Home Amines 519-98-2
519-98-2,MFCD00447796
Catalog No.:AA00DF1B

519-98-2 | 1,5-Dimethyl-4-(methylamino)-2-phenyl-1,2-dihydro-3h-pyrazol-3-one hydrochloride

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100mg
95%
in stock  
$365.00   $255.00
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250mg
95%
in stock  
$524.00   $367.00
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1g
95%
in stock  
$1,293.00   $905.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DF1B
Chemical Name:
1,5-Dimethyl-4-(methylamino)-2-phenyl-1,2-dihydro-3h-pyrazol-3-one hydrochloride
CAS Number:
519-98-2
Molecular Formula:
C12H15N3O
Molecular Weight:
217.2670
MDL Number:
MFCD00447796
SMILES:
CNc1c(C)n(n(c1=O)c1ccccc1)C
Properties
Computed Properties
 
Complexity:
318  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
0.8  

Literature

Title: High-performance liquid chromatographic assay for metamizol metabolites in rat plasma: application to pharmacokinetic studies.

Journal: Journal of pharmaceutical and biomedical analysis 20121201

Title: General unknown screening in hair by liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS).

Journal: Forensic science international 20120510

Title: Novel bioactive metabolites of dipyrone (metamizol).

Journal: Bioorganic & medicinal chemistry 20120101

Title: [Tetanus in older children in a pediatric hospital in Yaounde, Cameroon].

Journal: The Pan African medical journal 20120101

Title: Population pharmacokinetic analysis of the active product of dipyrone.

Journal: International journal of clinical pharmacology and therapeutics 20101201

Title: Investigation of the microbial degradation of phenazone-type drugs and their metabolites by natural biofilms derived from river water using liquid chromatography/tandem mass spectrometry (LC-MS/MS).

Journal: Water research 20100801

Title: Scavenging activity of aminoantipyrines against hydroxyl radical.

Journal: European journal of medicinal chemistry 20100601

Title: Quantification of 4-methylaminoantipyrine, the active metabolite of dipyrone, in human plasma.

Journal: Bioanalysis 20090501

Title: Treatment of postherpetic neuralgia: focus on pregabalin.

Journal: Clinical interventions in aging 20090101

Title: Photodegradation study of three dipyrone metabolites in various water systems: identification and toxicity of their photodegradation products.

Journal: Water research 20080501

Title: Pyrazolinone analgesics prevent the antiplatelet effect of aspirin and preserve human platelet thromboxane synthesis.

Journal: Journal of thrombosis and haemostasis : JTH 20080101

Title: Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury.

Journal: Critical care (London, England) 20080101

Title: [Favorable outcome of acute porphyric neuropathy after treatment with heme arginate].

Journal: Revue neurologique 20071101

Title: [Analysis of three metabolite residues of dipyrone in bovine muscle and pork muscle using high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20071101

Title: Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070801

Title: Solid-phase extraction followed by liquid chromatography-time-of-flight-mass spectrometry to evaluate pharmaceuticals in effluents. A pilot monitoring study.

Journal: Journal of environmental monitoring : JEM 20070701

Title: Inhibition of cyclooxygenases by dipyrone.

Journal: British journal of pharmacology 20070601

Title: [Drug-induced agranulocytosis in rheumatology. A retrospective study of 12 cases].

Journal: Annales de biologie clinique 20070101

Title: Simultaneous determination of residues of dipyrone and its major metabolites in milk, bovine muscle, and porcine muscle by liquid chromatography/mass spectrometry.

Journal: Journal of AOAC International 20050101

Title: Characterization of the role of physicochemical factors on the hydrolysis of dipyrone.

Journal: Journal of pharmaceutical and biomedical analysis 20040528

Title: Effect of metamizol on promyelocytic and terminally differentiated granulocytic cells. Comparative analysis with acetylsalicylic acid and diclofenac.

Journal: Biochemical pharmacology 20030115

Title: Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test.

Journal: Liver 20021201

Title: Bioavailability of two metamizole (dipyrone) solutions as single doses of 2 g versus metamizole capsules.

Journal: International journal of clinical pharmacology and therapeutics 20020701

Title: Benzydamine: an alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria.

Journal: Allergy 20020501

Title: Limited-sampling strategy models for estimating the pharmacokinetic parameters of 4-methylaminoantipyrine, an active metabolite of dipyrone.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20011101

Title: Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.

Journal: Immunopharmacology and immunotoxicology 20011101

Title: Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.

Journal: European journal of clinical pharmacology 20010901

Title: Acute hepatitis due to ketoprofen.

Journal: Clinical rheumatology 19910601

Title: Burmańczuk A, et al. Pharmacokinetic investigations of the marker active metabolites 4-methylamino-antipyrine and 4-amino-antipyrine after intramuscular injection of metamizole in healthy piglets. J Vet Pharmacol Ther. 2016 Dec;39(6):616-620.

Title: Campos C1, et al. Regulation of cyclooxygenase activity by metamizol. Eur J Pharmacol. 1999 Aug 13;378(3):339-47.

Title: Ariza A, et al. Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole. Sci Rep. 2016 Mar 31;6:23845.

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Tags:519-98-2 Molecular Formula|519-98-2 MDL|519-98-2 SMILES|519-98-2 1,5-Dimethyl-4-(methylamino)-2-phenyl-1,2-dihydro-3h-pyrazol-3-one hydrochloride