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52683-81-5,MFCD10697866
Catalog No.:AA00DCB8

52683-81-5 | (S)-4,4-Difluoropyrrolidine-2-carboxylic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
95%
in stock  
$23.00   $16.00
- +
250mg
95%
in stock  
$38.00   $27.00
- +
5g
98%
in stock  
$311.00   $218.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DCB8
Chemical Name:
(S)-4,4-Difluoropyrrolidine-2-carboxylic acid
CAS Number:
52683-81-5
Molecular Formula:
C5H7F2NO2
Molecular Weight:
151.1114
MDL Number:
MFCD10697866
SMILES:
OC(=O)[C@H]1NCC(C1)(F)F
Properties
Properties
 
BP:
254°C at 760 mmHg  
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
160  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
-2.1  

Upstream Synthesis Route

[1]Patent:US2008/9497,2008,A1,.Locationinpatent:Page/Pagecolumn109

[2]Patent:WO2014/82379,2014,A1,.Locationinpatent:Page/Pagecolumn158;159;163

[3]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

[1]JournalofFluorineChemistry,1994,vol.66,#1,p.87-90

[1]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

[2]Patent:WO2014/82379,2014,A1,

[1]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

[2]Patent:WO2014/82379,2014,A1,

[1]TetrahedronLetters,1998,vol.39,#10,p.1169-1172

Downstream Synthesis Route

[1]JournalofFluorineChemistry,1994,vol.66,p.87-90

82911-69-1    52683-81-5   
(2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4,4-difluoro-pyrrolidine-2-carboxylicacid 

[1]TetrahedronLetters,1998,vol.39,p.1169-1172

[1]Patent:US2008/9497,2008,A1.Locationinpatent:Page/Pagecolumn109

[2]Patent:WO2014/82379,2014,A1.Locationinpatent:Page/Pagecolumn158;159;163

[3]Patent:US2019/270739,2019,A1.Locationinpatent:Paragraph0739

[4]TetrahedronLetters,1998,vol.39,p.1169-1172

[1]TetrahedronLetters,1998,vol.39,p.1169-1172

Literature

Title: Origin of the stability conferred upon collagen by fluorination.

Journal: Bioorganic & medicinal chemistry letters 20090715

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SDS
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Tags:52683-81-5 Molecular Formula|52683-81-5 MDL|52683-81-5 SMILES|52683-81-5 (S)-4,4-Difluoropyrrolidine-2-carboxylic acid