Home Other Building Blocks 529488-28-6
529488-28-6,MFCD25976816
Catalog No.:AA00DB3E

529488-28-6 | Genz-644282

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Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$58.00   $40.00
- +
5mg
99%
in stock  
$244.00   $171.00
- +
25mg
95%
in stock  
$252.00   $177.00
- +
100mg
95%
in stock  
$601.00   $421.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DB3E
Chemical Name:
Genz-644282
CAS Number:
529488-28-6
Molecular Formula:
C22H21N3O5
Molecular Weight:
407.4192
MDL Number:
MFCD25976816
SMILES:
CNCCn1c(=O)c2cc(OC)c(cc2c2c1c1cc3OCOc3cc1nc2)OC
Properties
Computed Properties
 
Complexity:
636  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.2  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

[1]JournalofMedicinalChemistry,2005,vol.48,p.792-804

Literature

Title: Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program.

Journal: Pediatric blood & cancer 20120201

Title: Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.

Journal: Molecular cancer therapeutics 20110801

Title: Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110501

Title: 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.

Journal: Journal of medicinal chemistry 20050210

Title: Kurtzberg LS, et al. Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res. 2011 May 1;17(9):2777-87.

Title: Houghton PJ, et al. Testing of the topoisomerase 1 inhibitor Genz-644282 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Feb;58(2):200-9.

Title: Sooryakumar D, et al. Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Mol Cancer Ther. 2011 Aug;10(8):1490-9.

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