[1]Oparin[BiochemischeZeitschrift,1921,vol.124,p.92][Izv.ross.Akad.,vol.<6>16,p.543][ChemischesZentralblatt,1925,vol.96,#II,p.728]
[2]Oparin[BiochemischeZeitschrift,1921,vol.124,p.92][Izv.ross.Akad.,vol.<6>16,p.543][ChemischesZentralblatt,1925,vol.96,#II,p.728]
[1]Pollack[1906,vol.7,p.18]
[2]Viscontini[HelveticaChimicaActa,1946,vol.29,p.1496]
[1]Viscontini[HelveticaChimicaActa,1946,vol.29,p.1496]
[1]Kerp;Unger[ChemischeBerichte,1897,vol.30,p.590]
Title: The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.
Journal: Chemico-biological interactions 20160125
Title: Featured Article: Hypoxia-inducible factor-1α dependent nuclear entry of factor inhibiting HIF-1.
Journal: Experimental biology and medicine (Maywood, N.J.) 20151101
Title: Targeting the hypoxia-sensing pathway in clinical hematology.
Journal: Stem cells translational medicine 20140201
Title: Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.
Journal: The international journal of biochemistry & cell biology 20131101
Title: Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues.
Journal: The American journal of pathology 20121101
Title: Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor in dental pulp-derived cells.
Journal: Journal of endodontics 20121101
Title: α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4).
Journal: Pflugers Archiv : European journal of physiology 20121001
Title: Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes.
Journal: Journal of cellular and molecular medicine 20120901
Title: Increased activation of the hypoxia-inducible factor pathway in varicose veins.
Journal: Journal of vascular surgery 20120501
Title: Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases.
Journal: Journal of medicinal chemistry 20120412
Title: Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblasts.
Journal: Journal of periodontal research 20120401
Title: Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
Journal: Journal of medicinal chemistry 20120308
Title: HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice.
Journal: Journal of hepatology 20120201
Title: Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α.
Journal: Neurobiology of disease 20120201
Title: Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism.
Journal: Journal of dermatological science 20120201
Title: Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D.
Journal: PloS one 20120101
Title: Systemic preconditioning by a prolyl hydroxylase inhibitor promotes prevention of skin flap necrosis via HIF-1-induced bone marrow-derived cells.
Journal: PloS one 20120101
Title: Hypoxia-inducible factor activation protects the kidney from gentamicin-induced acute injury.
Journal: PloS one 20120101
Title: Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis.
Journal: Biochemical and biophysical research communications 20111216
Title: Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase.
Journal: Molecular and cellular biochemistry 20111201
Title: Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms.
Journal: Laboratory investigation; a journal of technical methods and pathology 20111201
Title: Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction.
Journal: American journal of physiology. Lung cellular and molecular physiology 20111201
Title: Hypoxia induced expression of histone lysine demethylases: implications in oxygen-dependent retinal neovascular diseases.
Journal: Biochemical and biophysical research communications 20111118
Title: Hypoxia-inducible factor regulates expression of surfactant protein in alveolar type II cells in vitro.
Journal: American journal of respiratory cell and molecular biology 20111101
Title: Curcumin provides potential protection against the activation of hypoxia and prolyl 4-hydroxylase inhibitors on prostate-specific antigen expression in human prostate carcinoma cells.
Journal: Molecular nutrition & food research 20111101
Title: Longitudinal quantification of inflammation in the murine dextran sodium sulfate-induced colitis model using μPET/CT.
Journal: Inflammatory bowel diseases 20111001
Title: Inhibition of prolyl hydroxylase domain-containing protein downregulates vascular angiotensin II type 1 receptor.
Journal: Hypertension (Dallas, Tex. : 1979) 20110901
Title: The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells.
Journal: Shock (Augusta, Ga.) 20110901
Title: Dimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivo.
Journal: Plastic and reconstructive surgery 20110801
Title: Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1α and VEGF production and improves functional recovery after acute ischemia/reperfusion.
Journal: Surgery 20110801
Title: Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells.
Journal: The Journal of surgical research 20110515
Title: Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue.
Journal: Blood 20110505
Title: [Effects of dimethyloxalyl glycine on hypoxic-ischemic brain damage in newborn rats].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110501
Title: Hypoxia-inducible factor-1α-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20110401
Title: Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.
Journal: British journal of cancer 20110329
Title: HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal.
Journal: Blood 20110324
Title: Structural basis for human PHF2 Jumonji domain interaction with metal ions.
Journal: Journal of molecular biology 20110211
Title: Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201
Title: Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110101
Title: Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Chemical biology of lysine demethylases.
Journal: Current chemical genomics 20110101
Title: Methods for Activity Analysis of the Proteins that Regulate Histone Methylation.
Journal: Current chemical genomics 20110101
Title: Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity.
Journal: PloS one 20110101
Title: von Hippel-Lindau β-domain-luciferase fusion protein as a bioluminescent hydroxyproline sensor for a hypoxia-inducible factor prolyl hydroxylase assay.
Journal: Analytical biochemistry 20101215
Title: Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade.
Journal: American journal of physiology. Renal physiology 20101201
Title: Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20101115
Title: Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
Journal: Bioorganic & medicinal chemistry letters 20101015
Title: Hypoxia and preeclampsia: increased expression of urocortin 2 and urocortin 3.
Journal: Reproductive sciences (Thousand Oaks, Calif.) 20100901
Title: Force field design and molecular dynamics simulations of factor-inhibiting HIF-1 and its complex with known inhibitors: implications for rational inhibitor design.
Journal: Journal of molecular graphics & modelling 20100901
Title: Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.
Journal: Journal of medicinal chemistry 20100812
Title: Acute hypoxia induces HIF-independent monocyte adhesion to endothelial cells through increased intercellular adhesion molecule-1 expression: the role of hypoxic inhibition of prolyl hydroxylase activity for the induction of NF-kappa B.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20100801
Title: Hydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus.
Journal: Neuroscience 20100602
Title: Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast.
Journal: Endocrinology 20100601
Title: Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway.
Journal: The Journal of biological chemistry 20100319
Title: Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia.
Journal: American journal of physiology. Renal physiology 20100301
Title: FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells.
Journal: The Journal of biological chemistry 20100212
Title: Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.
Journal: Journal of medicinal chemistry 20100128
Title: Attenuation of myocardial injury by postconditioning: role of hypoxia inducible factor-1alpha.
Journal: Basic research in cardiology 20100101
Title: Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100101
Title: Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes.
Journal: Cancer science 20100101
Title: Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
Journal: PloS one 20100101
Title: Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20091201
Title: Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma.
Journal: International journal of colorectal disease 20091101
Title: Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in human proximal tubular cell lines.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20091101
Title: 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
Journal: Bioorganic & medicinal chemistry letters 20091101
Title: Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice.
Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20091001
Title: Interferon-gamma induces prolyl hydroxylase (PHD)3 through a STAT1-dependent mechanism in human endothelial cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20090901
Title: Adenosine A2A receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20090630
Title: Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090515
Title: Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.
Journal: Journal of medicinal chemistry 20090514
Title: Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons.
Journal: Molecular pharmacology 20090501
Title: Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival.
Journal: Journal of cellular biochemistry 20090401
Title: Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
Journal: Molecular & cellular proteomics : MCP 20090301
Title: Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease.
Journal: Nature reviews. Drug discovery 20090201
Title: HIF-1 attenuates Ref-1 expression in endothelial cells: reversal by siRNA and inhibition of geranylgeranylation.
Journal: Vascular pharmacology 20090101
Title: Prolyl hydroxylase inhibition attenuates post-ischemic cardiac injury via induction of endoplasmic reticulum stress genes.
Journal: Vascular pharmacology 20090101
Title: Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.
Journal: PloS one 20090101
Title: Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
Journal: The Biochemical journal 20081215
Title: A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.
Journal: Molecular cancer therapeutics 20081201
Title: Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
Journal: Journal of medicinal chemistry 20081127
Title: HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model.
Journal: Neurobiology of disease 20080901
Title: Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning.
Journal: Circulation 20080708
Title: O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration.
Journal: American journal of physiology. Cell physiology 20080701
Title: Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae.
Journal: Biochemistry 20080513
Title: Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes.
Journal: Pflugers Archiv : European journal of physiology 20080501
Title: DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: potential role in the treatment of pulmonary arterial hypertension.
Journal: The Journal of steroid biochemistry and molecular biology 20080301
Title: The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis.
Journal: Gastroenterology 20080101
Title: Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints.
Journal: Arthritis research & therapy 20080101
Title: Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation.
Journal: Journal of neurochemistry 20071201
Title: HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes.
Journal: American journal of physiology. Endocrinology and metabolism 20071201
Title: Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes.
Journal: Arthritis and rheumatism 20071201
Title: Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.
Journal: The Journal of biological chemistry 20070914
Title: Effect of chemical stabilizers of hypoxia-inducible factors on early lung development.
Journal: American journal of physiology. Lung cellular and molecular physiology 20070901
Title: HIF stabilizing agents: shotgun or scalpel?
Journal: American journal of physiology. Lung cellular and molecular physiology 20070901
Title: Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance.
Journal: Acta physiologica (Oxford, England) 20070601
Title: Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans.
Journal: Biochemistry 20070508
Title: Hypoxia inducible factor-1 modulates hemin-induced IL-8 secretion in microvascular endothelium.
Journal: Microvascular research 20070501
Title: Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha.
Journal: Biochemical pharmacology 20070301
Title: The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition.
Journal: American journal of physiology. Cell physiology 20070201
Title: Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway.
Journal: Oncogene 20070111
Title: Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity.
Journal: Journal of cellular physiology 20070101
Title: Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
Journal: The Journal of biological chemistry 20060602
Title: Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes.
Journal: Biochemical and biophysical research communications 20060310
Title: [HIF-1alpha, HIF-2alpha and VHL mRNA expression in different cell lines during hypoxia].
Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20060101
Title: Kinetic and spectroscopic investigation of CoII, NiII, and N-oxalylglycine inhibition of the FeII/alpha-ketoglutarate dioxygenase, TauD.
Journal: Biochemical and biophysical research communications 20051209
Title: HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation.
Journal: American journal of physiology. Heart and circulatory physiology 20050801
Title: Activation of hypoxia-induced transcription in normoxia.
Journal: Experimental cell research 20050515
Title: Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron.
Journal: Experimental cell research 20050515
Title: Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells.
Journal: American journal of physiology. Cell physiology 20050501
Title: Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines.
Journal: Acta biochimica Polonica 20050101
Title: Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.
Journal: The Journal of physiology 20041001
Title: Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.
Journal: The Journal of biological chemistry 20021018
