Home Imidazoles 527-73-1
527-73-1,MFCD00005185
Catalog No.:AA003HPX

527-73-1 | 2-Nitroimidazole

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$6.00   $4.00
- +
1g
99%
in stock  
$12.00   $8.00
- +
5g
95%
in stock  
$37.00   $26.00
- +
10g
99%
in stock  
$55.00   $39.00
- +
25g
99%
in stock  
$136.00   $96.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003HPX
Chemical Name:
2-Nitroimidazole
CAS Number:
527-73-1
Molecular Formula:
C3H3N3O2
Molecular Weight:
113.0748
MDL Number:
MFCD00005185
SMILES:
[O-][N+](=O)c1ncc[nH]1
NSC Number:
105831
Properties
Properties
 
BP:
211.75°C (rough estimate)  
Form:
Solid  
MP:
287°C  
Refractive Index:
1.4264 (estimate)  
Solubility:
NH4OH: soluble50mg/mL, clear, yellow to orange  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
99.2  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
0.1  

Literature

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Dose-response relationships of FMISO between trace dose and various macro-doses in rat by ultra-performance liquid chromatography with mass spectrometry and radioactivity analysis.

Journal: Journal of pharmaceutical and biomedical analysis 20121101

Title: On the structural modification of 2-nitroimidazole-(99m)Tc(CO)(3) complex, a hypoxia marker, for improving in vivo pharmacokinetics.

Journal: Nuclear medicine and biology 20121101

Title: In vitro and in vivo evaluation of [(18)F]F-GAZ, a novel oxygen-mimetic azomycin-glucose conjugate, for imaging hypoxic tumor.

Journal: Cancer biotherapy & radiopharmaceuticals 20121001

Title: Synthesis and characterization of a hypoxia-sensitive MRI probe.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120727

Title: Synthetic control of framework zinc purinate crystallisation and properties of a large pore, decorated, mixed-linker RHO-type ZIF.

Journal: Chemical communications (Cambridge, England) 20120707

Title: Syntheses of 2-nitroimidazole derivatives conjugated with 1,4,7-triazacyclononane-N,N'-diacetic acid labeled with F-18 using an aluminum complex method for hypoxia imaging.

Journal: Journal of medicinal chemistry 20120412

Title: Development of hypoxia enhanced 111In-labeled Bombesin conjugates: design, synthesis, and in vitro evaluation in PC-3 human prostate cancer.

Journal: Bioconjugate chemistry 20120321

Title: 2-Nitroimidazole-tricarbocyanine conjugate as a near-infrared fluorescent probe for in vivo imaging of tumor hypoxia.

Journal: Bioconjugate chemistry 20120321

Title: The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120315

Title: Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.

Journal: Molecular cancer therapeutics 20120301

Title: Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120201

Title: Effect of a second nitroimidazole redox centre on the accumulation of a hypoxia marker: synthesis and in vitro evaluation of 99mTc-labeled bisnitroimidazole propylene amine oxime complexes.

Journal: Bioorganic & medicinal chemistry letters 20120101

Title: Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia.

Journal: PloS one 20120101

Title: Targeting tumor perfusion and oxygenation to improve the outcome of anticancer therapy.

Journal: Frontiers in pharmacology 20120101

Title: Stroma targeting nuclear imaging and radiopharmaceuticals.

Journal: International journal of molecular imaging 20120101

Title: Development of (99m)Tc-N4-NIM for molecular imaging of tumor hypoxia.

Journal: Journal of biomedicine & biotechnology 20120101

Title: Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.

Journal: Journal of medicinal chemistry 20111208

Title: Imaging hypoxia in gliomas.

Journal: The British journal of radiology 20111201

Title: Preparation of nucleosides derived from 2-nitroimidazole and D-arabinose, D-ribose, and D-galactose by the Vorbrüggen method and their conversion to potential precursors for tracers to image hypoxia.

Journal: The Journal of organic chemistry 20111021

Title: Nitroimidazole radiopharmaceuticals in hypoxia: part II cytotoxicity and radiosensitization applications.

Journal: Current radiopharmaceuticals 20111001

Title: Immunohistochemical assessment of intrinsic and extrinsic markers of hypoxia in reproductive tissue: differential expression of HIF1α and HIF2α in rat oviduct and endometrium.

Journal: Journal of molecular histology 20110801

Title: Synthesis and evaluation of two novel 2-nitroimidazole derivatives as potential PET radioligands for tumor imaging.

Journal: Nuclear medicine and biology 20110501

Title: Indirect competitive enzyme-linked immuno-sorbent assay (ELISA) for nitroimidazoles in food products.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20110501

Title: Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer.

Journal: Cancer research 20110415

Title: The biological characterization of (99m)Tc-BnAO-NI as a SPECT probe for imaging hypoxia in a sarcoma-bearing mouse model.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20110401

Title: Catabolic pathway for 2-nitroimidazole involves a novel nitrohydrolase that also confers drug resistance.

Journal: Environmental microbiology 20110401

Title: Radiosynthesis of the tumor hypoxia marker [18F]TFMISO via O-[18F]trifluoroethylation reveals a striking difference between trifluoroethyl tosylate and iodide in regiochemical reactivity toward oxygen nucleophiles.

Journal: Bioorganic & medicinal chemistry 20110401

Title: Nitroimidazole derivative-induced fixed drug eruptions: Not so uncommon.

Journal: Indian journal of pharmacology 20110401

Title: 2-Chloro-N-[(4-chloro-phen-yl)(phen-yl)meth-yl]-N-[2-(4-nitro-1H-imidazol-1-yl)eth-yl]ethanamine.

Journal: Acta crystallographica. Section E, Structure reports online 20110201

Title: Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment.

Journal: PloS one 20110101

Title: Oxygen, a Key Factor Regulating Cell Behavior during Neurogenesis and Cerebral Diseases.

Journal: Frontiers in molecular neuroscience 20110101

Title: Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study.

Journal: Radiation oncology (London, England) 20110101

Title: Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104.

Journal: PloS one 20110101

Title: Significant impact of different oxygen breathing conditions on noninvasive in vivo tumor-hypoxia imaging using [¹⁸F]-fluoro-azomycinarabino-furanoside ([¹⁸F]FAZA).

Journal: Radiation oncology (London, England) 20110101

Title: Targeting hypoxic tumour cells to overcome metastasis.

Journal: BMC cancer 20110101

Title: In vivo T cell activation in lymphoid tissues is inhibited in the oxygen-poor microenvironment.

Journal: Frontiers in immunology 20110101

Title: Biodistribution and dosimetry of (18)F-EF5 in cancer patients with preliminary comparison of (18)F-EF5 uptake versus EF5 binding in human glioblastoma.

Journal: European journal of nuclear medicine and molecular imaging 20101101

Title: Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302.

Journal: Biological trace element research 20100901

Title: Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[18F] fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new 18F-labeled 2-nitroimidazole analog.

Journal: Journal of neurosurgery 20100801

Title: PET imaging of hypoxia using [18F]HX4: a phase I trial.

Journal: European journal of nuclear medicine and molecular imaging 20100801

Title: Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma.

Journal: British journal of cancer 20100629

Title: Development of new anti-tuberculosis drug candidates.

Journal: The Tohoku journal of experimental medicine 20100601

Title: The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study.

Journal: Translational oncology 20100601

Title: Fixed drug eruption with ornidazole having cross-sensitivity to secnidazole but not to other nitro-imidazole compounds: a case report.

Journal: British journal of clinical pharmacology 20100601

Title: Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) - Potential combination agents for the PET imaging of hypoxia.

Journal: Journal of inorganic biochemistry 20100201

Title: The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors.

Journal: BMC cancer 20100101

Title: Hypoxia-specific targets in cancer therapy: role of splice variants.

Journal: BMC medicine 20100101

Title: Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens.

Journal: PloS one 20100101

Title: Synthesis and cloxacillin antimicrobial enhancement of 2-methylsulfonylimidazolyl-1,4-dihydropyridine derivatives.

Journal: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101

Title: A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy.

Journal: British journal of cancer 20091201

Title: A submarine journey: the pyrrole-imidazole alkaloids.

Journal: Marine drugs 20091201

Title: Design of silicon-based misonidazole analogues and (18)F-radiolabelling.

Journal: Nuclear medicine and biology 20091101

Title: Interventions for prevention of post-operative recurrence of Crohn's disease.

Journal: The Cochrane database of systematic reviews 20091007

Title: Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer.

Journal: Cancer chemotherapy and pharmacology 20091001

Title: Molecular imaging of hypoxia with radiolabelled agents.

Journal: European journal of nuclear medicine and molecular imaging 20091001

Title: Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours.

Journal: British journal of cancer 20090818

Title: Nitroimidazole-based bioreductive compounds bearing a quinazoline or a naphthyridine chromophore.

Journal: Anti-cancer drugs 20090701

Title: Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin.

Journal: PLoS pathogens 20090701

Title: Imaging and Targeting of the Hypoxia-inducible Factor 1-active Microenvironment.

Journal: Journal of toxicologic pathology 20090601

Title: Control of pore size and functionality in isoreticular zeolitic imidazolate frameworks and their carbon dioxide selective capture properties.

Journal: Journal of the American Chemical Society 20090325

Title: Ultra performance liquid chromatography tandem mass spectrometry performance evaluation for analysis of antibiotics in natural waters.

Journal: Analytical and bioanalytical chemistry 20090301

Title: Synthesis and hypoxia selective radiosensitization potential of beta-2-FAZA and beta-3-FAZL: fluorinated azomycin beta-nucleosides.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20090301

Title: Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy.

Journal: PloS one 20090101

Title: Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.

Journal: Journal of parasitology research 20090101

Title: The novel hypoxic cell radiosensitizer, TX-1877 has antitumor activity through suppression of angiogenesis and inhibits liver metastasis on xenograft model of pancreatic cancer.

Journal: Cancer letters 20081218

Title: Comparative pharmacokinetics, biodistribution, metabolism and hypoxia-dependent uptake of [18F]-EF3 and [18F]-MISO in rodent tumor models.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20081201

Title: Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors.

Journal: Radiation research 20081201

Title: On the isolation and evaluation of a novel unsubstituted 5-nitroimidazole derivative as an agent to target tumor hypoxia.

Journal: Bioorganic & medicinal chemistry letters 20081001

Title: Regulation of cell survival and death signals induced by oxidative stress.

Journal: Journal of clinical biochemistry and nutrition 20080901

Title: 1,2-Bis[2-(2-nitro-1H-imidazol-1-yl)eth-oxy]ethane.

Journal: Acta crystallographica. Section E, Structure reports online 20080901

Title: FDG uptake, a surrogate of tumour hypoxia?

Journal: European journal of nuclear medicine and molecular imaging 20080801

Title: O-(tert-Butyl-dimethyl-silyl)tris-(O-4-methyl-phenyl-sulfon-yl)penta-erythritol.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: Reactions of NO(2)Cl with imidazole: a model study for the corresponding reactions of guanine.

Journal: The journal of physical chemistry. B 20080703

Title: Determination of tumour hypoxia with [18F]EF3 in patients with head and neck tumours: a phase I study to assess the tracer pharmacokinetics, biodistribution and metabolism.

Journal: European journal of nuclear medicine and molecular imaging 20080701

Title: Bactericidal activity of 2-nitroimidazole against the active replicating stage of Mycobacterium bovis BCG and Mycobacterium tuberculosis with intracellular efficacy in THP-1 macrophages.

Journal: International journal of antimicrobial agents 20080701

Title: Design of antiangiogenic hypoxic cell radiosensitizers: 2-nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1,3-dione moiety.

Journal: Bioorganic & medicinal chemistry 20080601

Title: Stereospecific deuteration of alpha-furanosyl azomycin nucleosides: a model reaction for tritium radiolabeling.

Journal: Bioorganic & medicinal chemistry letters 20080601

Title: Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.

Journal: Journal of medicinal chemistry 20080424

Title: Novel nitroheterocyclic hypoxic markers for solid tumor: synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry 20080315

Title: Design, synthesis, and radiosensitizing activities of sugar-hybrid hypoxic cell radiosensitizers.

Journal: Bioorganic & medicinal chemistry 20080115

Title: NLNQ-1, a 2-[3-(2-nitro-1-imidazolyl) propylamino]-3-chloro-1,4-naphthoquinone, as a hypoxia-selective cytotoxin and radiosensitizer.

Journal: In vivo (Athens, Greece) 20080101

Title: Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints.

Journal: Arthritis research & therapy 20080101

Title: Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome.

Journal: International journal of radiation oncology, biology, physics 20071115

Title: Determination of tumour hypoxia with the PET tracer [18F]EF3: improvement of the tumour-to-background ratio in a mouse tumour model.

Journal: European journal of nuclear medicine and molecular imaging 20070901

Title: Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase.

Journal: PLoS biology 20070801

Title: Imaging oxygenation of human tumours.

Journal: European radiology 20070401

Title: In situ oxygen utilization in the rat intervertebral disc.

Journal: Journal of anatomy 20070301

Title: From 'Hellstrom Paradox' to anti-adenosinergic cancer immunotherapy.

Journal: Purinergic signalling 20070301

Title: Tacrolimus (FK506) limits accumulation of granulocytes and platelets and protects against brain damage after transient focal cerebral ischemia in rat.

Journal: Biological & pharmaceutical bulletin 20070201

Title: Initial evaluation of dynamic human imaging using 18F-FRP170 as a new PET tracer for imaging hypoxia.

Journal: Annals of nuclear medicine 20070201

Title: Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA--first small animal PET results.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101

Title: The radiosensitizing effect of doranidazole on human colorectal cancer cells exposed to high doses of irradiation.

Journal: BMC cancer 20070101

Title: Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia.

Journal: PloS one 20070101

Title: In vivo evaluation of the nitroimidazole-based thioflavin-T derivatives as cerebral ischemia markers.

Journal: International journal of biomedical imaging 20070101

Title: Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding.

Journal: The Journal of investigative dermatology 20061201

Title: Ruthenium(III) maltolato-nitroimidazole complexes: synthesis and biological activity.

Journal: Journal of inorganic biochemistry 20061201

Title: Azanonaboranes containing imidazole derivatives for boron neutron capture therapy: synthesis, characterization, and in vitro toxicity evaluation.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20061025

Title: Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation.

Journal: British journal of cancer 20061023

Title: Review article: recurrence of Crohn's disease after surgery - the need for treatment of new lesions.

Journal: Alimentary pharmacology & therapeutics 20061001

Title: Temporal and topographic profiles of tissue hypoxia following transient focal cerebral ischemia in rats.

Journal: The Journal of veterinary medical science 20060801

Title: Reaction of azole heterocycles with tris(dimethylamino)borane, a new method for the construction of tripodal borate-centred ligands.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060705

Title: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Journal: PLoS computational biology 20060601

Title: Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding.

Journal: Bioorganic & medicinal chemistry 20060501

Title: Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor.

Journal: Bioorganic & medicinal chemistry letters 20060315

Title: EF5 binding and clinical outcome in human soft tissue sarcomas.

Journal: International journal of radiation oncology, biology, physics 20060301

Title: Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension.

Journal: Cellular microbiology 20060201

Title: Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy.

Journal: Journal of translational medicine 20060101

Title: Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo.

Journal: Journal of radiation research 20051201

Title: TX-1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response: immune cell migration and nitric oxide production.

Journal: International journal of cancer 20050910

Title: Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imaging.

Journal: Molecular cancer therapeutics 20050901

Title: Synthesis, in vitro-antimycobacterial activity and cytotoxicity of some alkyl alpha-(5-aryl-1, 3, 4-thiadiazole-2-ylthio)acetates.

Journal: Archiv der Pharmazie 20050301

Title: A one-pot synthesis of 1-alpha- and 1-beta-D-arabinofuranosyl-2-nitroimidazoles: synthons to the markers of tumor hypoxia.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: HEGPOL: randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312].

Journal: BMC surgery 20050101

Title: Hypoxia is important in the biology and aggression of human glial brain tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041215

Title: Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry.

Journal: British journal of cancer 20041129

Title: Angiogenesis inhibitor TX-1898: syntheses of the enantiomers of sterically diverse haloacetylcarbamoyl-2-nitroimidazole hypoxic cell radiosensitizers.

Journal: Bioorganic & medicinal chemistry 20040915

Title: Preclinical validation of the hypoxia tracer 2-(2-nitroimidazol-1-yl)- N-(3,3,3-[(18)F]trifluoropropyl)acetamide, [(18)F]EF3.

Journal: European journal of nuclear medicine and molecular imaging 20040901

Title: Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo.

Journal: Neoplasia (New York, N.Y.) 20040701

Title: In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography.

Journal: British journal of cancer 20040601

Title: Propargylic sulfones possessing a 2-nitroimidazole function: novel hypoxic-cell radiosensitizers with intracellular non-protein thiol depletion ability.

Journal: Bioorganic & medicinal chemistry letters 20040517

Title: In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi.

Journal: Memorias do Instituto Oswaldo Cruz 20040301

Title: Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas.

Journal: British journal of cancer 20040209

Title: Overexpression of VEGF121, but not VEGF165 or FGF-1, improves oxygenation in MCF-7 breast tumours.

Journal: British journal of cancer 20040126

Title: The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031201

Title: A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031101

Title: Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.

Journal: British journal of cancer 20030804

Title: Pimonidazole binding in C6 rat brain glioma: relation with lipid droplet detection.

Journal: British journal of cancer 20030506

Title: 99mTcO(BAT-NI), a novel nitroimidazole tracer: in vivo uptake studies in ischaemic myocardium.

Journal: European journal of nuclear medicine and molecular imaging 20030401

Title: In vivo colocalization of 2-nitroimidazole EF5 fluorescence intensity and electron paramagnetic resonance oximetry in mouse tumors.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20030401

Title: Noninvasive imaging of tumor hypoxia in rats using the 2-nitroimidazole 18F-EF5.

Journal: European journal of nuclear medicine and molecular imaging 20030201

Title: A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors.

Journal: British journal of cancer 20030127

Title: Non-invasive PET and SPECT imaging of tissue hypoxia using isotopically labeled 2-nitroimidazoles.

Journal: Advances in experimental medicine and biology 20030101

Title: Monitoring the synthetic reaction of a polyamide/peptide conjugate using electrospray ionization mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: Genetic algorithm applied to the selection of factors in principal component-artificial neural networks: application to QSAR study of calcium channel antagonist activity of 1,4-dihydropyridines (nifedipine analogous).

Journal: Journal of chemical information and computer sciences 20030101

Title: Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.

Journal: Cancer research 20021201

Title: Quantitative structure-activity relationship study of recently synthesized 1,4-dihydropyridine calcium channel antagonists. Application of the Hansch analysis method.

Journal: Archiv der Pharmazie 20021201

Title: Adduct of 2-[18F]FDG and 2-nitroimidazole as a putative radiotracer for the detection of hypoxia with PET: synthesis, in vitro- and in vivo-characterization.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20021101

Title: [99mTc]Technetium labelled PnAo-azomycin glucuronides: a novel class of imaging markers of tissue hypoxia.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20021101

Title: DNA-targeted 2-nitroimidazoles: studies of the influence of the phenanthridine-linked nitroimidazoles, 2-NLP-3 and 2-NLP-4, on DNA damage induced by ionizing radiation.

Journal: Radiation research 20020901

Title: Phase 1 study to identify tumour hypoxia in patients with head and neck cancer using technetium-99m BRU 59-21.

Journal: European journal of nuclear medicine and molecular imaging 20020901

Title: Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020701

Title: Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis.

Journal: British journal of cancer 20020605

Title: The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020601

Title: Effect of a hypoxic cell sensitizer doranidazole on the radiation-induced apoptosis of mouse L5178Y lymphoma cells.

Journal: Journal of radiation research 20020601

Title: Comparison of hypoxic cell radiosensitizers, KIN-804, KIN-844, KIN-806 and TX-1877, on brain and liver metabolizing capacities in mice bearing Ehrlich ascites carcinoma.

Journal: Biological & pharmaceutical bulletin 20020501

Title: Synthesis and antihypertensive activities of new 1,4-dihydropyridine containing nitroimidazolyl substituent with a nitrooxy group at the 3-ester position.

Journal: Archiv der Pharmazie 20020301

Title: Radiation-chemical properties of the hypoxic cell radiosensitizer doranidazole (PR-350).

Journal: Journal of radiation research 20020301

Title: Isolation and characterization of 2-nitroimidazole produced by Streptomyces species as an inhibitor of both carbonic anhydrase and shell formation in the barnacle Balanus amphitrite.

Journal: Marine biotechnology (New York, N.Y.) 20020301

Title: Imaging of ischemic but viable myocardium using a new 18F-labeled 2-nitroimidazole analog, 18F-FRP170.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020101

Title: Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5.

Journal: Methods in enzymology 20020101

Title: Synthesis and calcium channel antagonist activity of 1,4-dihydropyridine derivatives containing 4-nitroimidazolyl substituents.

Journal: Arzneimittel-Forschung 20020101

Title: Bench-to-bedside review: Cytopathic hypoxia.

Journal: Critical care (London, England) 20020101

Title: Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation.

Journal: American journal of clinical oncology 20011001

Title: Imaging hypoxia in tumors.

Journal: Seminars in nuclear medicine 20011001

Title: Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles.

Journal: Cancer chemotherapy and pharmacology 20010901

Title: Fluorescent charge-neutral analogue of xanthosine: synthesis of a 2'-deoxyribonucleoside bearing a 5-aza-7-deazaxanthine base.

Journal: The Journal of organic chemistry 20010727

Title: Low pO2 and beta-estradiol induce VEGF in MCF-7 and MCF-7-5C cells: relationship to in vivo hypoxia.

Journal: Breast cancer research and treatment 20010501

Title: Hypoxia in radiation-induced blood-spinal cord barrier breakdown.

Journal: Cancer research 20010415

Title: Autonomic nervous system and gut-derived endotoxin: involvement in activation of Kupffer cells after in situ organ manipulation.

Journal: World journal of surgery 20010401

Title: The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.

Journal: Cancer research 20010301

Title: Hypoxia in human intraperitoneal and extremity sarcomas.

Journal: International journal of radiation oncology, biology, physics 20010201

Title: New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues.

Journal: Bioorganic & medicinal chemistry 20010201

Title: Phase Ia study of a hypoxic cell sensitizer doranidazole (PR-350) in combination with conventional radiotherapy.

Journal: Anti-cancer drugs 20010101

Title: Bioequivalence assessment of Azomycin (Julphar, UAE) as compared to Zithromax (Pfizer, USA)--two brands of azithromycin--in healthy human volunteers.

Journal: Biopharmaceutics & drug disposition 20010101

Title: Antituberculosis activity of certain antifungal and antihelmintic drugs.

Journal: Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 19990101

Title: Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.

Journal: Annals of tropical medicine and parasitology 19961201

Title: Screening for new compounds with antiherpes activity.

Journal: Antiviral research 19841001

Title: Shoji JH, et al. Isolation of azomycin from Pseudomonas fluorescens. J Antibiot (Tokyo). 1989 Oct;42(10):1513-4.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 527-73-1
Tags:527-73-1 Molecular Formula|527-73-1 MDL|527-73-1 SMILES|527-73-1 2-Nitroimidazole |Organic_Building_Blocks