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53598-01-9,MFCD00216150
Catalog No.:AA003SYT

53598-01-9 | NG-HydroXy-L-arginine Monoacetate

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10mg
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25mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003SYT
Chemical Name:
NG-HydroXy-L-arginine Monoacetate
CAS Number:
53598-01-9
Molecular Formula:
C8H18N4O5
Molecular Weight:
250.2523
MDL Number:
MFCD00216150
SMILES:
[O-]C(=O)C.ONC(=N)NCCC[C@@H](C(=O)O)[NH3+]
Properties
Properties
 
Form:
Solid  
MP:
>175°C (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
225  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
6  

Literature

Title: Cells derived from normal or cancer breast tissue exhibit different growth properties when deprived of arginine.

Journal: Medical oncology (Northwood, London, England) 20121201

Title: Electron paramagnetic resonance characterization of tetrahydrobiopterin radical formation in bacterial nitric oxide synthase compared to mammalian nitric oxide synthase.

Journal: Biophysical journal 20120703

Title: Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes.

Journal: American journal of physiology. Heart and circulatory physiology 20110301

Title: Competition of NO synthases and arginase in the airways hyperreactivity.

Journal: General physiology and biophysics 20110301

Title: Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC).

Journal: The Biochemical journal 20110115

Title: Comparison of wild type neuronal nitric oxide synthase and its Tyr588Phe mutant towards various L-arginine analogues.

Journal: Journal of inorganic biochemistry 20101001

Title: Species differences in expression pattern of arginase isoenzymes and differential effects of arginase inhibition on collagen synthesis in human and rat pulmonary fibroblasts.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100401

Title: Time course of desflurane-induced preconditioning in rabbits.

Journal: Journal of cardiothoracic and vascular anesthesia 20100201

Title: Single crystal structural and absorption spectral characterizations of nitric oxide synthase complexed with N(omega)-hydroxy-L-arginine and diatomic ligands.

Journal: Biochemistry 20091103

Title: EPR and ENDOR characterization of the reactive intermediates in the generation of NO by cryoreduced oxy-nitric oxide synthase from Geobacillus stearothermophilus.

Journal: Journal of the American Chemical Society 20091014

Title: Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.

Journal: British journal of haematology 20090501

Title: 4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase.

Journal: Bioorganic & medicinal chemistry letters 20090315

Title: The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries.

Journal: British journal of pharmacology 20090101

Title: Nitric oxide, N omega-hydroxy-L-arginine and breast cancer.

Journal: Nitric oxide : biology and chemistry 20080901

Title: Thermodynamic analysis of L-arginine and N omega-hydroxy-L-arginine binding to nitric oxide synthase.

Journal: Biochimica et biophysica acta 20080501

Title: Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles.

Journal: The Journal of physiology 20080215

Title: Synthetic approaches to N(delta)-methylated L-arginine, N(omega)-hydroxy-L-arginine, L-citrulline, and N(delta)-cyano-L-ornithine.

Journal: The Journal of organic chemistry 20080201

Title: Effect of NO-synthase and arginase inhibition in airway hyperreactivity.

Journal: Bratislavske lekarske listy 20080101

Title: Diabetic urethropathy compounds the effects of diabetic cystopathy.

Journal: The Journal of urology 20071101

Title: Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase.

Journal: Journal of the American Chemical Society 20070530

Title: Possible involvement of enhanced arginase activity due to up-regulated arginases and decreased hydroxyarginine in accelerating intimal hyperplasia with hyperglycemia.

Journal: Vascular pharmacology 20070101

Title: Reduction of Nomega-hydroxy-L-arginine to L-arginine by pig liver microsomes, mitochondria, and human liver microsomes.

Journal: Biochemical and biophysical research communications 20061020

Title: Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20060901

Title: Inducible and neuronal nitric oxide synthases (NOS) have complementary roles in recovery sleep induction.

Journal: The European journal of neuroscience 20060901

Title: Discriminating formation of HNO from other reactive nitrogen oxide species.

Journal: Free radical biology & medicine 20060315

Title: Nitrosyl-heme structures of Bacillus subtilis nitric oxide synthase have implications for understanding substrate oxidation.

Journal: Biochemistry 20060227

Title: Capillary electrophoresis of the electrochemical oxidation products of Ng-hydroxy-l-arginine at physiological pH.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

Title: Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents.

Journal: European journal of pharmacology 20050615

Title: Role of the adventitia in the cyclic GMP-mediated relaxant effect of N-hydroxy-L-arginine in rat aorta.

Journal: Journal of vascular research 20050101

Title: Regulation of plant arginase by wounding, jasmonate, and the phytotoxin coronatine.

Journal: The Journal of biological chemistry 20041029

Title: Quantum chemical calculations of the NHA bound nitric oxide synthase active site: O2 binding and implications for the catalytic mechanism.

Journal: Journal of the American Chemical Society 20040825

Title: Nitration of a peptide phytotoxin by bacterial nitric oxide synthase.

Journal: Nature 20040506

Title: Distribution and properties of arginase in the salivary glands of four species of laboratory mammals.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20040401

Title: Modulation of intrinsic cavernous tone and nitric oxide production by arginase in rabbit corpus cavernosum.

Journal: The Journal of urology 20040101

Title: Expression of nitric oxide synthase and effect of substrate manipulation of the nitric oxide pathway in mouse ovarian follicles.

Journal: Human reproduction (Oxford, England) 20040101

Title: Arginase induction promotes Trypanosoma cruzi intracellular replication in Cruzipain-treated J774 cells through the activation of multiple signaling pathways.

Journal: European journal of immunology 20040101

Title: A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase.

Journal: The Journal of biological chemistry 20031121

Title: Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity.

Journal: Biochemistry 20031118

Title: Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20031101

Title: Cyanide binding study of neuronal nitric oxide synthase: effects of inhibitors and mutations at the substrate binding site.

Journal: Journal of inorganic biochemistry 20030501

Title: Microperoxidase 8 catalysed nitrogen oxides formation from oxidation of N-hydroxyguanidines by hydrogen peroxide.

Journal: European journal of biochemistry 20030101

Title: Implication of intercellular adhesion molecule-1 (ICAM-1) and serum N(G)-hydroxy-L-arginine (L-NHA) in the pathogenesis of systemic sclerosis.

Journal: The Egyptian journal of immunology 20030101

Title: Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta.

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: Caspase-8-mediated BID cleavage and release of mitochondrial cytochrome c during Nomega-hydroxy-L-arginine-induced apoptosis in MDA-MB-468 cells. Antagonistic effects of L-ornithine.

Journal: The Journal of biological chemistry 20021004

Title: EPR and ENDOR characterization of intermediates in the cryoreduced oxy-nitric oxide synthase heme domain with bound L-arginine or N(G)-hydroxyarginine.

Journal: Biochemistry 20020820

Title: Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells.

Journal: Circulation research 20020628

Title: Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites.

Journal: Parasite immunology 20020301

Title: Effects of arginase isoforms on NO Production by nNOS.

Journal: Nitric oxide : biology and chemistry 20020201

Title: Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines.

Journal: Carcinogenesis 20011101

Title: L-Arginine is not the limiting factor for nitric oxide synthesis by human alveolar macrophages in vitro.

Journal: The European respiratory journal 20011001

Title: Oxidation of N(omega)-hydroxyarginine analogues by NO-synthase: the simple, non amino acid N-butyl N'-hydroxyguanidine is almost as efficient an NO precursor as N(omega)-hydroxyarginine.

Journal: Journal of medicinal chemistry 20010927

Title: Classical and slow-binding inhibitors of human type II arginase.

Journal: Biochemistry 20010807

Title: X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase.

Journal: Journal of biochemistry 20010801

Title: Th1/Th2-regulated arginase availability modulates Leishmania infection.

Journal: Trends in parasitology 20010601

Title: Mechanism of nitric oxide synthase. Evidence that direct hydrogen atom abstraction from the O-H bond of NG-hydroxyarginine is not relevant to the mechanism.

Journal: Journal of the American Chemical Society 20010321

Title: Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase.

Journal: Biochemistry 20010306

Title: Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.

Journal: Chemical research in toxicology 20010201

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