed Properties
 
Complexity:
692  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
1.6  

Downstream Synthesis Route
7-acetoxy-19α-methyl-(7ξ<i>H</i>,20α)-7<i>H</i>-18-oxa-yohimb-16-ene-16-carboxylicacidmethylester 
  5171-37-9 

[1]Pousset;Poisson;Shine;Shamma[BulletindelaSocieteChimiquedeFrance,1967,vol.8,p.2766-2779]

[1]Aimi;Yamanaka;Endo;etal.[Tetrahedron,1973,vol.29,#14,p.2015-2021]

C21H22N2O5 
  5171-37-9 

[1]Martin,StephenF.;Mortimore,Michael[TetrahedronLetters,1990,vol.31,#32,p.4557-4560]

[1]Laus,Gerhard;Broessner,Dagmar;Senn,Gilbert;Wurst,Klaus[JournaloftheChemicalSociety.PerkinTransactions2(2001),1996,vol.9,p.1931-1936]

[2]Martin,StephenF.;Mortimore,Michael[TetrahedronLetters,1990,vol.31,#32,p.4557-4560]

[1]Laus,Gerhard;Broessner,Dagmar;Senn,Gilbert;Wurst,Klaus[JournaloftheChemicalSociety.PerkinTransactions2(2001),1996,vol.9,p.1931-1936]

[2]Aimi;Yamanaka;Endo;etal.[Tetrahedron,1973,vol.29,#14,p.2015-2021]

Literature

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells.

Journal: British journal of haematology 20060301

Title: Pteropodine and isopteropodine positively modulate the function of rat muscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte.

Journal: European journal of pharmacology 20020524

Title: Two stereoisomeric pentacyclic oxindole alkaloids from Uncaria tomentosa: uncarine C and uncarine E.

Journal: Acta crystallographica. Section C, Crystal structure communications 20010401

Title: Tai-Hyun Kang,etc. Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte. European Journal of Pharmacology, Volume 444, Issues 1–2, 2002, Pages 39-45, ISSN 0014-2999,

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