[1]Patent:US3974281,1976,A
[1]Patent:WO2006/122154,2006,A2.Locationinpatent:Page/Pagecolumn64
[1]Patent:US2008/161361,2008,A1.Locationinpatent:Page/Pagecolumn8-9
[1]Patent:CN109593060,2019,A.Locationinpatent:Paragraph0016-0019
[2]Patent:US2008/319026,2008,A1.Locationinpatent:Page/Pagecolumn22
[3]Patent:WO2012/122165,2012,A2.Locationinpatent:Page/Pagecolumn62
Title: Pirfenidone protects against paraquat-induced lung injury and fibrosis in mice by modulation of inflammation, oxidative stress, and gene expression.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180201
Title: The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation.
Journal: The Journal of biological chemistry 20170908
Title: Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160901
Title: Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20140716
Title: Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury.
Journal: The Journal of pharmacology and experimental therapeutics 20140601
Title: A new hope for idiopathic pulmonary fibrosis.
Journal: The New England journal of medicine 20140529
Title: A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.
Journal: The New England journal of medicine 20140529
Title: Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.
Journal: Toxicology and applied pharmacology 20140115
Title: Antifibrotic effect of atorvastatin on paraquat-induced pulmonary fibrosis: role of PPARγ receptors.
Journal: European journal of pharmacology 20131115
Title: Chronic potentiation of cardiac L-type Ca(2+) channels by pirfenidone.
Journal: Cardiovascular research 20121101
Title: Fluorofenidone attenuates bleomycin-induced pulmonary inflammation and fibrosis in mice via restoring caveolin 1 expression and inhibiting mitogen-activated protein kinase signaling pathway.
Journal: Shock (Augusta, Ga.) 20121101
Title: Effects of an anti-transforming growth factor-β agent (pirfenidone) on strabismus surgery in rabbits.
Journal: Current eye research 20120901
Title: The big clinical trials in idiopathic pulmonary fibrosis.
Journal: Current opinion in pulmonary medicine 20120901
Title: Into the matrix: targeting fibroblasts in pulmonary fibrosis.
Journal: Current opinion in pulmonary medicine 20120901
Title: Effect of pirfenidone on pulmonary fibrosis due to paraquat poisoning in rats.
Journal: Clinical toxicology (Philadelphia, Pa.) 20120901
Title: Pirfenidone treatment in idiopathic pulmonary fibrosis: too much of a great expectation?
Journal: The European respiratory journal 20120901
Title: Genotoxic evaluation of pirfenidone using erythrocyte rodent micronucleus assay.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801
Title: 2012 update on diabetic kidney disease: the expanding spectrum, novel pathogenic insights and recent clinical trials.
Journal: Minerva medica 20120801
Title: Inhibitory effects of pirfenidone on dendritic cells and lung allograft rejection.
Journal: Transplantation 20120727
Title: Treating idiopathic pulmonary fibrosis: current opportunities and future challenges.
Journal: The clinical respiratory journal 20120701
Title: Pirfenidone: significant treatment effects in idiopathic pulmonary fibrosis.
Journal: The clinical respiratory journal 20120701
Title: Re: A controlled clinical trial with pirfenidone in the treatment of pathological skin scarring caused by burns in pediatric patients.
Journal: Annals of plastic surgery 20120701
Title: Update in diffuse parenchymal lung disease 2011.
Journal: American journal of respiratory and critical care medicine 20120701
Title: Clinical highlights from the 2011 ERS Congress in Amsterdam.
Journal: The European respiratory journal 20120601
Title: Assessing the treatment effect from multiple trials in idiopathic pulmonary fibrosis.
Journal: European respiratory review : an official journal of the European Respiratory Society 20120601
Title: Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis.
Journal: European respiratory review : an official journal of the European Respiratory Society 20120601
Title: Changing the idiopathic pulmonary fibrosis treatment approach and improving patient outcomes.
Journal: European respiratory review : an official journal of the European Respiratory Society 20120601
Title: Simultaneous determination of dextromethorphan and dextrophan in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.
Journal: Die Pharmazie 20120601
Title: Immunotherapy in miscellaneous medical disorders Graves ophthalmopathy, asthma, and regional painful syndrome.
Journal: The Medical clinics of North America 20120501
Title: p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription.
Journal: The Journal of biological chemistry 20120427
Title: Pirfenidone suppresses keloid fibroblast-embedded collagen gel contraction.
Journal: Archives of dermatological research 20120401
Title: Pirfenidone treatment of idiopathic pulmonary fibrosis.
Journal: Therapeutic advances in respiratory disease 20120401
Title: Synthesis and structure-activity relationship of 5-substituent-2(1H)-pyridone derivatives as anti-fibrosis agents.
Journal: Bioorganic & medicinal chemistry letters 20120315
Title: Pirfenidone restricts Th2 differentiation in vitro and limits Th2 response in experimental liver fibrosis.
Journal: European journal of pharmacology 20120305
Title: Management of idiopathic pulmonary fibrosis.
Journal: Clinics in chest medicine 20120301
Title: [Idiopathic pulmonary fibrosis: modern guideline-concordant diagnostics and innovative treatment].
Journal: Deutsche medizinische Wochenschrift (1946) 20120301
Title: Drugs of the future for Peyronie's disease.
Journal: Medical hypotheses 20120201
Title: Design, synthesis and antifibrotic activities of carbohydrate-modified 1-(substituted aryl)-5-trifluoromethyl-2(1H) pyridones.
Journal: Molecules (Basel, Switzerland) 20120117
Title: A controlled clinical trial with pirfenidone in the treatment of pathological skin scarring caused by burns in pediatric patients.
Journal: Annals of plastic surgery 20120101
Title: The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120101
Title: Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy.
Journal: PLoS pathogens 20120101
Title: [Chronic kidney disease, new therapeutic approaches].
Journal: La Revue du praticien 20120101
Title: Smoking and idiopathic pulmonary fibrosis.
Journal: Pulmonary medicine 20120101
Title: Active roles of tumor stroma in breast cancer metastasis.
Journal: International journal of breast cancer 20120101
Title: Pirfenidone inhibits transforming growth factor-β1-induced fibrogenesis by blocking nuclear translocation of Smads in human retinal pigment epithelial cell line ARPE-19.
Journal: Molecular vision 20120101
Title: Therapeutic potential of ginger against renal injury induced by carbon tetrachloride in rats.
Journal: TheScientificWorldJournal 20120101
Title: Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells.
Journal: BMC pulmonary medicine 20120101
Title: Antioxidants in kidney diseases: the impact of bardoxolone methyl.
Journal: International journal of nephrology 20120101
Title: Antifibrotic effects of pirfenidone in rat proximal tubular epithelial cells.
Journal: Renal failure 20120101
Title: Current and novel drug therapies for idiopathic pulmonary fibrosis.
Journal: Drug design, development and therapy 20120101
Title: Adverse events of pirfenidone for the treatment of pulmonary fibrosis: a meta-analysis of randomized controlled trials.
Journal: PloS one 20120101
Title: Clinical, molecular, and cellular features of non-Puerto Rican Hermansky-Pudlak syndrome patients of Hispanic descent.
Journal: The Journal of investigative dermatology 20111201
Title: [Innovative therapeutics for idiopathic pulmonary fibrosis].
Journal: Presse medicale (Paris, France : 1983) 20111201
Title: Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors.
Journal: Bioorganic & medicinal chemistry 20111201
Title: [Role of medical treatment for symptomatic leiomyoma management in premenopausal women].
Journal: Journal de gynecologie, obstetrique et biologie de la reproduction 20111201
Title: [Treatment of pulmonary fibrosis. New substances and new interventions].
Journal: Der Internist 20111201
Title: Fluorofenidone suppresses epithelial-mesenchymal transition and the expression of connective tissue growth factor via inhibiting TGF-beta/Smads signaling in human proximal tubular epithelial cells.
Journal: Die Pharmazie 20111201
Title: Pirfenidone: in idiopathic pulmonary fibrosis.
Journal: Drugs 20110910
Title: Newer modes of treating interstitial lung disease.
Journal: Current opinion in pulmonary medicine 20110901
Title: A first step against idiopathic pulmonary fibrosis.
Journal: European respiratory review : an official journal of the European Respiratory Society 20110901
Title: Emerging potential treatments: new hope for idiopathic pulmonary fibrosis patients?
Journal: European respiratory review : an official journal of the European Respiratory Society 20110901
Title: Fluorofenidone attenuates renal interstitial fibrosis in the rat model of obstructive nephropathy.
Journal: Molecular and cellular biochemistry 20110801
Title: Pirfenidone in idiopathic pulmonary fibrosis: the CAPACITY program.
Journal: Expert review of respiratory medicine 20110801
Title: Pirfenidone.
Journal: Nature reviews. Drug discovery 20110701
Title: Pirfenidone for the treatment of Hermansky-Pudlak syndrome pulmonary fibrosis.
Journal: Molecular genetics and metabolism 20110601
Title: Pirfenidone for diabetic nephropathy.
Journal: Journal of the American Society of Nephrology : JASN 20110601
Title: [Interstitial lung disease].
Journal: Deutsche medizinische Wochenschrift (1946) 20110601
Title: Trials and tribulations of new agents, novel biomarkers, and retarding renal progression.
Journal: Journal of the American Society of Nephrology : JASN 20110601
Title: Antifibrotic activities of pirfenidone in animal models.
Journal: European respiratory review : an official journal of the European Respiratory Society 20110601
Title: Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials.
Journal: Lancet (London, England) 20110521
Title: Pirfenidone for idiopathic pulmonary fibrosis.
Journal: Lancet (London, England) 20110521
Title: Evaluation of pirfenidone as a new postoperative antiscarring agent in experimental glaucoma surgery.
Journal: Investigative ophthalmology & visual science 20110516
Title: Novel therapeutic approaches for pulmonary fibrosis.
Journal: British journal of pharmacology 20110501
Title: Update on potential medical treatments for encapsulating peritoneal sclerosis; human and experimental data.
Journal: International urology and nephrology 20110301
Title: [The study of effects of pirfenidone on the pulmonary fibrosis induced by paraquat in mice].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20110201
Title: Scarred by disease.
Journal: Nature medicine 20110101
Title: Pirfenidone treatment of idiopathic pulmonary fibrosis.
Journal: Therapeutics and clinical risk management 20110101
Title: A massive abdominal wall desmoid tumor occurring in a laparotomy scar: a case report.
Journal: World journal of surgical oncology 20110101
Title: A Regenerative Antioxidant Protocol of Vitamin E and α-Lipoic Acid Ameliorates Cardiovascular and Metabolic Changes in Fructose-Fed Rats.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: The protective effect of Malva sylvestris on rat kidney damaged by vanadium.
Journal: Lipids in health and disease 20110101
Title: A rare cause of interstitial lung disease: Hermansky-Pudlak syndrome.
Journal: Tuberkuloz ve toraks 20110101
Title: Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice.
Journal: BMC cardiovascular disorders 20110101
Title: Diffuse alveolar damage: a common phenomenon in progressive interstitial lung disorders.
Journal: Pulmonary medicine 20110101
Title: Postoperative Acute Exacerbation of IPF after Lung Resection for Primary Lung Cancer.
Journal: Pulmonary medicine 20110101
Title: Antifibrotic treatment and other new strategies for improving renal outcomes.
Journal: Contributions to nephrology 20110101
Title: Decorin and colchicine as potential treatments for post-haemorrhagic ventricular dilatation in a neonatal rat model.
Journal: Neonatology 20110101
Title: The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial.
Journal: Respiratory research 20110101
Title: Role of TGF-β signaling in inherited and acquired myopathies.
Journal: Skeletal muscle 20110101
Title: Pharmacokinetics of pirfenidone after topical administration in rabbit eye.
Journal: Molecular vision 20110101
Title: An alternative therapy for idiopathic pulmonary fibrosis by doxycycline through matrix metalloproteinase inhibition.
Journal: Lung India : official organ of Indian Chest Society 20110101
Title: Stem cell therapy for idiopathic pulmonary fibrosis: a protocol proposal.
Journal: Journal of translational medicine 20110101
Title: Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment.
Journal: Respiratory research 20110101
Title: Treatment with etanercept in a patient with rheumatoid arthritis-associated interstitial lung disease.
Journal: Clinical medicine insights. Case reports 20110101
Title: In vitro effects of pirfenidone on cardiac fibroblasts: proliferation, myofibroblast differentiation, migration and cytokine secretion.
Journal: PloS one 20110101
Title: Safety of postoperative administration of human urinary trypsin inhibitor in lung cancer patients with idiopathic pulmonary fibrosis.
Journal: PloS one 20110101
Title: [Idiopathic pulmonary fibrosis -- progress in sight].
Journal: Duodecim; laaketieteellinen aikakauskirja 20110101
Title: The DOCA-Salt Hypertensive Rat as a Model of Cardiovascular Oxidative and Inflammatory Stress.
Journal: Current cardiology reviews 20101101
Title: Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias.
Journal: Heart rhythm 20101001
Title: [Pirfenidone diminishes SiO2 induced lung fibrosis in rats].
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20101001
Title: Non-steroid agents for idiopathic pulmonary fibrosis.
Journal: The Cochrane database of systematic reviews 20100908
Title: Oxidative stress and antioxidants in interstitial lung disease.
Journal: Current opinion in pulmonary medicine 20100901
Title: Progress toward novel treatments for chronic kidney disease.
Journal: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20100901
Title: [Interstitial lung diseases - historical development, current status, future prospects].
Journal: Pneumologie (Stuttgart, Germany) 20100901
Title: Pirfenidone in idiopathic pulmonary fibrosis.
Journal: The European respiratory journal 20100901
Title: Staphylococcal enterotoxins.
Journal: Toxins 20100801
Title: Current and future treatment options in idiopathic pulmonary fibrosis.
Journal: Inflammation & allergy drug targets 20100701
Title: Regulatory watch: Surprise setback for lung fibrosis drug highlights trial challenges.
Journal: Nature reviews. Drug discovery 20100701
Title: Pirfenidone in idiopathic pulmonary fibrosis.
Journal: Drugs of today (Barcelona, Spain : 1998) 20100701
Title: Antifibrotic effect of Pirfenidone on orbital fibroblasts of patients with thyroid-associated ophthalmopathy by decreasing TIMP-1 and collagen levels.
Journal: Investigative ophthalmology & visual science 20100601
Title: New pharmacological treatments for improving renal outcomes in diabetes.
Journal: Nature reviews. Nephrology 20100601
Title: Investigational approaches to therapies for idiopathic pulmonary fibrosis.
Journal: Expert opinion on investigational drugs 20100601
Title: Pirfenidone: antifibrotic agent for idiopathic pulmonary fibrosis.
Journal: Expert review of respiratory medicine 20100601
Title: Molecular basis and current treatment for alcoholic liver disease.
Journal: International journal of environmental research and public health 20100501
Title: Pirfenidone in idiopathic pulmonary fibrosis.
Journal: The European respiratory journal 20100401
Title: Idiopathic pulmonary fibrosis and pirfenidone.
Journal: The European respiratory journal 20100401
Title: FDA panel likes new treatment for idiopathic pulmonary fibrosis.
Journal: Managed care (Langhorne, Pa.) 20100401
Title: Renoprotective properties of pirfenidone in subtotally nephrectomized rats.
Journal: European journal of pharmacology 20100310
Title: Inhibition of matrix deposition: a new strategy for prevention of restenosis after balloon angioplasty.
Journal: Journal of cardiovascular pharmacology 20100201
Title: Pirfenidone: an anti-fibrotic therapy for progressive kidney disease.
Journal: Expert opinion on investigational drugs 20100201
Title: Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice.
Journal: PloS one 20100101
Title: Association between transforming growth factor beta1 polymorphisms and atrial fibrillation in essential hypertensive subjects.
Journal: Journal of biomedical science 20100101
Title: Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study.
Journal: Arthritis research & therapy 20100101
Title: Clinical use of biomarkers of survival in pulmonary fibrosis.
Journal: Respiratory research 20100101
Title: Interstitial lung diseases in children.
Journal: Orphanet journal of rare diseases 20100101
Title: Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management.
Journal: Arthritis research & therapy 20100101
Title: The multifaceted role of pirfenidone and its novel targets.
Journal: Fibrogenesis & tissue repair 20100101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100101
Title: Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study.
Journal: Cardiovascular diabetology 20100101
Title: Experimental models of duchenne muscular dystrophy: relationship with cardiovascular disease.
Journal: The open cardiovascular medicine journal 20100101
Title: Inflammatory cytokines and atrial fibrillation: current and prospective views.
Journal: Journal of inflammation research 20100101
Title: Alveolar macrophage dysregulation in Hermansky-Pudlak syndrome type 1.
Journal: American journal of respiratory and critical care medicine 20091201
Title: Fibrogenesis in kidney transplantation: potential targets for prevention and therapy.
Journal: Transplantation 20091127
Title: Pirfenidone inhibits carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents by preventing activation of hepatic stellate cells.
Journal: Clinical and experimental pharmacology & physiology 20091001
Title: Pirfenidone: a potential therapeutic option in the treatment of liver fibrosis.
Journal: Clinical and experimental pharmacology & physiology 20091001
Title: Fluorofenidone attenuates collagen I and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells.
Journal: Nephrology (Carlton, Vic.) 20090901
Title: Pirfenidone inhibits T-cell activation, proliferation, cytokine and chemokine production, and host alloresponses.
Journal: Transplantation 20090815
Title: Effects of pirfenidone on proliferation, migration, and collagen contraction of human Tenon's fibroblasts in vitro.
Journal: Investigative ophthalmology & visual science 20090801
Title: Effect of food and antacids on the pharmacokinetics of pirfenidone in older healthy adults.
Journal: Pulmonary pharmacology & therapeutics 20090801
Title: Pirfenidone is renoprotective in diabetic kidney disease.
Journal: Journal of the American Society of Nephrology : JASN 20090801
Title: Effects of intravenous administration of pirfenidone on horses with experimentally induced endotoxemia.
Journal: American journal of veterinary research 20090801
Title: [Pharmacological properties and clinical effects of the antifibrotic agent pirfenidone (Pirespa) for treatment of idiopathic pulmonary fibrosis].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20090801
Title: Recent advances in pharmacotherapy of atrial fibrillation.
Journal: Indian journal of pharmacology 20090801
Title: Recent advances in the treatment of systemic sclerosis.
Journal: Clinical reviews in allergy & immunology 20090601
Title: Established and newly proposed mechanisms of chronic cyclosporine nephropathy.
Journal: The Korean journal of internal medicine 20090601
Title: Advances in understanding of idiopathic pulmonary fibrosis.
Journal: Chinese medical journal 20090405
Title: Permutation test following covariate-adaptive randomization in randomized controlled trials.
Journal: Journal of biopharmaceutical statistics 20090101
Title: Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis.
Journal: Respiratory research 20090101
Title: Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-beta and extracellular matrix proteins.
Journal: BMC gastroenterology 20090101
Title: Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model.
Journal: Radiation oncology (London, England) 20090101
Title: New developments in the therapy of pulmonary fibrosis.
Journal: Advances in pharmacology (San Diego, Calif.) 20090101
Title: The role of long-term doxycycline in patients of idiopathic pulmonaryfibrosis: The results of an open prospective trial.
Journal: Lung India : official organ of Indian Chest Society 20090101
Title: Optimal treatment for idiopathic pulmonary fibrosis.
Journal: Thorax 20081201
Title: Role of TGF-beta on cardiac structural and electrical remodeling.
Journal: Vascular health and risk management 20081201
Title: Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy.
Journal: Hepatology international 20081201
Title: Current and future anti-fibrotic therapies for chronic liver disease.
Journal: Clinics in liver disease 20081101
Title: Potent antioxidant role of pirfenidone in experimental cirrhosis.
Journal: European journal of pharmacology 20081024
Title: Fibrogenic polymorphisms (TGF-beta, PAI-1, AT) in Mexican patients with established liver fibrosis. Potential correlation with pirfenidone treatment.
Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20081001
Title: Do drugs that block transforming growth factor beta reduce posthaemorrhagic ventricular dilatation in a neonatal rat model?
Journal: Acta paediatrica (Oslo, Norway : 1992) 20080901
Title: Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
Journal: European journal of pharmacology 20080820
Title: Superoxide scavenging activity of pirfenidone-iron complex.
Journal: Biochemical and biophysical research communications 20080718
Title: Pharmacokinetics and clinical effects of pirfenidone administered intravenously in horses.
Journal: American journal of veterinary research 20080701
Title: Acute exacerbation of idiopathic pulmonary fibrosis: a systematic review.
Journal: European journal of internal medicine 20080601
Title: Effects of three anti-TNF-alpha drugs: etanercept, infliximab and pirfenidone on release of TNF-alpha in medium and TNF-alpha associated with the cell in vitro.
Journal: International immunopharmacology 20080501
Title: Protective effects of pirfenidone on D-galactosamine and lipopolysaccharide-induced acute hepatotoxicity in rats.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080401
Title: Pharmacokinetics and metabolism of intravenous pirfenidone in sheep.
Journal: Biopharmaceutics & drug disposition 20080301
Title: Pirfenidone inhibits the expression of HSP47 in TGF-beta1-stimulated human lung fibroblasts.
Journal: Life sciences 20080116
Title: Pirfenidone prevents capsular contracture after mammary implantation.
Journal: Aesthetic plastic surgery 20080101
Title: The role of aldosterone blockade in murine lupus nephritis.
Journal: Arthritis research & therapy 20080101
Title: Idiopathic pulmonary fibrosis.
Journal: Orphanet journal of rare diseases 20080101
Title: Aggressive juvenile fibromatosis of the paranasal sinuses: case report and brief review.
Journal: Journal of hematology & oncology 20080101
Title: p63 - Key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis.
Journal: Experimental and molecular pathology 20071201
Title: Single- and multiple-dose pharmacokinetics of pirfenidone, an antifibrotic agent, in healthy Chinese volunteers.
Journal: Journal of clinical pharmacology 20071001
Title: Do we have a pill for renal fibrosis?
Journal: Clinical journal of the American Society of Nephrology : CJASN 20070901
Title: Pirfenidone slows renal function decline in patients with focal segmental glomerulosclerosis.
Journal: Clinical journal of the American Society of Nephrology : CJASN 20070901
Title: Pirfenidone: a novel potential therapeutic agent in the management of chronic allograft rejection.
Journal: Transplantation proceedings 20070901
Title: Novel oral agents for multiple sclerosis.
Journal: Current neurology and neuroscience reports 20070501
Title: Phase I trial of pirfenidone in children with neurofibromatosis 1 and plexiform neurofibromas.
Journal: Pediatric neurology 20070501
Title: Idiopathic pulmonary fibrosis.
Journal: The Journal of the Association of Physicians of India 20070501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070401
Title: Pirfenidone inhibits TGF-beta expression in malignant glioma cells.
Journal: Biochemical and biophysical research communications 20070309
Title: A comparison of factors associated with collagen metabolism in different skeletal muscles from dystrophic (mdx) mice: impact of pirfenidone.
Journal: Muscle & nerve 20070201
Title: Influence of pirfenidone on airway hyperresponsiveness and inflammation in a Brown-Norway rat model of asthma.
Journal: Pulmonary pharmacology & therapeutics 20070101
Title: The role of PDGF in radiation oncology.
Journal: Radiation oncology (London, England) 20070101
Title: Accelerated variant of idiopathic pulmonary fibrosis: clinical behavior and gene expression pattern.
Journal: PloS one 20070101
Title: Oral pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study.
Journal: Radiation oncology (London, England) 20070101
Title: Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options.
Journal: Comparative hepatology 20070101
Title: Platelet-derived growth factor as a therapeutic target for systemic autoimmune diseases.
Journal: Drug target insights 20070101
Title: Simple determination of pirfenidone in rat plasma via high-performance liquid chromatography.
Journal: Biomedical chromatography : BMC 20061201
Title: Phase II trial of pirfenidone in adults with neurofibromatosis type 1.
Journal: Neurology 20061128
Title: A pilot study in patients with established advanced liver fibrosis using pirfenidone.
Journal: Gut 20061101
Title: Pirfenidone prevents the development of a vulnerable substrate for atrial fibrillation in a canine model of heart failure.
Journal: Circulation 20061017
Title: Pirfenidone modulates airway responsiveness, inflammation, and remodeling after repeated challenge.
Journal: American journal of respiratory cell and molecular biology 20060901
Title: Long-term administration of pirfenidone improves cardiac function in mdx mice.
Journal: Muscle & nerve 20060901
Title: Low dose pirfenidone suppresses transforming growth factor beta-1 and tissue inhibitor of metalloproteinase-1, and protects rats from lung fibrosis induced by bleomycina.
Journal: Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20060901
Title: Novel pirfenidone analogues: synthesis of pyridin-2-ones for the treatment of pulmonary fibrosis.
Journal: Archiv der Pharmazie 20060801
Title: Pirfenidone for the treatment of idiopathic pulmonary fibrosis.
Journal: Expert opinion on investigational drugs 20060701
Title: [Newly developed therapeutic drugs for idiopathic interstitial pneumonias].
Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20060610
Title: Promising pharmacologic innovations in treating pulmonary fibrosis.
Journal: Current opinion in pharmacology 20060601
Title: Current perspectives on the treatment of idiopathic pulmonary fibrosis.
Journal: Proceedings of the American Thoracic Society 20060601
Title: Pirfenidone: anti-fibrotic agent with a potential therapeutic role in the management of transplantation patients.
Journal: European journal of pharmacology 20060501
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: [Pulmonary fibrosis--a therapeutic dilemma?].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20060415
Title: Pirfenidone and chronic progressive obliterative airway disease.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060401
Title: Therapeutic management of idiopathic pulmonary fibrosis: an evidence-based approach.
Journal: Clinics in chest medicine 20060301
Title: EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts.
Journal: Respiratory research 20060101
Title: Pulmonary fibrosis in hermansky-pudlak syndrome. a case report and review.
Journal: Respiration; international review of thoracic diseases 20060101
Title: Sequential testing for efficacy in clinical trials with non-transient effects.
Journal: Statistics in medicine 20051115
Title: Poor choice of primary outcome in a clinical trial of pirfenidone in patients with IPF.
Journal: American journal of respiratory and critical care medicine 20051101
Title: The questionable efficacy of pirfenidone in IPF.
Journal: American journal of respiratory and critical care medicine 20051101
Title: Pirfenidone for the treatment of idiopathic pulmonary fibrosis: therapeutic potential prompts further investigation.
Journal: Expert opinion on investigational drugs 20051101
Title: Pirfenidone inhibits obliterative airway disease in mouse tracheal allografts.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20051001
Title: Pirfenidone inhibits inflammatory responses and ameliorates allograft injury in a rat lung transplant model.
Journal: The Journal of thoracic and cardiovascular surgery 20050901
Title: Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20050601
Title: Treatment of idiopathic pulmonary fibrosis: is there anything new?
Journal: Respirology (Carlton, Vic.) 20050601
Title: [Drug treatments for idiopathic pulmonary fibrosis].
Journal: Revue de pneumologie clinique 20050601
Title: The experimental agent pirfenidone reduces pro-fibrotic gene expression in a model of tacrolimus-induced nephrotoxicity.
Journal: The Journal of surgical research 20050515
Title: Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis.
Journal: American journal of respiratory and critical care medicine 20050501
Title: Is idiopathic pulmonary fibrosis now treatable?
Journal: American journal of respiratory and critical care medicine 20050501
Title: [Interstitial pneumonia].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20050501
Title: Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats.
Journal: The Journal of pharmacology and experimental therapeutics 20050401
Title: A double-blind, randomized, controlled study of oral pirfenidone for treatment of secondary progressive multiple sclerosis.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20050401
Title: Effect of pirfenidone on apoptosis-regulatory genes in chronic cyclosporine nephrotoxicity.
Journal: Transplantation 20050227
Title: Pirfenidone and candesartan ameliorate morphological damage in mild chronic anti-GBM nephritis in rats.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20050101
Title: Retardation of kidney failure -- applying principles to practice.
Journal: Annals of the Academy of Medicine, Singapore 20050101
Title: [Expectation of new treatments for idiopathic interstitial pneumonias].
Journal: Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20050101
Title: The novel antifibrotic agent pirfenidone attenuates the profibrotic environment generated by calcineurin inhibitors in the rat salt-depletion model.
Journal: Transplantation proceedings 20050101
Title: Primary progressive multiple sclerosis : current and future treatment options.
Journal: CNS drugs 20050101
Title: Expression of HSP47 in usual interstitial pneumonia and nonspecific interstitial pneumonia.
Journal: Respiratory research 20050101
Title: Symptomatic and disease-modifying therapies for multiple sclerosis: recent developments: highlights of the 9th Annual Meeting of the Americas Committee for Treatment and Research in Multiple Sclerosis, October 3, 2004, Toronto, Ontario, Canada.
Journal: Reviews in neurological diseases 20050101
Title: Effects of topical application of pirfenidone ointment on thermoplasty-induced acute lameness in a double-blind and acute and chronic lameness of musculoskeletal origin in an open multi-centered field trial in horses.
Journal: Research communications in molecular pathology and pharmacology 20050101
Title: Transforming growth factor-beta: a clinical target for the treatment of diabetic nephropathy.
Journal: Current diabetes reports 20041201
Title: Pirfenidone inhibits the induction of iNOS stimulated by interleukin-1beta at a step of NF-kappaB DNA binding in hepatocytes.
Journal: Journal of hepatology 20041101
Title: The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen alpha1(I), TIMP-1 and MMP-2.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20041101
Title: Pharmacokinetics of orally administered pirfenidone in male and female beagles.
Journal: Journal of veterinary pharmacology and therapeutics 20041001
Title: Pirfenidone protects endotoxin-induced liver injury after hepatic ischemia in rats.
Journal: Transplantation proceedings 20040901
Title: Effects of pirfenidone on endotoxin-induced liver injury after partial hepatectomy in rats.
Journal: Transplantation proceedings 20040901
Title: Effect of pirfenidone on induction of chemokines in rat hepatocytes.
Journal: Transplantation proceedings 20040901
Title: Idiopathic pulmonary fibrosis: emerging concepts on pharmacotherapy.
Journal: Expert opinion on pharmacotherapy 20040801
Title: Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis.
Journal: The European respiratory journal 20040701
Title: Potential nonhormonal therapeutics for medical treatment of leiomyomas.
Journal: Seminars in reproductive medicine 20040501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040501
Title: Pirfenidone inhibits obliterative airway disease in a murine heterotopic tracheal transplant model.
Journal: Transplantation 20040315
Title: New perspectives in treatment of glomerulonephritis.
Journal: Pediatric nephrology (Berlin, Germany) 20040301
Title: Amelioration of doxorubicin-induced cardiac and renal toxicity by pirfenidone in rats.
Journal: Cancer chemotherapy and pharmacology 20040201
Title: Pirfenidone.
Journal: IDrugs : the investigational drugs journal 20040201
Title: Pirfenidone prevents endotoxin-induced liver injury after partial hepatectomy in rats.
Journal: Journal of hepatology 20040101
Title: Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches.
Journal: Drugs 20040101
Title: Prevention of progressive fibrosis in chronic renal diseases: antifibrotic agents.
Journal: Journal of nephrology 20040101
Title: Antirheumatic effect of pirfenidone in a double blind clinical pilot trial in humans.
Journal: Research communications in molecular pathology and pharmacology 20040101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20031201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20031101
Title: Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030901
Title: Desmoid tumors in familial adenomatous polyposis: a pilot project evaluating efficacy of treatment with pirfenidone.
Journal: The American journal of gastroenterology 20030801
Title: Pirfenidone suppressed the development of glomerulosclerosis in the FGS/Kist mouse.
Journal: Journal of Korean medical science 20030801
Title: Open-label study of pirfenidone in patients with progressive forms of multiple sclerosis.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20030601
Title: Inhibition of experimental acute pulmonary inflammation by pirfenidone.
Journal: Pulmonary pharmacology & therapeutics 20030101
Title: Modulation of articular chondrocyte activity by pirfenidone.
Journal: Research communications in molecular pathology and pharmacology 20030101
Title: Pirfenidone effectively reverses experimental liver fibrosis.
Journal: Journal of hepatology 20021201
Title: Open-label compassionate use one year-treatment with pirfenidone to patients with chronic pulmonary fibrosis.
Journal: Internal medicine (Tokyo, Japan) 20021201
Title: Pirfenidone attenuates ischaemia-reperfusion injury in the rat small intestine.
Journal: Clinical and experimental pharmacology & physiology 20021101
Title: Effect of pirfenidone on rat hepatic stellate cell proliferation and collagen production.
Journal: Journal of hepatology 20021101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20021101
Title: [Treatment of pulmonary fibrosis].
Journal: Presse medicale (Paris, France : 1983) 20021019
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20021001
Title: From anti-inflammatory drugs through antifibrotic agents to lung transplantation: a long road of research, clinical attempts, and failures in the treatment of idiopathic pulmonary fibrosis.
Journal: Chest 20020901
Title: Effect of pirfenidone against vanadate-induced kidney fibrosis in rats.
Journal: Biochemical pharmacology 20020801
Title: Pirfenidone inhibits early neointimal proliferation following arterial injury.
Journal: Transplantation proceedings 20020801
Title: Pharmacokinetics and metabolism of a novel antifibrotic drug pirfenidone, in mice following intravenous administration.
Journal: Biopharmaceutics & drug disposition 20020701
Title: Effect of pirfenidone on the pulmonary fibrosis of Hermansky-Pudlak syndrome.
Journal: Molecular genetics and metabolism 20020701
Title: Pirfenidone suppresses tumor necrosis factor-alpha, enhances interleukin-10 and protects mice from endotoxic shock.
Journal: European journal of pharmacology 20020620
Title: A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level.
Journal: European journal of pharmacology 20020620
Title: Pirfenidone blocks the in vitro and in vivo effects of staphylococcal enterotoxin B.
Journal: Infection and immunity 20020601
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Pirfenidone inhibits early myointimal proliferation but has no effect on late lesion size in rats.
Journal: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20020301
Title: Retinoic acid exacerbates experimental radiation nephropathy.
Journal: Radiation research 20020201
Title: Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats.
Journal: British journal of pharmacology 20020201
Title: Pirfenidone treatment decreases transforming growth factor-beta1 and matrix proteins and ameliorates fibrosis in chronic cyclosporine nephrotoxicity.
Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20020201
Title: Growth factors in idiopathic pulmonary fibrosis: relative roles.
Journal: Respiratory research 20020101
Title: Pirfenidone in the treatment of primary sclerosing cholangitis.
Journal: Digestive diseases and sciences 20020101
Title: Pirfenidone: A novel anti-fibrotic agent and progressive chronic allograft rejection.
Journal: Pulmonary pharmacology & therapeutics 20020101
Title: Idiopathic pulmonary fibrosis: current and future treatment options.
Journal: American journal of respiratory medicine : drugs, devices, and other interventions 20020101
Title: Antifibrotic therapy for the treatment of pulmonary fibrosis.
Journal: The American journal of the medical sciences 20011001
Title: Pirfenidone for chronic progressive multiple sclerosis.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20011001
Title: Modulation of airway remodeling-associated mediators by the antifibrotic compound, pirfenidone, and the matrix metalloproteinase inhibitor, batimastat, during acute lung injury in mice.
Journal: European journal of pharmacology 20010824
Title: Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.
Journal: Clinical and experimental pharmacology & physiology 20010701
Title: Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats.
Journal: British journal of pharmacology 20010701
Title: A phase II trial of pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), a novel anti-fibrosing agent, in myelofibrosis with myeloid metaplasia.
Journal: British journal of haematology 20010701
Title: The balance between collagen synthesis and degradation in diffuse lung disease.
Journal: Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 20010301
Title: Effects of pirfenidone on vascular smooth muscle cell proliferation and intimal hyperplasia following arterial balloon injury.
Journal: Transplantation proceedings 20010101
Title: Pirfenidone reduces in vitro rat renal fibroblast activation and mitogenesis.
Journal: Journal of nephrology 20010101
Title: Burghardt I, et al. Pirfenidone inhibits TGF-beta expression in malignant glioma cells. Biochem Biophys Res Commun. 2007 Mar 9;354(2):542-7.
Title: Nakazato H, et al. A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level. Eur J Pharmacol. 2002 Jun 20;446(1-3):177-85.
Title: Yang Y, et al. Inhibition of Pirfenidone on TGF-beta2 induced proliferation, migration and epithlial-mesenchymal transitionof human lens epithelial cells line SRA01/04. PLoS One. 2013;8(2):e56837.
Title: Inomata M, et al. Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis. Respir Res. 2014 Feb 8;15:16.
Title: Brooks D, et al. Limited fibrosis accompanies triple-negative breast cancer metastasis in multiple model systems and is not a preventive target. Oncotarget. 2018 May 4;9(34):23462-23481.
