Title: In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20170401
Title: Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
Journal: Journal of medicinal chemistry 20160526
Title: Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.
Journal: Toxicology letters 20160122
Title: Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.
Journal: Journal of medicinal chemistry 20140612
Title: Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors.
Journal: The Journal of biological chemistry 20140321
Title: One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
Journal: Chemico-biological interactions 20140125
Title: Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130901
Title: Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20130401
Title: Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions.
Journal: Journal of applied toxicology : JAT 20130201
Title: Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120801
Title: KCa channels and epoxyeicosatrienoic acids: major contributors to thermal hyperaemia in human skin.
Journal: The Journal of physiology 20120801
Title: Synthesis and evaluation of novel potent HCV NS5A inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120715
Title: Tolbutamide hydroxylation by hepatic microsomes from Atlantic salmon (Salmo salar L.).
Journal: Molecular biology reports 20120601
Title: Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein activities and expression to increased oral glibenclamide exposure in rats with streptozotocin-induced diabetes mellitus.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120601
Title: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Journal: Journal of medicinal chemistry 20120524
Title: Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120501
Title: Cytochrome P-450 2C9 exerts a vasoconstrictor influence on coronary resistance vessels in swine at rest and during exercise.
Journal: American journal of physiology. Heart and circulatory physiology 20120415
Title: Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates.
Journal: Drug metabolism and pharmacokinetics 20120101
Title: Sulfaphenazole attenuates myocardial cell apoptosis accompanied with cardiac ischemia-reperfusion by suppressing the expression of BimEL and Noxa.
Journal: Journal of pharmacological sciences 20120101
Title: Effects of sulfaphenazole after collagenase-induced experimental intracerebral hemorrhage in rats.
Journal: Biological & pharmaceutical bulletin 20120101
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: A non-acidic sulfaphenazole analog demonstrating high intrinsic clearance and selectivity by canine CYP2C21.
Journal: Drug metabolism letters 20111201
Title: Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis.
Journal: Journal of medicinal chemistry 20111027
Title: Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20111015
Title: Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes.
Journal: Journal of veterinary pharmacology and therapeutics 20111001
Title: Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices.
Journal: Chemico-biological interactions 20110905
Title: Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics.
Journal: Journal of pharmaceutical sciences 20110901
Title: Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction.
Journal: Journal of biomolecular screening 20110901
Title: SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.
Journal: PLoS neglected tropical diseases 20110601
Title: Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110501
Title: Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.
Journal: Journal of medicinal chemistry 20110414
Title: Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity.
Journal: European journal of drug metabolism and pharmacokinetics 20110301
Title: New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.
Journal: Journal of medicinal chemistry 20110127
Title: CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes.
Journal: European journal of medicinal chemistry 20110101
Title: In vitro characterization of the cytochrome P450 isoforms involved in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes.
Journal: Journal of translational medicine 20110101
Title: Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.
Journal: PloS one 20110101
Title: Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women.
Journal: International journal of women's health 20110101
Title: Endothelium-derived hyperpolarizing factor and vascular function.
Journal: Cardiology research and practice 20110101
Title: Co-expression of recombinant human CYP2C9 with human cytochrome P450 reductase in protease deficient S. cerevisiae strain at a higher scale yields an enzyme of higher specific activity.
Journal: Drug metabolism letters 20101201
Title: Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs.
Journal: Journal of veterinary pharmacology and therapeutics 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Autophagy induced by ischemic preconditioning is essential for cardioprotection.
Journal: Journal of cardiovascular translational research 20100801
Title: Nimesulide-induced electrophile stress activates Nrf2 in human hepatocytes and mice but is not sufficient to induce hepatotoxicity in Nrf2-deficient mice.
Journal: Chemical research in toxicology 20100517
Title: In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine.
Journal: Cancer chemotherapy and pharmacology 20100401
Title: 7-Benzyloxyresorufin-O-dealkylase activity as a marker for measuring cytochrome P450 CYP3A induction in mouse liver.
Journal: Analytical biochemistry 20100301
Title: A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo.
Journal: Cardiovascular research 20100201
Title: Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100201
Title: Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole.
Journal: American journal of physiology. Heart and circulatory physiology 20100201
Title: The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment.
Journal: The Journal of clinical endocrinology and metabolism 20100201
Title: High performance liquid chromatography determination of cytochrome P450 1A and 2C activities in bovine liver microsomes.
Journal: Veterinary journal (London, England : 1997) 20100101
Title: Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100101
Title: Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101
Title: Testosterone-metabolizing capacity and characteristics of adrenal microsomes in human fetus in vitro.
Journal: Journal of pediatric endocrinology & metabolism : JPEM 20100101
Title: Effects of sulfaphenazole derivatives on cardiac ischemia-reperfusion injury: association of cytochrome P450 activity and infarct size.
Journal: Journal of pharmacological sciences 20100101
Title: Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer.
Journal: Oxidative medicine and cellular longevity 20100101
Title: Effects of CYP2C9*3 and CYP2C9*13 on Diclofenac Metabolism and Inhibition-based Drug-Drug Interactions.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism.
Journal: PloS one 20100101
Title: 20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site.
Journal: The Journal of pharmacology and experimental therapeutics 20091201
Title: Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo.
Journal: The Journal of pharmacy and pharmacology 20091201
Title: Letter by Brown and Pretorius regarding article, 'effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients'.
Journal: Circulation 20091110
Title: Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes.
Journal: Basic & clinical pharmacology & toxicology 20091101
Title: [Metabolism of osthol in isolated hepatocytes of rat].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20091001
Title: Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.
Journal: Chemical research in toxicology 20090901
Title: Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090801
Title: The role of nitric oxide- and prostacyclin-independent vasodilatation in the human cutaneous microcirculation: effect of cytochrome P450 2C9 inhibition.
Journal: Clinical physiology and functional imaging 20090701
Title: Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes.
Journal: Toxicology letters 20090622
Title: Suppression of myocardial ischemia-reperfusion injury by inhibitors of cytochrome P450 in rats.
Journal: European journal of pharmacology 20090602
Title: As in humans, pregnancy increases the clearance of the protease inhibitor nelfinavir in the nonhuman primate Macaca nemestrina.
Journal: The Journal of pharmacology and experimental therapeutics 20090601
Title: Functional expression, inhibition and induction of CYP enzymes in HepaRG cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090601
Title: Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Journal: Journal of medicinal chemistry 20090423
Title: Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1.
Journal: Chemico-biological interactions 20090415
Title: Sulfaphenazole protects heart against ischemia-reperfusion injury and cardiac dysfunction by overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenation.
Journal: Antioxidants & redox signaling 20090401
Title: In vitro cytochrome p450 formation of a mono-hydroxylated metabolite of zearalenone exhibiting estrogenic activities: possible occurrence of this metabolite in vivo.
Journal: International journal of molecular sciences 20090401
Title: Effect of sulfaphenazole on tissue plasminogen activator release in normotensive subjects and hypertensive patients.
Journal: Circulation 20090331
Title: Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation.
Journal: Journal of lipid research 20090201
Title: Investigations on the cytochrome P450 (CYP) isoenzymes involved in the metabolism of the designer drugs N-(1-phenyl cyclohexyl)-2-ethoxyethanamine and N-(1-phenylcyclohexyl)-2-methoxyethanamine.
Journal: Biochemical pharmacology 20090201
Title: Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism.
Journal: The Journal of pharmacy and pharmacology 20090101
Title: Novel antitumor acetamide, pyrrole, pyrrolopyrimidine, thiocyanate, hydrazone, pyrazole, isothiocyanate and thiophene derivatives containing a biologically active pyrazole moiety.
Journal: Arzneimittel-Forschung 20090101
Title: In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Journal: Journal of medicinal chemistry 20081225
Title: CYP2C9-catalyzed metabolism of S-warfarin to 7-hydroxywarfarin in vivo and in vitro in chimeric mice with humanized liver.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20081201
Title: Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20081201
Title: Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes.
Journal: Acta pharmacologica Sinica 20081201
Title: Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
Journal: Journal of medicinal chemistry 20081009
Title: Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20081001
Title: A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080901
Title: Epoxyeicosatrienoic acids and/or their metabolites promote hypoxic response of cells.
Journal: Journal of pharmacological sciences 20080901
Title: [Effects of cytochrome P450 isozymes on aristolochic acid renal cytotoxicity].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901
Title: Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone.
Journal: Interdisciplinary toxicology 20080901
Title: Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
Journal: Journal of medicinal chemistry 20080828
Title: Cytochrome p450 2C enzymes contribute to peritransplant ischemic injury and cardiac allograft vasculopathy.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20080801
Title: Effects of cytochrome P450 (CYP) inducers and inhibitors on ondansetron pharmacokinetics in rats: involvement of hepatic CYP2D subfamily and 3A1/2 in ondansetron metabolism.
Journal: The Journal of pharmacy and pharmacology 20080701
Title: Application of micellar electrokinetic capillary chromatography for evaluation of inhibitory effects on cytochrome P450 reaction.
Journal: Journal of chromatography. A 20080502
Title: Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone.
Journal: The Journal of steroid biochemistry and molecular biology 20080501
Title: Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Journal: Journal of medicinal chemistry 20080410
Title: Synthesis of a new gadolinium complex with a high affinity for human serum albumin and its manifold physicochemical characterization by proton relaxation rate analysis, NMR diffusometry and electrospray mass spectrometry.
Journal: Journal of inorganic biochemistry 20080401
Title: Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro.
Journal: Acta pharmacologica Sinica 20080301
Title: Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells.
Journal: Investigative ophthalmology & visual science 20080301
Title: Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity.
Journal: Investigational new drugs 20080201
Title: Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors.
Journal: Circulation research 20080104
Title: Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice.
Journal: Vascular pharmacology 20080101
Title: Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes.
Journal: PloS one 20080101
Title: Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.
Journal: Journal of pharmacological and toxicological methods 20080101
Title: Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
Journal: Journal of medicinal chemistry 20071213
Title: Cardioprotection by sulfaphenazole, a cytochrome p450 inhibitor: mitigation of ischemia-reperfusion injury by scavenging of reactive oxygen species.
Journal: The Journal of pharmacology and experimental therapeutics 20071201
Title: Identification of the human cytochromes P450 catalysing the rate-limiting pathways of gliclazide elimination.
Journal: British journal of clinical pharmacology 20071001
Title: In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography.
Journal: Journal of pharmaceutical sciences 20070901
Title: Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels.
Journal: Investigative ophthalmology & visual science 20070901
Title: Cytochrome P450 2C9 is involved in flow-dependent vasodilation of peripheral conduit arteries in healthy subjects and in patients with chronic heart failure.
Journal: European journal of heart failure 20070801
Title: Chronic nitric oxide synthase inhibition blunts endothelium-dependent function of conduit coronary arteries, not arterioles.
Journal: American journal of physiology. Heart and circulatory physiology 20070601
Title: [Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070601
Title: Visible spectra of type II cytochrome P450-drug complexes: evidence that 'incomplete' heme coordination is common.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070401
Title: Smooth muscle mediates circumferential conduction of hyperpolarization and relaxation to focal endothelial cell activation in large coronary arteries.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070401
Title: Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes.
Journal: Life sciences 20070320
Title: Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070301
Title: Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.
Journal: Journal of medicinal chemistry 20070222
Title: Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways.
Journal: Investigative ophthalmology & visual science 20070201
Title: CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes.
Journal: Acta pharmacologica Sinica 20070101
Title: In-vitro antifungal activities of sulfa drugs against clinical isolates of Aspergillus and Cryptococcus species.
Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20070101
Title: Activity of endothelium-derived hyperpolarizing factor is augmented in monocrotaline-induced pulmonary hypertension of rat lungs.
Journal: Journal of vascular research 20070101
Title: Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 products.
Journal: Canadian journal of physiology and pharmacology 20070101
Title: Cloning of a cDNA encoding a novel marmoset CYP2C enzyme, expression in yeast cells and characterization of its enzymatic functions.
Journal: Biochemical pharmacology 20061215
Title: Critical role of free cytosolic calcium, but not uncoupling, in mitochondrial permeability transition and cell death induced by diclofenac oxidative metabolites in immortalized human hepatocytes.
Journal: Toxicology and applied pharmacology 20061215
Title: Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20061201
Title: OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.
Journal: PLoS medicine 20061101
Title: Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1 and 3A1/2 for the metabolism of metformin.
Journal: British journal of pharmacology 20061001
Title: [The inhibition of CYP2C9 isoenzyme in Cunninghamella blakesleeana AS 3. 910].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20061001
Title: Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes.
Journal: Acta pharmacologica Sinica 20060901
Title: Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060801
Title: Polysaccharide peptides from COV-1 strain of Coriolus versicolor inhibit tolbutamide 4-hydroxylation in the rat in vitro and in vivo.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060801
Title: The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone.
Journal: European journal of clinical pharmacology 20060801
Title: Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients.
Journal: Journal of the American College of Cardiology 20060801
Title: Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous omeprazole in rats.
Journal: Biopharmaceutics & drug disposition 20060701
Title: Role of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the regulation of blood pressure by leptin in lean and obese rats.
Journal: Life sciences 20060530
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Metabolism and effect of para-toluene-sulfonamide on rat liver microsomal cytochrome P450 from in vivo and in vitro studies.
Journal: Acta pharmacologica Sinica 20060501
Title: Oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes.
Journal: Biochemical pharmacology 20060428
Title: Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling.
Journal: Hypertension (Dallas, Tex. : 1979) 20060401
Title: Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous ipriflavone in rats.
Journal: The Journal of pharmacy and pharmacology 20060401
Title: Role of vascular heme oxygenase in reduced myogenic reactivity following chronic hypoxia.
Journal: Microcirculation (New York, N.Y. : 1994) 20060301
Title: Territrems B and C metabolism in human liver microsomes: major role of CYP3A4 and CYP3A5.
Journal: Toxicology 20060201
Title: Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.
Journal: Chemical research in toxicology 20060101
Title: Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.
Journal: Clinical pharmacokinetics 20060101
Title: Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis.
Journal: Journal of cell science 20051201
Title: Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101
Title: Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K+ channels in ETB-induced relaxation.
Journal: British journal of pharmacology 20051101
Title: Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium.
Journal: Circulation research 20051028
Title: Cytochrome p450 2C inhibition reduces post-ischemic vascular dysfunction.
Journal: Vascular pharmacology 20051001
Title: Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801
Title: Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801
Title: Urotensin II-induced hypotensive responses in Wistar-Kyoto (Wky) and spontaneously hypertensive (Shr) rats.
Journal: Peptides 20050801
Title: Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050801
Title: Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous torasemide in rats.
Journal: International journal of pharmaceutics 20050714
Title: Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050701
Title: Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors.
Journal: Journal of medicinal chemistry 20050602
Title: Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050601
Title: The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist.
Journal: Journal of clinical pharmacology 20050601
Title: Alteration in endothelial function and modulation by treatment with pioglitazone in rabbit renal artery from short-term hypercholesterolemia.
Journal: Vascular pharmacology 20050601
Title: Electrochemical characterisation of the human cytochrome P450 CYP2C9.
Journal: Biochemical pharmacology 20050515
Title: Nitric oxide- and EDHF-mediated arteriolar tone in uremia is unaffected by selective inhibition of vascular cytochrome P450 2C9.
Journal: Kidney international 20050501
Title: Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism.
Journal: British journal of clinical pharmacology 20050501
Title: Effect of enzyme inducers and inhibitors on the pharmacokinetics of oltipraz in rats.
Journal: The Journal of pharmacy and pharmacology 20050401
Title: Role of human liver cytochrome P450 2C9 in the metabolism of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035.
Journal: Drug metabolism and pharmacokinetics 20050401
Title: Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium.
Journal: Vascular health and risk management 20050301
Title: Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20050201
Title: The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation.
Journal: Cardiovascular research 20050201
Title: SuperLigands - a database of ligand structures derived from the Protein Data Bank.
Journal: BMC bioinformatics 20050101
Title: Simultaneous determination of 16 sulfonamides in honey by liquid chromatography/tandem mass spectrometry.
Journal: Journal of AOAC International 20050101
Title: Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.
Journal: Biochemistry 20041214
Title: Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20041201
Title: The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20041101
Title: Inhibition of cardiac cytochrome P450: a new approach to cardiac ischaemia and reperfusion damage.
Journal: Expert opinion on therapeutic targets 20041001
Title: Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways.
Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20040901
Title: Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338.
Journal: European journal of pharmacology 20040823
Title: Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation.
Journal: Chemical research in toxicology 20040801
Title: Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line.
Journal: Drug metabolism and pharmacokinetics 20040801
Title: The mechanism of EDHF-mediated responses in subcutaneous small arteries from healthy pregnant women.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20040601
Title: Validated assays for human cytochrome P450 activities.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040601
Title: Stereoselective glucuronidation and hydroxylation of etodolac by UGT1A9 and CYP2C9 in man.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040501
Title: Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040401
Title: In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040301
Title: Mediators of bradykinin-induced vasorelaxation in human coronary microarteries.
Journal: Hypertension (Dallas, Tex. : 1979) 20040201
Title: Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: application of simple method for detecting quasi-irreversible and irreversible inhibitors.
Journal: Drug metabolism and pharmacokinetics 20040201
Title: Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease.
Journal: Circulation 20040120
Title: Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed.
Journal: Journal of vascular research 20040101
Title: Identification of the cytochrome P450 enzymes involved in the metabolism of domperidone.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040101
Title: Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells.
Journal: Journal of the American College of Nutrition 20031201
Title: Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20031201
Title: Baseline blood flow and bradykinin-induced vasodilator responses in the human forearm are insensitive to the cytochrome P450 2C9 (CYP2C9) inhibitor sulphaphenazole.
Journal: Clinical science (London, England : 1979) 20031001
Title: Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery.
Journal: Hypertension (Dallas, Tex. : 1979) 20031001
Title: Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.
Journal: European journal of biochemistry 20030901
Title: Role of human hepatic cytochrome P-450s in territrem A metabolism.
Journal: Journal of toxicology and environmental health. Part A 20030711
Title: Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia.
Journal: American journal of physiology. Heart and circulatory physiology 20030701
Title: Electron spin resonance detection of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in porcine coronary microvessels.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20030701
Title: Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030701
Title: Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030701
Title: Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes.
Journal: Biochemistry 20030603
Title: Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.
Journal: Journal of hepatology 20030601
Title: EDHF-mediated vasodilation involves different mechanisms in normotensive and hypertensive rat lungs.
Journal: American journal of physiology. Heart and circulatory physiology 20030501
Title: Characterization of the endothelium-derived hyperpolarizing factor (EDHF) response in the human interlobar artery.
Journal: Kidney international 20030501
Title: Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030501
Title: Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401
Title: Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030301
Title: Metabolism and metabolic inhibition of cilnidipine in human liver microsomes.
Journal: Acta pharmacologica Sinica 20030301
Title: Mediation of arachidonic acid metabolite(s) produced by endothelial cytochrome P-450 3A4 in monkey arterial relaxation.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20030301
Title: Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
Journal: Archives of biochemistry and biophysics 20030101
Title: Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid.
Journal: Archives of biochemistry and biophysics 20030101
Title: High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20030101
Title: Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humans.
Journal: The Journal of physiology 20030101
Title: Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate.
Journal: Rapid communications in mass spectrometry : RCM 20030101
Title: Identification of glutathione conjugates of troglitazone in human hepatocytes.
Journal: Chemico-biological interactions 20021110
Title: Mechanisms underlying endothelium-dependent, nitric oxide- and prostanoid-independent relaxation in monkey and dog coronary arteries.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20021101
Title: The contribution of cytochrome P-450 isoenzymes to the metabolism of phenothiazine neuroleptics.
Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001
Title: EDHF, but not NO or prostaglandins, is critical to evoke a conducted dilation upon ACh in hamster arterioles.
Journal: American journal of physiology. Heart and circulatory physiology 20020901
Title: Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity.
Journal: Life sciences 20020816
Title: The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.
Journal: Pharmaceutical research 20020701
Title: Cytochrome P450 2C9-induced endothelial cell proliferation involves induction of mitogen-activated protein (MAP) kinase phosphatase-1, inhibition of the c-Jun N-terminal kinase, and up-regulation of cyclin D1.
Journal: The Journal of biological chemistry 20020503
Title: Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020501
Title: In vitro metabolic characteristics of cytochrome P-450 2A6 in Chinese liver microsomes.
Journal: Acta pharmacologica Sinica 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid.
Journal: Circulation research 20020419
Title: Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids.
Journal: Biochemical pharmacology 20020301
Title: Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
Journal: Pharmacology & toxicology 20020301
Title: Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020201
Title: Contribution of cytochrome P450 metabolites to bradykinin-induced vasodilation in endothelial NO synthase deficient mouse hearts.
Journal: British journal of pharmacology 20020201
Title: Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries.
Journal: Biochemical and biophysical research communications 20020125
Title: Design and application of fluorometric assays for human cytochrome P450 inhibition.
Journal: Methods in enzymology 20020101
Title: Major cytochrome P450 enzymes responsible for microsomal aldehyde oxygenation of 11-oxo-Delta8-tetrahydrocannabinol and 9-anthraldehyde in human liver.
Journal: Drug metabolism and pharmacokinetics 20020101
Title: Quantitative determination of sulfonamide in meat by liquid chromatography-electrospray-mass spectrometry.
Journal: Talanta 20011224
Title: Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.
Journal: Journal of medicinal chemistry 20011025
Title: Interaction of new sulfaphenazole derivatives with human liver cytochrome p450 2Cs: structural determinants required for selective recognition by CYP 2C9 and for inhibition of human CYP 2Cs.
Journal: Archives of biochemistry and biophysics 20011015
Title: Metabolism of vanoxerine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010901
Title: Role of CYP2C9 polymorphism in losartan oxidation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010701
Title: The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells.
Journal: Pflugers Archiv : European journal of physiology 20010701
Title: Involvement of CYP2B6 in n-demethylation of ketamine in human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010601
Title: Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20010601
Title: Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010501
Title: Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors.
Journal: Epilepsy research 20010401
Title: Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine.
Journal: European journal of clinical pharmacology 20010401
Title: Metabolic characterization of the major human small intestinal cytochrome p450s.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010301
Title: CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010201
Title: Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline.
Journal: Pharmacogenetics 20010201
Title: Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries.
Journal: Circulation research 20010119
Title: A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20010101
Title: Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes.
Journal: Acta pharmacologica Sinica 20010101
Title: Cytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effect.
Journal: Antimicrobial agents and chemotherapy 20001001
Title: Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20000601
Title: Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.
Journal: The Journal of pharmacology and experimental therapeutics 19980201
Title: Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 19980201
Title: Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 19961201
Title: Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.
Journal: Annals of tropical medicine and parasitology 19961201
Title: Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 19960701
Title: Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9.
Journal: Biochemical and biophysical research communications 19910329
