Home Amines 54-96-6
54-96-6,MFCD00006401
Catalog No.:AA003ICP
54-96-6 | 3,4-Diaminopyridine
Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98+%
in stock  
$11.00   $8.00
- +
5g
98%
in stock  
$29.00   $20.00
- +
25g
98%
in stock  
$86.00   $60.00
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Q & A
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003ICP
Chemical Name:
3,4-Diaminopyridine
CAS Number:
54-96-6
Molecular Formula:
C5H7N3
Molecular Weight:
109.1292
MDL Number:
MFCD00006401
IUPAC Name:
pyridine-3,4-diamine
InChI:
InChI=1S/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8)
InChI Key:
OYTKINVCDFNREN-UHFFFAOYSA-N
SMILES:
Nc1cnccc1N
EC Number:
200-220-9
UNII:
RU4S6E2G0J
NSC Number:
521760
Properties
Computed Properties
 
Complexity:
74.1  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
109.064g/mol
Formal Charge:
0
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
109.132g/mol
Monoisotopic Mass:
109.064g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
64.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.5  

Synonyms
 
3,4 Diaminopyridine 
3,4-diaminopyridine 
Firdapse 
HY-14946 
L421 
SC-05267 
AB0014693 
AB1000895 
DB-011105 
LS-131135 
ST2413732 
TC-062692 
TL8003599 
Diamino-3,4 pyridine 
4CH-015905 
AM20070030 
FT-0614203 
ST50946583 
D10228 
M-3620 
76674-EP2305250A1 
76674-EP2308868A1 
006D401 
AC-907/34116043 
4,5-Diaminopyridine 
J-610017 
W-105592 
F0001-1409 
InChI=1/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8 
L89 
Nc1ccncc1N 
Firdapse (TN) 
Amifampridine phosphate 
3,4-diaminopyridin 
2,3-Diaminopyridine 
3,4-DAP 
Amifampridine [INN] 
pyridine-2,3-diamine 
Amifampridine [INN:BAN] 
C5H7N3 
3,4-Diaminopyridine, 98% 1g 
CID5918 
C5-H7-N3 
3,4-Diaminopyridine, 98% - 25G 25g 
A7127 
A7976 
SC10 
D1149 
C016361 
D000077770 
Dap 
452-58-4 
Zenas 
Pyridine, 3,4-diamino- 
UNII-RU4S6E2G0J 
Diamino-3,4-Pyridine 
3-amino-4-pyridinylamine 
amifampridine 
EINECS 200-220-9 
MFCD00006401 
NSC 521760 
BRN 0110232 
RU4S6E2G0J 
CHEMBL354077 
54-96-6 3,4-diaminopyridine 
OYTKINVCDFNREN-UHFFFAOYSA-N 
WT559 
NCGC00167560-01 
amifampridine phosphate 
DSSTox_CID_26715 
DSSTox_RID_81847 
DSSTox_GSID_46715 
3,4-Diaminopyridine, 98% 
amifampridin 
CAS-54-96-6 
SMR000752913 
3,4 Diaminopyridine 
3,4-diamine-pyridine 
Amifampridine [USAN:INN:BAN] 
Firdapse 
Pyridine,4-diamino- 
Amifampridine (INN) 
PubChem1295 
3,4-diamino pyridine 
3,4-diamino-pyridine 
ACMC-209lkh 
3,4-Diammoniopyridinium 
AC1L1LEX 
WLN: T6NJ CZ DZ 
4-DAP 
3,4-DIAMINOPYRIDINE 
SCHEMBL21273 
5-22-11-00266 (Beilstein Handbook Reference) 
KSC270S1P 
MLS001304911 
MLS001333181 
MLS001333182 
GTPL8032 
3,4-Diamino[3,4-b]pyridine 
DTXSID6046715 
AMPD00217 
pyridine-3,4-diamine 
CTK1H0917 
CHEBI:135948 
HMS2233K06 
ZINC164000 
ACN-S003268 
ACT01546 
ALBB-005969 
BCP22343 
KS-000002IW 
Amifampridin (3,4-Diaminopyridine) 
54-96-6 
Tox21_112555 
ANW-32223 
BBL013269 
BDBM50416493 
CD-463 
CL0116 
NSC521760 
SBB004341 
STK503647 
AKOS000672436 
Amifampridine 
Tox21_112555_1 
ACN-026994 
CM14022 
CS-2778 
LS00018 
MCULE-5478459845 
NSC-521760 
PS-9273 
QC-1804 
RP00483 
3,4-Pyridinediamine 
RTC-062692 
TRA0066361 
NCGC00167560-02 
AK-26114 
AN-41664 
BC222447 
BP-12781 
BR-26114 
D219 
HC150250 
Literature

Title: Complete reversal of Lambert-Eaton myasthenic syndrome synaptic impairment by the combined use of a K+ channel blocker and a Ca2+ channel agonist.

Journal: The Journal of physiology 20140815

Title: Ectopic uterine tissue as a chronic pain generator.

Journal: Neuroscience 20121206

Title: Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations.

Journal: Neurochemistry international 20121101

Title: Mutations in DPAGT1 cause a limb-girdle congenital myasthenic syndrome with tubular aggregates.

Journal: American journal of human genetics 20120713

Title: The safety profile of dalfampridine extended release in multiple sclerosis clinical trials.

Journal: Clinical therapeutics 20120501

Title: 3,4-Diaminopyridine improves neuromuscular transmission in a MuSK antibody-induced mouse model of myasthenia gravis.

Journal: Journal of neuroimmunology 20120401

Title: Recurrent COLQ mutation in congenital myasthenic syndrome.

Journal: Pediatric neurology 20120401

Title: The dynamic relationships between the three events that release individual Na⁺ ions from the Na⁺/K⁺-ATPase.

Journal: Nature communications 20120214

Title: Content variability of active drug substance in compounded oral 3,4-diaminopyridine products.

Journal: Journal of clinical pharmacy and therapeutics 20120201

Title: Clinical features in a series of fast channel congenital myasthenia syndrome.

Journal: Neuromuscular disorders : NMD 20120201

Title: Long-term disease history, clinical symptoms, health status, and healthcare utilization in patients suffering from Lambert Eaton myasthenic syndrome: Results of a patient interview survey in Germany.

Journal: Journal of medical economics 20120101

Title: Hypotension due to Chemotherapy in a Patient with Small Cell Lung Cancer and Lambert-Eaton Myasthenic Syndrome Undergoing Hemodialysis: A First Case Report.

Journal: Case reports in oncology 20120101

Title: Nervous System of Periplaneta americana Cockroach as a Model in Toxinological Studies: A Short Historical and Actual View.

Journal: Journal of toxicology 20120101

Title: The use of aminopyridines in neurological disorders.

Journal: Clinical neuropharmacology 20120101

Title: The Effects of K(+) Channel Blockade on Eccentric and Isotonic Twitch and Fatiguing Contractions in situ.

Journal: Frontiers in physiology 20120101

Title: [Aminopyridines for symptomatic treatment of multiple sclerosis].

Journal: Ugeskrift for laeger 20111212

Title: Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus.

Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20111201

Title: John Newsom-Davis: clinician-scientist and so much more.

Journal: Brain : a journal of neurology 20111201

Title: Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards subcommittee of the American Academy of Neurology.

Journal: Neurology 20111108

Title: Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization.

Journal: Bioorganic & medicinal chemistry 20111101

Title: One collective case of type A foodborne botulism in Corsica.

Journal: Clinical toxicology (Philadelphia, Pa.) 20111001

Title: Role of calcium-activated potassium channels in the genesis of 3,4-diaminopyridine-induced periodic contractions in isolated canine coronary artery smooth muscles.

Journal: The Journal of pharmacology and experimental therapeutics 20110901

Title: Autoimmune neuromuscular disorders.

Journal: Current neuropharmacology 20110901

Title: Autoimmune channelopathies of the nervous system.

Journal: Current neuropharmacology 20110901

Title: Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110817

Title: Single-pixel optical fluctuation analysis of calcium channel function in active zones of motor nerve terminals.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803

Title: Beneficial effect of albuterol in congenital myasthenic syndrome with epsilon-subunit mutations.

Journal: Muscle & nerve 20110801

Title: Pharmacotherapy of vestibular and ocular motor disorders, including nystagmus.

Journal: Journal of neurology 20110701

Title: Preclinical evaluation of caprylic acid-fractionated IgG antivenom for the treatment of Taipan (Oxyuranus scutellatus) envenoming in Papua New Guinea.

Journal: PLoS neglected tropical diseases 20110501

Title: Medical treatment for botulism.

Journal: The Cochrane database of systematic reviews 20110316

Title: Effects of 3-4 diaminopyridine (DAP) in motor neuron diseases.

Journal: Journal of clinical neuromuscular disease 20110301

Title: Treatment for Lambert-Eaton myasthenic syndrome.

Journal: The Cochrane database of systematic reviews 20110216

Title: A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function.

Journal: The Journal of biological chemistry 20110128

Title: Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells.

Journal: Journal of biomedical science 20110101

Title: Suramin inhibits the early effects of PLA(2) neurotoxins at mouse neuromuscular junctions: A twitch tension study.

Journal: Journal of venom research 20110101

Title: Pricing and reimbursement of orphan drugs: the need for more transparency.

Journal: Orphanet journal of rare diseases 20110101

Title: Update on treatment options for Lambert-Eaton myasthenic syndrome: focus on use of amifampridine.

Journal: Neuropsychiatric disease and treatment 20110101

Title: The neuromuscular activity of Micrurus pyrrhocryptus venom and its neutralization by commercial and specific coral snake antivenoms.

Journal: Journal of venom research 20110101

Title: Cerebellum and ocular motor control.

Journal: Frontiers in neurology 20110101

Title: Lambert-eaton myasthenic syndrome; pathogenesis, diagnosis, and therapy.

Journal: Autoimmune diseases 20110101

Title: Symptomatic relief of botulinum neurotoxin/a intoxication with aminopyridines: a new twist on an old molecule.

Journal: ACS chemical biology 20101217

Title: Orphan drugs. BioMarin Europe replies.

Journal: BMJ (Clinical research ed.) 20101207

Title: Orphan drugs. Regulation is flawed.

Journal: BMJ (Clinical research ed.) 20101207

Title: 3,4-diaminopyridine for the treatment of Lambert-Eaton myasthenic syndrome.

Journal: Expert review of clinical immunology 20101101

Title: 3,4-Diaminopyridinium 2-carboxy-4,6-dinitrophenolate.

Journal: Acta crystallographica. Section E, Structure reports online 20101101

Title: State of the art in hereditary muscle channelopathies.

Journal: Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 20101001

Title: Anharmonic vibrational analysis of 3,4-diaminopyridine and 3-aminopyridine by density functional theory calculations.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100901

Title: The price you pay.

Journal: Drug and therapeutics bulletin 20100901

Title: 3-D-QSAR and docking studies on the neuronal choline transporter.

Journal: Bioorganic & medicinal chemistry letters 20100815

Title: Guidelines for treatment of autoimmune neuromuscular transmission disorders.

Journal: European journal of neurology 20100701

Title: Lambert-Eaton myasthenic syndrome as a cause of persistent neuromuscular weakness after a mediastinoscopic biopsy -A case report-.

Journal: Korean journal of anesthesiology 20100701

Title: Mutations in MUSK causing congenital myasthenic syndrome impair MuSK-Dok-7 interaction.

Journal: Human molecular genetics 20100615

Title: 3,4-diaminopyridine safety in clinical practice: an observational, retrospective cohort study.

Journal: Journal of neurology 20100601

Title: Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions.

Journal: Neuropharmacology 20100601

Title: Current therapy for Lambert-Eaton myasthenic syndrome: development of 3,4-diaminopyridine phosphate salt as first-line symptomatic treatment.

Journal: Current medical research and opinion 20100601

Title: The effect of 3,4-diaminopyridine on the patients with hereditary pure cerebellar ataxia.

Journal: Journal of the neurological sciences 20100515

Title: Ephedrine treatment in congenital myasthenic syndrome due to mutations in DOK7.

Journal: Neurology 20100511

Title: The zinc-dependent protease activity of the botulinum neurotoxins.

Journal: Toxins 20100501

Title: [Lambert-Eaton myasthenic syndrome (LEMS)].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20100401

Title: Neuropharmacology of vestibular system disorders.

Journal: Current neuropharmacology 20100301

Title: 4-Amino-3-ammonio-pyridinium dinitrate.

Journal: Acta crystallographica. Section E, Structure reports online 20100301

Title: Quantification of 4-aminopyridine in plasma by capillary electrophoresis with electrokinetic injection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201

Title: Effect of pantoprazole and its interactions with vecuronium on the neuromuscular junction.

Journal: Indian journal of pharmacology 20100201

Title: Improvement of diaphragm and limb muscle isotonic contractile performance by K+ channel blockade.

Journal: Journal of neuroengineering and rehabilitation 20100101

Title: [Lambert-Eaton myasthenic syndrome associated with pulmonary squamous cell carcinoma and circulating anti-P/Q-type voltage-gated calcium channel antibody].

Journal: Rinsho shinkeigaku = Clinical neurology 20100101

Title: New methods for diagnosis and treatment of vestibular diseases.

Journal: F1000 medicine reports 20100101

Title: Eye disorders in patients with multiple sclerosis: natural history and management.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101

Title: Sensing the deadliest toxin: technologies for botulinum neurotoxin detection.

Journal: Toxins 20100101

Title: Gold and silver nanoparticles conjugated with heparin derivative possess anti-angiogenesis properties.

Journal: Nanotechnology 20091111

Title: 3,4-Diaminopyridine is more effective than placebo in a randomized, double-blind, cross-over drug study in LEMS.

Journal: Muscle & nerve 20091101

Title: {2,2'-[Pyridine-3,4-diylbis(nitrilo-methyl-idyne)]diphenolato}zinc(II).

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: Management of myasthenic conditions: nonimmune issues.

Journal: Current opinion in neurology 20091001

Title: 3,4-Diamino-pyridinium 4-nitro-benzoate-4-nitro-benzoic acid (1/1).

Journal: Acta crystallographica. Section E, Structure reports online 20090801

Title: Efficacy of 3,4-diaminopyridine and pyridostigmine in the treatment of Lambert-Eaton myasthenic syndrome: a randomized, double-blind, placebo-controlled, crossover study.

Journal: Clinical pharmacology and therapeutics 20090701

Title: Skeletal muscle contraction-induced vasodilator complement production is dependent on stimulus and contraction frequency.

Journal: American journal of physiology. Heart and circulatory physiology 20090701

Title: 3,4-Diamino-pyridinium hydrogen succinate.

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: Mutations in LAMB2 causing a severe form of synaptic congenital myasthenic syndrome.

Journal: Journal of medical genetics 20090301

Title: [Treatment approach to congenital myasthenic syndrome in a patient with acetylcholine receptor deficiency].

Journal: No to hattatsu = Brain and development 20090101

Title: [A case of Lambert-Eaton myasthenic syndrome with small cell lung cancer, treated with 3,4-diaminopyridine].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20090101

Title: 4-Amino-3-ammonio-pyridinium dichloride.

Journal: Acta crystallographica. Section E, Structure reports online 20090101

Title: [Pharmacotherapy of central oculomotor disorders].

Journal: Der Nervenarzt 20081201

Title: Long-lasting in vivo inotropic effects of the K(+) channel blocker 3,4-diaminopyridine during fatigue-inducing stimulation.

Journal: Muscle & nerve 20081201

Title: Therapeutic strategies in congenital myasthenic syndromes.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20081001

Title: Lambert-Eaton myasthenic syndrome: search for alternative autoimmune targets and possible compensatory mechanisms based on presynaptic calcium homeostasis.

Journal: Journal of neuroimmunology 20080915

Title: Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression.

Journal: Brain structure & function 20080901

Title: Mechanisms of neuromodulation as dissected using Sr2+ at motor nerve endings.

Journal: Journal of neurophysiology 20080601

Title: Onset dynamics of type A botulinum neurotoxin-induced paralysis.

Journal: Journal of pharmacokinetics and pharmacodynamics 20080601

Title: Inotropic effects of the K+ channel blocker 3,4-diaminopyridine on fatigued diaphragm muscle.

Journal: Respiratory physiology & neurobiology 20080101

Title: [Lambert-Eaton Myasthenic Syndrome associated with vocal cord carcinoma].

Journal: Revue neurologique 20080101

Title: L-type Ca2+ channel function is linked to dystrophin expression in mammalian muscle.

Journal: PloS one 20080101

Title: Autoantibodies in neuromuscular transmission disorders.

Journal: Annals of Indian Academy of Neurology 20080101

Title: [Successful treatment of a Lambert-Eaton myasthenic syndrome patient with 3,4-diaminopyridine].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20070810

Title: Beneficial effects of 3,4-diaminopyridine on positioning downbeat nystagmus in a circumscribed uvulo-nodular lesion.

Journal: Journal of neurology 20070801

Title: Childhood myasthenia: clinical subtypes and practical management.

Journal: Developmental medicine and child neurology 20070801

Title: Myasthenia gravis and Lambert-Eaton myasthenic syndrome in the same patient.

Journal: Muscle & nerve 20070701

Title: Potassium initiates vasodilatation induced by a single skeletal muscle contraction in hamster cremaster muscle.

Journal: The Journal of physiology 20070601

Title: Molecular docking study of the binding of aminopyridines within the K+ channel.

Journal: Journal of molecular modeling 20070501

Title: Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C.

Journal: The European journal of neuroscience 20070501

Title: The therapy of congenital myasthenic syndromes.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070401

Title: Stability studies of ionised and non-ionised 3,4-diaminopyridine: hypothesis of degradation pathways and chemical structure of degradation products.

Journal: Journal of pharmaceutical and biomedical analysis 20070104

Title: [Treatment of Lambert-Eaton syndrome with 3,4- diaminopyridine and pyridostigmine].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101

Title: Inotropic effects of the K+ channel blocker 3,4-diaminopyridine: differential responses of rat soleus and extensor digitorum longus.

Journal: IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society 20061201

Title: Altered diaphragm muscle action potentials in Zucker diabetic fatty (ZDF) rats.

Journal: Respiratory physiology & neurobiology 20060928

Title: Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine.

Journal: Neurology 20060912

Title: Extrusion of Ca2+ from mouse motor terminal mitochondria via a Na+-Ca2+ exchanger increases post-tetanic evoked release.

Journal: The Journal of physiology 20060801

Title: Pre- and post-synaptic abnormalities associated with impaired neuromuscular transmission in a group of patients with 'limb-girdle myasthenia'.

Journal: Brain : a journal of neurology 20060801

Title: Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment.

Journal: Pharmacology & therapeutics 20060701

Title: Available treatment options for the management of Lambert-Eaton myasthenic syndrome.

Journal: Expert opinion on pharmacotherapy 20060701

Title: Guidelines for the treatment of autoimmune neuromuscular transmission disorders.

Journal: European journal of neurology 20060701

Title: No benefit of 3,4-diaminopyridine in essential tremor: a placebo-controlled crossover study.

Journal: Neurology 20060613

Title: The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction.

Journal: The European journal of neuroscience 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Fetal exposure to 3,4-diaminopyridine in a pregnant woman with congenital myasthenia syndrome.

Journal: The Annals of pharmacotherapy 20060401

Title: [Fatigue and episodic exhaustion as a feature of multiple sclerosis].

Journal: Revue neurologique 20060301

Title: [Pathophysiology and treatment of fatigue in multiple sclerosis].

Journal: Revue neurologique 20060301

Title: NCAM 180 acting via a conserved C-terminal domain and MLCK is essential for effective transmission with repetitive stimulation.

Journal: Neuron 20050616

Title: Taicatoxin inhibits the calcium-dependent slow motility of mammalian outer hair cells.

Journal: Hearing research 20050501

Title: Treatment for Lambert-Eaton myasthenic syndrome.

Journal: The Cochrane database of systematic reviews 20050418

Title: Effect of 3,4-diaminopyridine on the postural control in patients with downbeat nystagmus.

Journal: Annals of the New York Academy of Sciences 20050401

Title: Cognitive deficits in aged rats correlate with levels of L-arginine, not with nNOS expression or 3,4-DAP-evoked transmitter release in the frontoparietal cortex.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050301

Title: Electrophysiological and pharmacological characterization of K+-currents in muscle fibres isolated from the ventral sucker of Fasciola hepatica.

Journal: Parasitology 20041201

Title: Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries.

Journal: Hypertension (Dallas, Tex. : 1979) 20040901

Title: Upbeat about downbeat nystagmus.

Journal: Neurology 20040824

Title: Effect of 3,4-diaminopyridine on the gravity dependence of ocular drift in downbeat nystagmus.

Journal: Neurology 20040824

Title: Determination of A 3,4-diaminopyridine in plasma by liquid chromatography with electrochemical detection using solid-phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040615

Title: Enhanced brain motor activity in patients with MS after a single dose of 3,4-diaminopyridine.

Journal: Neurology 20040608

Title: Distinct phenotypes of congenital acetylcholine receptor deficiency.

Journal: Neuromuscular disorders : NMD 20040601

Title: Paraneoplastic syndromes: when to suspect, how to confirm, and how to manage.

Journal: Journal of neurology, neurosurgery, and psychiatry 20040601

Title: Cure of experimental botulism and antibotulismic effect of toosendanin.

Journal: Acta pharmacologica Sinica 20040601

Title: Combination of variable frequency train stimulation and K+ channel blockade to augment skeletal muscle force.

Journal: IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society 20040601

Title: Dual effects of nitric oxide in the mouse forced swimming test: possible contribution of nitric oxide-mediated serotonin release and potassium channel modulation.

Journal: Pharmacology, biochemistry, and behavior 20040301

Title: Novel truncating RAPSN mutations causing congenital myasthenic syndrome responsive to 3,4-diaminopyridine.

Journal: Neuromuscular disorders : NMD 20040301

Title: Lambert-Eaton myasthenic syndrome.

Journal: Revue neurologique 20040201

Title: 3,4-DAP-evoked transmitter release in hippocampal slices of aged rats with impaired memory.

Journal: Brain research bulletin 20031215

Title: [Formulation and stability of hospital preparation of 3,4-diaminopyridine capsules].

Journal: Annales pharmaceutiques francaises 20031101

Title: Sternohyoid muscle fatigue properties of dy/dy dystrophic mice, an animal model of merosin-deficient congenital muscular dystrophy.

Journal: Pediatric research 20031001

Title: Lambert-eaton myasthenic syndrome: diagnosis and treatment.

Journal: Annals of the New York Academy of Sciences 20030901

Title: Wheel-running exercise alters rat diaphragm action potentials and their regulation by K+ channels.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20030801

Title: Potassium channels, the cerebellum, and treatment for downbeat nystagmus.

Journal: Neurology 20030722

Title: Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study.

Journal: Neurology 20030722

Title: Rational modelling of the voltage-dependent K+ channel inactivation by aminopyridines.

Journal: Biophysical chemistry 20030601

Title: Therapy in myasthenia gravis and Lambert-Eaton myasthenic syndrome.

Journal: Seminars in neurology 20030601

Title: The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats.

Journal: European journal of pharmacology 20030418

Title: Streptozotocin-diabetes alters action potentials in rat diaphragm.

Journal: Respiratory physiology & neurobiology 20030415

Title: Quantitative estimate of mitochondrial [Ca2+] in stimulated motor nerve terminals.

Journal: Cell calcium 20030301

Title: Membrane properties related to the firing behavior of zebrafish motoneurons.

Journal: Journal of neurophysiology 20030201

Title: Exacerbation of Lambert-Eaton myasthenic syndrome caused by an L-type Ca2+ channel antagonist.

Journal: Japanese heart journal 20030101

Title: Treatment for Lambert-Eaton myasthenic syndrome.

Journal: The Cochrane database of systematic reviews 20030101

Title: Effect of thymol on kinetic properties of Ca and K currents in rat skeletal muscle.

Journal: BMC pharmacology 20030101

Title: Raphé grafts and 3,4-diaminopyridine-evoked overflow of serotonin in the rat hippocampus after 5,7-dihydroxytryptamine lesions: evidence for 5-HT1A autoreceptors.

Journal: Neuroreport 20021028

Title: Analysis of the pressor response to the K+ channel inhibitor 4-aminopyridine.

Journal: European journal of pharmacology 20021011

Title: Preparation of 3,4-diaminopyridine microparticles by solvent-evaporation methods.

Journal: International journal of pharmaceutics 20020821

Title: Improvement of dy/dy dystrophic diaphragm by 3,4-diaminopyridine.

Journal: Muscle & nerve 20020701

Title: The nature of the receptor site for the reversible K+ channel blocking by aminopyridines.

Journal: Biophysical chemistry 20020410

Title: [Treatment of severe botulism with 3,4-diaminopyridine]].

Journal: Presse medicale (Paris, France : 1983) 20020406

Title: Potassium channel KV alpha1 subunit expression and function in human detrusor muscle.

Journal: The Journal of urology 20020401

Title: Action of Micrurus dumerilii carinicauda coral snake venom on the mammalian neuromuscular junction.

Journal: Toxicon : official journal of the International Society on Toxinology 20020201

Title: Activation thresholds of K(V), BK andCl(Ca) channels in smooth muscle cells in pial precapillary arterioles.

Journal: Journal of vascular research 20020101

Title: Role of K+ channels in L-6 myoblast migration.

Journal: Journal of muscle research and cell motility 20020101

Title: Aminopyridines for symptomatic treatment in multiple sclerosis.

Journal: The Cochrane database of systematic reviews 20020101

Title: [Lambert-Eaton myasthenic syndrome: diagnosis and treatment].

Journal: Clinical calcium 20011101

Title: Expression and function of native potassium channel [K(V)alpha1] subunits in terminal arterioles of rabbit.

Journal: The Journal of physiology 20010801

Title: [Quantitative evaluation of the effect of 3,4-diaminopyridine in a patient with Lambert-Eaton myasthenic syndrome using dynamic dynamometry].

Journal: Rinsho shinkeigaku = Clinical neurology 20010801

Title: Theoretical analysis of the molecular determinants responsible for the K(+) channel blocking by aminopyridines.

Journal: Biophysical chemistry 20010615

Title: Neuromuscular monitoring in myasthenic syndrome.

Journal: Anaesthesia 20010601

Title: Electrophysiological analysis of the neurotoxic action of a funnel-web spider toxin, delta-atracotoxin-HV1a, on insect voltage-gated Na+ channels.

Journal: The Journal of experimental biology 20010201

Title: Modulation of diaphragm action potentials by K(+) channel blockers.

Journal: Respiration physiology 20010201

Title: Validation of a CE assay for the analysis of isomeric aminopyridines and diaminopyridines.

Journal: Journal of pharmaceutical and biomedical analysis 20010201

Title: Neurogenic bladder in Lambert-Eaton myasthenic syndrome and its response to 3,4-diaminopyridine.

Journal: Journal of the neurological sciences 20010115

Title: [Proximal muscle weakness, depressed tendon reflexes and autonomic dysfunction: the Lambert-Eaton myasthenic syndrome].

Journal: Nederlands tijdschrift voor geneeskunde 20010113

Title: Development and validation of a capillary electrophoresis assay for the determination of 3,4-diaminopyridine and 4-aminopyridine including related substances.

Journal: Journal of chromatography. A 20010112

Title: Persistence of botulinum neurotoxin A demonstrated by sequential administration of serotypes A and E in rat EDL muscle.

Journal: Toxicon : official journal of the International Society on Toxinology 20010101

Title: Aminopyridines for symptomatic treatment in multiple sclerosis.

Journal: The Cochrane database of systematic reviews 20010101

Title: Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps.

Journal: Toxicon : official journal of the International Society on Toxinology 20001001

Title: Antagonism of botulinum toxin-induced muscle weakness by 3,4-diaminopyridine in rat phrenic nerve-hemidiaphragm preparations.

Journal: Toxicon : official journal of the International Society on Toxinology 19950401

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Additional Info:
Q & A