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54522-52-0,MFCD30478892
Catalog No.:AA00DB66

54522-52-0 | Methyl protodioscin

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Purity
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Price(USD)
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1mg
≥98%
in stock  
$52.00   $36.00
- +
5mg
≥98%
in stock  
$232.00   $162.00
- +
10mg
≥98%
in stock  
$409.00   $286.00
- +
100mg
98%
in stock  
$433.00   $303.00
- +
250mg
98%
in stock  
$812.00   $569.00
- +
1g
98%
in stock  
$1,955.00   $1,369.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DB66
Chemical Name:
Methyl protodioscin
CAS Number:
54522-52-0
Molecular Formula:
C52H86O22
Molecular Weight:
1063.2260
MDL Number:
MFCD30478892
SMILES:
OC[C@H]1O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H]3CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@H](C)[C@@](O4)(OC)CC[C@H](CO[C@@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O)C)C)C2)C)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O
Properties
Computed Properties
 
Complexity:
1920  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
74  
Hydrogen Bond Acceptor Count:
22  
Hydrogen Bond Donor Count:
12  
Rotatable Bond Count:
15  
Undefined Atom Stereocenter Count:
31  
XLogP3:
-0.7  

Literature

Title: Pharmacokinetics of methyl protodioscin in rats.

Journal: Die Pharmazie 20100501

Title: [Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100401

Title: [Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

Title: New thinking in the development of novel derivatization reagents for liquid chromatography-mass spectrometric detection.

Journal: Biomedical chromatography : BMC 20090101

Title: [Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

Title: Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20080401

Title: Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.

Journal: Analytica chimica acta 20070905

Title: Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.

Journal: Cancer letters 20060908

Title: Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines.

Journal: Steroids 20060901

Title: Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid.

Journal: The Journal of steroid biochemistry and molecular biology 20060701

Title: Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.

Journal: Organic letters 20060622

Title: [Study on chemical constituents in total saponin from Trigonella foenum-graecum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050901

Title: Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.

Journal: Cancer letters 20050628

Title: In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin.

Journal: Planta medica 20040301

Title: The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro.

Journal: Cancer investigation 20030601

Title: Total synthesis of methyl protodioscin: a potent agent with antitumor activity.

Journal: The Journal of organic chemistry 20030502

Title: Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.

Journal: Biological & pharmaceutical bulletin 20010201

Title: Bai Y, et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells. Pharmacogn Mag. 2014 Jul;10(39):318-24.

Title: Ma W, et al. Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels. Atherosclerosis. 2015 Apr;239(2):566-70.

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