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55-45-8,MFCD00055068
Catalog No.:AA00DGQN

55-45-8 | 4-(N-[3-CHLOROPHENYL]-CARBAMOYLOXY)-2-BUTYNYLTRIMETHYLAMMONIUM CHLORIDE

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10mg
≥98%
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$45.00   $31.00
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25mg
≥98%
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$82.00   $57.00
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50mg
≥98%
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$128.00   $89.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DGQN
Chemical Name:
4-(N-[3-CHLOROPHENYL]-CARBAMOYLOXY)-2-BUTYNYLTRIMETHYLAMMONIUM CHLORIDE
CAS Number:
55-45-8
Molecular Formula:
C14H18Cl2N2O2
Molecular Weight:
317.2109
MDL Number:
MFCD00055068
SMILES:
O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-]
Properties
Computed Properties
 
Complexity:
365  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  

Literature

Title: International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

Journal: Pharmacological reviews 20141001

Title: M-type potassium channels modulate Schaffer collateral-CA1 glutamatergic synaptic transmission.

Journal: The Journal of physiology 20120815

Title: The pharmacology of McN-A-343.

Journal: Pharmacology & therapeutics 20120801

Title: [Acetylcholine induces human detrusor muscle cell proliferation: molecular and pharmacological characterization].

Journal: Urologia 20120101

Title: Muscarinic receptor subtypes involved in regulation of colonic motility in mice: functional studies using muscarinic receptor-deficient mice.

Journal: European journal of pharmacology 20111116

Title: Investigation of gastrin-releasing peptide as a mediator for 5'-guanidinonaltrindole-induced compulsive scratching in mice.

Journal: Peptides 20110201

Title: Mutagenesis of nucleophilic residues near the orthosteric binding pocket of M1 and M2 muscarinic receptors: effect on the binding of nitrogen mustard analogs of acetylcholine and McN-A-343.

Journal: Molecular pharmacology 20101001

Title: Investigating the interaction of McN-A-343 with the M muscarinic receptor using its nitrogen mustard derivative and ACh mustard.

Journal: British journal of pharmacology 20100701

Title: Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.

Journal: The Journal of biological chemistry 20100618

Title: Investigating the interaction of McN-A-343 with the M2 muscarinic receptor using its nitrogen mustard derivative.

Journal: Biochemical pharmacology 20100401

Title: Properly substituted 1,4-dioxane nucleus favours the selective M3 muscarinic receptor activation.

Journal: Bioorganic & medicinal chemistry 20091215

Title: Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate.

Journal: Neuroscience letters 20090814

Title: The spinal muscarinic M(1) receptors and GABA(A) receptors contribute to the McN-A-343-induced antinociceptive effects during thermal stimulation of mice.

Journal: Journal of pharmacological sciences 20081201

Title: Use of acetylcholine mustard to study allosteric interactions at the M(2) muscarinic receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20081101

Title: A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

Journal: The Journal of biological chemistry 20081024

Title: Antagonist of M1 muscarinic acetylcholine receptor prevents neurotoxicity induced by amphetamine via nitric oxide pathway.

Journal: Annals of the New York Academy of Sciences 20081001

Title: Resveratrol inhibits nicotinic stimulation-evoked catecholamine release from the adrenal medulla.

Journal: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20080801

Title: N-desmethylclozapine an M1 receptor agonist enhances nitric oxide's cardiac vagal facilitation in the isolated innervated rat right atrium.

Journal: Autonomic neuroscience : basic & clinical 20071230

Title: Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.

Journal: Bioorganic & medicinal chemistry 20071215

Title: Influence of polyphenolic compounds isolated from Rubus coreanum on catecholamine release in the rat adrenal medulla.

Journal: Archives of pharmacal research 20071001

Title: Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.

Journal: Molecular pharmacology 20070801

Title: Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.

Journal: The Journal of pharmacology and experimental therapeutics 20070601

Title: Differential development of carbachol-induced desensitization in receptor-mediated Ca2+ influx and Ca2+ release pathways in smooth muscle of guinea-pig taenia caeci.

Journal: Clinical and experimental pharmacology & physiology 20070301

Title: Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors.

Journal: Molecular pharmacology 20060801

Title: Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors.

Journal: Autonomic & autacoid pharmacology 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Differential Rho-kinase dependency of full and partial muscarinic receptor agonists in airway smooth muscle contraction.

Journal: British journal of pharmacology 20060401

Title: Muscarinic suppression in stratum radiatum of CA1 shows dependence on presynaptic M1 receptors and is not dependent on effects at GABA(B) receptors.

Journal: Neurobiology of learning and memory 20060301

Title: Pharmacological characterization of muscarinic receptor subtypes mediating vasoconstriction of human umbilical vein.

Journal: British journal of pharmacology 20060301

Title: Arecoline inhibits catecholamine release from perfused rat adrenal gland.

Journal: Acta pharmacologica Sinica 20060101

Title: Behavioral and neurochemical alterations following thiamine deficiency in rodents: relationship to functions of cholinergic neurons.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050701

Title: Protein kinase A and Ca(v)1 (L-Type) channels are common targets to facilitatory adenosine A2A and muscarinic M1 receptors on rat motoneurons.

Journal: Neuro-Signals 20050101

Title: Intrathecal clonidine inhibits mechanical allodynia via activation of the spinal muscarinic M1 receptor in streptozotocin-induced diabetic mice.

Journal: European journal of pharmacology 20041128

Title: Influence of lobeline on catecholamine release from the isolated perfused rat adrenal gland.

Journal: Autonomic neuroscience : basic & clinical 20040130

Title: Cotinine inhibits catecholamine release evoked by cholinergic stimulation from the rat adrenal medulla.

Journal: Archives of pharmacal research 20030901

Title: Receptor signaling mechanisms underlying muscarinic agonist-evoked contraction in guinea-pig ileal longitudinal smooth muscle.

Journal: British journal of pharmacology 20030501

Title: Inhibitory mechanism of bromocriptine on catecholamine release evoked by cholinergic stimulation and membrane depolarization from the rat adrenal medulla.

Journal: Archives of pharmacal research 20020801

Title: Altered cardiovascular responses in mice lacking the M(1) muscarinic acetylcholine receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20020401

Title: The spinal antinociceptive effects of cholinergic drugs in rats: receptor subtype specificity in different nociceptive tests.

Journal: BMC pharmacology 20020101

Title: Alteration of cardiovascular and neuronal function in M1 knockout mice.

Journal: Life sciences 20010427

Title: Effects of brucine, a plant alkaloid, on M(1) muscarinic receptors and alpha(1)-adrenoceptors in the rabbit vas deferens preparation.

Journal: Toxicon : official journal of the International Society on Toxinology 20010401

Title: Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors.

Journal: The Journal of pharmacy and pharmacology 20010401

Title: Infralimbic muscarinic M1 receptors modulate anxiety-like behaviour and spontaneous working memory in mice.

Journal: Psychopharmacology 20010401

Title: Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra-amines.

Journal: British journal of pharmacology 20010301

Title: Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

Journal: Neuroscience 20010101

Title: Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.

Journal: Molecular pharmacology 19970701

Title: Human muscarinic receptors expressed in A9L and CHO cells: activation by full and partial agonists.

Journal: British journal of pharmacology 19950301

Title: Application of transfected cell lines in studies of functional receptor subtype selectivity of muscarinic agonists.

Journal: The Journal of pharmacology and experimental therapeutics 19930701

Title: New functionally selective muscarinic agonists.

Journal: Life sciences 19930101

Title: Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells.

Journal: The Journal of pharmacology and experimental therapeutics 19890201

Title: The effect of misoprostol on base-line and stimulated acid secretion and on gastrin and histamine release in the totally isolated, vascularly perfused rat stomach.

Journal: Scandinavian journal of gastroenterology 19880801

Title: Binding and functional profiles of the selective M1 muscarinic receptor antagonists trihexyphenidyl and dicyclomine.

Journal: British journal of pharmacology 19860901

Title: Subclassification of muscarinic receptors in the heart, urinary bladder and sympathetic ganglia in the pithed rat. Selectivity of some classical agonists.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19851201

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Tags:55-45-8 Molecular Formula|55-45-8 MDL|55-45-8 SMILES|55-45-8 4-(N-[3-CHLOROPHENYL]-CARBAMOYLOXY)-2-BUTYNYLTRIMETHYLAMMONIUM CHLORIDE